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Reviewed, UniProtKB/Swiss-Prot P01733 (TVB1_HUMAN)

Last modified January 19, 2010. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    T-cell receptor beta chain V region YT35
Gene names
Name: TRBV12-3
Synonyms: TCRBV8S1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length135 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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Ontologies

Keywords
   DomainImmunoglobulin domain
Signal
   Molecular functionReceptor
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processimmune response Ref.1

Non-traceable author statement. Source: UniProtKB

   Cellular componentplasma membrane Ref.1

Non-traceable author statement. Source: UniProtKB

   Molecular functionMHC protein binding Ref.1

Non-traceable author statement. Source: UniProtKB

peptide antigen binding Ref.1

Non-traceable author statement. Source: UniProtKB

receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 135114T-cell receptor beta chain V region YT35
PRO_0000033597

Amino acid modifications

Glycosylation901N-linked (GlcNAc...) Ref.4

Experimental info

Sequence conflict115 – 1195FSTCS → LATAL in AAC13336. Ref.2
Non-terminal residue1351

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Sequences

Sequence LengthMass (Da)Tools
P01733-1 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 9FBF913D33967CC9

FASTA13515,097
        10         20         30         40         50         60 
MDSWTFCCVS LCILVAKHTD AGVIQSPRHE VTEMGQEVTL RCKPISGHNS LFWYRQTMMR 

        70         80         90        100        110        120 
GLELLIYFNN NVPIDDSGMP EDRFSAKMPN ASFSTLKIQP SEPRDSAVYF CASSFSTCSA 

       130 
NYGYTFGSGT RLTVV

« Hide

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References

« Hide 'large scale' references
[1]"A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains."
Yanagi Y., Yoshikai Y., Leggett K., Clark S.P., Aleksander I., Mak T.W.
Nature 308:145-149(1984) [PubMed: 6336315] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed: 12853948] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain."
Toyonaga B., Yoshikai Y., Vadasz V., Chin B., Mak T.W.
Proc. Natl. Acad. Sci. U.S.A. 82:8624-8628(1985) [PubMed: 3866244] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 121-135.
[4]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-90, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U66060 Genomic DNA. Translation: AAC13336.1.
U66061 Genomic DNA. No translation available.
M14158 Genomic DNA. Translation: AAA60669.1.
IPIIPI00003986.
PIRRWHUVY. A02000.
S03488.
S03510.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP01733.

Proteomic databases

PRIDEP01733.

Organism-specific databases

GeneCardsGC07P141949.
HGNCHGNC:12185. TRBV12-3.
GenAtlasSearch...

Phylogenomic databases

eggNOGmaNOG23302.
HOVERGENP01733.
InParanoidP01733.

Enzyme and pathway databases

ReactomeREACT_6900. Signaling in Immune system.

Gene expression databases

GenevestigatorP01733.
GermOnlineENSG00000198446. Homo sapiens.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameTVB1_HUMAN
AccessionPrimary (citable) accession number: P01733
Secondary accession number(s): A0A5A7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 19, 2010
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents