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P01733

- TVB1_HUMAN

UniProt

P01733 - TVB1_HUMAN

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Protein

T-cell receptor beta chain V region YT35

Gene

TRBV12-3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. MHC protein binding Source: UniProtKB
  2. peptide antigen binding Source: UniProtKB

GO - Biological processi

  1. immune response Source: UniProtKB
  2. regulation of immune response Source: Reactome
  3. T cell costimulation Source: Reactome
  4. T cell receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell receptor beta chain V region YT35
Gene namesi
Name:TRBV12-3
Synonyms:TCRBV8S1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:12185. TRBV12-3.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 135114T-cell receptor beta chain V region YT35PRO_0000033597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP01733.
PRIDEiP01733.

Expressioni

Gene expression databases

GenevestigatoriP01733.

Interactioni

Protein-protein interaction databases

IntActiP01733. 2 interactions.
MINTiMINT-4328927.

Structurei

3D structure databases

ProteinModelPortaliP01733.
SMRiP01733. Positions 20-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

HOVERGENiHBG100543.
InParanoidiP01733.
PhylomeDBiP01733.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01733-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSWTFCCVS LCILVAKHTD AGVIQSPRHE VTEMGQEVTL RCKPISGHNS
60 70 80 90 100
LFWYRQTMMR GLELLIYFNN NVPIDDSGMP EDRFSAKMPN ASFSTLKIQP
110 120 130
SEPRDSAVYF CASSFSTCSA NYGYTFGSGT RLTVV
Length:135
Mass (Da):15,097
Last modified:July 21, 1986 - v1
Checksum:i9FBF913D33967CC9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1195FSTCS → LATAL in AAC13336. (PubMed:12853948)Curated
Non-terminal residuei135 – 1351

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36092 Genomic DNA. Translation: AAC13336.1.
U66061 Genomic DNA. No translation available.
M14158 Genomic DNA. Translation: AAA60669.1.
PIRiA02000. RWHUVY.
S03488.
S03510.

Polymorphism databases

DMDMi136492.

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36092 Genomic DNA. Translation: AAC13336.1 .
U66061 Genomic DNA. No translation available.
M14158 Genomic DNA. Translation: AAA60669.1 .
PIRi A02000. RWHUVY.
S03488.
S03510.

3D structure databases

ProteinModelPortali P01733.
SMRi P01733. Positions 20-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P01733. 2 interactions.
MINTi MINT-4328927.

Polymorphism databases

DMDMi 136492.

Proteomic databases

MaxQBi P01733.
PRIDEi P01733.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC07Pg41640.
HGNCi HGNC:12185. TRBV12-3.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG100543.
InParanoidi P01733.
PhylomeDBi P01733.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.

Miscellaneous databases

PROi P01733.

Gene expression databases

Genevestigatori P01733.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains."
    Yanagi Y., Yoshikai Y., Leggett K., Clark S.P., Aleksander I., Mak T.W.
    Nature 308:145-149(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain."
    Toyonaga B., Yoshikai Y., Vadasz V., Chin B., Mak T.W.
    Proc. Natl. Acad. Sci. U.S.A. 82:8624-8628(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 121-135.
  4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-90.
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiTVB1_HUMAN
AccessioniPrimary (citable) accession number: P01733
Secondary accession number(s): A0A5A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 1, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM

External Data

Dasty 3