Reviewed, UniProtKB/Swiss-Prot P01831 (THY1_MOUSE)

Names and origin

Protein names

Recommended name:
    Thy-1 membrane glycoprotein
Alternative name(s):
    Thy-1 antigen
    CD_antigen=CD90

Gene names

Name:	Thy1
Synonyms:	Thy-1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	162 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor. Ref.6
Polymorphism	There are two major alleles; Thy-1.1 (CD90.1) and Thy-1.2 (CD90.2).
Sequence similarities	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein Pyrrolidone carboxylic acid
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	T cell receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB angiogenesis Inferred from direct assay. Source: UniProtKB cell-cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB cytoskeleton organization Inferred from sequence or structural similarity. Source: UniProtKB focal adhesion formation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of T cell receptor signaling pathway Inferred from direct assay. Source: UniProtKB negative regulation of axonogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell migration Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of protein kinase activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of GTPase activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of T cell activation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of release of sequestered calcium ion into cytosol Inferred from sequence or structural similarity. Source: UniProtKB retinal cone cell development Inferred from mutant phenotype. Source: UniProtKB
Cellular component	anchored to external side of plasma membrane Inferred from direct assay. Source: MGI dendrite Inferred from direct assay. Source: MGI growth cone Inferred from sequence or structural similarity. Source: UniProtKB membrane raft Inferred from direct assay. Source: MGI
Molecular function	GPI anchor binding Inferred from sequence or structural similarity. Source: UniProtKB Rho GTPase activator activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Ref.6
	Chain	20 – 131	112	Thy-1 membrane glycoprotein		PRO_0000014977
	Propeptide	132 – 162	31	Removed in mature form		PRO_0000014978
Regions
	Domain	20 – 127	108	Ig-like V-type
Amino acid modifications
	Modified residue	20	1	Pyrrolidone carboxylic acid Ref.6
	Lipidation	131	1	GPI-anchor amidated cysteine
	Glycosylation	42	1	N-linked (GlcNAc...) Ref.6
	Glycosylation	94	1	N-linked (GlcNAc...) Ref.6
	Glycosylation	118	1	N-linked (GlcNAc...) Ref.6
	Disulfide bond	28 ↔ 131		Ref.6
	Disulfide bond	38 ↔ 105		Ref.6
Natural variations
	Natural variant	108	1	Q → R in allele Thy-1.1.

Sequences

	Sequence		Length	Mass (Da)
	P01831-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 397BF7D3A9F2C77B	FASTA	162	18,080
	10 20 30 40 50 60 MNPAISVALL LSVLQVSRGQ KVTSLTACLV NQNLRLDCRH ENNTKDNSIQ HEFSLTREKR 70 80 90 100 110 120 KHVLSGTLGI PEHTYRSRVT LSNQPYIKVL TLANFTTKDE GDYFCELQVS GANPMSSNKS 130 140 150 160 ISVYRDKLVK CGGISLLVQN TSWMLLLLLS LSLLQALDFI SL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A hydrophobic transmembrane segment at the carboxyl terminus of thy-1." Seki T., Chang H.-C., Moriuchi T., Denome R., Ploegh H., Silver J. Science 227:649-651(1985) [PubMed: 2857501] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Structure of the murine Thy-1 gene." Giguere V., Isobe K., Grosveld F. EMBO J. 4:2017-2024(1985) [PubMed: 2866091] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE). Strain: BALB/c.
[3]	"Isolation and characterization of mouse Thy-1 genomic clones." Chang H.-C., Seki T., Moriuchi T., Silver J. Proc. Natl. Acad. Sci. U.S.A. 82:3819-3823(1985) [PubMed: 2582427] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE).
[4]	"The mouse Thy-1.2 glycoprotein gene: complete sequence and identification of an unusual promoter." Ingraham H.A., Lawless G.M., Evans G.A. J. Immunol. 136:1482-1489(1986) [PubMed: 2868059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE).
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Olfactory epithelium.
[6]	"Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin." Williams A.F., Gagnon J. Science 216:696-703(1982) [PubMed: 6177036] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-131, PYROGLUTAMATE FORMATION AT GLN-20, GPI-ANCHOR AT CYS-131.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X03151 Genomic DNA. Translation: CAA26930.1. X02771 Genomic DNA. Translation: CAA26548.1. X02772 Genomic DNA. Translation: CAA26549.1. Sequence problems. X02773 Genomic DNA. Translation: CAA26550.1. Sequence problems. M10246 Genomic DNA. Translation: AAA40440.1. M11160 Genomic DNA. Translation: AAA40441.1. M12379 Genomic DNA. Translation: AAA40443.1. BC054436 mRNA. Translation: AAH54436.1.
IPI	IPI00109727.
PIR	TDMS. A94278.
RefSeq	NP_033408.1.
UniGene	Mm.3951
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P01831.
Proteomic databases
PRIDE	P01831.
Genome annotation databases
Ensembl	ENSMUST00000034509; ENSMUSP00000034509; ENSMUSG00000032011; Mus musculus. [Genome view] ENSMUST00000114840; ENSMUSP00000110489; ENSMUSG00000032011; Mus musculus. [Genome view]
GeneID	21838.
KEGG	mmu:21838.
UCSC	uc009pbl.1. mouse.
Organism-specific databases
CTD	21838.
MGI	MGI:98747. Thy1.
Phylogenomic databases
HOGENOM	P01831.
HOVERGEN	P01831.
OMA	LPIQYEF.
Gene expression databases
ArrayExpress	P01831.
Bgee	P01831.
CleanEx	MM_THY1.
Genevestigator	P01831.
GermOnline	ENSMUSG00000032011. Mus musculus.
Family and domain databases
InterPro	IPR013151. Ig. IPR007110. Ig-like. IPR003596. Ig_V-set_sub. [Graphical view]
Pfam	PF00047. ig. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	301298.
SOURCE	Search...

Entry information

Entry name

THY1_MOUSE

Accession

Primary (citable) accession number: P01831

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	November 3, 2009
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)