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P01837 (IGKC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig kappa chain C region
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length106 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 106›106Ig kappa chain C region
PRO_0000153597

Regions

Domain5 – 10298Ig-like

Amino acid modifications

Disulfide bond26 ↔ 86 Ref.2
Disulfide bond106Interchain (with a heavy chain) Ref.2

Experimental info

Non-terminal residue11

Secondary structure

........................ 106
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01837 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 4B51FF5EF49BAEB5

FASTA10611,778
        10         20         30         40         50         60 
ADAAPTVSIF PPSSEQLTSG GASVVCFLNN FYPKDINVKW KIDGSERQNG VLNSWTDQDS 

        70         80         90        100 
KDSTYSMSST LTLTKDEYER HNSYTCEATH KTSTSPIVKS FNRNEC 

« Hide

References

[1]"The complete amino acid sequence of a mouse kappa light chain."
Svasti J., Milstein C.
Biochem. J. 128:427-444(1972) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE (MOPC 21).
[2]"The disulphide bridges of a mouse immunoglobulin G1 protein."
Svasti J., Milstein C.
Biochem. J. 126:837-850(1972) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BONDS (MOPC 21).
[3]"Complete sequence of constant and 3' noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing."
Hamlyn P.H., Brownlee G.G., Cheng C.-C., Gait M.J., Milstein C.
Cell 15:1067-1075(1978) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION TO 53-59.
[4]"Complete sequence of an immunoglobulin mRNA using specific priming and the dideoxynucleotide method of RNA sequencing."
Hamlyn P.H., Gait M.J., Milstein C.
Nucleic Acids Res. 9:4485-4494(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes."
Max E.E., Maizel J.V. Jr., Leder P.
J. Biol. Chem. 256:5116-5120(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"DNA sequence of the constant gene region of the mouse immunoglobulin kappa chain."
Altenburger W., Neumaier P.S., Steinmetz M., Zachau H.G.
Nucleic Acids Res. 9:971-981(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"Expression in non-lymphoid cells of mouse recombinant immunoglobulin directed against the tumour marker human placental alkaline phosphatase."
de Waele P., Feys V., van de Voorde A., Molemans F., Fiers W.
Eur. J. Biochem. 176:287-295(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V00807 Genomic DNA. Translation: CAA24189.1.
PIRK1MS. B90262.
UniGeneMm.333124.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
15C8X-ray2.50L1-104[»]
1A0QX-ray2.30L1-105[»]
1A3LX-ray1.95L1-104[»]
1AHWX-ray3.00A1-106[»]
1AI1X-ray2.80L1-103[»]
1AIFX-ray2.90A/L1-106[»]
1C12X-ray2.60A1-105[»]
1CF8X-ray2.70L1-106[»]
1CFNX-ray2.65A1-106[»]
1CFQX-ray2.80A1-106[»]
1CFSX-ray2.75A1-106[»]
1CFTX-ray2.80A1-106[»]
1CICX-ray2.50A1-106[»]
1CK0X-ray2.50L1-103[»]
1CT8X-ray2.20A/C1-106[»]
1DQJX-ray2.00A1-106[»]
1DQMX-ray2.10L1-106[»]
1DQQX-ray1.80A/C1-106[»]
1E4WX-ray1.95L1-106[»]
1EHLX-ray2.40L1-105[»]
1EMTX-ray2.25L1-106[»]
1FAIX-ray2.70L1-106[»]
1FBIX-ray3.00L/P1-106[»]
1FDLX-ray2.50L1-106[»]
1FE8X-ray2.03L/M/N1-103[»]
1FJ1X-ray2.68A/C1-105[»]
1FL3X-ray2.45B/L1-102[»]
1FNSX-ray2.00L1-106[»]
1FRGX-ray2.80L1-103[»]
1FSKX-ray2.90B/E/H/K1-106[»]
1GPOX-ray1.95L/M1-106[»]
1I8MX-ray2.10A/L1-106[»]
1IGYX-ray3.20A/C1-106[»]
1JNLX-ray3.00L1-103[»]
1JNNX-ray3.20L1-103[»]
1JRHX-ray2.80L1-106[»]
1K4CX-ray2.00B1-104[»]
1K4DX-ray2.30B1-104[»]
1KB5X-ray2.50L1-106[»]
1KC5X-ray2.50L1-106[»]
1KCRX-ray2.90L1-106[»]
1KCSX-ray2.50L1-106[»]
1KCUX-ray2.20L1-106[»]
1KCVX-ray1.80L1-106[»]
1KENX-ray3.50L/U1-104[»]
1KNOX-ray3.20A/C/E1-106[»]
1LO0X-ray2.00L/X1-106[»]
1MF2X-ray2.60L/M1-103[»]
1MH5X-ray2.10A/L1-106[»]
1MLBX-ray2.10A1-106[»]
1MLCX-ray2.50A/C1-106[»]
1N5YX-ray3.10L1-103[»]
1N6QX-ray3.00L1-103[»]
1NBYX-ray1.80A1-106[»]
1NBZX-ray1.85A1-106[»]
1NDGX-ray1.90A1-106[»]
1NDMX-ray2.10A1-106[»]
1OAKX-ray2.20L1-104[»]
1OB1X-ray2.90A/D1-106[»]
1ORQX-ray3.20A1-106[»]
1ORSX-ray1.90A1-106[»]
1OSPX-ray1.95L1-106[»]
1OTSX-ray2.51D/F1-104[»]
1OTTX-ray3.00D/F1-104[»]
1OTUX-ray3.30D/F1-104[»]
1P2CX-ray2.00A/D1-104[»]
1P7KX-ray1.75A/L1-106[»]
1PSKX-ray2.80L1-106[»]
1Q9OX-ray1.79A/C1-106[»]
1Q9WX-ray1.75A/C1-106[»]
1QGCelectron microscopy30.0041-106[»]
1R0AX-ray2.80L1-103[»]
1R24X-ray3.10A/C1-98[»]
1R3IX-ray2.40L1-104[»]
1R3JX-ray1.90A1-104[»]
1R3KX-ray2.80A1-104[»]
1R3LX-ray2.41A1-104[»]
1RIHX-ray2.50L1-106[»]
1RUQX-ray1.86L1-104[»]
1RURX-ray1.50L1-104[»]
1S5HX-ray2.20A1-104[»]
1SEQX-ray1.78L1-106[»]
1T03X-ray3.10L1-103[»]
1T4KX-ray2.50C1-104[»]
1UB5X-ray2.00B/L1-101[»]
1UB6X-ray2.12B/L1-101[»]
1UWXX-ray2.20K/L1-105[»]
1XF2X-ray2.30A/L1-106[»]
1XF3X-ray2.30A/L1-106[»]
1XF4X-ray2.50A/L1-106[»]
1XGPX-ray2.10A1-106[»]
1XGQX-ray2.10A1-106[»]
25C8X-ray2.00L1-103[»]
2A6DX-ray2.90L1-106[»]
2A6KX-ray3.00A/L1-106[»]
2ADFX-ray1.90L1-102[»]
2ADJX-ray2.90A1-106[»]
2AJSX-ray1.70L1-103[»]
2AJUX-ray1.50L1-103[»]
2AJXX-ray1.85L1-103[»]
2AJYX-ray2.10L1-103[»]
2AJZX-ray2.30A/L1-103[»]
2AK1X-ray1.85L1-103[»]
2BOBX-ray2.76B1-104[»]
2BOCX-ray3.01B1-104[»]
2CK0X-ray2.20L1-103[»]
2F19X-ray2.80L1-106[»]
2FR4X-ray1.95A1-106[»]
2G5BX-ray2.30C/E/G1-104[»]
2H8PX-ray2.25B1-104[»]
2HG5X-ray2.75B1-104[»]
2HRPX-ray2.20L/M1-106[»]
2MPAX-ray2.60L8-12[»]
2NR6X-ray2.81C/E1-103[»]
2Q76X-ray2.00A/C1-104[»]
2R1WX-ray1.70A1-106[»]
2R1YX-ray1.60A1-106[»]
2R23X-ray1.65A1-106[»]
2R2BX-ray1.60A1-106[»]
2UYLX-ray2.50A/M/V/X1-106[»]
2V17X-ray1.65L1-106[»]
2V7HX-ray2.80A/L1-106[»]
2VC2X-ray3.10L1-106[»]
2VDKX-ray2.80L1-106[»]
2VDLX-ray2.75L1-106[»]
2VDMX-ray2.90L1-106[»]
2VDNX-ray2.90L1-106[»]
2VDOX-ray2.51L1-106[»]
2VDPX-ray2.80L1-106[»]
2VDQX-ray2.59L1-106[»]
2VDRX-ray2.40L1-106[»]
2VL5X-ray2.10B/D1-106[»]
2VQ1X-ray2.50A/E1-104[»]
2VWEX-ray3.40C/J1-106[»]
2W60X-ray1.50B1-104[»]
2W65X-ray2.21B/D1-104[»]
2W9DX-ray1.57L1-105[»]
2W9EX-ray2.90L1-105[»]
2Z91X-ray2.60B/D1-106[»]
2Z92X-ray2.30B1-106[»]
2Z93X-ray2.40B/D1-106[»]
2ZJSX-ray3.20L1-106[»]
35C8X-ray2.00L1-103[»]
3BAEX-ray1.59L1-105[»]
3BGFX-ray3.00C/L1-104[»]
3BKCX-ray1.90L1-106[»]
3BKJX-ray1.59L1-106[»]
3BKMX-ray1.60L1-106[»]
3BPCX-ray1.85A1-106[»]
3BQUX-ray3.00C1-103[»]
3BSZX-ray3.38L/M1-103[»]
3BT2X-ray2.50L1-106[»]
3BZ4X-ray1.80A/C/E/G1-106[»]
3C5SX-ray2.00A/C1-106[»]
3C6SX-ray1.80A/C/E/G1-106[»]
3CFBX-ray1.60A/L1-106[»]
3CFCX-ray1.70L1-106[»]
3CFDX-ray2.50A/L1-106[»]
3CFEX-ray2.99A/L1-106[»]
3CK0X-ray3.00L1-103[»]
3CLEX-ray2.50L1-106[»]
3CLFX-ray2.00L1-106[»]
3CMOX-ray2.30L/X1-103[»]
3CVHX-ray2.90L/R1-102[»]
3CVIX-ray1.80L1-102[»]
3D9AX-ray1.20L1-105[»]
3EOTX-ray1.90L1-106[»]
3HFMX-ray3.00L1-106[»]
6FABX-ray1.90L1-106[»]
ProteinModelPortalP01837.
SMRP01837. Positions 1-105.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP01837. 1 interaction.
MINTMINT-147676.

Protein family/group databases

IMGTSearch...

PTM databases

PhosphoSiteP01837.

Proteomic databases

PaxDbP01837.
PRIDEP01837.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:96495. Igk-C.

Phylogenomic databases

eggNOGNOG116969.
HOVERGENHBG039526.
InParanoidP01837.
OMASFNRNEC.
PhylomeDBP01837.

Enzyme and pathway databases

ReactomeREACT_98458. Immune System.

Gene expression databases

BgeeP01837.
GenevestigatorP01837.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01837.
PROP01837.

Entry information

Entry nameIGKC_MOUSE
AccessionPrimary (citable) accession number: P01837
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot