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Reviewed, UniProtKB/Swiss-Prot P01837 (IGKC_MOUSE)

Last modified November 3, 2009. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ig kappa chain C region
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length106 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

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Ontologies

Keywords
   DomainImmunoglobulin C region
Immunoglobulin domain
   PTMDisulfide bond
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Molecular functionantigen binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 106›106Ig kappa chain C region
PRO_0000153597

Regions

Domain5 – 10298Ig-like

Amino acid modifications

Disulfide bond26 ↔ 86 Ref.2
Disulfide bond106Interchain (with a heavy chain) Ref.2

Experimental info

Non-terminal residue11

Secondary structure

1 ...................... 106
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P01837-1 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 4B51FF5EF49BAEB5

FASTA10611,778
        10         20         30         40         50         60 
ADAAPTVSIF PPSSEQLTSG GASVVCFLNN FYPKDINVKW KIDGSERQNG VLNSWTDQDS 

        70         80         90        100 
KDSTYSMSST LTLTKDEYER HNSYTCEATH KTSTSPIVKS FNRNEC

« Hide

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References

[1]"The complete amino acid sequence of a mouse kappa light chain."
Svasti J., Milstein C.
Biochem. J. 128:427-444(1972) [PubMed: 4638343] [Abstract]
Cited for: PROTEIN SEQUENCE (MOPC 21).
[2]"The disulphide bridges of a mouse immunoglobulin G1 protein."
Svasti J., Milstein C.
Biochem. J. 126:837-850(1972) [PubMed: 5073237] [Abstract]
Cited for: DISULFIDE BONDS (MOPC 21).
[3]"Complete sequence of constant and 3' noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing."
Hamlyn P.H., Brownlee G.G., Cheng C.-C., Gait M.J., Milstein C.
Cell 15:1067-1075(1978) [PubMed: 103625] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION TO 53-59.
[4]"Complete sequence of an immunoglobulin mRNA using specific priming and the dideoxynucleotide method of RNA sequencing."
Hamlyn P.H., Gait M.J., Milstein C.
Nucleic Acids Res. 9:4485-4494(1981) [PubMed: 6170937] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes."
Max E.E., Maizel J.V. Jr., Leder P.
J. Biol. Chem. 256:5116-5120(1981) [PubMed: 6262318] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"DNA sequence of the constant gene region of the mouse immunoglobulin kappa chain."
Altenburger W., Neumaier P.S., Steinmetz M., Zachau H.G.
Nucleic Acids Res. 9:971-981(1981) [PubMed: 6785724] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"Expression in non-lymphoid cells of mouse recombinant immunoglobulin directed against the tumour marker human placental alkaline phosphatase."
de Waele P., Feys V., van de Voorde A., Molemans F., Fiers W.
Eur. J. Biochem. 176:287-295(1988) [PubMed: 3138116] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

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Cross-references

Sequence databases

V00807 Genomic DNA. Translation: CAA24189.1.
IPIIPI00850020.
PIRK1MS. B90262.
UniGeneMm.333124

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
15C8X-ray2.50L1-104[»]
1A0QX-ray2.30L1-105[»]
1A3LX-ray1.95L1-104[»]
1AHWX-ray3.00A1-106[»]
1AI1X-ray2.80L1-103[»]
1AIFX-ray2.90A/L1-106[»]
1C12X-ray2.60A1-105[»]
1CF8X-ray2.70L1-106[»]
1CK0X-ray2.50L1-103[»]
1CT8X-ray2.20A/C1-106[»]
1DQJX-ray2.00A1-106[»]
1DQMX-ray2.10L1-106[»]
1DQQX-ray1.80A/C1-106[»]
1E4WX-ray1.95L1-106[»]
1EMTX-ray2.25L1-106[»]
1FAIX-ray2.70L1-106[»]
1FBIX-ray3.00L/P1-106[»]
1FDLX-ray2.50L1-106[»]
1FE8X-ray2.03L/M/N1-103[»]
1FJ1X-ray2.68A/C1-105[»]
1FL3X-ray2.45B/L1-102[»]
1FNSX-ray2.00L1-106[»]
1FSKX-ray2.90B/E/H/K1-106[»]
1GPOX-ray1.95L/M1-106[»]
1I8MX-ray2.10A/L1-106[»]
1IGYX-ray3.20A/C1-106[»]
1JNLX-ray3.00L1-103[»]
1JNNX-ray3.20L1-103[»]
1JRHX-ray2.80L1-106[»]
1K4CX-ray2.00B1-104[»]
1K4DX-ray2.30B1-104[»]
1KB5X-ray2.50L1-106[»]
1KC5X-ray2.50L1-106[»]
1KCRX-ray2.90L1-106[»]
1KCSX-ray2.50L1-106[»]
1KCUX-ray2.20L1-106[»]
1KCVX-ray1.80L1-106[»]
1KENX-ray3.50L/U1-104[»]
1KNOX-ray3.20A/C/E1-106[»]
1LO0X-ray2.00L/X1-106[»]
1MF2X-ray2.60L/M1-103[»]
1MLBX-ray2.10A1-106[»]
1MLCX-ray2.50A/C1-106[»]
1N5YX-ray3.10L1-103[»]
1N6QX-ray3.00L1-103[»]
1NBYX-ray1.80A1-106[»]
1NBZX-ray1.85A1-106[»]
1NDGX-ray1.90A1-106[»]
1NDMX-ray2.10A1-106[»]
1OAKX-ray2.20L1-104[»]
1OB1X-ray2.90A/D1-106[»]
1ORQX-ray3.20A1-106[»]
1ORSX-ray1.90A1-106[»]
1OSPX-ray1.95L1-106[»]
1P2CX-ray2.00A/D1-104[»]
1P7KX-ray1.75A/L1-106[»]
1PSKX-ray2.80L1-106[»]
1Q9OX-ray1.79A/C1-106[»]
1Q9WX-ray1.75A/C1-106[»]
1R0AX-ray2.80L1-103[»]
1R24X-ray3.10A/C1-98[»]
1R3IX-ray2.40L1-104[»]
1R3JX-ray1.90A1-104[»]
1R3KX-ray2.80A1-104[»]
1R3LX-ray2.41A1-104[»]
1RIHX-ray2.50L1-106[»]
1RUQX-ray1.86L1-104[»]
1RURX-ray1.50L1-104[»]
1S5HX-ray2.20A1-104[»]
1SEQX-ray1.78L1-106[»]
1T03X-ray3.10L1-103[»]
1T4KX-ray2.50C1-104[»]
1UB6X-ray2.12B/L1-101[»]
1UWXX-ray2.20K/L1-105[»]
1XF2X-ray2.30A/L1-106[»]
1XF3X-ray2.30A/L1-106[»]
1XF4X-ray2.50A/L1-106[»]
1XGPX-ray2.10A1-106[»]
1XGQX-ray2.10A1-106[»]
25C8X-ray2.00L1-103[»]
2A6DX-ray2.90L1-106[»]
2A6KX-ray3.00A/L1-106[»]
2ADFX-ray1.90L1-102[»]
2ADJX-ray2.90A1-106[»]
2AJZX-ray2.30A/L1-103[»]
2AK1X-ray1.85L1-103[»]
2BOBX-ray2.76B1-104[»]
2BOCX-ray3.01B1-104[»]
2CK0X-ray2.20L1-103[»]
2F19X-ray2.80L1-106[»]
2FR4X-ray1.95A1-106[»]
2G5BX-ray2.30C/E/G1-104[»]
2H8PX-ray2.25B1-104[»]
2HG5X-ray2.75B1-104[»]
2HRPX-ray2.20L/M1-106[»]
2NR6X-ray2.81C/E1-103[»]
2Q76X-ray2.00A/C1-104[»]
2R1WX-ray1.70A1-106[»]
2R1YX-ray1.60A1-106[»]
2R23X-ray1.65A1-106[»]
2R2BX-ray1.60A1-106[»]
2UYLX-ray2.50A/M/V/X1-106[»]
2V17X-ray1.65L1-106[»]
2V7HX-ray2.80A/L1-106[»]
2VC2X-ray3.10L1-106[»]
2VDKX-ray2.80L1-106[»]
2VDLX-ray2.75L1-106[»]
2VDMX-ray2.90L1-106[»]
2VDNX-ray2.90L1-106[»]
2VDOX-ray2.51L1-106[»]
2VDPX-ray2.80L1-106[»]
2VDQX-ray2.59L1-106[»]
2VDRX-ray2.40L1-106[»]
2VL5X-ray2.10B/D1-106[»]
2VQ1X-ray2.50A/E1-104[»]
2VWEX-ray3.40C/J1-106[»]
2W60X-ray1.50B1-104[»]
2W65X-ray2.21B/D1-104[»]
2W9DX-ray1.57L1-105[»]
2W9EX-ray2.90L1-105[»]
2Z91X-ray2.60B/D1-106[»]
2Z92X-ray2.30B1-106[»]
2Z93X-ray2.40B/D1-106[»]
2ZJSX-ray3.20L1-106[»]
35C8X-ray2.00L1-103[»]
3BAEX-ray1.59L1-105[»]
3BGFX-ray3.00C/L1-104[»]
3BKCX-ray1.90L1-106[»]
3BKJX-ray1.59L1-106[»]
3BKMX-ray1.60L1-106[»]
3BPCX-ray1.85A1-106[»]
3BQUX-ray3.00C1-103[»]
3BSZX-ray3.38L/M1-103[»]
3BT2X-ray2.50L1-106[»]
3BZ4X-ray1.80A/C/E/G1-106[»]
3C5SX-ray2.00A/C1-106[»]
3C6SX-ray1.80A/C/E/G1-106[»]
3CFBX-ray1.60A/L1-106[»]
3CFCX-ray1.70L1-106[»]
3CFDX-ray2.50A/L1-106[»]
3CFEX-ray2.99A/L1-106[»]
3CK0X-ray3.00L1-103[»]
3CLEX-ray2.50L1-106[»]
3CLFX-ray2.00L1-106[»]
3CMOX-ray2.30L/X1-103[»]
3CVHX-ray2.90L/R1-102[»]
3CVIX-ray1.80L1-102[»]
3D9AX-ray1.20L1-105[»]
3EOTX-ray1.90L1-106[»]
3HFMX-ray3.00L1-106[»]
6FABX-ray1.90L1-106[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGP01837.

Protein family/group databases

IMGTSearch...

Proteomic databases

PRIDEP01837.

Genome annotation databases

EnsemblENSMUST00000103410; ENSMUSP00000100206; ENSMUSG00000076609; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:96495. Igk-C.

Phylogenomic databases

HOGENOMP01837.
HOVERGENP01837.
OMASKDSTYS.

Gene expression databases

ArrayExpressP01837.
BgeeP01837.
GenevestigatorP01837.
GermOnlineENSMUSG00000061260. Mus musculus.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF07654. C1-set. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameIGKC_MOUSE
AccessionPrimary (citable) accession number: P01837
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 3, 2009
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents