P01756 (HVM12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig heavy chain V region MOPC 104E
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous	The sequence of the light chain of this IgM myeloma protein has also been determined. This protein binds dextran.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Molecular function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›117	›117	Ig heavy chain V region MOPC 104E		PRO_0000059870
Regions
	Domain	1 – 116	116	Ig-like
Amino acid modifications
	Glycosylation	55	1	N-linked (GlcNAc...) (high mannose); atypical Ref.1
	Disulfide bond	22 ↔ 96		By similarity
Experimental info
	Non-terminal residue	117	1

Sequences

	Sequence		Length	Mass (Da)
	P01756 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 3CF8ACE4BE447E41	FASTA	117	12,983
	10 20 30 40 50 60 EVQLQQSGPE LVKPGASVKM SCKASGYTFT DYYMKWVKQS HGKSLEWIGD INPNNGGTSY 70 80 90 100 110 NQKFKGKATL TVDKSSSTAY MQLNSLTSED SAVYYCARDY DWYFDVWGAG TTVTVSS

References

[1]	"Complete amino acid sequence of a mouse mu chain: homology among heavy chain constant region domains." Kehry M.R., Fuhrman J.S., Schilling J.W., Rogers J., Sibley C.H., Hood L.E. Biochemistry 21:5415-5424(1982) [PubMed: 6816276] [Abstract] Cited for: PROTEIN SEQUENCE, GLYCOSYLATION AT ASN-55.
+	Additional computationally mapped references.

Cross-references

Sequence databases
IPI	IPI00626084.
PIR	MHMS4E. A02039.
3D structure databases
ProteinModelPortal	P01756.
SMR	P01756. Positions 1-117.
ModBase	Search...
Protein-protein interaction databases
STRING	P01756.
Proteomic databases
PRIDE	P01756.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG018013.
Gene expression databases
Genevestigator	P01756.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_subgr. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HVM12_MOUSE

Accession

Primary (citable) accession number: P01756

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	September 21, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program