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P01751

- HVM07_MOUSE

UniProt

P01751 - HVM07_MOUSE

Protein

Ig heavy chain V region B1-8/186-2

Gene

Ighv1-72

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB-KW

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ig heavy chain V region B1-8/186-2
    Gene namesi
    Name:Ighv1-72
    Synonyms:Gm16709
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:4439633. Ighv1-72.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 139120Ig heavy chain V region B1-8/186-2PRO_0000015220Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 115PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP01751.

    Expressioni

    Gene expression databases

    BgeeiP01751.
    GenevestigatoriP01751.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-255631.

    Structurei

    Secondary structure

    1
    139
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi22 – 254
    Beta strandi29 – 313
    Beta strandi37 – 4610
    Helixi48 – 503
    Beta strandi51 – 588
    Beta strandi60 – 623
    Beta strandi64 – 707
    Turni72 – 743
    Beta strandi77 – 793
    Helixi81 – 833
    Turni84 – 863
    Beta strandi87 – 926
    Turni93 – 964
    Beta strandi97 – 1026
    Helixi107 – 1093
    Beta strandi111 – 1199
    Turni120 – 1234
    Beta strandi126 – 1294
    Beta strandi133 – 1375

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1A6UX-ray2.10H20-139[»]
    1A6VX-ray1.80H/I/J20-139[»]
    1A6WX-ray2.00H20-139[»]
    1NGPX-ray2.40H20-139[»]
    1NGQX-ray2.40H20-139[»]
    1NQBX-ray2.00A/C20-139[»]
    1OAQX-ray1.50H21-139[»]
    1OARX-ray2.23H/I/J/K21-139[»]
    1OAUX-ray1.80H/I/J/K21-139[»]
    1OAXX-ray2.67H/I/J/K21-139[»]
    1OAYX-ray2.66H/I/J/K21-139[»]
    1OAZX-ray2.78H/J21-139[»]
    1OCWX-ray2.00H21-139[»]
    2BJMX-ray2.15H21-139[»]
    ProteinModelPortaliP01751.
    SMRiP01751. Positions 20-139.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01751.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 4930Framework-1Add
    BLAST
    Regioni50 – 545Complementarity-determining-1
    Regioni55 – 6814Framework-2Add
    BLAST
    Regioni69 – 8517Complementarity-determining-2Add
    BLAST
    Regioni86 – 11732Framework-3Add
    BLAST
    Regioni118 – 1247D segment
    Regioni125 – 13915JH2 segmentAdd
    BLAST

    Keywords - Domaini

    Immunoglobulin domain, Immunoglobulin V region, Signal

    Phylogenomic databases

    eggNOGiNOG67637.
    HOGENOMiHOG000154831.
    HOVERGENiHBG018013.
    InParanoidiP01751.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01751-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGWSCIMLFL AATATGVHSQ VQLQQPGAEL VKPGASVKLS CKASGYTFTS    50
    YWMHWVKQRP GRGLEWIGRI DPNSGGTKYN EKFKSKATLT VDKPSSTAYM 100
    QLSSLTSEDS AVYYCARYDY YGSSYFDYWG QGTTLTVSS 139
    Length:139
    Mass (Da):15,419
    Last modified:July 21, 1986 - v1
    Checksum:i1B57DD4FD0C9F465
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei139 – 1391

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00529 mRNA. Translation: AAA38170.1.
    PIRiA90809. MHMS18.
    UniGeneiMm.304472.
    Mm.425791.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00529 mRNA. Translation: AAA38170.1 .
    PIRi A90809. MHMS18.
    UniGenei Mm.304472.
    Mm.425791.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1A6U X-ray 2.10 H 20-139 [» ]
    1A6V X-ray 1.80 H/I/J 20-139 [» ]
    1A6W X-ray 2.00 H 20-139 [» ]
    1NGP X-ray 2.40 H 20-139 [» ]
    1NGQ X-ray 2.40 H 20-139 [» ]
    1NQB X-ray 2.00 A/C 20-139 [» ]
    1OAQ X-ray 1.50 H 21-139 [» ]
    1OAR X-ray 2.23 H/I/J/K 21-139 [» ]
    1OAU X-ray 1.80 H/I/J/K 21-139 [» ]
    1OAX X-ray 2.67 H/I/J/K 21-139 [» ]
    1OAY X-ray 2.66 H/I/J/K 21-139 [» ]
    1OAZ X-ray 2.78 H/J 21-139 [» ]
    1OCW X-ray 2.00 H 21-139 [» ]
    2BJM X-ray 2.15 H 21-139 [» ]
    ProteinModelPortali P01751.
    SMRi P01751. Positions 20-139.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-255631.

    Protein family/group databases

    IMGTi Search...

    Proteomic databases

    PRIDEi P01751.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:4439633. Ighv1-72.

    Phylogenomic databases

    eggNOGi NOG67637.
    HOGENOMi HOG000154831.
    HOVERGENi HBG018013.
    InParanoidi P01751.

    Miscellaneous databases

    EvolutionaryTracei P01751.
    PROi P01751.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01751.
    Genevestigatori P01751.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region."
      Bothwell A.L.M., Paskind M., Reth M., Imanishi-Kari T., Rajewsky K., Baltimore D.
      Cell 24:625-637(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.

    Entry informationi

    Entry nameiHVM07_MOUSE
    AccessioniPrimary (citable) accession number: P01751
    Secondary accession number(s): P01752
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The B1-8 mu chain mRNA was cloned from a hybridoma making antibodies to the hapten (4-hydroxy-3-nitrophenyl)acetyl (NPb antibodies).

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3