P01749 (HVM05_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ig heavy chain V region 3

Gene names

Name:

Igh-VJ558

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous

This germline gene belongs to a set of closely related genes that could encode V regions of NPb antibodies.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain Signal
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

19

Chain

20 – 117

98

Ig heavy chain V region 3

PRO_0000015218

Regions

Region

20 – 49

30

Framework-1

Region

50 – 54

5

Complementarity-determining-1

Region

55 – 68

14

Framework-2

Region

69 – 85

17

Complementarity-determining-2

Region

86 – 117

32

Framework-3

Amino acid modifications

Disulfide bond

41 ↔ 115

By similarity

Experimental info

Non-terminal residue

117

1

Secondary structure

1

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117

Helix Strand Turn

Details...

Beta strand

22 – 25

4

Beta strand

38 – 46

9

Helix

48 – 50

3

Beta strand

53 – 59

7

Turn

60 – 62

3

Beta strand

63 – 70

8

Turn

72 – 74

3

Beta strand

77 – 79

3

Helix

81 – 83

3

Turn

84 – 86

3

Beta strand

89 – 92

4

Turn

93 – 96

4

Beta strand

97 – 101

5

Helix

107 – 109

3

Sequences

	Sequence		Length	Mass (Da)
	P01749 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 427C861C53975EDC	FASTA	117	13,016
	10 20 30 40 50 60 MGWSCIILFL VATATGVHSQ VQLQQPGAEL VRPGSSVKLS CKASGYTFTS YWMDWVKQRP 70 80 90 100 110 GQGLEWIGNI YPSDSETHYN QKFKDKATLT VDKSSSTAYM QLSSLTSEDS AVYYCAR

References

[1]	"Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region." Bothwell A.L.M., Paskind M., Reth M., Imanishi-Kari T., Rajewsky K., Baltimore D. Cell 24:625-637(1981) [PubMed: 6788376] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

J00536 Genomic DNA. Translation: AAA38605.1.

IPI

IPI00340755.

PIR

HVMS3. A02031.
PH1163.
PH1164.

UniGene

Mm.246497.
Mm.304472.
Mm.305376.
Mm.313447.
Mm.313465.
Mm.313480.
Mm.313488.
Mm.335723.
Mm.342177.
Mm.342187.
Mm.351752.
Mm.390491.
Mm.390523.
Mm.390541.
Mm.423002.
Mm.423936.
Mm.425757.
Mm.425779.
Mm.427704.
Mm.435577.
Mm.436242.
Mm.436336.
Mm.436337.
Mm.458003.
Mm.485305.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1A14	X-ray	2.50	H	20-117	[»]

ProteinModelPortal

P01749.

SMR

P01749. Positions 20-117.

ModBase

Search...

Protein-protein interaction databases

STRING

P01749.

Protein family/group databases

IMGT

Search...

Proteomic databases

PRIDE

P01749.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Organism-specific databases

MGI

MGI:96486. Igh-VJ558.

Phylogenomic databases

eggNOG

roNOG16474.

GeneTree

ENSGT00580000081342.

HOGENOM

HBG716786.

HOVERGEN

HBG018013.

InParanoid

P01749.

OMA

WIGNIYP.

OrthoDB

EOG4V6ZJ5.

Gene expression databases

Genevestigator

P01749.

GermOnline

ENSMUSG00000066292. Mus musculus.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

Pfam

PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00406. IGv. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

SOURCE

Search...

Entry information

Entry name

HVM05_MOUSE

Accession

Primary (citable) accession number: P01749

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	December 14, 2011
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program