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Protein

Ig heavy chain V region MOPC 104E

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain V region MOPC 104E
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›117›117Ig heavy chain V region MOPC 104EPRO_0000059870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 96PROSITE-ProRule annotation
Glycosylationi55 – 551N-linked (GlcNAc...) (high mannose); atypical1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP01756.
PRIDEiP01756.

Structurei

Secondary structure

1
117
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63Combined sources
Beta strandi10 – 123Combined sources
Beta strandi18 – 236Combined sources
Helixi29 – 313Combined sources
Beta strandi34 – 407Combined sources
Beta strandi46 – 516Combined sources
Beta strandi53 – 553Combined sources
Beta strandi58 – 603Combined sources
Turni62 – 676Combined sources
Beta strandi68 – 736Combined sources
Helixi74 – 763Combined sources
Beta strandi78 – 836Combined sources
Helixi88 – 903Combined sources
Beta strandi92 – 987Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BQUX-ray3.00D2-98[»]
ProteinModelPortaliP01756.
SMRiP01756. Positions 1-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 116116Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region

Phylogenomic databases

HOVERGENiHBG018013.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EVQLQQSGPE LVKPGASVKM SCKASGYTFT DYYMKWVKQS HGKSLEWIGD
60 70 80 90 100
INPNNGGTSY NQKFKGKATL TVDKSSSTAY MQLNSLTSED SAVYYCARDY
110
DWYFDVWGAG TTVTVSS
Length:117
Mass (Da):12,983
Last modified:July 21, 1986 - v1
Checksum:i3CF8ACE4BE447E41
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei117 – 1171

Sequence databases

PIRiA02039. MHMS4E.

Cross-referencesi

Sequence databases

PIRiA02039. MHMS4E.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BQUX-ray3.00D2-98[»]
ProteinModelPortaliP01756.
SMRiP01756. Positions 1-117.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiP01756.
PRIDEiP01756.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG018013.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete amino acid sequence of a mouse mu chain: homology among heavy chain constant region domains."
    Kehry M.R., Fuhrman J.S., Schilling J.W., Rogers J., Sibley C.H., Hood L.E.
    Biochemistry 21:5415-5424(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, GLYCOSYLATION AT ASN-55.

Entry informationi

Entry nameiHVM12_MOUSE
AccessioniPrimary (citable) accession number: P01756
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The sequence of the light chain of this IgM myeloma protein has also been determined.
This protein binds dextran.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.