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Protein

Ig lambda-1 chain C region

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig lambda-1 chain C region
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153608‹1 – 105Ig lambda-1 chain C regionAdd BLAST›105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 86
Disulfide bondi104Interchain (with heavy chain)

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP01843.
MaxQBiP01843.
PeptideAtlasiP01843.
PRIDEiP01843.

Interactioni

Protein-protein interaction databases

MINTiMINT-231225.

Structurei

Secondary structure

1105
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi15 – 18Combined sources4
Turni19 – 21Combined sources3
Beta strandi22 – 35Combined sources14
Beta strandi38 – 43Combined sources6
Beta strandi46 – 48Combined sources3
Beta strandi52 – 54Combined sources3
Beta strandi58 – 60Combined sources3
Turni61 – 63Combined sources3
Beta strandi64 – 74Combined sources11
Helixi75 – 80Combined sources6
Beta strandi84 – 90Combined sources7
Beta strandi93 – 99Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JN6X-ray2.70A1-100[»]
1JNHX-ray2.85A/C/E/G1-100[»]
ProteinModelPortaliP01843.
SMRiP01843.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01843.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 100Ig-likeAdd BLAST95

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

HOVERGENiHBG039526.
OMAiTDFYPGV.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QPKSSPSVTL FPPSSEELET NKATLVCTIT DFYPGVVTVD WKVDGTPVTQ
60 70 80 90 100
GMETTQPSKQ SNNKYMASSY LTLTARAWER HSSYSCQVTH EGHTVEKSLS

RADCS
Length:105
Mass (Da):11,575
Last modified:July 21, 1986 - v1
Checksum:iA89F2B09BCFCA018
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti19 – 20ET → TE AA sequence (PubMed:5276767).Curated2
Sequence conflicti56Q → E AA sequence (PubMed:5276767).Curated1
Sequence conflicti75Missing AA sequence (PubMed:5276767).Curated1
Sequence conflicti81 – 82HS → SH AA sequence (PubMed:5276767).Curated2
Sequence conflicti85S → SS AA sequence (PubMed:5276767).Curated1
Sequence conflicti96E → Q AA sequence (PubMed:5276767).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00582 mRNA. Translation: AAA51636.1.
J00587 Genomic DNA. Translation: AAB59672.1.
PIRiA93922. L1MS.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00582 mRNA. Translation: AAA51636.1.
J00587 Genomic DNA. Translation: AAB59672.1.
PIRiA93922. L1MS.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JN6X-ray2.70A1-100[»]
1JNHX-ray2.85A/C/E/G1-100[»]
ProteinModelPortaliP01843.
SMRiP01843.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-231225.

Protein family/group databases

IMGTiSearch...
Search...

Proteomic databases

EPDiP01843.
MaxQBiP01843.
PeptideAtlasiP01843.
PRIDEiP01843.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG039526.
OMAiTDFYPGV.

Enzyme and pathway databases

ReactomeiR-MMU-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Miscellaneous databases

EvolutionaryTraceiP01843.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC1_MOUSE
AccessioniPrimary (citable) accession number: P01843
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The MOPC-315 cell line produces 2 light chains, 1 normal lambda-2 chain and 1 abnormal lambda-1 chain that is missing a large part of the V region. The C region sequence (shown here) appears completely normal.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.