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Protein

Ig lambda-1 chain V regions MOPC 104E/RPC20/J558/S104

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig lambda-1 chain V regions MOPC 104E/RPC20/J558/S104
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 193 PublicationsAdd BLAST19
ChainiPRO_000001520220 – 129Ig lambda-1 chain V regions MOPC 104E/RPC20/J558/S104Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20Pyrrolidone carboxylic acid1 Publication1

Keywords - PTMi

Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiP01724.

Interactioni

Protein-protein interaction databases

MINTiMINT-138421.

Structurei

Secondary structure

1129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 25Combined sources3
Beta strandi27 – 31Combined sources5
Beta strandi36 – 43Combined sources8
Beta strandi44 – 46Combined sources3
Helixi50 – 52Combined sources3
Beta strandi55 – 60Combined sources6
Turni61 – 63Combined sources3
Beta strandi64 – 70Combined sources7
Turni71 – 73Combined sources3
Beta strandi83 – 88Combined sources6
Beta strandi91 – 98Combined sources8
Helixi101 – 103Combined sources3
Beta strandi105 – 113Combined sources9
Beta strandi116 – 119Combined sources4
Beta strandi123 – 127Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A6UX-ray2.10L21-128[»]
1A6VX-ray1.80L/M/N20-128[»]
1A6WX-ray2.00L21-128[»]
1DL7X-ray2.35L20-128[»]
1OAQX-ray1.50L20-129[»]
1OARX-ray2.23L/M/N/O20-128[»]
1OAUX-ray1.80L/M/N/O20-128[»]
1OAXX-ray2.67L/M/N/O20-128[»]
1OAYX-ray2.66L/M/N/O20-128[»]
1OAZX-ray2.78L/N20-128[»]
1OCWX-ray2.00L20-128[»]
1Q0YX-ray2.00L21-129[»]
2BJMX-ray2.15L20-128[»]
ProteinModelPortaliP01724.
SMRiP01724.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01724.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 125Ig-likeAdd BLAST106

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

HOGENOMiHOG000059537.
HOVERGENiHBG018013.
PhylomeDBiP01724.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01724-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWISLILSL LALSSGAISQ AVVTQESALT TSPGETVTLT CRSSTGAVTT
60 70 80 90 100
SNYANWVQQK PDHLFTGLIG GTNNRAPGVP ARFSGSLIGN KAALTITGAQ
110 120
TEDEAIYFCA LWYSNHWVFG GGTKLTVLG
Length:129
Mass (Da):13,479
Last modified:July 21, 1986 - v1
Checksum:i03629939D5791AC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1291

Sequence databases

PIRiB93815. L1MS4E.
PH1089.
UniGeneiMm.326349.
Mm.456234.
Mm.469795.

Cross-referencesi

Sequence databases

PIRiB93815. L1MS4E.
PH1089.
UniGeneiMm.326349.
Mm.456234.
Mm.469795.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A6UX-ray2.10L21-128[»]
1A6VX-ray1.80L/M/N20-128[»]
1A6WX-ray2.00L21-128[»]
1DL7X-ray2.35L20-128[»]
1OAQX-ray1.50L20-129[»]
1OARX-ray2.23L/M/N/O20-128[»]
1OAUX-ray1.80L/M/N/O20-128[»]
1OAXX-ray2.67L/M/N/O20-128[»]
1OAYX-ray2.66L/M/N/O20-128[»]
1OAZX-ray2.78L/N20-128[»]
1OCWX-ray2.00L20-128[»]
1Q0YX-ray2.00L21-129[»]
2BJMX-ray2.15L20-128[»]
ProteinModelPortaliP01724.
SMRiP01724.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-138421.

Proteomic databases

PRIDEiP01724.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000059537.
HOVERGENiHBG018013.
PhylomeDBiP01724.

Miscellaneous databases

EvolutionaryTraceiP01724.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLV1B_MOUSE
AccessioniPrimary (citable) accession number: P01724
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Compositions and partial sequences of RPC 20 show no differences from MOPC 104E. The sequences of J558 and S104 seems identical with that shown.
These proteins were isolated from serum or urine of tumor-bearing mice.
The MOPC 104E precursor was synthesized in a cell-free system directed by mRNA isolated from MOPC 104E myeloma polysomes. Met-1 was lacking in 90% of the chains. It is probably rapidly cleaved after synthesis.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.