P01831 (THY1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thy-1 membrane glycoprotein

Alternative name(s):
Thy-1 antigen
CD_antigen=CD90

Gene names

Name:	Thy1
Synonyms:	Thy-1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	162 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Ref.6.
Polymorphism	There are two major alleles; Thy-1.1 (CD90.1) and Thy-1.2 (CD90.2).
Sequence similarities	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein Pyrrolidone carboxylic acid
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	T cell receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB angiogenesis Inferred from direct assay. Source: UniProtKB cell-cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB cytoskeleton organization Inferred from sequence or structural similarity. Source: UniProtKB focal adhesion assembly Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of T cell receptor signaling pathway Inferred from direct assay. Source: UniProtKB negative regulation of axonogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell migration Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of protein kinase activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of T cell activation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of release of sequestered calcium ion into cytosol Inferred from sequence or structural similarity. Source: UniProtKB retinal cone cell development Inferred from mutant phenotype. Source: UniProtKB
Cellular component	anchored to external side of plasma membrane Inferred from direct assay. Source: MGI dendrite Inferred from direct assay. Source: MGI growth cone Inferred from sequence or structural similarity. Source: UniProtKB membrane raft Inferred from direct assay. Source: MGI
Molecular function	GPI anchor binding Inferred from sequence or structural similarity. Source: UniProtKB Rho GTPase activator activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Ref.6
	Chain	20 – 131	112	Thy-1 membrane glycoprotein		PRO_0000014977
	Propeptide	132 – 162	31	Removed in mature form		PRO_0000014978
Regions
	Domain	20 – 127	108	Ig-like V-type
Amino acid modifications
	Modified residue	20	1	Pyrrolidone carboxylic acid Ref.6
	Lipidation	131	1	GPI-anchor amidated cysteine Ref.6
	Glycosylation	42	1	N-linked (GlcNAc...) Ref.6
	Glycosylation	94	1	N-linked (GlcNAc...) Ref.6
	Glycosylation	118	1	N-linked (GlcNAc...) Ref.6
	Disulfide bond	28 ↔ 131		Ref.6
	Disulfide bond	38 ↔ 105		Ref.6
Natural variations
	Natural variant	108	1	Q → R in allele Thy-1.1.

Sequences

	Sequence		Length	Mass (Da)
	P01831 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 397BF7D3A9F2C77B	FASTA	162	18,080
	10 20 30 40 50 60 MNPAISVALL LSVLQVSRGQ KVTSLTACLV NQNLRLDCRH ENNTKDNSIQ HEFSLTREKR 70 80 90 100 110 120 KHVLSGTLGI PEHTYRSRVT LSNQPYIKVL TLANFTTKDE GDYFCELQVS GANPMSSNKS 130 140 150 160 ISVYRDKLVK CGGISLLVQN TSWMLLLLLS LSLLQALDFI SL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A hydrophobic transmembrane segment at the carboxyl terminus of thy-1." Seki T., Chang H.-C., Moriuchi T., Denome R., Ploegh H., Silver J. Science 227:649-651(1985) [PubMed: 2857501] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Structure of the murine Thy-1 gene." Giguere V., Isobe K., Grosveld F. EMBO J. 4:2017-2024(1985) [PubMed: 2866091] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE). Strain: BALB/c.
[3]	"Isolation and characterization of mouse Thy-1 genomic clones." Chang H.-C., Seki T., Moriuchi T., Silver J. Proc. Natl. Acad. Sci. U.S.A. 82:3819-3823(1985) [PubMed: 2582427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE).
[4]	"The mouse Thy-1.2 glycoprotein gene: complete sequence and identification of an unusual promoter." Ingraham H.A., Lawless G.M., Evans G.A. J. Immunol. 136:1482-1489(1986) [PubMed: 2868059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE).
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Olfactory epithelium.
[6]	"Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin." Williams A.F., Gagnon J. Science 216:696-703(1982) [PubMed: 6177036] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-131, PYROGLUTAMATE FORMATION AT GLN-20, GPI-ANCHOR AT CYS-131.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X03151 Genomic DNA. Translation: CAA26930.1. X02771 Genomic DNA. Translation: CAA26548.1. X02772 Genomic DNA. Translation: CAA26549.1. Sequence problems. X02773 Genomic DNA. Translation: CAA26550.1. Sequence problems. M10246 Genomic DNA. Translation: AAA40440.1. M11160 Genomic DNA. Translation: AAA40441.1. M12379 Genomic DNA. Translation: AAA40443.1. BC054436 mRNA. Translation: AAH54436.1.
IPI	IPI00109727.
PIR	TDMS. A94278.
RefSeq	NP_033408.1. NM_009382.3.
UniGene	Mm.3951.
3D structure databases
ProteinModelPortal	P01831.
SMR	P01831. Positions 28-111.
ModBase	Search...
Protein-protein interaction databases
IntAct	P01831. 4 interactions.
STRING	P01831.
PTM databases
PhosphoSite	P01831.
Proteomic databases
PRIDE	P01831.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000114840; ENSMUSP00000110489; ENSMUSG00000032011.
GeneID	21838.
KEGG	mmu:21838.
UCSC	uc009pbl.1. mouse.
Organism-specific databases
CTD	7070.
MGI	MGI:98747. Thy1.
Phylogenomic databases
eggNOG	roNOG17327.
HOGENOM	HBG279081.
HOVERGEN	HBG002958.
InParanoid	P01831.
OMA	TCELRLS.
OrthoDB	EOG4SF977.
PhylomeDB	P01831.
Gene expression databases
ArrayExpress	P01831.
Bgee	P01831.
CleanEx	MM_THY1.
Genevestigator	P01831.
GermOnline	ENSMUSG00000032011. Mus musculus.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003596. Ig_V-set_subgr. IPR013151. Immunoglobulin. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
KO	K06514.
Pfam	PF00047. ig. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	301298.
SOURCE	Search...

Entry information

Entry name

THY1_MOUSE

Accession

Primary (citable) accession number: P01831

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	November 16, 2011
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program