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Protein

Ig lambda-1 chain C region

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

The MOPC-315 cell line produces 2 light chains, 1 normal lambda-2 chain and 1 abnormal lambda-1 chain that is missing a large part of the V region. The C region sequence (shown here) appears completely normal.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Ig lambda-1 chain C region
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153608‹1 – 105Ig lambda-1 chain C regionAdd BLAST›105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 86
Disulfide bondi104Interchain (with heavy chain)

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP01843
MaxQBiP01843
PeptideAtlasiP01843
PRIDEiP01843

PTM databases

iPTMnetiP01843

Interactioni

Protein-protein interaction databases

MINTiP01843

Structurei

Secondary structure

1105
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi15 – 18Combined sources4
Turni19 – 21Combined sources3
Beta strandi22 – 35Combined sources14
Beta strandi38 – 43Combined sources6
Beta strandi46 – 48Combined sources3
Beta strandi52 – 54Combined sources3
Beta strandi58 – 60Combined sources3
Turni61 – 63Combined sources3
Beta strandi64 – 74Combined sources11
Helixi75 – 80Combined sources6
Beta strandi84 – 90Combined sources7
Beta strandi93 – 99Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JN6X-ray2.70A1-100[»]
1JNHX-ray2.85A/C/E/G1-100[»]
ProteinModelPortaliP01843
SMRiP01843
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01843

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 100Ig-likeAdd BLAST95

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

HOVERGENiHBG039526
OMAiTDFYPGV

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

P01843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QPKSSPSVTL FPPSSEELET NKATLVCTIT DFYPGVVTVD WKVDGTPVTQ
60 70 80 90 100
GMETTQPSKQ SNNKYMASSY LTLTARAWER HSSYSCQVTH EGHTVEKSLS

RADCS
Length:105
Mass (Da):11,575
Last modified:July 21, 1986 - v1
Checksum:iA89F2B09BCFCA018
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti19 – 20ET → TE AA sequence (PubMed:5276767).Curated2
Sequence conflicti56Q → E AA sequence (PubMed:5276767).Curated1
Sequence conflicti75Missing AA sequence (PubMed:5276767).Curated1
Sequence conflicti81 – 82HS → SH AA sequence (PubMed:5276767).Curated2
Sequence conflicti85S → SS AA sequence (PubMed:5276767).Curated1
Sequence conflicti96E → Q AA sequence (PubMed:5276767).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00582 mRNA Translation: AAA51636.1
J00587 Genomic DNA Translation: AAB59672.1
PIRiA93922 L1MS

Similar proteinsi

Entry informationi

Entry nameiLAC1_MOUSE
AccessioniPrimary (citable) accession number: P01843
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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