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Protein

Ig heavy chain V region 3

Gene

Ighv1-61

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This germline gene belongs to a set of closely related genes that could encode V regions of NPb antibodies.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain V region 3
Gene namesi
Name:Ighv1-61
Synonyms:Igh-VJ558
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:4439824 Ighv1-61

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001521820 – 117Ig heavy chain V region 3Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 115PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP01749
PeptideAtlasiP01749
PRIDEiP01749

Expressioni

Gene expression databases

BgeeiENSMUSG00000094087

Interactioni

GO - Molecular functioni

Structurei

Secondary structure

1117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 25Combined sources4
Beta strandi38 – 46Combined sources9
Helixi48 – 50Combined sources3
Beta strandi53 – 59Combined sources7
Turni60 – 62Combined sources3
Beta strandi63 – 70Combined sources8
Turni72 – 74Combined sources3
Beta strandi77 – 79Combined sources3
Helixi81 – 83Combined sources3
Turni84 – 86Combined sources3
Beta strandi89 – 92Combined sources4
Turni93 – 96Combined sources4
Beta strandi97 – 101Combined sources5
Helixi107 – 109Combined sources3
Beta strandi111 – 117Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A14X-ray2.50H20-117[»]
ProteinModelPortaliP01749
SMRiP01749
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01749

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 49Framework-1Add BLAST30
Regioni50 – 54Complementarity-determining-15
Regioni55 – 68Framework-2Add BLAST14
Regioni69 – 85Complementarity-determining-2Add BLAST17
Regioni86 – 117Framework-3Add BLAST32

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

GeneTreeiENSGT00820000126987
HOGENOMiHOG000154831
HOVERGENiHBG018013
InParanoidiP01749
OMAiIDWTWRI
TreeFamiTF352061

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWSCIILFL VATATGVHSQ VQLQQPGAEL VRPGSSVKLS CKASGYTFTS
60 70 80 90 100
YWMDWVKQRP GQGLEWIGNI YPSDSETHYN QKFKDKATLT VDKSSSTAYM
110
QLSSLTSEDS AVYYCAR
Length:117
Mass (Da):13,016
Last modified:July 21, 1986 - v1
Checksum:i427C861C53975EDC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00536 Genomic DNA Translation: AAA38605.1
PIRiA02031 HVMS3
PH1163
PH1164
UniGeneiMm.246497
Mm.304472
Mm.305376
Mm.313447
Mm.313465
Mm.313480
Mm.313488
Mm.335723
Mm.342177
Mm.342187
Mm.351752
Mm.390491
Mm.390518
Mm.390523
Mm.390541
Mm.423002
Mm.423936
Mm.425757
Mm.425779
Mm.427704
Mm.435577
Mm.436242
Mm.436336
Mm.436337
Mm.458003
Mm.475073

Genome annotation databases

EnsembliENSMUST00000103531; ENSMUSP00000100312; ENSMUSG00000094087

Similar proteinsi

Entry informationi

Entry nameiHVM05_MOUSE
AccessioniPrimary (citable) accession number: P01749
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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