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Protein

Ig heavy chain V region PJ14

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB-KW
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain V region PJ14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 11596Ig heavy chain V region PJ14PRO_0000015230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Pyrrolidone carboxylic acidBy similarity

Keywords - PTMi

Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP01820.
PaxDbiP01820.

Expressioni

Gene expression databases

GenevestigatoriP01820.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
P017231EBI-1027999,EBI-1037949

Protein-protein interaction databases

IntActiP01820. 1 interaction.
MINTiMINT-135771.

Structurei

Secondary structure

1
115
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 265Combined sources
Beta strandi29 – 313Combined sources
Beta strandi37 – 4610Combined sources
Beta strandi50 – 589Combined sources
Turni60 – 623Combined sources
Beta strandi65 – 706Combined sources
Beta strandi72 – 743Combined sources
Beta strandi76 – 783Combined sources
Turni80 – 823Combined sources
Helixi83 – 853Combined sources
Beta strandi86 – 916Combined sources
Helixi92 – 943Combined sources
Beta strandi96 – 1016Combined sources
Helixi106 – 1083Combined sources
Beta strandi110 – 1156Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A2YX-ray1.50B20-115[»]
1A7NX-ray2.01H20-115[»]
1A7OX-ray2.00H20-115[»]
1A7PX-ray2.01H20-115[»]
1A7QX-ray2.00H20-115[»]
1A7RX-ray2.01H20-115[»]
1DL7X-ray2.35H20-115[»]
1DVFX-ray1.90B20-115[»]
1G7HX-ray1.85B20-115[»]
1G7IX-ray1.80B20-115[»]
1G7JX-ray1.75B20-115[»]
1G7LX-ray2.00B20-115[»]
1G7MX-ray1.90B20-115[»]
1KIRX-ray2.00B20-115[»]
1P4BX-ray2.35H21-114[»]
1P4IX-ray2.80H21-114[»]
1VFAX-ray1.80B20-115[»]
1VFBX-ray1.80B20-115[»]
43C9X-ray2.20B/D/F/H20-114[»]
43CAX-ray2.30B/D/F/H20-114[»]
ProteinModelPortaliP01820.
SMRiP01820. Positions 20-115.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01820.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – ›115›96Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

eggNOGiNOG28103.
HOGENOMiHOG000154831.
HOVERGENiHBG018013.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLALLFCL VTFPSCILSQ VQLKESGPGL VAPSQSLSIT CTVSGFSLTG
60 70 80 90 100
YGVNWVRQPP GKGLEWLGMI WGDGSTDYNS ALKSRLSISK DNSKSQVFLK
110
MNSLQTDDTA RYYCA
Length:115
Mass (Da):12,447
Last modified:July 21, 1986 - v1
Checksum:i7569DD4A4843D500
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei115 – 1151

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00767 Genomic DNA. Translation: CAA24148.1.
PIRiA02095. HVMS14.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00767 Genomic DNA. Translation: CAA24148.1.
PIRiA02095. HVMS14.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A2YX-ray1.50B20-115[»]
1A7NX-ray2.01H20-115[»]
1A7OX-ray2.00H20-115[»]
1A7PX-ray2.01H20-115[»]
1A7QX-ray2.00H20-115[»]
1A7RX-ray2.01H20-115[»]
1DL7X-ray2.35H20-115[»]
1DVFX-ray1.90B20-115[»]
1G7HX-ray1.85B20-115[»]
1G7IX-ray1.80B20-115[»]
1G7JX-ray1.75B20-115[»]
1G7LX-ray2.00B20-115[»]
1G7MX-ray1.90B20-115[»]
1KIRX-ray2.00B20-115[»]
1P4BX-ray2.35H21-114[»]
1P4IX-ray2.80H21-114[»]
1VFAX-ray1.80B20-115[»]
1VFBX-ray1.80B20-115[»]
43C9X-ray2.20B/D/F/H20-114[»]
43CAX-ray2.30B/D/F/H20-114[»]
ProteinModelPortaliP01820.
SMRiP01820. Positions 20-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01820. 1 interaction.
MINTiMINT-135771.

Protein family/group databases

IMGTiSearch...

Proteomic databases

MaxQBiP01820.
PaxDbiP01820.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG28103.
HOGENOMiHOG000154831.
HOVERGENiHBG018013.

Miscellaneous databases

EvolutionaryTraceiP01820.

Gene expression databases

GenevestigatoriP01820.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes."
    Sakano H., Maki R., Kurosawa Y., Roeder W., Tonegawa S.
    Nature 286:676-683(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHVM44_MOUSE
AccessioniPrimary (citable) accession number: P01820
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 1, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.