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Protein

Ig lambda-1 chain C region

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

The MOPC-315 cell line produces 2 light chains, 1 normal lambda-2 chain and 1 abnormal lambda-1 chain that is missing a large part of the V region. The C region sequence (shown here) appears completely normal.

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig lambda-1 chain C region
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153608‹1 – 105Ig lambda-1 chain C regionAdd BLAST›105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 86
Disulfide bondi104Interchain (with heavy chain)

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP01843.
MaxQBiP01843.
PeptideAtlasiP01843.
PRIDEiP01843.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Ighg1P018682EBI-7139621,EBI-7139648

Protein-protein interaction databases

IntActiP01843. 1 interactor.
MINTiMINT-231225.

Structurei

Secondary structure

1105
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi15 – 18Combined sources4
Turni19 – 21Combined sources3
Beta strandi22 – 35Combined sources14
Beta strandi38 – 43Combined sources6
Beta strandi46 – 48Combined sources3
Beta strandi52 – 54Combined sources3
Beta strandi58 – 60Combined sources3
Turni61 – 63Combined sources3
Beta strandi64 – 74Combined sources11
Helixi75 – 80Combined sources6
Beta strandi84 – 90Combined sources7
Beta strandi93 – 99Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JN6X-ray2.70A1-100[»]
1JNHX-ray2.85A/C/E/G1-100[»]
ProteinModelPortaliP01843.
SMRiP01843.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01843.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 100Ig-likeAdd BLAST95

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

HOVERGENiHBG039526.
OMAiTDFYPGV.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

P01843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QPKSSPSVTL FPPSSEELET NKATLVCTIT DFYPGVVTVD WKVDGTPVTQ
60 70 80 90 100
GMETTQPSKQ SNNKYMASSY LTLTARAWER HSSYSCQVTH EGHTVEKSLS

RADCS
Length:105
Mass (Da):11,575
Last modified:July 21, 1986 - v1
Checksum:iA89F2B09BCFCA018
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti19 – 20ET → TE AA sequence (PubMed:5276767).Curated2
Sequence conflicti56Q → E AA sequence (PubMed:5276767).Curated1
Sequence conflicti75Missing AA sequence (PubMed:5276767).Curated1
Sequence conflicti81 – 82HS → SH AA sequence (PubMed:5276767).Curated2
Sequence conflicti85S → SS AA sequence (PubMed:5276767).Curated1
Sequence conflicti96E → Q AA sequence (PubMed:5276767).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00582 mRNA. Translation: AAA51636.1.
J00587 Genomic DNA. Translation: AAB59672.1.
PIRiA93922. L1MS.

Similar proteinsi

Entry informationi

Entry nameiLAC1_MOUSE
AccessioniPrimary (citable) accession number: P01843
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 27, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references