Reviewed, UniProtKB/Swiss-Prot P01750 (HVM06_MOUSE)

Names and origin

Protein names	Recommended name:     Ig heavy chain V region 102
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Miscellaneous

This germline gene belongs to a set of closely related genes that could encode V regions of NPb antibodies.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain Signal
PTM	Disulfide bond
Technical term	3D-structure
Gene Ontology (GO)
Molecular function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

19

Chain

20 – 117

98

Ig heavy chain V region 102

PRO_0000015219

Regions

Region

20 – 49

30

Framework-1

Region

50 – 54

5

Complementarity-determining-1

Region

55 – 68

14

Framework-2

Region

69 – 85

17

Complementarity-determining-2

Region

86 – 117

32

Framework-3

Amino acid modifications

Disulfide bond

41 ↔ 115

By similarity

Experimental info

Non-terminal residue

117

1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

117

Helix Strand Turn

Details...

Beta strand

22 – 26

5

Beta strand

35 – 44

10

Beta strand

48 – 51

4

Beta strand

53 – 59

7

Beta strand

65 – 71

7

Turn

72 – 75

4

Turn

81 – 86

6

Beta strand

87 – 92

6

Turn

93 – 96

4

Beta strand

97 – 105

9

Helix

107 – 109

3

Sequences

	Sequence		Length	Mass (Da)
	P01750-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 740A65DD851FCA8C	FASTA	117	12,867
	10 20 30 40 50 60 MGWSCIILFL VATATGVHSH VQLQQPGAEL VKPGASVKVS CKASGYTFTS YWMHWVKQRP 70 80 90 100 110 GQGLEWIGRI HPSDSDTNYN QKFKGKATLT VDKSSSTAYM QLSSLTSEDS AVYYCAI

References

[1]	"Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region." Bothwell A.L.M., Paskind M., Reth M., Imanishi-Kari T., Rajewsky K., Baltimore D. Cell 24:625-637(1981) [PubMed: 6788376] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6.
+	Additional computationally mapped references.

Cross-references

Sequence databases

IPI

IPI00108700.

PIR

HVMS02. A02032.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1QNZ	NMR	-	H	21-117	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

P01750.

Proteomic databases

PRIDE

P01750.

Genome annotation databases

Ensembl

ENSMUST00000103543; ENSMUSP00000100324; ENSMUSG00000076734; Mus musculus. [Genome view]

Phylogenomic databases

HOVERGEN

P01750.

Gene expression databases

Bgee

P01750.

Genevestigator

P01750.

GermOnline

ENSMUSG00000072794. Mus musculus.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_sub.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

Pfam

PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00406. IGv. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

HVM06_MOUSE

Accession

Primary (citable) accession number: P01750

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	October 13, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)