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Protein

Ig heavy chain V region 3

Gene

Ighv1-61

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain V region 3
Gene namesi
Name:Ighv1-61
Synonyms:Igh-VJ558
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:4439824. Ighv1-61.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001521820 – 117Ig heavy chain V region 3Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 115PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP01749.
PeptideAtlasiP01749.
PRIDEiP01749.

Expressioni

Gene expression databases

BgeeiENSMUSG00000094087.

Interactioni

GO - Molecular functioni

Structurei

Secondary structure

1117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 25Combined sources4
Beta strandi38 – 46Combined sources9
Helixi48 – 50Combined sources3
Beta strandi53 – 59Combined sources7
Turni60 – 62Combined sources3
Beta strandi63 – 70Combined sources8
Turni72 – 74Combined sources3
Beta strandi77 – 79Combined sources3
Helixi81 – 83Combined sources3
Turni84 – 86Combined sources3
Beta strandi89 – 92Combined sources4
Turni93 – 96Combined sources4
Beta strandi97 – 101Combined sources5
Helixi107 – 109Combined sources3
Beta strandi111 – 117Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A14X-ray2.50H20-117[»]
ProteinModelPortaliP01749.
SMRiP01749.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01749.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 49Framework-1Add BLAST30
Regioni50 – 54Complementarity-determining-15
Regioni55 – 68Framework-2Add BLAST14
Regioni69 – 85Complementarity-determining-2Add BLAST17
Regioni86 – 117Framework-3Add BLAST32

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

GeneTreeiENSGT00820000126987.
HOGENOMiHOG000154831.
HOVERGENiHBG018013.
InParanoidiP01749.
OMAiWIGNIYP.
TreeFamiTF352061.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWSCIILFL VATATGVHSQ VQLQQPGAEL VRPGSSVKLS CKASGYTFTS
60 70 80 90 100
YWMDWVKQRP GQGLEWIGNI YPSDSETHYN QKFKDKATLT VDKSSSTAYM
110
QLSSLTSEDS AVYYCAR
Length:117
Mass (Da):13,016
Last modified:July 21, 1986 - v1
Checksum:i427C861C53975EDC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00536 Genomic DNA. Translation: AAA38605.1.
PIRiA02031. HVMS3.
PH1163.
PH1164.
UniGeneiMm.246497.
Mm.304472.
Mm.305376.
Mm.313447.
Mm.313465.
Mm.313480.
Mm.313488.
Mm.335723.
Mm.342177.
Mm.342187.
Mm.351752.
Mm.390491.
Mm.390518.
Mm.390523.
Mm.390541.
Mm.423002.
Mm.423936.
Mm.425757.
Mm.425779.
Mm.427704.
Mm.435577.
Mm.436242.
Mm.436336.
Mm.436337.
Mm.458003.
Mm.475073.

Genome annotation databases

EnsembliENSMUST00000103531; ENSMUSP00000100312; ENSMUSG00000094087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00536 Genomic DNA. Translation: AAA38605.1.
PIRiA02031. HVMS3.
PH1163.
PH1164.
UniGeneiMm.246497.
Mm.304472.
Mm.305376.
Mm.313447.
Mm.313465.
Mm.313480.
Mm.313488.
Mm.335723.
Mm.342177.
Mm.342187.
Mm.351752.
Mm.390491.
Mm.390518.
Mm.390523.
Mm.390541.
Mm.423002.
Mm.423936.
Mm.425757.
Mm.425779.
Mm.427704.
Mm.435577.
Mm.436242.
Mm.436336.
Mm.436337.
Mm.458003.
Mm.475073.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A14X-ray2.50H20-117[»]
ProteinModelPortaliP01749.
SMRiP01749.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

IMGTiSearch...

Proteomic databases

MaxQBiP01749.
PeptideAtlasiP01749.
PRIDEiP01749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103531; ENSMUSP00000100312; ENSMUSG00000094087.

Organism-specific databases

MGIiMGI:4439824. Ighv1-61.

Phylogenomic databases

GeneTreeiENSGT00820000126987.
HOGENOMiHOG000154831.
HOVERGENiHBG018013.
InParanoidiP01749.
OMAiWIGNIYP.
TreeFamiTF352061.

Miscellaneous databases

EvolutionaryTraceiP01749.
PROiP01749.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000094087.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHVM05_MOUSE
AccessioniPrimary (citable) accession number: P01749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This germline gene belongs to a set of closely related genes that could encode V regions of NPb antibodies.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.