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P01749

- HVM05_MOUSE

UniProt

P01749 - HVM05_MOUSE

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Protein

Ig heavy chain V region 3

Gene

Ighv1-61

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB-KW
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain V region 3
Gene namesi
Name:Ighv1-61
Synonyms:Igh-VJ558
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:4439824. Ighv1-61.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 11798Ig heavy chain V region 3PRO_0000015218Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 115PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01749.
PRIDEiP01749.

Expressioni

Gene expression databases

GenevestigatoriP01749.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100312.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 254
Beta strandi38 – 469
Helixi48 – 503
Beta strandi53 – 597
Turni60 – 623
Beta strandi63 – 708
Turni72 – 743
Beta strandi77 – 793
Helixi81 – 833
Turni84 – 863
Beta strandi89 – 924
Turni93 – 964
Beta strandi97 – 1015
Helixi107 – 1093
Beta strandi111 – 1177

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A14X-ray2.50H20-117[»]
ProteinModelPortaliP01749.
SMRiP01749. Positions 20-117.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01749.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 4930Framework-1Add
BLAST
Regioni50 – 545Complementarity-determining-1
Regioni55 – 6814Framework-2Add
BLAST
Regioni69 – 8517Complementarity-determining-2Add
BLAST
Regioni86 – 11732Framework-3Add
BLAST

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

eggNOGiNOG67637.
HOGENOMiHOG000154831.
HOVERGENiHBG018013.
InParanoidiP01749.
OMAiYCVRDTM.
TreeFamiTF352061.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01749-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGWSCIILFL VATATGVHSQ VQLQQPGAEL VRPGSSVKLS CKASGYTFTS
60 70 80 90 100
YWMDWVKQRP GQGLEWIGNI YPSDSETHYN QKFKDKATLT VDKSSSTAYM
110
QLSSLTSEDS AVYYCAR
Length:117
Mass (Da):13,016
Last modified:July 21, 1986 - v1
Checksum:i427C861C53975EDC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei117 – 1171

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J00536 Genomic DNA. Translation: AAA38605.1.
PIRiA02031. HVMS3.
PH1163.
PH1164.
UniGeneiMm.246497.
Mm.304472.
Mm.305376.
Mm.313447.
Mm.313465.
Mm.313480.
Mm.313488.
Mm.335723.
Mm.342177.
Mm.342187.
Mm.351752.
Mm.390491.
Mm.390523.
Mm.390541.
Mm.423002.
Mm.423936.
Mm.425757.
Mm.425779.
Mm.427704.
Mm.435577.
Mm.436242.
Mm.436336.
Mm.436337.
Mm.458003.
Mm.475073.

Genome annotation databases

EnsembliENSMUST00000103531; ENSMUSP00000100312; ENSMUSG00000094087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J00536 Genomic DNA. Translation: AAA38605.1 .
PIRi A02031. HVMS3.
PH1163.
PH1164.
UniGenei Mm.246497.
Mm.304472.
Mm.305376.
Mm.313447.
Mm.313465.
Mm.313480.
Mm.313488.
Mm.335723.
Mm.342177.
Mm.342187.
Mm.351752.
Mm.390491.
Mm.390523.
Mm.390541.
Mm.423002.
Mm.423936.
Mm.425757.
Mm.425779.
Mm.427704.
Mm.435577.
Mm.436242.
Mm.436336.
Mm.436337.
Mm.458003.
Mm.475073.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A14 X-ray 2.50 H 20-117 [» ]
ProteinModelPortali P01749.
SMRi P01749. Positions 20-117.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000100312.

Protein family/group databases

IMGTi Search...

Proteomic databases

PaxDbi P01749.
PRIDEi P01749.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000103531 ; ENSMUSP00000100312 ; ENSMUSG00000094087 .

Organism-specific databases

MGIi MGI:4439824. Ighv1-61.

Phylogenomic databases

eggNOGi NOG67637.
HOGENOMi HOG000154831.
HOVERGENi HBG018013.
InParanoidi P01749.
OMAi YCVRDTM.
TreeFami TF352061.

Miscellaneous databases

EvolutionaryTracei P01749.
SOURCEi Search...

Gene expression databases

Genevestigatori P01749.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region."
    Bothwell A.L.M., Paskind M., Reth M., Imanishi-Kari T., Rajewsky K., Baltimore D.
    Cell 24:625-637(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiHVM05_MOUSE
AccessioniPrimary (citable) accession number: P01749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 1, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This germline gene belongs to a set of closely related genes that could encode V regions of NPb antibodies.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3