Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P01831

- THY1_MOUSE

UniProt

P01831 - THY1_MOUSE

Protein

Thy-1 membrane glycoprotein

Gene

Thy1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

    GO - Molecular functioni

    1. GPI anchor binding Source: UniProtKB
    2. Rho GTPase activator activity Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. cytoskeleton organization Source: UniProtKB
    3. focal adhesion assembly Source: UniProtKB
    4. negative regulation of axonogenesis Source: UniProtKB
    5. negative regulation of cell migration Source: UniProtKB
    6. negative regulation of protein kinase activity Source: UniProtKB
    7. negative regulation of T cell receptor signaling pathway Source: UniProtKB
    8. positive regulation of GTPase activity Source: UniProtKB
    9. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
    10. positive regulation of T cell activation Source: UniProtKB
    11. retinal cone cell development Source: UniProtKB
    12. single organismal cell-cell adhesion Source: UniProtKB
    13. T cell receptor signaling pathway Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thy-1 membrane glycoprotein
    Alternative name(s):
    Thy-1 antigen
    CD_antigen: CD90
    Gene namesi
    Name:Thy1
    Synonyms:Thy-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:98747. Thy1.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of external side of plasma membrane Source: MGI
    2. apical plasma membrane Source: Ensembl
    3. cytosol Source: Ensembl
    4. dendrite Source: MGI
    5. endoplasmic reticulum Source: Ensembl
    6. external side of plasma membrane Source: UniProtKB
    7. growth cone Source: UniProtKB
    8. membrane raft Source: MGI
    9. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 131112Thy-1 membrane glycoproteinPRO_0000014977Add
    BLAST
    Propeptidei132 – 16231Removed in mature formPRO_0000014978Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei20 – 201Pyrrolidone carboxylic acid1 Publication
    Disulfide bondi28 ↔ 1311 PublicationPROSITE-ProRule annotation
    Disulfide bondi38 ↔ 1051 PublicationPROSITE-ProRule annotation
    Glycosylationi42 – 421N-linked (GlcNAc...)1 Publication
    Glycosylationi94 – 941N-linked (GlcNAc...)1 Publication
    Glycosylationi118 – 1181N-linked (GlcNAc...)1 Publication
    Lipidationi131 – 1311GPI-anchor amidated cysteine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    MaxQBiP01831.
    PaxDbiP01831.
    PRIDEiP01831.

    PTM databases

    PhosphoSiteiP01831.

    Expressioni

    Gene expression databases

    BgeeiP01831.
    CleanExiMM_THY1.
    GenevestigatoriP01831.

    Interactioni

    Protein-protein interaction databases

    BioGridi204188. 2 interactions.
    IntActiP01831. 9 interactions.
    MINTiMINT-4137766.
    STRINGi10090.ENSMUSP00000034509.

    Structurei

    3D structure databases

    ProteinModelPortaliP01831.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 127108Ig-like V-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG43439.
    GeneTreeiENSGT00390000012352.
    HOGENOMiHOG000048719.
    HOVERGENiHBG002958.
    InParanoidiP01831.
    KOiK06514.
    OMAiTCELRLS.
    OrthoDBiEOG789CCZ.
    PhylomeDBiP01831.
    TreeFamiTF336059.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003596. Ig_V-set_subgr.
    IPR013151. Immunoglobulin.
    [Graphical view]
    PfamiPF00047. ig. 1 hit.
    [Graphical view]
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01831-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPAISVALL LSVLQVSRGQ KVTSLTACLV NQNLRLDCRH ENNTKDNSIQ    50
    HEFSLTREKR KHVLSGTLGI PEHTYRSRVT LSNQPYIKVL TLANFTTKDE 100
    GDYFCELQVS GANPMSSNKS ISVYRDKLVK CGGISLLVQN TSWMLLLLLS 150
    LSLLQALDFI SL 162
    Length:162
    Mass (Da):18,080
    Last modified:July 21, 1986 - v1
    Checksum:i397BF7D3A9F2C77B
    GO

    Polymorphismi

    There are two major alleles; Thy-1.1 (CD90.1) and Thy-1.2 (CD90.2).

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081Q → R in allele Thy-1.1.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03151 Genomic DNA. Translation: CAA26930.1.
    X02771 Genomic DNA. Translation: CAA26548.1.
    X02772 Genomic DNA. Translation: CAA26549.1. Sequence problems.
    X02773 Genomic DNA. Translation: CAA26550.1. Sequence problems.
    M10246 Genomic DNA. Translation: AAA40440.1.
    M11160 Genomic DNA. Translation: AAA40441.1.
    M12379 Genomic DNA. Translation: AAA40443.1.
    BC054436 mRNA. Translation: AAH54436.1.
    CCDSiCCDS23093.1.
    PIRiA94278. TDMS.
    RefSeqiNP_033408.1. NM_009382.3.
    UniGeneiMm.3951.

    Genome annotation databases

    EnsembliENSMUST00000114840; ENSMUSP00000110489; ENSMUSG00000032011.
    GeneIDi21838.
    KEGGimmu:21838.
    UCSCiuc009pbl.1. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03151 Genomic DNA. Translation: CAA26930.1 .
    X02771 Genomic DNA. Translation: CAA26548.1 .
    X02772 Genomic DNA. Translation: CAA26549.1 . Sequence problems.
    X02773 Genomic DNA. Translation: CAA26550.1 . Sequence problems.
    M10246 Genomic DNA. Translation: AAA40440.1 .
    M11160 Genomic DNA. Translation: AAA40441.1 .
    M12379 Genomic DNA. Translation: AAA40443.1 .
    BC054436 mRNA. Translation: AAH54436.1 .
    CCDSi CCDS23093.1.
    PIRi A94278. TDMS.
    RefSeqi NP_033408.1. NM_009382.3.
    UniGenei Mm.3951.

    3D structure databases

    ProteinModelPortali P01831.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204188. 2 interactions.
    IntActi P01831. 9 interactions.
    MINTi MINT-4137766.
    STRINGi 10090.ENSMUSP00000034509.

    PTM databases

    PhosphoSitei P01831.

    Proteomic databases

    MaxQBi P01831.
    PaxDbi P01831.
    PRIDEi P01831.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114840 ; ENSMUSP00000110489 ; ENSMUSG00000032011 .
    GeneIDi 21838.
    KEGGi mmu:21838.
    UCSCi uc009pbl.1. mouse.

    Organism-specific databases

    CTDi 7070.
    MGIi MGI:98747. Thy1.

    Phylogenomic databases

    eggNOGi NOG43439.
    GeneTreei ENSGT00390000012352.
    HOGENOMi HOG000048719.
    HOVERGENi HBG002958.
    InParanoidi P01831.
    KOi K06514.
    OMAi TCELRLS.
    OrthoDBi EOG789CCZ.
    PhylomeDBi P01831.
    TreeFami TF336059.

    Miscellaneous databases

    NextBioi 301298.
    PROi P01831.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01831.
    CleanExi MM_THY1.
    Genevestigatori P01831.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003596. Ig_V-set_subgr.
    IPR013151. Immunoglobulin.
    [Graphical view ]
    Pfami PF00047. ig. 1 hit.
    [Graphical view ]
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A hydrophobic transmembrane segment at the carboxyl terminus of thy-1."
      Seki T., Chang H.-C., Moriuchi T., Denome R., Ploegh H., Silver J.
      Science 227:649-651(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Structure of the murine Thy-1 gene."
      Giguere V., Isobe K., Grosveld F.
      EMBO J. 4:2017-2024(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE).
      Strain: BALB/c.
    3. "Isolation and characterization of mouse Thy-1 genomic clones."
      Chang H.-C., Seki T., Moriuchi T., Silver J.
      Proc. Natl. Acad. Sci. U.S.A. 82:3819-3823(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE).
    4. "The mouse Thy-1.2 glycoprotein gene: complete sequence and identification of an unusual promoter."
      Ingraham H.A., Lawless G.M., Evans G.A.
      J. Immunol. 136:1482-1489(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.
    6. "Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin."
      Williams A.F., Gagnon J.
      Science 216:696-703(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-131, PYROGLUTAMATE FORMATION AT GLN-20, GPI-ANCHOR AT CYS-131.

    Entry informationi

    Entry nameiTHY1_MOUSE
    AccessioniPrimary (citable) accession number: P01831
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3