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Protein

Ig heavy chain V region B1-8/186-2

Gene

Ighv1-72

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB-KW
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain V region B1-8/186-2
Gene namesi
Name:Ighv1-72
Synonyms:Gm16709
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:4439633. Ighv1-72.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 139120Ig heavy chain V region B1-8/186-2PRO_0000015220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 115PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP01751.

Expressioni

Gene expression databases

BgeeiP01751.
ExpressionAtlasiP01751. baseline.
GenevestigatoriP01751.

Interactioni

Protein-protein interaction databases

MINTiMINT-255631.

Structurei

Secondary structure

1
139
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 254Combined sources
Beta strandi29 – 313Combined sources
Beta strandi37 – 4610Combined sources
Helixi48 – 503Combined sources
Beta strandi51 – 588Combined sources
Beta strandi60 – 623Combined sources
Beta strandi64 – 707Combined sources
Turni72 – 743Combined sources
Beta strandi77 – 793Combined sources
Helixi81 – 833Combined sources
Turni84 – 863Combined sources
Beta strandi87 – 926Combined sources
Turni93 – 964Combined sources
Beta strandi97 – 1026Combined sources
Helixi107 – 1093Combined sources
Beta strandi111 – 1199Combined sources
Turni120 – 1234Combined sources
Beta strandi126 – 1294Combined sources
Beta strandi133 – 1375Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A6UX-ray2.10H20-139[»]
1A6VX-ray1.80H/I/J20-139[»]
1A6WX-ray2.00H20-139[»]
1NGPX-ray2.40H20-139[»]
1NGQX-ray2.40H20-139[»]
1NQBX-ray2.00A/C20-139[»]
1OAQX-ray1.50H21-139[»]
1OARX-ray2.23H/I/J/K21-139[»]
1OAUX-ray1.80H/I/J/K21-139[»]
1OAXX-ray2.67H/I/J/K21-139[»]
1OAYX-ray2.66H/I/J/K21-139[»]
1OAZX-ray2.78H/J21-139[»]
1OCWX-ray2.00H21-139[»]
2BJMX-ray2.15H21-139[»]
ProteinModelPortaliP01751.
SMRiP01751. Positions 20-139.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01751.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 4930Framework-1Add
BLAST
Regioni50 – 545Complementarity-determining-1
Regioni55 – 6814Framework-2Add
BLAST
Regioni69 – 8517Complementarity-determining-2Add
BLAST
Regioni86 – 11732Framework-3Add
BLAST
Regioni118 – 1247D segment
Regioni125 – 13915JH2 segmentAdd
BLAST

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

eggNOGiNOG67637.
HOGENOMiHOG000154831.
HOVERGENiHBG018013.
InParanoidiP01751.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWSCIMLFL AATATGVHSQ VQLQQPGAEL VKPGASVKLS CKASGYTFTS
60 70 80 90 100
YWMHWVKQRP GRGLEWIGRI DPNSGGTKYN EKFKSKATLT VDKPSSTAYM
110 120 130
QLSSLTSEDS AVYYCARYDY YGSSYFDYWG QGTTLTVSS
Length:139
Mass (Da):15,419
Last modified:July 21, 1986 - v1
Checksum:i1B57DD4FD0C9F465
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei139 – 1391

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00529 mRNA. Translation: AAA38170.1.
PIRiA90809. MHMS18.
UniGeneiMm.304472.
Mm.425791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00529 mRNA. Translation: AAA38170.1.
PIRiA90809. MHMS18.
UniGeneiMm.304472.
Mm.425791.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A6UX-ray2.10H20-139[»]
1A6VX-ray1.80H/I/J20-139[»]
1A6WX-ray2.00H20-139[»]
1NGPX-ray2.40H20-139[»]
1NGQX-ray2.40H20-139[»]
1NQBX-ray2.00A/C20-139[»]
1OAQX-ray1.50H21-139[»]
1OARX-ray2.23H/I/J/K21-139[»]
1OAUX-ray1.80H/I/J/K21-139[»]
1OAXX-ray2.67H/I/J/K21-139[»]
1OAYX-ray2.66H/I/J/K21-139[»]
1OAZX-ray2.78H/J21-139[»]
1OCWX-ray2.00H21-139[»]
2BJMX-ray2.15H21-139[»]
ProteinModelPortaliP01751.
SMRiP01751. Positions 20-139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-255631.

Protein family/group databases

IMGTiSearch...

Proteomic databases

PRIDEiP01751.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:4439633. Ighv1-72.

Phylogenomic databases

eggNOGiNOG67637.
HOGENOMiHOG000154831.
HOVERGENiHBG018013.
InParanoidiP01751.

Miscellaneous databases

EvolutionaryTraceiP01751.
PROiP01751.
SOURCEiSearch...

Gene expression databases

BgeeiP01751.
ExpressionAtlasiP01751. baseline.
GenevestigatoriP01751.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region."
    Bothwell A.L.M., Paskind M., Reth M., Imanishi-Kari T., Rajewsky K., Baltimore D.
    Cell 24:625-637(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiHVM07_MOUSE
AccessioniPrimary (citable) accession number: P01751
Secondary accession number(s): P01752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 4, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The B1-8 mu chain mRNA was cloned from a hybridoma making antibodies to the hapten (4-hydroxy-3-nitrophenyl)acetyl (NPb antibodies).

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.