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P01831 (THY1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thy-1 membrane glycoprotein
Alternative name(s):
Thy-1 antigen
CD_antigen=CD90
Gene names
Name:Thy1
Synonyms:Thy-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length162 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor Ref.6.

Polymorphism

There are two major alleles; Thy-1.1 (CD90.1) and Thy-1.2 (CD90.2).

Sequence similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Signal
   PTMDisulfide bond
Glycoprotein
GPI-anchor
Lipoprotein
Pyrrolidone carboxylic acid
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processT cell receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

angiogenesis

Inferred from direct assay PubMed 9576104. Source: UniProtKB

cell-cell adhesion

Inferred from sequence or structural similarity. Source: UniProtKB

cytoskeleton organization

Inferred from sequence or structural similarity. Source: UniProtKB

focal adhesion assembly

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of T cell receptor signaling pathway

Inferred from direct assay PubMed 9285719. Source: UniProtKB

negative regulation of axonogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of protein kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of GTPase activity

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of T cell activation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of release of sequestered calcium ion into cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

retinal cone cell development

Inferred from mutant phenotype PubMed 10567740. Source: UniProtKB

   Cellular_componentanchored component of external side of plasma membrane

Inferred from direct assay PubMed 10567740PubMed 14707049. Source: MGI

apical plasma membrane

Inferred from electronic annotation. Source: Ensembl

cytosol

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from direct assay PubMed 15677725. Source: MGI

endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

external side of plasma membrane

Inferred from direct assay PubMed 7983148. Source: UniProtKB

growth cone

Inferred from sequence or structural similarity. Source: UniProtKB

membrane raft

Inferred from direct assay PubMed 17341485. Source: MGI

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionGPI anchor binding

Inferred from sequence or structural similarity. Source: UniProtKB

Rho GTPase activator activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.6
Chain20 – 131112Thy-1 membrane glycoprotein
PRO_0000014977
Propeptide132 – 16231Removed in mature form
PRO_0000014978

Regions

Domain20 – 127108Ig-like V-type

Amino acid modifications

Modified residue201Pyrrolidone carboxylic acid Ref.6
Lipidation1311GPI-anchor amidated cysteine Ref.6
Glycosylation421N-linked (GlcNAc...) Ref.6
Glycosylation941N-linked (GlcNAc...) Ref.6
Glycosylation1181N-linked (GlcNAc...) Ref.6
Disulfide bond28 ↔ 131 Ref.6
Disulfide bond38 ↔ 105 Ref.6

Natural variations

Natural variant1081Q → R in allele Thy-1.1.

Sequences

Sequence LengthMass (Da)Tools
P01831 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 397BF7D3A9F2C77B

FASTA16218,080
        10         20         30         40         50         60 
MNPAISVALL LSVLQVSRGQ KVTSLTACLV NQNLRLDCRH ENNTKDNSIQ HEFSLTREKR 

        70         80         90        100        110        120 
KHVLSGTLGI PEHTYRSRVT LSNQPYIKVL TLANFTTKDE GDYFCELQVS GANPMSSNKS 

       130        140        150        160 
ISVYRDKLVK CGGISLLVQN TSWMLLLLLS LSLLQALDFI SL 

« Hide

References

« Hide 'large scale' references
[1]"A hydrophobic transmembrane segment at the carboxyl terminus of thy-1."
Seki T., Chang H.-C., Moriuchi T., Denome R., Ploegh H., Silver J.
Science 227:649-651(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Structure of the murine Thy-1 gene."
Giguere V., Isobe K., Grosveld F.
EMBO J. 4:2017-2024(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE).
Strain: BALB/c.
[3]"Isolation and characterization of mouse Thy-1 genomic clones."
Chang H.-C., Seki T., Moriuchi T., Silver J.
Proc. Natl. Acad. Sci. U.S.A. 82:3819-3823(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE).
[4]"The mouse Thy-1.2 glycoprotein gene: complete sequence and identification of an unusual promoter."
Ingraham H.A., Lawless G.M., Evans G.A.
J. Immunol. 136:1482-1489(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE).
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
[6]"Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin."
Williams A.F., Gagnon J.
Science 216:696-703(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-131, PYROGLUTAMATE FORMATION AT GLN-20, GPI-ANCHOR AT CYS-131.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X03151 Genomic DNA. Translation: CAA26930.1.
X02771 Genomic DNA. Translation: CAA26548.1.
X02772 Genomic DNA. Translation: CAA26549.1. Sequence problems.
X02773 Genomic DNA. Translation: CAA26550.1. Sequence problems.
M10246 Genomic DNA. Translation: AAA40440.1.
M11160 Genomic DNA. Translation: AAA40441.1.
M12379 Genomic DNA. Translation: AAA40443.1.
BC054436 mRNA. Translation: AAH54436.1.
PIRTDMS. A94278.
RefSeqNP_033408.1. NM_009382.3.
UniGeneMm.3951.

3D structure databases

ProteinModelPortalP01831.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204188. 2 interactions.
IntActP01831. 9 interactions.
MINTMINT-4137766.
STRING10090.ENSMUSP00000034509.

PTM databases

PhosphoSiteP01831.

Proteomic databases

PaxDbP01831.
PRIDEP01831.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000114840; ENSMUSP00000110489; ENSMUSG00000032011.
GeneID21838.
KEGGmmu:21838.
UCSCuc009pbl.1. mouse.

Organism-specific databases

CTD7070.
MGIMGI:98747. Thy1.

Phylogenomic databases

eggNOGNOG43439.
GeneTreeENSGT00390000012352.
HOGENOMHOG000048719.
HOVERGENHBG002958.
InParanoidP01831.
KOK06514.
OMATCELRLS.
OrthoDBEOG789CCZ.
PhylomeDBP01831.
TreeFamTF336059.

Gene expression databases

BgeeP01831.
CleanExMM_THY1.
GenevestigatorP01831.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003596. Ig_V-set_subgr.
IPR013151. Immunoglobulin.
[Graphical view]
PfamPF00047. ig. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio301298.
PROP01831.
SOURCESearch...

Entry information

Entry nameTHY1_MOUSE
AccessionPrimary (citable) accession number: P01831
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot