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P01751 (HVM07_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig heavy chain V region B1-8/186-2
Gene names
Name:Gm16709
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length139 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Miscellaneous

The B1-8 mu chain mRNA was cloned from a hybridoma making antibodies to the hapten (4-hydroxy-3-nitrophenyl)acetyl (NPb antibodies).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 139120Ig heavy chain V region B1-8/186-2
PRO_0000015220

Regions

Region20 – 4930Framework-1
Region50 – 545Complementarity-determining-1
Region55 – 6814Framework-2
Region69 – 8517Complementarity-determining-2
Region86 – 11732Framework-3
Region118 – 1247D segment
Region125 – 13915JH2 segment

Amino acid modifications

Disulfide bond41 ↔ 115 By similarity

Experimental info

Non-terminal residue1391

Secondary structure

................................. 139
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01751 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 1B57DD4FD0C9F465

FASTA13915,419
        10         20         30         40         50         60 
MGWSCIMLFL AATATGVHSQ VQLQQPGAEL VKPGASVKLS CKASGYTFTS YWMHWVKQRP 

        70         80         90        100        110        120 
GRGLEWIGRI DPNSGGTKYN EKFKSKATLT VDKPSSTAYM QLSSLTSEDS AVYYCARYDY 

       130 
YGSSYFDYWG QGTTLTVSS 

« Hide

References

[1]"Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region."
Bothwell A.L.M., Paskind M., Reth M., Imanishi-Kari T., Rajewsky K., Baltimore D.
Cell 24:625-637(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J00529 mRNA. Translation: AAA38170.1.
PIRMHMS18. A90809.
UniGeneMm.304472.
Mm.425791.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1A6UX-ray2.10H20-139[»]
1A6VX-ray1.80H/I/J20-139[»]
1A6WX-ray2.00H20-139[»]
1NGPX-ray2.40H20-139[»]
1NGQX-ray2.40H20-139[»]
1NQBX-ray2.00A/C20-139[»]
1OAQX-ray1.50H21-139[»]
1OARX-ray2.23H/I/J/K21-139[»]
1OAUX-ray1.80H/I/J/K21-139[»]
1OAXX-ray2.67H/I/J/K21-139[»]
1OAYX-ray2.66H/I/J/K21-139[»]
1OAZX-ray2.78H/J21-139[»]
1OCWX-ray2.00H21-139[»]
2BJMX-ray2.15H21-139[»]
ProteinModelPortalP01751.
SMRP01751. Positions 20-139.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-255631.

Protein family/group databases

IMGTSearch...

Proteomic databases

PRIDEP01751.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:4439633. Gm16709.

Phylogenomic databases

eggNOGNOG67637.
HOGENOMHOG000154831.
HOVERGENHBG018013.
InParanoidP01751.

Gene expression databases

BgeeP01751.
GenevestigatorP01751.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01751.
PROP01751.
SOURCESearch...

Entry information

Entry nameHVM07_MOUSE
AccessionPrimary (citable) accession number: P01751
Secondary accession number(s): P01752
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 19, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot