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Protein

Thy-1 membrane glycoprotein

Gene

Thy1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thy-1 membrane glycoprotein
Alternative name(s):
Thy-1 antigen
CD_antigen: CD90
Gene namesi
Name:Thy1
Synonyms:Thy-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:98747. Thy1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of external side of plasma membrane Source: MGI
  • apical plasma membrane Source: MGI
  • cytosol Source: Ensembl
  • dendrite Source: MGI
  • endoplasmic reticulum Source: MGI
  • external side of plasma membrane Source: UniProtKB
  • extracellular exosome Source: MGI
  • focal adhesion Source: MGI
  • growth cone Source: UniProtKB
  • membrane raft Source: MGI
  • myelin sheath Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001497720 – 131Thy-1 membrane glycoproteinAdd BLAST112
PropeptideiPRO_0000014978132 – 162Removed in mature formAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi28 ↔ 131AlternatePROSITE-ProRule annotation1 Publication
Disulfide bondi38 ↔ 105PROSITE-ProRule annotation1 Publication
Glycosylationi42N-linked (GlcNAc...)1 Publication1
Glycosylationi94N-linked (GlcNAc...)1 Publication1
Glycosylationi118N-linked (GlcNAc...)1 Publication1
Lipidationi131GPI-anchor amidated cysteine; alternate1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP01831.
MaxQBiP01831.
PaxDbiP01831.
PeptideAtlasiP01831.
PRIDEiP01831.

PTM databases

iPTMnetiP01831.
PhosphoSitePlusiP01831.
SwissPalmiP01831.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032011.
CleanExiMM_THY1.
GenevisibleiP01831. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204188. 2 interactors.
IntActiP01831. 9 interactors.
MINTiMINT-4137766.
STRINGi10090.ENSMUSP00000110489.

Structurei

3D structure databases

ProteinModelPortaliP01831.
SMRiP01831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 127Ig-like V-typeAdd BLAST108

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IVXA. Eukaryota.
ENOG410YYC2. LUCA.
GeneTreeiENSGT00390000012352.
HOGENOMiHOG000048719.
HOVERGENiHBG002958.
InParanoidiP01831.
KOiK06514.
OMAiTCELRLS.
OrthoDBiEOG091G0RWU.
PhylomeDBiP01831.
TreeFamiTF336059.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
IPR033292. THY1.
[Graphical view]
PANTHERiPTHR19226:SF2. PTHR19226:SF2. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPAISVALL LSVLQVSRGQ KVTSLTACLV NQNLRLDCRH ENNTKDNSIQ
60 70 80 90 100
HEFSLTREKR KHVLSGTLGI PEHTYRSRVT LSNQPYIKVL TLANFTTKDE
110 120 130 140 150
GDYFCELQVS GANPMSSNKS ISVYRDKLVK CGGISLLVQN TSWMLLLLLS
160
LSLLQALDFI SL
Length:162
Mass (Da):18,080
Last modified:July 21, 1986 - v1
Checksum:i397BF7D3A9F2C77B
GO

Polymorphismi

There are two major alleles; Thy-1.1 (CD90.1) and Thy-1.2 (CD90.2).4 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti108Q → R in allele Thy-1.1. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03151 Genomic DNA. Translation: CAA26930.1.
X02771 Genomic DNA. Translation: CAA26548.1.
X02772 Genomic DNA. Translation: CAA26549.1. Sequence problems.
X02773 Genomic DNA. Translation: CAA26550.1. Sequence problems.
M10246 Genomic DNA. Translation: AAA40440.1.
M11160 Genomic DNA. Translation: AAA40441.1.
M12379 Genomic DNA. Translation: AAA40443.1.
BC054436 mRNA. Translation: AAH54436.1.
CCDSiCCDS23093.1.
PIRiA94278. TDMS.
RefSeqiNP_033408.1. NM_009382.3.
UniGeneiMm.3951.

Genome annotation databases

EnsembliENSMUST00000114840; ENSMUSP00000110489; ENSMUSG00000032011.
GeneIDi21838.
KEGGimmu:21838.
UCSCiuc009pbl.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03151 Genomic DNA. Translation: CAA26930.1.
X02771 Genomic DNA. Translation: CAA26548.1.
X02772 Genomic DNA. Translation: CAA26549.1. Sequence problems.
X02773 Genomic DNA. Translation: CAA26550.1. Sequence problems.
M10246 Genomic DNA. Translation: AAA40440.1.
M11160 Genomic DNA. Translation: AAA40441.1.
M12379 Genomic DNA. Translation: AAA40443.1.
BC054436 mRNA. Translation: AAH54436.1.
CCDSiCCDS23093.1.
PIRiA94278. TDMS.
RefSeqiNP_033408.1. NM_009382.3.
UniGeneiMm.3951.

3D structure databases

ProteinModelPortaliP01831.
SMRiP01831.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204188. 2 interactors.
IntActiP01831. 9 interactors.
MINTiMINT-4137766.
STRINGi10090.ENSMUSP00000110489.

PTM databases

iPTMnetiP01831.
PhosphoSitePlusiP01831.
SwissPalmiP01831.

Proteomic databases

EPDiP01831.
MaxQBiP01831.
PaxDbiP01831.
PeptideAtlasiP01831.
PRIDEiP01831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114840; ENSMUSP00000110489; ENSMUSG00000032011.
GeneIDi21838.
KEGGimmu:21838.
UCSCiuc009pbl.1. mouse.

Organism-specific databases

CTDi7070.
MGIiMGI:98747. Thy1.

Phylogenomic databases

eggNOGiENOG410IVXA. Eukaryota.
ENOG410YYC2. LUCA.
GeneTreeiENSGT00390000012352.
HOGENOMiHOG000048719.
HOVERGENiHBG002958.
InParanoidiP01831.
KOiK06514.
OMAiTCELRLS.
OrthoDBiEOG091G0RWU.
PhylomeDBiP01831.
TreeFamiTF336059.

Miscellaneous databases

PROiP01831.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032011.
CleanExiMM_THY1.
GenevisibleiP01831. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
IPR033292. THY1.
[Graphical view]
PANTHERiPTHR19226:SF2. PTHR19226:SF2. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHY1_MOUSE
AccessioniPrimary (citable) accession number: P01831
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.