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Protein

Thy-1 membrane glycoprotein

Gene

Thy1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

GO - Molecular functioni

  1. GPI anchor binding Source: UniProtKB
  2. integrin binding Source: MGI
  3. Rho GTPase activator activity Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. cytoskeleton organization Source: UniProtKB
  3. focal adhesion assembly Source: UniProtKB
  4. negative regulation of axonogenesis Source: UniProtKB
  5. negative regulation of cell migration Source: UniProtKB
  6. negative regulation of protein kinase activity Source: UniProtKB
  7. negative regulation of T cell receptor signaling pathway Source: UniProtKB
  8. positive regulation of GTPase activity Source: UniProtKB
  9. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  10. positive regulation of T cell activation Source: UniProtKB
  11. retinal cone cell development Source: UniProtKB
  12. single organismal cell-cell adhesion Source: UniProtKB
  13. T cell receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thy-1 membrane glycoprotein
Alternative name(s):
Thy-1 antigen
CD_antigen: CD90
Gene namesi
Name:Thy1
Synonyms:Thy-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:98747. Thy1.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of external side of plasma membrane Source: MGI
  2. apical plasma membrane Source: MGI
  3. cytosol Source: Ensembl
  4. dendrite Source: MGI
  5. endoplasmic reticulum Source: MGI
  6. external side of plasma membrane Source: UniProtKB
  7. extracellular vesicular exosome Source: MGI
  8. focal adhesion Source: MGI
  9. growth cone Source: UniProtKB
  10. membrane raft Source: MGI
  11. myelin sheath Source: UniProtKB
  12. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 131112Thy-1 membrane glycoproteinPRO_0000014977Add
BLAST
Propeptidei132 – 16231Removed in mature formPRO_0000014978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Pyrrolidone carboxylic acid1 Publication
Disulfide bondi28 ↔ 131PROSITE-ProRule annotation1 Publication
Disulfide bondi38 ↔ 105PROSITE-ProRule annotation1 Publication
Glycosylationi42 – 421N-linked (GlcNAc...)1 Publication
Glycosylationi94 – 941N-linked (GlcNAc...)1 Publication
Glycosylationi118 – 1181N-linked (GlcNAc...)1 Publication
Lipidationi131 – 1311GPI-anchor amidated cysteine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP01831.
PaxDbiP01831.
PRIDEiP01831.

PTM databases

PhosphoSiteiP01831.

Expressioni

Gene expression databases

BgeeiP01831.
CleanExiMM_THY1.
GenevestigatoriP01831.

Interactioni

Protein-protein interaction databases

BioGridi204188. 2 interactions.
IntActiP01831. 9 interactions.
MINTiMINT-4137766.
STRINGi10090.ENSMUSP00000034509.

Structurei

3D structure databases

ProteinModelPortaliP01831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 127108Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG43439.
GeneTreeiENSGT00390000012352.
HOGENOMiHOG000048719.
HOVERGENiHBG002958.
InParanoidiP01831.
KOiK06514.
OMAiGVPEHSY.
OrthoDBiEOG789CCZ.
PhylomeDBiP01831.
TreeFamiTF336059.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003596. Ig_V-set_subgr.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPAISVALL LSVLQVSRGQ KVTSLTACLV NQNLRLDCRH ENNTKDNSIQ
60 70 80 90 100
HEFSLTREKR KHVLSGTLGI PEHTYRSRVT LSNQPYIKVL TLANFTTKDE
110 120 130 140 150
GDYFCELQVS GANPMSSNKS ISVYRDKLVK CGGISLLVQN TSWMLLLLLS
160
LSLLQALDFI SL
Length:162
Mass (Da):18,080
Last modified:July 21, 1986 - v1
Checksum:i397BF7D3A9F2C77B
GO

Polymorphismi

There are two major alleles; Thy-1.1 (CD90.1) and Thy-1.2 (CD90.2).

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081Q → R in allele Thy-1.1.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03151 Genomic DNA. Translation: CAA26930.1.
X02771 Genomic DNA. Translation: CAA26548.1.
X02772 Genomic DNA. Translation: CAA26549.1. Sequence problems.
X02773 Genomic DNA. Translation: CAA26550.1. Sequence problems.
M10246 Genomic DNA. Translation: AAA40440.1.
M11160 Genomic DNA. Translation: AAA40441.1.
M12379 Genomic DNA. Translation: AAA40443.1.
BC054436 mRNA. Translation: AAH54436.1.
CCDSiCCDS23093.1.
PIRiA94278. TDMS.
RefSeqiNP_033408.1. NM_009382.3.
UniGeneiMm.3951.

Genome annotation databases

EnsembliENSMUST00000114840; ENSMUSP00000110489; ENSMUSG00000032011.
GeneIDi21838.
KEGGimmu:21838.
UCSCiuc009pbl.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03151 Genomic DNA. Translation: CAA26930.1.
X02771 Genomic DNA. Translation: CAA26548.1.
X02772 Genomic DNA. Translation: CAA26549.1. Sequence problems.
X02773 Genomic DNA. Translation: CAA26550.1. Sequence problems.
M10246 Genomic DNA. Translation: AAA40440.1.
M11160 Genomic DNA. Translation: AAA40441.1.
M12379 Genomic DNA. Translation: AAA40443.1.
BC054436 mRNA. Translation: AAH54436.1.
CCDSiCCDS23093.1.
PIRiA94278. TDMS.
RefSeqiNP_033408.1. NM_009382.3.
UniGeneiMm.3951.

3D structure databases

ProteinModelPortaliP01831.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204188. 2 interactions.
IntActiP01831. 9 interactions.
MINTiMINT-4137766.
STRINGi10090.ENSMUSP00000034509.

PTM databases

PhosphoSiteiP01831.

Proteomic databases

MaxQBiP01831.
PaxDbiP01831.
PRIDEiP01831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114840; ENSMUSP00000110489; ENSMUSG00000032011.
GeneIDi21838.
KEGGimmu:21838.
UCSCiuc009pbl.1. mouse.

Organism-specific databases

CTDi7070.
MGIiMGI:98747. Thy1.

Phylogenomic databases

eggNOGiNOG43439.
GeneTreeiENSGT00390000012352.
HOGENOMiHOG000048719.
HOVERGENiHBG002958.
InParanoidiP01831.
KOiK06514.
OMAiGVPEHSY.
OrthoDBiEOG789CCZ.
PhylomeDBiP01831.
TreeFamiTF336059.

Miscellaneous databases

NextBioi301298.
PROiP01831.
SOURCEiSearch...

Gene expression databases

BgeeiP01831.
CleanExiMM_THY1.
GenevestigatoriP01831.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003596. Ig_V-set_subgr.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A hydrophobic transmembrane segment at the carboxyl terminus of thy-1."
    Seki T., Chang H.-C., Moriuchi T., Denome R., Ploegh H., Silver J.
    Science 227:649-651(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Structure of the murine Thy-1 gene."
    Giguere V., Isobe K., Grosveld F.
    EMBO J. 4:2017-2024(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE).
    Strain: BALB/c.
  3. "Isolation and characterization of mouse Thy-1 genomic clones."
    Chang H.-C., Seki T., Moriuchi T., Silver J.
    Proc. Natl. Acad. Sci. U.S.A. 82:3819-3823(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE).
  4. "The mouse Thy-1.2 glycoprotein gene: complete sequence and identification of an unusual promoter."
    Ingraham H.A., Lawless G.M., Evans G.A.
    J. Immunol. 136:1482-1489(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (THY-1.2 ALLOTYPE).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  6. "Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin."
    Williams A.F., Gagnon J.
    Science 216:696-703(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-131, PYROGLUTAMATE FORMATION AT GLN-20, GPI-ANCHOR AT CYS-131.

Entry informationi

Entry nameiTHY1_MOUSE
AccessioniPrimary (citable) accession number: P01831
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 4, 2015
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.