ID THY1_MOUSE Reviewed; 162 AA. AC P01831; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 16-NOV-2011, entry version 114. DE RecName: Full=Thy-1 membrane glycoprotein; DE AltName: Full=Thy-1 antigen; DE AltName: CD_antigen=CD90; DE Flags: Precursor; GN Name=Thy1; Synonyms=Thy-1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85115360; PubMed=2857501; DOI=10.1126/science.2857501; RA Seki T., Chang H.-C., Moriuchi T., Denome R., Ploegh H., Silver J.; RT "A hydrophobic transmembrane segment at the carboxyl terminus of thy- RT 1."; RL Science 227:649-651(1985). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE). RC STRAIN=BALB/c; RX MEDLINE=86055760; PubMed=2866091; RA Giguere V., Isobe K., Grosveld F.; RT "Structure of the murine Thy-1 gene."; RL EMBO J. 4:2017-2024(1985). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE). RX MEDLINE=85216583; PubMed=2582427; DOI=10.1073/pnas.82.11.3819; RA Chang H.-C., Seki T., Moriuchi T., Silver J.; RT "Isolation and characterization of mouse Thy-1 genomic clones."; RL Proc. Natl. Acad. Sci. U.S.A. 82:3819-3823(1985). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE). RX MEDLINE=86113437; PubMed=2868059; RA Ingraham H.A., Lawless G.M., Evans G.A.; RT "The mouse Thy-1.2 glycoprotein gene: complete sequence and RT identification of an unusual promoter."; RL J. Immunol. 136:1482-1489(1986). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Olfactory epithelium; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP PROTEIN SEQUENCE OF 20-131, PYROGLUTAMATE FORMATION AT GLN-20, AND RP GPI-ANCHOR AT CYS-131. RX MEDLINE=82199396; PubMed=6177036; DOI=10.1126/science.6177036; RA Williams A.F., Gagnon J.; RT "Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin."; RL Science 216:696-703(1982). CC -!- FUNCTION: May play a role in cell-cell or cell-ligand interactions CC during synaptogenesis and other events in the brain. CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. CC -!- POLYMORPHISM: There are two major alleles; Thy-1.1 (CD90.1) and CC Thy-1.2 (CD90.2). CC -!- SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) CC domain. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X03151; CAA26930.1; -; Genomic_DNA. DR EMBL; X02771; CAA26548.1; -; Genomic_DNA. DR EMBL; X02772; CAA26549.1; ALT_SEQ; Genomic_DNA. DR EMBL; X02773; CAA26550.1; ALT_SEQ; Genomic_DNA. DR EMBL; M10246; AAA40440.1; -; Genomic_DNA. DR EMBL; M11160; AAA40441.1; -; Genomic_DNA. DR EMBL; M12379; AAA40443.1; -; Genomic_DNA. DR EMBL; BC054436; AAH54436.1; -; mRNA. DR IPI; IPI00109727; -. DR PIR; A94278; TDMS. DR RefSeq; NP_033408.1; NM_009382.3. DR UniGene; Mm.3951; -. DR ProteinModelPortal; P01831; -. DR SMR; P01831; 28-111. DR IntAct; P01831; 4. DR STRING; P01831; -. DR PhosphoSite; P01831; -. DR PRIDE; P01831; -. DR Ensembl; ENSMUST00000114840; ENSMUSP00000110489; ENSMUSG00000032011. DR GeneID; 21838; -. DR KEGG; mmu:21838; -. DR UCSC; uc009pbl.1; mouse. DR CTD; 7070; -. DR MGI; MGI:98747; Thy1. DR eggNOG; roNOG17327; -. DR HOGENOM; HBG279081; -. DR HOVERGEN; HBG002958; -. DR InParanoid; P01831; -. DR OMA; TCELRLS; -. DR OrthoDB; EOG4SF977; -. DR PhylomeDB; P01831; -. DR NextBio; 301298; -. DR ArrayExpress; P01831; -. DR Bgee; P01831; -. DR CleanEx; MM_THY1; -. DR Genevestigator; P01831; -. DR GermOnline; ENSMUSG00000032011; Mus musculus. DR GO; GO:0031362; C:anchored to external side of plasma membrane; IDA:MGI. DR GO; GO:0030425; C:dendrite; IDA:MGI. DR GO; GO:0030426; C:growth cone; ISS:UniProtKB. DR GO; GO:0045121; C:membrane raft; IDA:MGI. DR GO; GO:0034235; F:GPI anchor binding; ISS:UniProtKB. DR GO; GO:0005100; F:Rho GTPase activator activity; ISS:UniProtKB. DR GO; GO:0001525; P:angiogenesis; IDA:UniProtKB. DR GO; GO:0016337; P:cell-cell adhesion; ISS:UniProtKB. DR GO; GO:0007010; P:cytoskeleton organization; ISS:UniProtKB. DR GO; GO:0048041; P:focal adhesion assembly; ISS:UniProtKB. DR GO; GO:0050771; P:negative regulation of axonogenesis; ISS:UniProtKB. DR GO; GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB. DR GO; GO:0006469; P:negative regulation of protein kinase activity; ISS:UniProtKB. DR GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IDA:UniProtKB. DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB. DR GO; GO:0050870; P:positive regulation of T cell activation; ISS:UniProtKB. DR GO; GO:0046549; P:retinal cone cell development; IMP:UniProtKB. DR GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003596; Ig_V-set_subgr. DR InterPro; IPR013151; Immunoglobulin. DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1. DR KO; K06514; -. DR Pfam; PF00047; ig; 1. DR SMART; SM00406; IGv; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Cell membrane; Complete proteome; Direct protein sequencing; KW Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain; KW Lipoprotein; Membrane; Polymorphism; Pyrrolidone carboxylic acid; KW Reference proteome; Signal. FT SIGNAL 1 19 FT CHAIN 20 131 Thy-1 membrane glycoprotein. FT /FTId=PRO_0000014977. FT PROPEP 132 162 Removed in mature form. FT /FTId=PRO_0000014978. FT DOMAIN 20 127 Ig-like V-type. FT MOD_RES 20 20 Pyrrolidone carboxylic acid. FT LIPID 131 131 GPI-anchor amidated cysteine. FT CARBOHYD 42 42 N-linked (GlcNAc...). FT CARBOHYD 94 94 N-linked (GlcNAc...). FT CARBOHYD 118 118 N-linked (GlcNAc...). FT DISULFID 28 131 FT DISULFID 38 105 FT VARIANT 108 108 Q -> R (in allele Thy-1.1). SQ SEQUENCE 162 AA; 18080 MW; 397BF7D3A9F2C77B CRC64; MNPAISVALL LSVLQVSRGQ KVTSLTACLV NQNLRLDCRH ENNTKDNSIQ HEFSLTREKR KHVLSGTLGI PEHTYRSRVT LSNQPYIKVL TLANFTTKDE GDYFCELQVS GANPMSSNKS ISVYRDKLVK CGGISLLVQN TSWMLLLLLS LSLLQALDFI SL //