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Protein

Polymeric immunoglobulin receptor

Gene

PIGR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

GO - Molecular functioni

  • polymeric immunoglobulin receptor activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
  • epidermal growth factor receptor signaling pathway Source: UniProtKB
  • Fc receptor signaling pathway Source: UniProtKB
  • immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor Source: UniProtKB
  • receptor clustering Source: UniProtKB
  • retina homeostasis Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Polymeric immunoglobulin receptor
Short name:
PIgR
Short name:
Poly-Ig receptor
Alternative name(s):
Hepatocellular carcinoma-associated protein TB6
Cleaved into the following chain:
Gene namesi
Name:PIGR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8968. PIGR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 638620ExtracellularSequence analysisAdd
BLAST
Transmembranei639 – 66123HelicalSequence analysisAdd
BLAST
Topological domaini662 – 764103CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: UniProtKB
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33300.

Polymorphism and mutation databases

BioMutaiPIGR.
DMDMi150421625.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18182 PublicationsAdd
BLAST
Chaini19 – 764746Polymeric immunoglobulin receptorPRO_0000014900Add
BLAST
Chaini19 – 603585Secretory componentPRO_0000014901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 110PROSITE-ProRule annotation1 Publication
Disulfide bondi56 ↔ 64PROSITE-ProRule annotation1 Publication
Glycosylationi83 – 831N-linked (GlcNAc...)4 Publications
Glycosylationi90 – 901N-linked (GlcNAc...)5 Publications
Glycosylationi135 – 1351N-linked (GlcNAc...)2 Publications
Disulfide bondi152 ↔ 220PROSITE-ProRule annotation1 Publication
Glycosylationi186 – 1861N-linked (GlcNAc...)3 Publications
Disulfide bondi257 ↔ 325PROSITE-ProRule annotation1 Publication
Disulfide bondi271 ↔ 279PROSITE-ProRule annotation1 Publication
Disulfide bondi371 ↔ 441PROSITE-ProRule annotation1 Publication
Disulfide bondi385 ↔ 395PROSITE-ProRule annotation1 Publication
Glycosylationi421 – 4211N-linked (GlcNAc...)6 Publications
Glycosylationi469 – 4691N-linked (GlcNAc...) (complex)7 Publications
Disulfide bondi482 ↔ 544PROSITE-ProRule annotation1 Publication
Disulfide bondi486 ↔ 520PROSITE-ProRule annotation1 Publication
Disulfide bondi496 ↔ 503PROSITE-ProRule annotation1 Publication
Glycosylationi499 – 4991N-linked (GlcNAc...)3 Publications
Modified residuei673 – 6731PhosphoserineBy similarity
Modified residuei682 – 6821PhosphoserineBy similarity
Modified residuei689 – 6891PhosphoserineBy similarity
Modified residuei735 – 7351PhosphoserineBy similarity

Post-translational modificationi

N-glycosylation is not necessary for Ig binding.7 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01833.
PeptideAtlasiP01833.
PRIDEiP01833.

PTM databases

iPTMnetiP01833.
PhosphoSiteiP01833.
UniCarbKBiP01833.

Expressioni

Gene expression databases

BgeeiENSG00000162896.
CleanExiHS_PIGR.
GenevisibleiP01833. HS.

Organism-specific databases

HPAiCAB009454.
HPA006154.
HPA012012.

Interactioni

Protein-protein interaction databases

BioGridi111302. 26 interactions.
IntActiP01833. 5 interactions.
STRINGi9606.ENSP00000348888.

Structurei

Secondary structure

1
764
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 316Combined sources
Beta strandi36 – 416Combined sources
Helixi46 – 505Combined sources
Beta strandi53 – 575Combined sources
Beta strandi60 – 623Combined sources
Beta strandi65 – 728Combined sources
Turni76 – 816Combined sources
Beta strandi82 – 876Combined sources
Turni88 – 914Combined sources
Beta strandi92 – 976Combined sources
Helixi102 – 1043Combined sources
Beta strandi106 – 1138Combined sources
Helixi115 – 1173Combined sources
Beta strandi120 – 1278Combined sources
Beta strandi136 – 1438Combined sources
Beta strandi148 – 1536Combined sources
Helixi156 – 1583Combined sources
Beta strandi163 – 17816Combined sources
Turni185 – 1895Combined sources
Beta strandi190 – 1956Combined sources
Beta strandi201 – 2077Combined sources
Helixi212 – 2143Combined sources
Beta strandi216 – 2227Combined sources
Beta strandi224 – 2274Combined sources
Beta strandi229 – 23810Combined sources
Beta strandi243 – 2486Combined sources
Beta strandi253 – 2575Combined sources
Turni262 – 2654Combined sources
Beta strandi268 – 2736Combined sources
Beta strandi275 – 2773Combined sources
Beta strandi279 – 2879Combined sources
Helixi291 – 2933Combined sources
Beta strandi296 – 2994Combined sources
Beta strandi308 – 3125Combined sources
Helixi317 – 3193Combined sources
Beta strandi321 – 3277Combined sources
Beta strandi339 – 3479Combined sources
Beta strandi357 – 3615Combined sources
Beta strandi365 – 3728Combined sources
Helixi375 – 3773Combined sources
Beta strandi383 – 3864Combined sources
Turni390 – 3923Combined sources
Beta strandi397 – 4004Combined sources
Helixi407 – 4093Combined sources
Turni410 – 4123Combined sources
Beta strandi413 – 4197Combined sources
Beta strandi421 – 43010Combined sources
Helixi433 – 4353Combined sources
Beta strandi437 – 4426Combined sources
Beta strandi451 – 4577Combined sources
Beta strandi463 – 4653Combined sources
Beta strandi468 – 4736Combined sources
Beta strandi478 – 4847Combined sources
Turni487 – 4904Combined sources
Beta strandi491 – 4977Combined sources
Beta strandi508 – 5103Combined sources
Beta strandi516 – 5194Combined sources
Beta strandi521 – 5233Combined sources
Beta strandi525 – 5339Combined sources
Helixi536 – 5383Combined sources
Beta strandi540 – 5489Combined sources
Beta strandi551 – 56515Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XEDX-ray1.90A/B/C/D/E/F19-127[»]
2OCWX-ray-A19-603[»]
3CHNOther1.00J353-458[»]
S19-603[»]
3CM9Other1.00J353-458[»]
S19-603[»]
5D4KX-ray2.60A/B19-565[»]
ProteinModelPortaliP01833.
SMRiP01833. Positions 20-441, 469-564.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01833.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 120102Ig-like V-type 1Add
BLAST
Domaini145 – 23793Ig-like V-type 2Add
BLAST
Domaini250 – 352103Ig-like V-type 3Add
BLAST
Domaini364 – 45895Ig-like V-type 4Add
BLAST
Domaini462 – 561100Ig-like V-type 5Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHXB. Eukaryota.
ENOG41128ZA. LUCA.
GeneTreeiENSGT00530000063436.
HOGENOMiHOG000115545.
HOVERGENiHBG008199.
InParanoidiP01833.
KOiK13073.
OMAiYWCGVKQ.
OrthoDBiEOG091G03V3.
PhylomeDBiP01833.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 5 hits.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00406. IGv. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLFVLTCLL AVFPAISTKS PIFGPEEVNS VEGNSVSITC YYPPTSVNRH
60 70 80 90 100
TRKYWCRQGA RGGCITLISS EGYVSSKYAG RANLTNFPEN GTFVVNIAQL
110 120 130 140 150
SQDDSGRYKC GLGINSRGLS FDVSLEVSQG PGLLNDTKVY TVDLGRTVTI
160 170 180 190 200
NCPFKTENAQ KRKSLYKQIG LYPVLVIDSS GYVNPNYTGR IRLDIQGTGQ
210 220 230 240 250
LLFSVVINQL RLSDAGQYLC QAGDDSNSNK KNADLQVLKP EPELVYEDLR
260 270 280 290 300
GSVTFHCALG PEVANVAKFL CRQSSGENCD VVVNTLGKRA PAFEGRILLN
310 320 330 340 350
PQDKDGSFSV VITGLRKEDA GRYLCGAHSD GQLQEGSPIQ AWQLFVNEES
360 370 380 390 400
TIPRSPTVVK GVAGGSVAVL CPYNRKESKS IKYWCLWEGA QNGRCPLLVD
410 420 430 440 450
SEGWVKAQYE GRLSLLEEPG NGTFTVILNQ LTSRDAGFYW CLTNGDTLWR
460 470 480 490 500
TTVEIKIIEG EPNLKVPGNV TAVLGETLKV PCHFPCKFSS YEKYWCKWNN
510 520 530 540 550
TGCQALPSQD EGPSKAFVNC DENSRLVSLT LNLVTRADEG WYWCGVKQGH
560 570 580 590 600
FYGETAAVYV AVEERKAAGS RDVSLAKADA APDEKVLDSG FREIENKAIQ
610 620 630 640 650
DPRLFAEEKA VADTRDQADG SRASVDSGSS EEQGGSSRAL VSTLVPLGLV
660 670 680 690 700
LAVGAVAVGV ARARHRKNVD RVSIRSYRTD ISMSDFENSR EFGANDNMGA
710 720 730 740 750
SSITQETSLG GKEEFVATTE STTETKEPKK AKRSSKEEAE MAYKDFLLQS
760
STVAAEAQDG PQEA
Length:764
Mass (Da):83,284
Last modified:June 26, 2007 - v4
Checksum:i927461F4EB3B05C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361D → Q AA sequence (PubMed:6526384).Curated
Sequence conflicti136 – 1361D → Q AA sequence (PubMed:1859628).Curated
Sequence conflicti158 – 1581N → D AA sequence (PubMed:6526384).Curated
Sequence conflicti158 – 1581N → D AA sequence (PubMed:1859628).Curated
Sequence conflicti208 – 2092NQ → DE AA sequence (PubMed:6526384).Curated
Sequence conflicti208 – 2092NQ → DE AA sequence (PubMed:1859628).Curated
Sequence conflicti229 – 2291Missing AA sequence (PubMed:6526384).Curated
Sequence conflicti229 – 2291Missing AA sequence (PubMed:1859628).Curated
Sequence conflicti234 – 2341D → N AA sequence (PubMed:6526384).Curated
Sequence conflicti234 – 2341D → N AA sequence (PubMed:1859628).Curated
Sequence conflicti241 – 2411E → Q AA sequence (PubMed:6526384).Curated
Sequence conflicti241 – 2411E → Q AA sequence (PubMed:1859628).Curated
Sequence conflicti262 – 2621E → Q AA sequence (PubMed:6526384).Curated
Sequence conflicti262 – 2621E → Q AA sequence (PubMed:1859628).Curated
Sequence conflicti280 – 2801D → N AA sequence (PubMed:6526384).Curated
Sequence conflicti280 – 2801D → N AA sequence (PubMed:1859628).Curated
Sequence conflicti392 – 3921N → D AA sequence (PubMed:6526384).Curated
Sequence conflicti392 – 3921N → D AA sequence (PubMed:1859628).Curated
Sequence conflicti500 – 5001N → D AA sequence (PubMed:6526384).Curated
Sequence conflicti500 – 5001N → D AA sequence (PubMed:1859628).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti365 – 3651G → S.6 Publications
Corresponds to variant rs2275531 [ dbSNP | Ensembl ].
VAR_025283
Natural varianti555 – 5551T → I.
Corresponds to variant rs7542760 [ dbSNP | Ensembl ].
VAR_032822
Natural varianti580 – 5801A → V.
Corresponds to variant rs291102 [ dbSNP | Ensembl ].
VAR_003920

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62403 mRNA. Translation: AAB20203.1.
S43449
, S43437, S43441, S43442, S43443, S43444, S43445, S43446, S43447, S43448 Genomic DNA. Translation: AAB23176.1.
AF272149 mRNA. Translation: AAN65630.1.
CR749533 mRNA. Translation: CAH18339.1.
M24559 mRNA. Translation: AAA36102.1.
CCDSiCCDS1474.1.
PIRiA46537. QRHUGS.
RefSeqiNP_002635.2. NM_002644.3.
XP_011507931.1. XM_011509629.1.
UniGeneiHs.497589.

Genome annotation databases

EnsembliENST00000356495; ENSP00000348888; ENSG00000162896.
GeneIDi5284.
KEGGihsa:5284.
UCSCiuc001hez.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62403 mRNA. Translation: AAB20203.1.
S43449
, S43437, S43441, S43442, S43443, S43444, S43445, S43446, S43447, S43448 Genomic DNA. Translation: AAB23176.1.
AF272149 mRNA. Translation: AAN65630.1.
CR749533 mRNA. Translation: CAH18339.1.
M24559 mRNA. Translation: AAA36102.1.
CCDSiCCDS1474.1.
PIRiA46537. QRHUGS.
RefSeqiNP_002635.2. NM_002644.3.
XP_011507931.1. XM_011509629.1.
UniGeneiHs.497589.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XEDX-ray1.90A/B/C/D/E/F19-127[»]
2OCWX-ray-A19-603[»]
3CHNOther1.00J353-458[»]
S19-603[»]
3CM9Other1.00J353-458[»]
S19-603[»]
5D4KX-ray2.60A/B19-565[»]
ProteinModelPortaliP01833.
SMRiP01833. Positions 20-441, 469-564.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111302. 26 interactions.
IntActiP01833. 5 interactions.
STRINGi9606.ENSP00000348888.

PTM databases

iPTMnetiP01833.
PhosphoSiteiP01833.
UniCarbKBiP01833.

Polymorphism and mutation databases

BioMutaiPIGR.
DMDMi150421625.

Proteomic databases

PaxDbiP01833.
PeptideAtlasiP01833.
PRIDEiP01833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356495; ENSP00000348888; ENSG00000162896.
GeneIDi5284.
KEGGihsa:5284.
UCSCiuc001hez.4. human.

Organism-specific databases

CTDi5284.
GeneCardsiPIGR.
H-InvDBHIX0028583.
HGNCiHGNC:8968. PIGR.
HPAiCAB009454.
HPA006154.
HPA012012.
MIMi173880. gene.
neXtProtiNX_P01833.
PharmGKBiPA33300.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHXB. Eukaryota.
ENOG41128ZA. LUCA.
GeneTreeiENSGT00530000063436.
HOGENOMiHOG000115545.
HOVERGENiHBG008199.
InParanoidiP01833.
KOiK13073.
OMAiYWCGVKQ.
OrthoDBiEOG091G03V3.
PhylomeDBiP01833.
TreeFamiTF334441.

Miscellaneous databases

ChiTaRSiPIGR. human.
EvolutionaryTraceiP01833.
GeneWikiiPolymeric_immunoglobulin_receptor.
GenomeRNAii5284.
PROiP01833.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162896.
CleanExiHS_PIGR.
GenevisibleiP01833. HS.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 5 hits.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00406. IGv. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIGR_HUMAN
AccessioniPrimary (citable) accession number: P01833
Secondary accession number(s): Q68D81, Q8IZY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 26, 2007
Last modified: September 7, 2016
This is version 170 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.