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P01749 (HVM05_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig heavy chain V region 3
Gene names
Name:Ighv1-61
Synonyms:Igh-VJ558
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length117 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Miscellaneous

This germline gene belongs to a set of closely related genes that could encode V regions of NPb antibodies.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 11798Ig heavy chain V region 3
PRO_0000015218

Regions

Region20 – 4930Framework-1
Region50 – 545Complementarity-determining-1
Region55 – 6814Framework-2
Region69 – 8517Complementarity-determining-2
Region86 – 11732Framework-3

Amino acid modifications

Disulfide bond41 ↔ 115 By similarity

Experimental info

Non-terminal residue1171

Secondary structure

......................... 117
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01749 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 427C861C53975EDC

FASTA11713,016
        10         20         30         40         50         60 
MGWSCIILFL VATATGVHSQ VQLQQPGAEL VRPGSSVKLS CKASGYTFTS YWMDWVKQRP 

        70         80         90        100        110 
GQGLEWIGNI YPSDSETHYN QKFKDKATLT VDKSSSTAYM QLSSLTSEDS AVYYCAR 

« Hide

References

[1]"Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region."
Bothwell A.L.M., Paskind M., Reth M., Imanishi-Kari T., Rajewsky K., Baltimore D.
Cell 24:625-637(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J00536 Genomic DNA. Translation: AAA38605.1.
PIRHVMS3. A02031.
PH1163.
PH1164.
UniGeneMm.246497.
Mm.304472.
Mm.305376.
Mm.313447.
Mm.313465.
Mm.313480.
Mm.313488.
Mm.335723.
Mm.342177.
Mm.342187.
Mm.351752.
Mm.390491.
Mm.390523.
Mm.390541.
Mm.423002.
Mm.423936.
Mm.425757.
Mm.425779.
Mm.427704.
Mm.435577.
Mm.436242.
Mm.436336.
Mm.436337.
Mm.458003.
Mm.475073.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1A14X-ray2.50H20-117[»]
ProteinModelPortalP01749.
SMRP01749. Positions 20-117.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000100312.

Protein family/group databases

IMGTSearch...

Proteomic databases

PaxDbP01749.
PRIDEP01749.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000103531; ENSMUSP00000100312; ENSMUSG00000094087.

Organism-specific databases

MGIMGI:4439824. Ighv1-61.

Phylogenomic databases

eggNOGNOG67637.
HOGENOMHOG000154831.
HOVERGENHBG018013.
InParanoidP01749.
OMAYCVRDTM.
TreeFamTF352061.

Gene expression databases

GenevestigatorP01749.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01749.
SOURCESearch...

Entry information

Entry nameHVM05_MOUSE
AccessionPrimary (citable) accession number: P01749
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 11, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot