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Protein

Ig heavy chain V region M603

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei33 – 331H-bond with the phosphate group of phosphorylcholine
Sitei52 – 521H-bond with the phosphate group of phosphorylcholine

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain V region M603
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›122›122Ig heavy chain V region M603PRO_0000059875Add
BLAST

Proteomic databases

EPDiP01789.

Interactioni

Protein-protein interaction databases

MINTiMINT-1504974.

Structurei

Secondary structure

1
122
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 75Combined sources
Beta strandi10 – 123Combined sources
Beta strandi18 – 2710Combined sources
Helixi29 – 313Combined sources
Beta strandi34 – 396Combined sources
Beta strandi41 – 433Combined sources
Beta strandi46 – 516Combined sources
Helixi54 – 563Combined sources
Beta strandi60 – 623Combined sources
Helixi64 – 663Combined sources
Turni67 – 693Combined sources
Beta strandi70 – 756Combined sources
Turni76 – 794Combined sources
Beta strandi80 – 856Combined sources
Helixi90 – 923Combined sources
Beta strandi94 – 1018Combined sources
Turni104 – 1063Combined sources
Beta strandi107 – 1126Combined sources
Beta strandi116 – 1205Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MCPX-ray2.70H1-122[»]
2CJUX-ray2.50H1-121[»]
2MCPX-ray3.10H1-122[»]
ProteinModelPortaliP01789.
SMRiP01789. Positions 1-122.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01789.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 121121Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region

Phylogenomic databases

HOVERGENiHBG018013.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01789-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EVKLVESGGG LVQPGGSLRL SCATSGFTFS DFYMEWVRQP PGKRLEWIAA
60 70 80 90 100
SRNKGNKYTT EYSASVKGRF IVSRDTSQSI LYLQMNALRA EDTAIYYCAR
110 120
NYYGSTWYFD VWGAGTTVTV SS
Length:122
Mass (Da):13,626
Last modified:July 21, 1986 - v1
Checksum:iBA2C864438B64F0F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei122 – 1221

Sequence databases

PIRiA30539.
A30556.
B30540.
B30556.
B90795. AVMS63.
D30556.
E30539.
H30539.
I30535.
PT0354.

Cross-referencesi

Sequence databases

PIRiA30539.
A30556.
B30540.
B30556.
B90795. AVMS63.
D30556.
E30539.
H30539.
I30535.
PT0354.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MCPX-ray2.70H1-122[»]
2CJUX-ray2.50H1-121[»]
2MCPX-ray3.10H1-122[»]
ProteinModelPortaliP01789.
SMRiP01789. Positions 1-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1504974.

Proteomic databases

EPDiP01789.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG018013.

Miscellaneous databases

EvolutionaryTraceiP01789.
NextBioi35563490.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH."
    Early P., Huang H., Davis M., Calame K., Hood L.
    Cell 19:981-992(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Variable region sequence of the heavy chain from a phosphorylcholine binding myeloma protein."
    Rudikoff S., Potter M.
    Biochemistry 13:4033-4038(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-120.
  3. "The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site."
    Segal D.M., Padlan E.A., Cohen G.H., Rudikoff S., Potter M., Davies D.R.
    Proc. Natl. Acad. Sci. U.S.A. 71:4298-4302(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF FAB FRAGMENT.

Entry informationi

Entry nameiHVM20_MOUSE
AccessioniPrimary (citable) accession number: P01789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This chain was isolated from a myeloma protein that binds phosphorylcholine.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.