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Protein

Ig heavy chain V region 3

Gene

Ighv1-61

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain V region 3
Gene namesi
Name:Ighv1-61
Synonyms:Igh-VJ558
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:4439824. Ighv1-61.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 11798Ig heavy chain V region 3PRO_0000015218Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 115PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP01749.
PaxDbiP01749.
PRIDEiP01749.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 254Combined sources
Beta strandi38 – 469Combined sources
Helixi48 – 503Combined sources
Beta strandi53 – 597Combined sources
Turni60 – 623Combined sources
Beta strandi63 – 708Combined sources
Turni72 – 743Combined sources
Beta strandi77 – 793Combined sources
Helixi81 – 833Combined sources
Turni84 – 863Combined sources
Beta strandi89 – 924Combined sources
Turni93 – 964Combined sources
Beta strandi97 – 1015Combined sources
Helixi107 – 1093Combined sources
Beta strandi111 – 1177Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A14X-ray2.50H20-117[»]
ProteinModelPortaliP01749.
SMRiP01749. Positions 20-117.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01749.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 4930Framework-1Add
BLAST
Regioni50 – 545Complementarity-determining-1
Regioni55 – 6814Framework-2Add
BLAST
Regioni69 – 8517Complementarity-determining-2Add
BLAST
Regioni86 – 11732Framework-3Add
BLAST

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

eggNOGiNOG67637.
GeneTreeiENSGT00630000089564.
HOGENOMiHOG000154831.
HOVERGENiHBG018013.
InParanoidiP01749.
OMAiWIGNIYP.
TreeFamiTF352061.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWSCIILFL VATATGVHSQ VQLQQPGAEL VRPGSSVKLS CKASGYTFTS
60 70 80 90 100
YWMDWVKQRP GQGLEWIGNI YPSDSETHYN QKFKDKATLT VDKSSSTAYM
110
QLSSLTSEDS AVYYCAR
Length:117
Mass (Da):13,016
Last modified:July 21, 1986 - v1
Checksum:i427C861C53975EDC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei117 – 1171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00536 Genomic DNA. Translation: AAA38605.1.
PIRiA02031. HVMS3.
PH1163.
PH1164.
UniGeneiMm.246497.
Mm.304472.
Mm.305376.
Mm.313447.
Mm.313465.
Mm.313480.
Mm.313488.
Mm.335723.
Mm.342177.
Mm.342187.
Mm.351752.
Mm.390491.
Mm.390518.
Mm.390523.
Mm.390541.
Mm.423002.
Mm.423936.
Mm.425757.
Mm.425779.
Mm.427704.
Mm.435577.
Mm.436242.
Mm.436336.
Mm.436337.
Mm.458003.
Mm.475073.

Genome annotation databases

EnsembliENSMUST00000103531; ENSMUSP00000100312; ENSMUSG00000094087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00536 Genomic DNA. Translation: AAA38605.1.
PIRiA02031. HVMS3.
PH1163.
PH1164.
UniGeneiMm.246497.
Mm.304472.
Mm.305376.
Mm.313447.
Mm.313465.
Mm.313480.
Mm.313488.
Mm.335723.
Mm.342177.
Mm.342187.
Mm.351752.
Mm.390491.
Mm.390518.
Mm.390523.
Mm.390541.
Mm.423002.
Mm.423936.
Mm.425757.
Mm.425779.
Mm.427704.
Mm.435577.
Mm.436242.
Mm.436336.
Mm.436337.
Mm.458003.
Mm.475073.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A14X-ray2.50H20-117[»]
ProteinModelPortaliP01749.
SMRiP01749. Positions 20-117.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

IMGTiSearch...

Proteomic databases

MaxQBiP01749.
PaxDbiP01749.
PRIDEiP01749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103531; ENSMUSP00000100312; ENSMUSG00000094087.

Organism-specific databases

MGIiMGI:4439824. Ighv1-61.

Phylogenomic databases

eggNOGiNOG67637.
GeneTreeiENSGT00630000089564.
HOGENOMiHOG000154831.
HOVERGENiHBG018013.
InParanoidiP01749.
OMAiWIGNIYP.
TreeFamiTF352061.

Miscellaneous databases

EvolutionaryTraceiP01749.
PROiP01749.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region."
    Bothwell A.L.M., Paskind M., Reth M., Imanishi-Kari T., Rajewsky K., Baltimore D.
    Cell 24:625-637(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiHVM05_MOUSE
AccessioniPrimary (citable) accession number: P01749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 22, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This germline gene belongs to a set of closely related genes that could encode V regions of NPb antibodies.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.