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Protein

T-cell receptor alpha chain V region PY14

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • MHC protein binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-389948. PD-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell receptor alpha chain V region PY14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi136490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000003359521 – 135T-cell receptor alpha chain V region PY14Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP01737.
PeptideAtlasiP01737.
PRIDEiP01737.

Expressioni

Gene expression databases

BgeeiENSG00000211790.

Interactioni

GO - Molecular functioni

  • MHC protein binding Source: UniProtKB

Protein-protein interaction databases

IntActiP01737. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP01737.
SMRiP01737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 112V segmentAdd BLAST92
Regioni113 – 118D segment6
Regioni119 – 135J segmentAdd BLAST17

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

HOVERGENiHBG105972.
PhylomeDBiP01737.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLVPVLE VIFTLGGTRA QSVTQLGSHV SVSEGALVLL RCNYSSSVPP
60 70 80 90 100
YLFWYVQYPN QGLQLLLKYT SAATLVKGIN GFEAEFKKSE TSFHLTKPSA
110 120 130
HMSDAAEYFC AVSDLEPNSS ASKIIFGSGT RLSIR
Length:135
Mass (Da):14,708
Last modified:July 21, 1986 - v1
Checksum:i0A1656F4AAE468F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1351

Sequence databases

PIRiA02011. RWHUAV.

Cross-referencesi

Sequence databases

PIRiA02011. RWHUAV.

3D structure databases

ProteinModelPortaliP01737.
SMRiP01737.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01737. 1 interactor.

Polymorphism and mutation databases

DMDMi136490.

Proteomic databases

MaxQBiP01737.
PeptideAtlasiP01737.
PRIDEiP01737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiTRAV8-4.

Phylogenomic databases

HOVERGENiHBG105972.
PhylomeDBiP01737.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-389948. PD-1 signaling.

Gene expression databases

BgeeiENSG00000211790.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTVA3_HUMAN
AccessioniPrimary (citable) accession number: P01737
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This clone was isolated from a human leukemic T-cell line, Jurkat.
This alpha chain V region shows sequence homology to its beta chain counterpart.
The gene corresponding to this mRNA is rearranged specifically in T-cells; its organization is similar to an Ig gene, with V, D, J, and C regions.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.