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P01733

- TVB1_HUMAN

UniProt

P01733 - TVB1_HUMAN

Protein

T-cell receptor beta chain V region YT35

Gene

TRBV12-3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. MHC protein binding Source: UniProtKB
    2. peptide antigen binding Source: UniProtKB

    GO - Biological processi

    1. immune response Source: UniProtKB
    2. regulation of immune response Source: Reactome
    3. T cell costimulation Source: Reactome
    4. T cell receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell receptor beta chain V region YT35
    Gene namesi
    Name:TRBV12-3
    Synonyms:TCRBV8S1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:12185. TRBV12-3.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 135114T-cell receptor beta chain V region YT35PRO_0000033597Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi90 – 901N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP01733.
    PRIDEiP01733.

    Expressioni

    Gene expression databases

    GenevestigatoriP01733.

    Interactioni

    Protein-protein interaction databases

    IntActiP01733. 2 interactions.
    MINTiMINT-4328927.

    Structurei

    3D structure databases

    ProteinModelPortaliP01733.
    SMRiP01733. Positions 20-135.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    HOVERGENiHBG100543.
    InParanoidiP01733.
    PhylomeDBiP01733.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01733-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSWTFCCVS LCILVAKHTD AGVIQSPRHE VTEMGQEVTL RCKPISGHNS    50
    LFWYRQTMMR GLELLIYFNN NVPIDDSGMP EDRFSAKMPN ASFSTLKIQP 100
    SEPRDSAVYF CASSFSTCSA NYGYTFGSGT RLTVV 135
    Length:135
    Mass (Da):15,097
    Last modified:July 21, 1986 - v1
    Checksum:i9FBF913D33967CC9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti115 – 1195FSTCS → LATAL in AAC13336. (PubMed:12853948)Curated
    Non-terminal residuei135 – 1351

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36092 Genomic DNA. Translation: AAC13336.1.
    U66061 Genomic DNA. No translation available.
    M14158 Genomic DNA. Translation: AAA60669.1.
    PIRiA02000. RWHUVY.
    S03488.
    S03510.

    Polymorphism databases

    DMDMi136492.

    Cross-referencesi

    Web resourcesi

    IMGT/GENE-DB

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36092 Genomic DNA. Translation: AAC13336.1 .
    U66061 Genomic DNA. No translation available.
    M14158 Genomic DNA. Translation: AAA60669.1 .
    PIRi A02000. RWHUVY.
    S03488.
    S03510.

    3D structure databases

    ProteinModelPortali P01733.
    SMRi P01733. Positions 20-135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P01733. 2 interactions.
    MINTi MINT-4328927.

    Polymorphism databases

    DMDMi 136492.

    Proteomic databases

    MaxQBi P01733.
    PRIDEi P01733.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC07Pg41640.
    HGNCi HGNC:12185. TRBV12-3.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG100543.
    InParanoidi P01733.
    PhylomeDBi P01733.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.

    Miscellaneous databases

    PROi P01733.

    Gene expression databases

    Genevestigatori P01733.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains."
      Yanagi Y., Yoshikai Y., Leggett K., Clark S.P., Aleksander I., Mak T.W.
      Nature 308:145-149(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain."
      Toyonaga B., Yoshikai Y., Vadasz V., Chin B., Mak T.W.
      Proc. Natl. Acad. Sci. U.S.A. 82:8624-8628(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 121-135.
    4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-90.
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiTVB1_HUMAN
    AccessioniPrimary (citable) accession number: P01733
    Secondary accession number(s): A0A5A7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM

    External Data

    Dasty 3