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Protein

T-cell receptor beta chain V region YT35

Gene

TRBV12-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • MHC protein binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB

GO - Biological processi

  • immune response Source: UniProtKB
  • regulation of immune response Source: Reactome
  • T cell receptor signaling pathway Source: Reactome

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-389948 PD-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell receptor beta chain V region YT35
Gene namesi
Name:TRBV12-3
Synonyms:TCRBV8S1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:12185 TRBV12-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi136492

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003359722 – 135T-cell receptor beta chain V region YT35Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP01733
PeptideAtlasiP01733
PRIDEiP01733

PTM databases

iPTMnetiP01733
PhosphoSitePlusiP01733

Interactioni

GO - Molecular functioni

  • MHC protein binding Source: UniProtKB

Protein-protein interaction databases

IntActiP01733, 2 interactors
MINTiP01733

Structurei

3D structure databases

ProteinModelPortaliP01733
SMRiP01733
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

HOVERGENiHBG100543
InParanoidiP01733
PhylomeDBiP01733

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSWTFCCVS LCILVAKHTD AGVIQSPRHE VTEMGQEVTL RCKPISGHNS
60 70 80 90 100
LFWYRQTMMR GLELLIYFNN NVPIDDSGMP EDRFSAKMPN ASFSTLKIQP
110 120 130
SEPRDSAVYF CASSFSTCSA NYGYTFGSGT RLTVV
Length:135
Mass (Da):15,097
Last modified:July 21, 1986 - v1
Checksum:i9FBF913D33967CC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115 – 119FSTCS → LATAL in AAC13336 (PubMed:12853948).Curated5
Non-terminal residuei1351

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36092 Genomic DNA Translation: AAC13336.1
U66061 Genomic DNA No translation available.
M14158 Genomic DNA Translation: AAA60669.1
PIRiA02000 RWHUVY
S03488
S03510

Similar proteinsi

Entry informationi

Entry nameiTVB1_HUMAN
AccessioniPrimary (citable) accession number: P01733
Secondary accession number(s): A0A5A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM

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