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Protein

Polymeric immunoglobulin receptor

Gene

PIGR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

GO - Molecular functioni

  • polymeric immunoglobulin receptor activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
  • epidermal growth factor receptor signaling pathway Source: UniProtKB
  • Fc receptor signaling pathway Source: UniProtKB
  • immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor Source: UniProtKB
  • receptor clustering Source: UniProtKB
  • retina homeostasis Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162896-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Polymeric immunoglobulin receptor
Short name:
PIgR
Short name:
Poly-Ig receptor
Alternative name(s):
Hepatocellular carcinoma-associated protein TB6
Cleaved into the following chain:
Gene namesi
Name:PIGR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8968. PIGR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 638ExtracellularSequence analysisAdd BLAST620
Transmembranei639 – 661HelicalSequence analysisAdd BLAST23
Topological domaini662 – 764CytoplasmicSequence analysisAdd BLAST103

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: UniProtKB
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5284.
OpenTargetsiENSG00000162896.
PharmGKBiPA33300.

Polymorphism and mutation databases

BioMutaiPIGR.
DMDMi150421625.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 182 PublicationsAdd BLAST18
ChainiPRO_000001490019 – 764Polymeric immunoglobulin receptorAdd BLAST746
ChainiPRO_000001490119 – 603Secretory componentAdd BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 110PROSITE-ProRule annotation1 Publication
Disulfide bondi56 ↔ 64PROSITE-ProRule annotation1 Publication
Glycosylationi83N-linked (GlcNAc...)4 Publications1
Glycosylationi90N-linked (GlcNAc...)5 Publications1
Glycosylationi135N-linked (GlcNAc...)2 Publications1
Disulfide bondi152 ↔ 220PROSITE-ProRule annotation1 Publication
Glycosylationi186N-linked (GlcNAc...)3 Publications1
Disulfide bondi257 ↔ 325PROSITE-ProRule annotation1 Publication
Disulfide bondi271 ↔ 279PROSITE-ProRule annotation1 Publication
Disulfide bondi371 ↔ 441PROSITE-ProRule annotation1 Publication
Disulfide bondi385 ↔ 395PROSITE-ProRule annotation1 Publication
Glycosylationi421N-linked (GlcNAc...)6 Publications1
Glycosylationi469N-linked (GlcNAc...) (complex)7 Publications1
Disulfide bondi482 ↔ 544PROSITE-ProRule annotation1 Publication
Disulfide bondi486 ↔ 520PROSITE-ProRule annotation1 Publication
Disulfide bondi496 ↔ 503PROSITE-ProRule annotation1 Publication
Glycosylationi499N-linked (GlcNAc...)3 Publications1
Modified residuei673PhosphoserineBy similarity1
Modified residuei682PhosphoserineBy similarity1
Modified residuei689PhosphoserineBy similarity1
Modified residuei735PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylation is not necessary for Ig binding.7 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01833.
PeptideAtlasiP01833.
PRIDEiP01833.

PTM databases

iPTMnetiP01833.
PhosphoSitePlusiP01833.
UniCarbKBiP01833.

Expressioni

Gene expression databases

BgeeiENSG00000162896.
CleanExiHS_PIGR.
GenevisibleiP01833. HS.

Organism-specific databases

HPAiCAB009454.
HPA006154.
HPA012012.

Interactioni

Protein-protein interaction databases

BioGridi111302. 26 interactors.
IntActiP01833. 6 interactors.
STRINGi9606.ENSP00000348888.

Structurei

Secondary structure

1764
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 31Combined sources6
Beta strandi36 – 41Combined sources6
Helixi46 – 50Combined sources5
Beta strandi53 – 57Combined sources5
Beta strandi60 – 62Combined sources3
Beta strandi65 – 72Combined sources8
Turni76 – 81Combined sources6
Beta strandi82 – 87Combined sources6
Turni88 – 91Combined sources4
Beta strandi92 – 97Combined sources6
Helixi102 – 104Combined sources3
Beta strandi106 – 113Combined sources8
Helixi115 – 117Combined sources3
Beta strandi120 – 127Combined sources8
Beta strandi136 – 143Combined sources8
Beta strandi148 – 153Combined sources6
Helixi156 – 158Combined sources3
Beta strandi163 – 178Combined sources16
Turni185 – 189Combined sources5
Beta strandi190 – 195Combined sources6
Beta strandi201 – 207Combined sources7
Helixi212 – 214Combined sources3
Beta strandi216 – 222Combined sources7
Beta strandi224 – 227Combined sources4
Beta strandi229 – 238Combined sources10
Beta strandi243 – 248Combined sources6
Beta strandi253 – 257Combined sources5
Turni262 – 265Combined sources4
Beta strandi268 – 273Combined sources6
Beta strandi275 – 277Combined sources3
Beta strandi279 – 287Combined sources9
Helixi291 – 293Combined sources3
Beta strandi296 – 299Combined sources4
Beta strandi308 – 312Combined sources5
Helixi317 – 319Combined sources3
Beta strandi321 – 327Combined sources7
Beta strandi339 – 347Combined sources9
Beta strandi357 – 361Combined sources5
Beta strandi365 – 372Combined sources8
Helixi375 – 377Combined sources3
Beta strandi383 – 386Combined sources4
Turni390 – 392Combined sources3
Beta strandi397 – 400Combined sources4
Helixi407 – 409Combined sources3
Turni410 – 412Combined sources3
Beta strandi413 – 419Combined sources7
Beta strandi421 – 430Combined sources10
Helixi433 – 435Combined sources3
Beta strandi437 – 442Combined sources6
Beta strandi451 – 457Combined sources7
Beta strandi463 – 465Combined sources3
Beta strandi468 – 473Combined sources6
Beta strandi478 – 484Combined sources7
Turni487 – 490Combined sources4
Beta strandi491 – 497Combined sources7
Beta strandi508 – 510Combined sources3
Beta strandi516 – 519Combined sources4
Beta strandi521 – 523Combined sources3
Beta strandi525 – 533Combined sources9
Helixi536 – 538Combined sources3
Beta strandi540 – 548Combined sources9
Beta strandi551 – 565Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XEDX-ray1.90A/B/C/D/E/F19-127[»]
2OCWX-ray-A19-603[»]
3CHNOther1.00J353-458[»]
S19-603[»]
3CM9Other1.00J353-458[»]
S19-603[»]
5D4KX-ray2.60A/B19-565[»]
ProteinModelPortaliP01833.
SMRiP01833.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01833.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 120Ig-like V-type 1Add BLAST102
Domaini145 – 237Ig-like V-type 2Add BLAST93
Domaini250 – 352Ig-like V-type 3Add BLAST103
Domaini364 – 458Ig-like V-type 4Add BLAST95
Domaini462 – 561Ig-like V-type 5Add BLAST100

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHXB. Eukaryota.
ENOG41128ZA. LUCA.
GeneTreeiENSGT00530000063436.
HOGENOMiHOG000115545.
HOVERGENiHBG008199.
InParanoidiP01833.
KOiK13073.
OMAiYWCGVKQ.
OrthoDBiEOG091G03V3.
PhylomeDBiP01833.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 5 hits.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00406. IGv. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLFVLTCLL AVFPAISTKS PIFGPEEVNS VEGNSVSITC YYPPTSVNRH
60 70 80 90 100
TRKYWCRQGA RGGCITLISS EGYVSSKYAG RANLTNFPEN GTFVVNIAQL
110 120 130 140 150
SQDDSGRYKC GLGINSRGLS FDVSLEVSQG PGLLNDTKVY TVDLGRTVTI
160 170 180 190 200
NCPFKTENAQ KRKSLYKQIG LYPVLVIDSS GYVNPNYTGR IRLDIQGTGQ
210 220 230 240 250
LLFSVVINQL RLSDAGQYLC QAGDDSNSNK KNADLQVLKP EPELVYEDLR
260 270 280 290 300
GSVTFHCALG PEVANVAKFL CRQSSGENCD VVVNTLGKRA PAFEGRILLN
310 320 330 340 350
PQDKDGSFSV VITGLRKEDA GRYLCGAHSD GQLQEGSPIQ AWQLFVNEES
360 370 380 390 400
TIPRSPTVVK GVAGGSVAVL CPYNRKESKS IKYWCLWEGA QNGRCPLLVD
410 420 430 440 450
SEGWVKAQYE GRLSLLEEPG NGTFTVILNQ LTSRDAGFYW CLTNGDTLWR
460 470 480 490 500
TTVEIKIIEG EPNLKVPGNV TAVLGETLKV PCHFPCKFSS YEKYWCKWNN
510 520 530 540 550
TGCQALPSQD EGPSKAFVNC DENSRLVSLT LNLVTRADEG WYWCGVKQGH
560 570 580 590 600
FYGETAAVYV AVEERKAAGS RDVSLAKADA APDEKVLDSG FREIENKAIQ
610 620 630 640 650
DPRLFAEEKA VADTRDQADG SRASVDSGSS EEQGGSSRAL VSTLVPLGLV
660 670 680 690 700
LAVGAVAVGV ARARHRKNVD RVSIRSYRTD ISMSDFENSR EFGANDNMGA
710 720 730 740 750
SSITQETSLG GKEEFVATTE STTETKEPKK AKRSSKEEAE MAYKDFLLQS
760
STVAAEAQDG PQEA
Length:764
Mass (Da):83,284
Last modified:June 26, 2007 - v4
Checksum:i927461F4EB3B05C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136D → Q AA sequence (PubMed:6526384).Curated1
Sequence conflicti136D → Q AA sequence (PubMed:1859628).Curated1
Sequence conflicti158N → D AA sequence (PubMed:6526384).Curated1
Sequence conflicti158N → D AA sequence (PubMed:1859628).Curated1
Sequence conflicti208 – 209NQ → DE AA sequence (PubMed:6526384).Curated2
Sequence conflicti208 – 209NQ → DE AA sequence (PubMed:1859628).Curated2
Sequence conflicti229Missing AA sequence (PubMed:6526384).Curated1
Sequence conflicti229Missing AA sequence (PubMed:1859628).Curated1
Sequence conflicti234D → N AA sequence (PubMed:6526384).Curated1
Sequence conflicti234D → N AA sequence (PubMed:1859628).Curated1
Sequence conflicti241E → Q AA sequence (PubMed:6526384).Curated1
Sequence conflicti241E → Q AA sequence (PubMed:1859628).Curated1
Sequence conflicti262E → Q AA sequence (PubMed:6526384).Curated1
Sequence conflicti262E → Q AA sequence (PubMed:1859628).Curated1
Sequence conflicti280D → N AA sequence (PubMed:6526384).Curated1
Sequence conflicti280D → N AA sequence (PubMed:1859628).Curated1
Sequence conflicti392N → D AA sequence (PubMed:6526384).Curated1
Sequence conflicti392N → D AA sequence (PubMed:1859628).Curated1
Sequence conflicti500N → D AA sequence (PubMed:6526384).Curated1
Sequence conflicti500N → D AA sequence (PubMed:1859628).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025283365G → S.6 PublicationsCorresponds to variant rs2275531dbSNPEnsembl.1
Natural variantiVAR_032822555T → I.Corresponds to variant rs7542760dbSNPEnsembl.1
Natural variantiVAR_003920580A → V.Corresponds to variant rs291102dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62403 mRNA. Translation: AAB20203.1.
S43449
, S43437, S43441, S43442, S43443, S43444, S43445, S43446, S43447, S43448 Genomic DNA. Translation: AAB23176.1.
AF272149 mRNA. Translation: AAN65630.1.
CR749533 mRNA. Translation: CAH18339.1.
M24559 mRNA. Translation: AAA36102.1.
CCDSiCCDS1474.1.
PIRiA46537. QRHUGS.
RefSeqiNP_002635.2. NM_002644.3.
XP_011507931.1. XM_011509629.1.
UniGeneiHs.497589.

Genome annotation databases

EnsembliENST00000356495; ENSP00000348888; ENSG00000162896.
GeneIDi5284.
KEGGihsa:5284.
UCSCiuc001hez.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62403 mRNA. Translation: AAB20203.1.
S43449
, S43437, S43441, S43442, S43443, S43444, S43445, S43446, S43447, S43448 Genomic DNA. Translation: AAB23176.1.
AF272149 mRNA. Translation: AAN65630.1.
CR749533 mRNA. Translation: CAH18339.1.
M24559 mRNA. Translation: AAA36102.1.
CCDSiCCDS1474.1.
PIRiA46537. QRHUGS.
RefSeqiNP_002635.2. NM_002644.3.
XP_011507931.1. XM_011509629.1.
UniGeneiHs.497589.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XEDX-ray1.90A/B/C/D/E/F19-127[»]
2OCWX-ray-A19-603[»]
3CHNOther1.00J353-458[»]
S19-603[»]
3CM9Other1.00J353-458[»]
S19-603[»]
5D4KX-ray2.60A/B19-565[»]
ProteinModelPortaliP01833.
SMRiP01833.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111302. 26 interactors.
IntActiP01833. 6 interactors.
STRINGi9606.ENSP00000348888.

PTM databases

iPTMnetiP01833.
PhosphoSitePlusiP01833.
UniCarbKBiP01833.

Polymorphism and mutation databases

BioMutaiPIGR.
DMDMi150421625.

Proteomic databases

PaxDbiP01833.
PeptideAtlasiP01833.
PRIDEiP01833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356495; ENSP00000348888; ENSG00000162896.
GeneIDi5284.
KEGGihsa:5284.
UCSCiuc001hez.4. human.

Organism-specific databases

CTDi5284.
DisGeNETi5284.
GeneCardsiPIGR.
H-InvDBHIX0028583.
HGNCiHGNC:8968. PIGR.
HPAiCAB009454.
HPA006154.
HPA012012.
MIMi173880. gene.
neXtProtiNX_P01833.
OpenTargetsiENSG00000162896.
PharmGKBiPA33300.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHXB. Eukaryota.
ENOG41128ZA. LUCA.
GeneTreeiENSGT00530000063436.
HOGENOMiHOG000115545.
HOVERGENiHBG008199.
InParanoidiP01833.
KOiK13073.
OMAiYWCGVKQ.
OrthoDBiEOG091G03V3.
PhylomeDBiP01833.
TreeFamiTF334441.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162896-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiPIGR. human.
EvolutionaryTraceiP01833.
GeneWikiiPolymeric_immunoglobulin_receptor.
GenomeRNAii5284.
PROiP01833.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162896.
CleanExiHS_PIGR.
GenevisibleiP01833. HS.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 5 hits.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00406. IGv. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIGR_HUMAN
AccessioniPrimary (citable) accession number: P01833
Secondary accession number(s): Q68D81, Q8IZY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 26, 2007
Last modified: November 30, 2016
This is version 173 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.