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Protein

Ig lambda-1 chain C region

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig lambda-1 chain C region
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 105›105Ig lambda-1 chain C regionPRO_0000153608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 86
Disulfide bondi104 – 104Interchain (with heavy chain)

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP01843.
MaxQBiP01843.
PRIDEiP01843.

Interactioni

Protein-protein interaction databases

MINTiMINT-231225.

Structurei

Secondary structure

1
105
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 115Combined sources
Helixi15 – 184Combined sources
Turni19 – 213Combined sources
Beta strandi22 – 3514Combined sources
Beta strandi38 – 436Combined sources
Beta strandi46 – 483Combined sources
Beta strandi52 – 543Combined sources
Beta strandi58 – 603Combined sources
Turni61 – 633Combined sources
Beta strandi64 – 7411Combined sources
Helixi75 – 806Combined sources
Beta strandi84 – 907Combined sources
Beta strandi93 – 997Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JN6X-ray2.70A1-100[»]
1JNHX-ray2.85A/C/E/G1-100[»]
ProteinModelPortaliP01843.
SMRiP01843. Positions 1-102.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01843.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 10095Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

HOVERGENiHBG039526.
OMAiTDFYPGV.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QPKSSPSVTL FPPSSEELET NKATLVCTIT DFYPGVVTVD WKVDGTPVTQ
60 70 80 90 100
GMETTQPSKQ SNNKYMASSY LTLTARAWER HSSYSCQVTH EGHTVEKSLS

RADCS
Length:105
Mass (Da):11,575
Last modified:July 21, 1986 - v1
Checksum:iA89F2B09BCFCA018
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Sequence conflicti19 – 202ET → TE AA sequence (PubMed:5276767).Curated
Sequence conflicti56 – 561Q → E AA sequence (PubMed:5276767).Curated
Sequence conflicti75 – 751Missing AA sequence (PubMed:5276767).Curated
Sequence conflicti81 – 822HS → SH AA sequence (PubMed:5276767).Curated
Sequence conflicti85 – 851S → SS AA sequence (PubMed:5276767).Curated
Sequence conflicti96 – 961E → Q AA sequence (PubMed:5276767).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00582 mRNA. Translation: AAA51636.1.
J00587 Genomic DNA. Translation: AAB59672.1.
PIRiA93922. L1MS.
UniGeneiMm.326349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00582 mRNA. Translation: AAA51636.1.
J00587 Genomic DNA. Translation: AAB59672.1.
PIRiA93922. L1MS.
UniGeneiMm.326349.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JN6X-ray2.70A1-100[»]
1JNHX-ray2.85A/C/E/G1-100[»]
ProteinModelPortaliP01843.
SMRiP01843. Positions 1-102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-231225.

Protein family/group databases

IMGTiSearch...
Search...

Proteomic databases

EPDiP01843.
MaxQBiP01843.
PRIDEiP01843.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG039526.
OMAiTDFYPGV.

Miscellaneous databases

EvolutionaryTraceiP01843.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Dual expression of lambda genes in the MOPC-315 plasmacytoma."
    Bothwell A.L.M., Paskind M., Schwartz R.C., Sonenshein G.E., Gefter M.L., Baltimore D.
    Nature 290:65-67(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (MOPC 315).
  3. "Somatic variants of murine immunoglobulin lambda light chains."
    Bothwell A.L.M., Paskind M., Reth M., Imanishi-Kari T., Rajewsky K., Baltimore D.
    Nature 298:380-382(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (S43).
  4. "Amino acid sequences of two mouse immunoglobulin lambda chains."
    Appella E.
    Proc. Natl. Acad. Sci. U.S.A. 68:590-594(1971) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (MYELOMA PROTEIN MOPC 104E).

Entry informationi

Entry nameiLAC1_MOUSE
AccessioniPrimary (citable) accession number: P01843
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 11, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The MOPC-315 cell line produces 2 light chains, 1 normal lambda-2 chain and 1 abnormal lambda-1 chain that is missing a large part of the V region. The C region sequence (shown here) appears completely normal.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.