ID   HVM46_MOUSE             Reviewed;         137 AA.
AC   P01822;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 2.
DT   24-NOV-2009, entry version 69.
DE   RecName: Full=Ig heavy chain V region MOPC 315;
DE   Flags: Precursor;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=89238351; PubMed=2497341; DOI=10.1016/0161-5890(89)90133-8;
RA   Rinfret A., Horne C., Dorrington K.J., Klein M.;
RT   "Cloning, sequencing and expression of the rearranged MOPC 315 VH gene
RT   segment.";
RL   Mol. Immunol. 26:431-434(1989).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-31.
RX   MEDLINE=78094475; PubMed=414225; DOI=10.1073/pnas.74.12.5692;
RA   Jilka R.L., Pestka S.;
RT   "Amino acid sequence of the precursor region of MOPC-315 mouse
RT   immunoglobulin heavy chain.";
RL   Proc. Natl. Acad. Sci. U.S.A. 74:5692-5696(1977).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-21.
RX   MEDLINE=79148758; PubMed=428562;
RA   Schechter I., Wolf O., Zemell R., Burstein Y.;
RT   "Structure and function of immunoglobulin genes and precursors.";
RL   Fed. Proc. 38:1839-1845(1979).
RN   [4]
RP   PROTEIN SEQUENCE OF 19-136.
RX   MEDLINE=74170779; PubMed=4524622; DOI=10.1073/pnas.71.4.1123;
RA   Francis S.H., Leslie R.G.Q., Hood L., Eisen H.N.;
RT   "Amino-acid sequence of the variable region of the heavy (alpha) chain
RT   of a mouse myeloma protein with anti-hapten activity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 71:1123-1127(1974).
RN   [5]
RP   SEQUENCE REVISION TO 53.
RX   MEDLINE=77244979; PubMed=268248;
RA   Padlan E.A., Davies D.R., Pecht I., Givol D., Wright C.;
RT   "Model-building studies of antigen-binding sites: the hapten-binding
RT   site of mopc-315.";
RL   Cold Spring Harb. Symp. Quant. Biol. 41:627-637(1977).
CC   -!- MISCELLANEOUS: This alpha chain was isolated from a myeloma
CC       protein that has anti-dinitrophenyl activity.
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DR   EMBL; M27638; AAA61337.1; -; Genomic_DNA.
DR   EMBL; X07880; CAA30727.1; -; Genomic_DNA.
DR   IPI; IPI00457481; -.
DR   PIR; PL0102; AVMS35.
DR   SMR; P01822; 20-137.
DR   STRING; P01822; -.
DR   Ensembl; ENSMUST00000103481; ENSMUSP00000100262; ENSMUSG00000076672; Mus musculus.
DR   HOVERGEN; P01822; -.
DR   Genevestigator; P01822; -.
DR   GO; GO:0003823; F:antigen binding; IEA:UniProtKB-KW.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR003596; Ig_V-set_sub.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00406; IGv; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Immunoglobulin domain;
KW   Immunoglobulin V region; Signal.
FT   SIGNAL        1     18
FT   CHAIN        19    137       Ig heavy chain V region MOPC 315.
FT                                /FTId=PRO_0000015232.
FT   REGION       19     48       Framework-1.
FT   REGION       49     54       Complementarity-determining-1.
FT   REGION       55     68       Framework-2.
FT   REGION       69     84       Complementarity-determining-2.
FT   REGION       85    116       Framework-3.
FT   REGION      117    126       Complementarity-determining-3.
FT   REGION      127    137       Framework-4.
FT   DISULFID     40    114       By similarity.
FT   CONFLICT     15     15       G -> GG (in Ref. 1; CAA30727).
FT   CONFLICT     15     15       G -> H (in Ref. 2; AA sequence).
FT   CONFLICT     77     78       GY -> YG (in Ref. 4; AA sequence).
FT   CONFLICT    102    102       N -> D (in Ref. 4; AA sequence).
FT   CONFLICT    123    123       Missing (in Ref. 4; AA sequence).
FT   NON_TER     137    137
SQ   SEQUENCE   137 AA;  15399 MW;  FB3828304C2B81DC CRC64;
     MKVLSLLYLL TAIPGIMSDV QLQESGPGLV KPSQSLSLTC SVTGYSITSG YFWNWIRQFP
     GNKLEWLGFI KYDGSNGYNP SLKNRVSITR DTSENQFFLK LNSVTTEDTA TYYCAGDNDH
     LYYFDYWGQG TTLTVSS
//