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P01749

- HVM05_MOUSE

UniProt

P01749 - HVM05_MOUSE

Protein

Ig heavy chain V region 3

Gene

Ighv1-61

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB-KW

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ig heavy chain V region 3
    Gene namesi
    Name:Ighv1-61
    Synonyms:Igh-VJ558
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:4439824. Ighv1-61.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 11798Ig heavy chain V region 3PRO_0000015218Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 115PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP01749.
    PRIDEiP01749.

    Expressioni

    Gene expression databases

    GenevestigatoriP01749.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000100312.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi22 – 254
    Beta strandi38 – 469
    Helixi48 – 503
    Beta strandi53 – 597
    Turni60 – 623
    Beta strandi63 – 708
    Turni72 – 743
    Beta strandi77 – 793
    Helixi81 – 833
    Turni84 – 863
    Beta strandi89 – 924
    Turni93 – 964
    Beta strandi97 – 1015
    Helixi107 – 1093
    Beta strandi111 – 1177

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1A14X-ray2.50H20-117[»]
    ProteinModelPortaliP01749.
    SMRiP01749. Positions 20-117.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01749.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 4930Framework-1Add
    BLAST
    Regioni50 – 545Complementarity-determining-1
    Regioni55 – 6814Framework-2Add
    BLAST
    Regioni69 – 8517Complementarity-determining-2Add
    BLAST
    Regioni86 – 11732Framework-3Add
    BLAST

    Keywords - Domaini

    Immunoglobulin domain, Immunoglobulin V region, Signal

    Phylogenomic databases

    eggNOGiNOG67637.
    HOGENOMiHOG000154831.
    HOVERGENiHBG018013.
    InParanoidiP01749.
    OMAiYCVRDTM.
    TreeFamiTF352061.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01749-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGWSCIILFL VATATGVHSQ VQLQQPGAEL VRPGSSVKLS CKASGYTFTS    50
    YWMDWVKQRP GQGLEWIGNI YPSDSETHYN QKFKDKATLT VDKSSSTAYM 100
    QLSSLTSEDS AVYYCAR 117
    Length:117
    Mass (Da):13,016
    Last modified:July 21, 1986 - v1
    Checksum:i427C861C53975EDC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei117 – 1171

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00536 Genomic DNA. Translation: AAA38605.1.
    PIRiA02031. HVMS3.
    PH1163.
    PH1164.
    UniGeneiMm.246497.
    Mm.304472.
    Mm.305376.
    Mm.313447.
    Mm.313465.
    Mm.313480.
    Mm.313488.
    Mm.335723.
    Mm.342177.
    Mm.342187.
    Mm.351752.
    Mm.390491.
    Mm.390523.
    Mm.390541.
    Mm.423002.
    Mm.423936.
    Mm.425757.
    Mm.425779.
    Mm.427704.
    Mm.435577.
    Mm.436242.
    Mm.436336.
    Mm.436337.
    Mm.458003.
    Mm.475073.

    Genome annotation databases

    EnsembliENSMUST00000103531; ENSMUSP00000100312; ENSMUSG00000094087.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00536 Genomic DNA. Translation: AAA38605.1 .
    PIRi A02031. HVMS3.
    PH1163.
    PH1164.
    UniGenei Mm.246497.
    Mm.304472.
    Mm.305376.
    Mm.313447.
    Mm.313465.
    Mm.313480.
    Mm.313488.
    Mm.335723.
    Mm.342177.
    Mm.342187.
    Mm.351752.
    Mm.390491.
    Mm.390523.
    Mm.390541.
    Mm.423002.
    Mm.423936.
    Mm.425757.
    Mm.425779.
    Mm.427704.
    Mm.435577.
    Mm.436242.
    Mm.436336.
    Mm.436337.
    Mm.458003.
    Mm.475073.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1A14 X-ray 2.50 H 20-117 [» ]
    ProteinModelPortali P01749.
    SMRi P01749. Positions 20-117.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000100312.

    Protein family/group databases

    IMGTi Search...

    Proteomic databases

    PaxDbi P01749.
    PRIDEi P01749.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000103531 ; ENSMUSP00000100312 ; ENSMUSG00000094087 .

    Organism-specific databases

    MGIi MGI:4439824. Ighv1-61.

    Phylogenomic databases

    eggNOGi NOG67637.
    HOGENOMi HOG000154831.
    HOVERGENi HBG018013.
    InParanoidi P01749.
    OMAi YCVRDTM.
    TreeFami TF352061.

    Miscellaneous databases

    EvolutionaryTracei P01749.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P01749.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region."
      Bothwell A.L.M., Paskind M., Reth M., Imanishi-Kari T., Rajewsky K., Baltimore D.
      Cell 24:625-637(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6.

    Entry informationi

    Entry nameiHVM05_MOUSE
    AccessioniPrimary (citable) accession number: P01749
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This germline gene belongs to a set of closely related genes that could encode V regions of NPb antibodies.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3