Ig kappa chain C region - Mus musculus (Mouse)

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P01837 (IGKC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 116. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names	Recommended name: Ig kappa chain C region
Organism	Mus musculus (Mouse) [Reference proteome]
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	106 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Domain	Immunoglobulin C region Immunoglobulin domain
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	plasma membrane Traceable author statement. Source: Reactome
Molecular_function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 106

›106

Ig kappa chain C region

PRO_0000153597

Regions

Domain

5 – 102

Ig-like

Amino acid modifications

Disulfide bond

26 ↔ 86

Ref.2

Disulfide bond

106

Interchain (with a heavy chain) Ref.2

Experimental info

Non-terminal residue

Secondary structure

106

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P01837 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 4B51FF5EF49BAEB5
Show »

FASTA

106

11,778

        10         20         30         40         50         60 
ADAAPTVSIF PPSSEQLTSG GASVVCFLNN FYPKDINVKW KIDGSERQNG VLNSWTDQDS 

        70         80         90        100 
KDSTYSMSST LTLTKDEYER HNSYTCEATH KTSTSPIVKS FNRNEC

« Hide

References

[1]	"The complete amino acid sequence of a mouse kappa light chain." Svasti J., Milstein C. Biochem. J. 128:427-444(1972) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE (MOPC 21).
[2]	"The disulphide bridges of a mouse immunoglobulin G1 protein." Svasti J., Milstein C. Biochem. J. 126:837-850(1972) [PubMed] [Europe PMC] [Abstract] Cited for: DISULFIDE BONDS (MOPC 21).
[3]	"Complete sequence of constant and 3' noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing." Hamlyn P.H., Brownlee G.G., Cheng C.-C., Gait M.J., Milstein C. Cell 15:1067-1075(1978) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION TO 53-59.
[4]	"Complete sequence of an immunoglobulin mRNA using specific priming and the dideoxynucleotide method of RNA sequencing." Hamlyn P.H., Gait M.J., Milstein C. Nucleic Acids Res. 9:4485-4494(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes." Max E.E., Maizel J.V. Jr., Leder P. J. Biol. Chem. 256:5116-5120(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"DNA sequence of the constant gene region of the mouse immunoglobulin kappa chain." Altenburger W., Neumaier P.S., Steinmetz M., Zachau H.G. Nucleic Acids Res. 9:971-981(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"Expression in non-lymphoid cells of mouse recombinant immunoglobulin directed against the tumour marker human placental alkaline phosphatase." de Waele P., Feys V., van de Voorde A., Molemans F., Fiers W. Eur. J. Biochem. 176:287-295(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

V00807 Genomic DNA. Translation: CAA24189.1.

IPI

IPI00850020.

PIR

K1MS. B90262.

UniGene

Mm.333124.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
15C8	X-ray	2.50	L	1-104	[»]
1A0Q	X-ray	2.30	L	1-105	[»]
1A3L	X-ray	1.95	L	1-104	[»]
1AHW	X-ray	3.00	A	1-106	[»]
1AI1	X-ray	2.80	L	1-103	[»]
1AIF	X-ray	2.90	A/L	1-106	[»]
1C12	X-ray	2.60	A	1-105	[»]
1CF8	X-ray	2.70	L	1-106	[»]
1CK0	X-ray	2.50	L	1-103	[»]
1CT8	X-ray	2.20	A/C	1-106	[»]
1DQJ	X-ray	2.00	A	1-106	[»]
1DQM	X-ray	2.10	L	1-106	[»]
1DQQ	X-ray	1.80	A/C	1-106	[»]
1E4W	X-ray	1.95	L	1-106	[»]
1EMT	X-ray	2.25	L	1-106	[»]
1FAI	X-ray	2.70	L	1-106	[»]
1FBI	X-ray	3.00	L/P	1-106	[»]
1FDL	X-ray	2.50	L	1-106	[»]
1FE8	X-ray	2.03	L/M/N	1-103	[»]
1FJ1	X-ray	2.68	A/C	1-105	[»]
1FL3	X-ray	2.45	B/L	1-102	[»]
1FNS	X-ray	2.00	L	1-106	[»]
1FSK	X-ray	2.90	B/E/H/K	1-106	[»]
1GPO	X-ray	1.95	L/M	1-106	[»]
1I8M	X-ray	2.10	A/L	1-106	[»]
1IGY	X-ray	3.20	A/C	1-106	[»]
1JNL	X-ray	3.00	L	1-103	[»]
1JNN	X-ray	3.20	L	1-103	[»]
1JRH	X-ray	2.80	L	1-106	[»]
1K4C	X-ray	2.00	B	1-104	[»]
1K4D	X-ray	2.30	B	1-104	[»]
1KB5	X-ray	2.50	L	1-106	[»]
1KC5	X-ray	2.50	L	1-106	[»]
1KCR	X-ray	2.90	L	1-106	[»]
1KCS	X-ray	2.50	L	1-106	[»]
1KCU	X-ray	2.20	L	1-106	[»]
1KCV	X-ray	1.80	L	1-106	[»]
1KEN	X-ray	3.50	L/U	1-104	[»]
1KNO	X-ray	3.20	A/C/E	1-106	[»]
1LO0	X-ray	2.00	L/X	1-106	[»]
1MF2	X-ray	2.60	L/M	1-103	[»]
1MLB	X-ray	2.10	A	1-106	[»]
1MLC	X-ray	2.50	A/C	1-106	[»]
1N5Y	X-ray	3.10	L	1-103	[»]
1N6Q	X-ray	3.00	L	1-103	[»]
1NBY	X-ray	1.80	A	1-106	[»]
1NBZ	X-ray	1.85	A	1-106	[»]
1NDG	X-ray	1.90	A	1-106	[»]
1NDM	X-ray	2.10	A	1-106	[»]
1OAK	X-ray	2.20	L	1-104	[»]
1OB1	X-ray	2.90	A/D	1-106	[»]
1ORQ	X-ray	3.20	A	1-106	[»]
1ORS	X-ray	1.90	A	1-106	[»]
1OSP	X-ray	1.95	L	1-106	[»]
1P2C	X-ray	2.00	A/D	1-104	[»]
1P7K	X-ray	1.75	A/L	1-106	[»]
1PSK	X-ray	2.80	L	1-106	[»]
1Q9O	X-ray	1.79	A/C	1-106	[»]
1Q9W	X-ray	1.75	A/C	1-106	[»]
1R0A	X-ray	2.80	L	1-103	[»]
1R24	X-ray	3.10	A/C	1-98	[»]
1R3I	X-ray	2.40	L	1-104	[»]
1R3J	X-ray	1.90	A	1-104	[»]
1R3K	X-ray	2.80	A	1-104	[»]
1R3L	X-ray	2.41	A	1-104	[»]
1RIH	X-ray	2.50	L	1-106	[»]
1RUQ	X-ray	1.86	L	1-104	[»]
1RUR	X-ray	1.50	L	1-104	[»]
1S5H	X-ray	2.20	A	1-104	[»]
1SEQ	X-ray	1.78	L	1-106	[»]
1T03	X-ray	3.10	L	1-103	[»]
1T4K	X-ray	2.50	C	1-104	[»]
1UB6	X-ray	2.12	B/L	1-101	[»]
1UWX	X-ray	2.20	K/L	1-105	[»]
1XF2	X-ray	2.30	A/L	1-106	[»]
1XF3	X-ray	2.30	A/L	1-106	[»]
1XF4	X-ray	2.50	A/L	1-106	[»]
1XGP	X-ray	2.10	A	1-106	[»]
1XGQ	X-ray	2.10	A	1-106	[»]
25C8	X-ray	2.00	L	1-103	[»]
2A6D	X-ray	2.90	L	1-106	[»]
2A6K	X-ray	3.00	A/L	1-106	[»]
2ADF	X-ray	1.90	L	1-102	[»]
2ADJ	X-ray	2.90	A	1-106	[»]
2AJZ	X-ray	2.30	A/L	1-103	[»]
2AK1	X-ray	1.85	L	1-103	[»]
2BOB	X-ray	2.76	B	1-104	[»]
2BOC	X-ray	3.01	B	1-104	[»]
2CK0	X-ray	2.20	L	1-103	[»]
2F19	X-ray	2.80	L	1-106	[»]
2FR4	X-ray	1.95	A	1-106	[»]
2G5B	X-ray	2.30	C/E/G	1-104	[»]
2H8P	X-ray	2.25	B	1-104	[»]
2HG5	X-ray	2.75	B	1-104	[»]
2HRP	X-ray	2.20	L/M	1-106	[»]
2NR6	X-ray	2.81	C/E	1-103	[»]
2Q76	X-ray	2.00	A/C	1-104	[»]
2R1W	X-ray	1.70	A	1-106	[»]
2R1Y	X-ray	1.60	A	1-106	[»]
2R23	X-ray	1.65	A	1-106	[»]
2R2B	X-ray	1.60	A	1-106	[»]
2UYL	X-ray	2.50	A/M/V/X	1-106	[»]
2V17	X-ray	1.65	L	1-106	[»]
2V7H	X-ray	2.80	A/L	1-106	[»]
2VC2	X-ray	3.10	L	1-106	[»]
2VDK	X-ray	2.80	L	1-106	[»]
2VDL	X-ray	2.75	L	1-106	[»]
2VDM	X-ray	2.90	L	1-106	[»]
2VDN	X-ray	2.90	L	1-106	[»]
2VDO	X-ray	2.51	L	1-106	[»]
2VDP	X-ray	2.80	L	1-106	[»]
2VDQ	X-ray	2.59	L	1-106	[»]
2VDR	X-ray	2.40	L	1-106	[»]
2VL5	X-ray	2.10	B/D	1-106	[»]
2VQ1	X-ray	2.50	A/E	1-104	[»]
2VWE	X-ray	3.40	C/J	1-106	[»]
2W60	X-ray	1.50	B	1-104	[»]
2W65	X-ray	2.21	B/D	1-104	[»]
2W9D	X-ray	1.57	L	1-105	[»]
2W9E	X-ray	2.90	L	1-105	[»]
2Z91	X-ray	2.60	B/D	1-106	[»]
2Z92	X-ray	2.30	B	1-106	[»]
2Z93	X-ray	2.40	B/D	1-106	[»]
2ZJS	X-ray	3.20	L	1-106	[»]
35C8	X-ray	2.00	L	1-103	[»]
3BAE	X-ray	1.59	L	1-105	[»]
3BGF	X-ray	3.00	C/L	1-104	[»]
3BKC	X-ray	1.90	L	1-106	[»]
3BKJ	X-ray	1.59	L	1-106	[»]
3BKM	X-ray	1.60	L	1-106	[»]
3BPC	X-ray	1.85	A	1-106	[»]
3BQU	X-ray	3.00	C	1-103	[»]
3BSZ	X-ray	3.38	L/M	1-103	[»]
3BT2	X-ray	2.50	L	1-106	[»]
3BZ4	X-ray	1.80	A/C/E/G	1-106	[»]
3C5S	X-ray	2.00	A/C	1-106	[»]
3C6S	X-ray	1.80	A/C/E/G	1-106	[»]
3CFB	X-ray	1.60	A/L	1-106	[»]
3CFC	X-ray	1.70	L	1-106	[»]
3CFD	X-ray	2.50	A/L	1-106	[»]
3CFE	X-ray	2.99	A/L	1-106	[»]
3CK0	X-ray	3.00	L	1-103	[»]
3CLE	X-ray	2.50	L	1-106	[»]
3CLF	X-ray	2.00	L	1-106	[»]
3CMO	X-ray	2.30	L/X	1-103	[»]
3CVH	X-ray	2.90	L/R	1-102	[»]
3CVI	X-ray	1.80	L	1-102	[»]
3D9A	X-ray	1.20	L	1-105	[»]
3EOT	X-ray	1.90	L	1-106	[»]
3HFM	X-ray	3.00	L	1-106	[»]
6FAB	X-ray	1.90	L	1-106	[»]

ProteinModelPortal

P01837.

SMR

P01837. Positions 1-105.

ModBase

Search...

Protein-protein interaction databases

IntAct

P01837. 1 interaction.

MINT

MINT-147676.

Protein family/group databases

IMGT

Search...

PTM databases

PhosphoSite

P01837.

Proteomic databases

PaxDb

P01837.

PRIDE

P01837.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Organism-specific databases

MGI

MGI:96495. Igk-C.

Phylogenomic databases

eggNOG

NOG116969.

HOVERGEN

HBG039526.

InParanoid

P01837.

OMA

CEISHES.

OrthoDB

EOG4XSKRF.

Enzyme and pathway databases

Reactome

REACT_107772. Immune System.

Gene expression databases

Bgee

P01837.

Genevestigator

P01837.

GermOnline

ENSMUSG00000061260. Mus musculus.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
[Graphical view]

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P01837.

Entry information

Entry name

IGKC_MOUSE

Accession

Primary (citable) accession number: P01837

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents