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P01830

- THY1_RAT

UniProt

P01830 - THY1_RAT

Protein

Thy-1 membrane glycoprotein

Gene

Thy1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

    GO - Molecular functioni

    1. enzyme binding Source: RGD
    2. GPI anchor binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. protein kinase binding Source: RGD
    5. Rho GTPase activator activity Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. cytoskeleton organization Source: UniProtKB
    3. focal adhesion assembly Source: UniProtKB
    4. mast cell activation Source: UniProtKB
    5. negative regulation of apoptotic process Source: UniProtKB
    6. negative regulation of axonogenesis Source: UniProtKB
    7. negative regulation of cell migration Source: UniProtKB
    8. negative regulation of fibroblast proliferation Source: UniProtKB
    9. negative regulation of protein kinase activity Source: UniProtKB
    10. negative regulation of T cell receptor signaling pathway Source: UniProtKB
    11. positive regulation of GTPase activity Source: UniProtKB
    12. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    13. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
    14. positive regulation of Rho GTPase activity Source: GOC
    15. positive regulation of T cell activation Source: UniProtKB
    16. retinal cone cell development Source: UniProtKB
    17. single organismal cell-cell adhesion Source: UniProtKB
    18. T cell receptor signaling pathway Source: UniProtKB

    Keywords - Ligandi

    Sialic acid

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thy-1 membrane glycoprotein
    Alternative name(s):
    Thy-1 antigen
    CD_antigen: CD90
    Gene namesi
    Name:Thy1
    Synonyms:Thy-1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi3860. Thy1.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of external side of plasma membrane Source: Ensembl
    2. anchored component of plasma membrane Source: RGD
    3. apical plasma membrane Source: Ensembl
    4. cell surface Source: RGD
    5. cytosol Source: UniProtKB
    6. dendrite Source: Ensembl
    7. endoplasmic reticulum Source: Ensembl
    8. external side of plasma membrane Source: UniProtKB
    9. growth cone Source: UniProtKB
    10. membrane raft Source: Ensembl
    11. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 130111Thy-1 membrane glycoproteinPRO_0000014979Add
    BLAST
    Propeptidei131 – 16131Removed in mature formPRO_0000014980Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei20 – 201Pyrrolidone carboxylic acid1 Publication
    Disulfide bondi28 ↔ 1301 PublicationPROSITE-ProRule annotation
    Disulfide bondi38 ↔ 1041 PublicationPROSITE-ProRule annotation
    Glycosylationi42 – 421N-linked (GlcNAc...) (high mannose or complex)1 Publication
    Glycosylationi93 – 931N-linked (GlcNAc...) (complex)1 Publication
    Glycosylationi117 – 1171N-linked (GlcNAc...) (high mannose or hybrid); in brain1 Publication
    Lipidationi130 – 1301GPI-anchor amidated cysteine

    Post-translational modificationi

    Glycosylation is tissue specific. Sialylation of N-glycans at Asn-93 in brain and at Asn-42, Asn-93 and Asn-117 in thymus.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    PaxDbiP01830.
    PRIDEiP01830.

    PTM databases

    PhosphoSiteiP01830.

    Expressioni

    Tissue specificityi

    Abundant in lymphoid tissues.

    Gene expression databases

    GenevestigatoriP01830.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-1031N.
    IntActiP01830. 1 interaction.
    MINTiMINT-4996320.
    STRINGi10116.ENSRNOP00000008685.

    Structurei

    3D structure databases

    ProteinModelPortaliP01830.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 126107Ig-like V-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG43439.
    GeneTreeiENSGT00390000012352.
    HOGENOMiHOG000048719.
    HOVERGENiHBG002958.
    InParanoidiP01830.
    KOiK06514.
    OMAiTCELRLS.
    OrthoDBiEOG789CCZ.
    PhylomeDBiP01830.
    TreeFamiTF336059.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    [Graphical view]
    PfamiPF00047. ig. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01830-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPVISITLL LSVLQMSRGQ RVISLTACLV NQNLRLDCRH ENNTNLPIQH    50
    EFSLTREKKK HVLSGTLGVP EHTYRSRVNL FSDRFIKVLT LANFTTKDEG 100
    DYMCELRVSG QNPTSSNKTI NVIRDKLVKC GGISLLVQNT SWLLLLLLSL 150
    SFLQATDFIS L 161
    Length:161
    Mass (Da):18,172
    Last modified:August 13, 1987 - v1
    Checksum:i3285748F3C2C5AB2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti71 – 711E → Q in CAA26931. (PubMed:2864289)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03152 Genomic DNA. Translation: CAA26931.1.
    X03150 mRNA. Translation: CAA26929.1.
    X02002 Genomic DNA. Translation: CAA26033.1.
    M18002 mRNA. Translation: AAA42243.1.
    M10666 mRNA. Translation: AAA42242.1.
    PIRiB45909. TDRT.
    RefSeqiNP_036805.1. NM_012673.2.
    UniGeneiRn.108198.

    Genome annotation databases

    EnsembliENSRNOT00000008685; ENSRNOP00000008685; ENSRNOG00000006604.
    GeneIDi24832.
    KEGGirno:24832.
    UCSCiRGD:3860. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03152 Genomic DNA. Translation: CAA26931.1 .
    X03150 mRNA. Translation: CAA26929.1 .
    X02002 Genomic DNA. Translation: CAA26033.1 .
    M18002 mRNA. Translation: AAA42243.1 .
    M10666 mRNA. Translation: AAA42242.1 .
    PIRi B45909. TDRT.
    RefSeqi NP_036805.1. NM_012673.2.
    UniGenei Rn.108198.

    3D structure databases

    ProteinModelPortali P01830.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-1031N.
    IntActi P01830. 1 interaction.
    MINTi MINT-4996320.
    STRINGi 10116.ENSRNOP00000008685.

    PTM databases

    PhosphoSitei P01830.

    Proteomic databases

    PaxDbi P01830.
    PRIDEi P01830.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000008685 ; ENSRNOP00000008685 ; ENSRNOG00000006604 .
    GeneIDi 24832.
    KEGGi rno:24832.
    UCSCi RGD:3860. rat.

    Organism-specific databases

    CTDi 7070.
    RGDi 3860. Thy1.

    Phylogenomic databases

    eggNOGi NOG43439.
    GeneTreei ENSGT00390000012352.
    HOGENOMi HOG000048719.
    HOVERGENi HBG002958.
    InParanoidi P01830.
    KOi K06514.
    OMAi TCELRLS.
    OrthoDBi EOG789CCZ.
    PhylomeDBi P01830.
    TreeFami TF336059.

    Miscellaneous databases

    NextBioi 604560.
    PROi P01830.

    Gene expression databases

    Genevestigatori P01830.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    [Graphical view ]
    Pfami PF00047. ig. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Thy-1: a hydrophobic transmembrane segment at the carboxyl terminus."
      Seki T., Chang H.-C., Moriuchi T., Denome R., Silver J.
      Fed. Proc. 44:2865-2869(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Thy-1 cDNA sequence suggests a novel regulatory mechanism."
      Moriuchi T., Chang H.-C., Denome R., Silver J.
      Nature 301:80-82(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-122.
    3. "Structural organization of the rat thy-1 gene."
      Seki T., Moriuchi T., Chang H.-C., Denome R., Silver J.
      Nature 313:485-487(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-161.
    4. "Rat Thy-1 antigen has a hydrophobic segment at the carboxyl terminus."
      Moriuchi T., Silver J.
      FEBS Lett. 178:105-108(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 20-161.
    5. "Rat brain Thy-1 glycoprotein. The amino acid sequence, disulphide bonds and an unusual hydrophobic region."
      Campbell D.G., Gagnon J., Reid K.B.M., Williams A.F.
      Biochem. J. 195:15-30(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-130, PYROGLUTAMATE FORMATION AT GLN-20, GLYCOSYLATION AT ASN-42; ASN-93 AND ASN-117, DISULFIDE BONDS.
    6. Lubec G., Chen W.-Q., Kang S.U.
      Submitted (JUL-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 78-84 AND 119-124, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain and Hippocampus.
    7. "Tissue-specific N-glycosylation, site-specific oligosaccharide patterns and lentil lectin recognition of rat Thy-1."
      Parekh R.B., Tse A.G.D., Dwek R.A., Williams A.F., Rademacher T.W.
      EMBO J. 6:1233-1244(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE OF CARBOHYDRATES.
    8. "Complete structure of the glycosyl phosphatidylinositol membrane anchor of rat brain Thy-1 glycoprotein."
      Homans S.W., Ferguson M.A., Dwek R.A., Rademacher T.W., Anand R., Williams A.F.
      Nature 333:269-272(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE OF THE GPI-ANCHOR AT CYS-130.

    Entry informationi

    Entry nameiTHY1_RAT
    AccessioniPrimary (citable) accession number: P01830
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3