P01764 (HV303_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig heavy chain V-III region VH26
Organism	Homo sapiens (Human)
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain Signal
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	complement activation, classical pathway Traceable author statement. Source: Reactome innate immune response Traceable author statement. Source: Reactome
Cellular component	extracellular region Non-traceable author statement Ref.1. Source: UniProtKB
Molecular function	antigen binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

19

Chain

20 – 117

98

Ig heavy chain V-III region VH26

PRO_0000015249

Regions

Domain

20 – ›117

›98

Ig-like

Experimental info

Non-terminal residue

117

1

Secondary structure

1

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117

Helix Strand Turn

Details...

Beta strand

22 – 26

5

Beta strand

29 – 31

3

Beta strand

37 – 46

10

Helix

48 – 50

3

Beta strand

51 – 59

9

Turn

60 – 62

3

Beta strand

63 – 71

9

Turn

72 – 74

3

Beta strand

77 – 79

3

Turn

81 – 86

6

Beta strand

87 – 92

6

Turn

93 – 96

4

Beta strand

97 – 102

6

Helix

107 – 109

3

Sequences

	Sequence		Length	Mass (Da)
	P01764 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: E826733F1A3CB0F1	FASTA	117	12,582
	10 20 30 40 50 60 MEFGLSWLFL VAILKGVQCE VQLLESGGGL VQPGGSLRLS CAASGFTFSS YAMSWVRQAP 70 80 90 100 110 GKGLEWVSAI SGSGGSTYYG DSVKGRFTIS RDNSKNTLYL QMNSLRAEDT AVYYCAK

References

[1]	"Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region." Matthyssens G., Rabbitts T.H. Proc. Natl. Acad. Sci. U.S.A. 77:6561-6565(1980) [PubMed: 6450418] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein." Mariette X., Tsapis A., Brouet J.C. Eur. J. Immunol. 23:846-851(1993) [PubMed: 7681398] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-117.
[3]	"Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain." Toyonaga B., Yoshikai Y., Vadasz V., Chin B., Mak T.W. Proc. Natl. Acad. Sci. U.S.A. 82:8624-8628(1985) [PubMed: 3866244] [Abstract] Cited for: 3D-STRUCTURE MODELING OF 20-117.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M35415 Genomic DNA. Translation: AAA58735.1.

IPI

IPI00827940.

PIR

H3HU26. A02047.

UniGene

Hs.719895.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1HOU	model	-	H	20-117	[»]
1OHQ	X-ray	2.00	A/B	20-116	[»]
3BN9	X-ray	2.17	D/F	21-116	[»]

ProteinModelPortal

P01764.

SMR

P01764. Positions 20-117.

ModBase

Search...

Protein-protein interaction databases

IntAct

P01764. 1 interaction.

STRING

P01764.

Protein family/group databases

IMGT

Search...

Polymorphism databases

DMDM

123843.

Proteomic databases

PRIDE

P01764.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000390609; ENSP00000375018; ENSG00000211949.

Organism-specific databases

GeneCards

GC14M106726.
GC14U900507.

H-InvDB

HIX0175879.

HGNC

HGNC:5545. IGHV@.

Orphanet

67038. Chronic B-cell lymphocytic leukemia.

Phylogenomic databases

GeneTree

ENSGT00580000081253.

HOVERGEN

HBG018013.

InParanoid

P01764.

OrthoDB

EOG4SF97H.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

Bgee

P01764.

Genevestigator

P01764.

GermOnline

ENSG00000130076. Homo sapiens.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

Pfam

PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00406. IGv. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

HV303_HUMAN

Accession

Primary (citable) accession number: P01764

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	January 25, 2012
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.