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P01751

- HVM07_MOUSE

UniProt

P01751 - HVM07_MOUSE

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Protein

Ig heavy chain V region B1-8/186-2

Gene

Ighv1-72

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB-KW
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain V region B1-8/186-2
Gene namesi
Name:Ighv1-72
Synonyms:Gm16709
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:4439633. Ighv1-72.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 139120Ig heavy chain V region B1-8/186-2PRO_0000015220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 115PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP01751.

Expressioni

Gene expression databases

BgeeiP01751.
GenevestigatoriP01751.

Interactioni

Protein-protein interaction databases

MINTiMINT-255631.

Structurei

Secondary structure

1
139
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 254Combined sources
Beta strandi29 – 313Combined sources
Beta strandi37 – 4610Combined sources
Helixi48 – 503Combined sources
Beta strandi51 – 588Combined sources
Beta strandi60 – 623Combined sources
Beta strandi64 – 707Combined sources
Turni72 – 743Combined sources
Beta strandi77 – 793Combined sources
Helixi81 – 833Combined sources
Turni84 – 863Combined sources
Beta strandi87 – 926Combined sources
Turni93 – 964Combined sources
Beta strandi97 – 1026Combined sources
Helixi107 – 1093Combined sources
Beta strandi111 – 1199Combined sources
Turni120 – 1234Combined sources
Beta strandi126 – 1294Combined sources
Beta strandi133 – 1375Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A6UX-ray2.10H20-139[»]
1A6VX-ray1.80H/I/J20-139[»]
1A6WX-ray2.00H20-139[»]
1NGPX-ray2.40H20-139[»]
1NGQX-ray2.40H20-139[»]
1NQBX-ray2.00A/C20-139[»]
1OAQX-ray1.50H21-139[»]
1OARX-ray2.23H/I/J/K21-139[»]
1OAUX-ray1.80H/I/J/K21-139[»]
1OAXX-ray2.67H/I/J/K21-139[»]
1OAYX-ray2.66H/I/J/K21-139[»]
1OAZX-ray2.78H/J21-139[»]
1OCWX-ray2.00H21-139[»]
2BJMX-ray2.15H21-139[»]
ProteinModelPortaliP01751.
SMRiP01751. Positions 20-139.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01751.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 4930Framework-1Add
BLAST
Regioni50 – 545Complementarity-determining-1
Regioni55 – 6814Framework-2Add
BLAST
Regioni69 – 8517Complementarity-determining-2Add
BLAST
Regioni86 – 11732Framework-3Add
BLAST
Regioni118 – 1247D segment
Regioni125 – 13915JH2 segmentAdd
BLAST

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

eggNOGiNOG67637.
HOGENOMiHOG000154831.
HOVERGENiHBG018013.
InParanoidiP01751.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01751-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGWSCIMLFL AATATGVHSQ VQLQQPGAEL VKPGASVKLS CKASGYTFTS
60 70 80 90 100
YWMHWVKQRP GRGLEWIGRI DPNSGGTKYN EKFKSKATLT VDKPSSTAYM
110 120 130
QLSSLTSEDS AVYYCARYDY YGSSYFDYWG QGTTLTVSS
Length:139
Mass (Da):15,419
Last modified:July 21, 1986 - v1
Checksum:i1B57DD4FD0C9F465
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei139 – 1391

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00529 mRNA. Translation: AAA38170.1.
PIRiA90809. MHMS18.
UniGeneiMm.304472.
Mm.425791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00529 mRNA. Translation: AAA38170.1 .
PIRi A90809. MHMS18.
UniGenei Mm.304472.
Mm.425791.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A6U X-ray 2.10 H 20-139 [» ]
1A6V X-ray 1.80 H/I/J 20-139 [» ]
1A6W X-ray 2.00 H 20-139 [» ]
1NGP X-ray 2.40 H 20-139 [» ]
1NGQ X-ray 2.40 H 20-139 [» ]
1NQB X-ray 2.00 A/C 20-139 [» ]
1OAQ X-ray 1.50 H 21-139 [» ]
1OAR X-ray 2.23 H/I/J/K 21-139 [» ]
1OAU X-ray 1.80 H/I/J/K 21-139 [» ]
1OAX X-ray 2.67 H/I/J/K 21-139 [» ]
1OAY X-ray 2.66 H/I/J/K 21-139 [» ]
1OAZ X-ray 2.78 H/J 21-139 [» ]
1OCW X-ray 2.00 H 21-139 [» ]
2BJM X-ray 2.15 H 21-139 [» ]
ProteinModelPortali P01751.
SMRi P01751. Positions 20-139.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-255631.

Protein family/group databases

IMGTi Search...

Proteomic databases

PRIDEi P01751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:4439633. Ighv1-72.

Phylogenomic databases

eggNOGi NOG67637.
HOGENOMi HOG000154831.
HOVERGENi HBG018013.
InParanoidi P01751.

Miscellaneous databases

EvolutionaryTracei P01751.
PROi P01751.
SOURCEi Search...

Gene expression databases

Bgeei P01751.
Genevestigatori P01751.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region."
    Bothwell A.L.M., Paskind M., Reth M., Imanishi-Kari T., Rajewsky K., Baltimore D.
    Cell 24:625-637(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiHVM07_MOUSE
AccessioniPrimary (citable) accession number: P01751
Secondary accession number(s): P01752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The B1-8 mu chain mRNA was cloned from a hybridoma making antibodies to the hapten (4-hydroxy-3-nitrophenyl)acetyl (NPb antibodies).

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3