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P01709 (LV206_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig lambda chain V-II region MGC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length111 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Miscellaneous

This is a Bence-Jones protein.

The MCG-type C region appears to be correlated with a very unusual V-region substitution, 103-Thr above for Gly, suggesting that the V-C joining mechanism is not always random.

The C region of this chain has the Kern+ and Mcg+ markers.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›111›111Ig lambda chain V-II region MGC
PRO_0000059835

Regions

Domain1 – 108108Ig-like

Amino acid modifications

Modified residue11Pyrrolidone carboxylic acid Ref.1
Disulfide bond22 ↔ 90 By similarity

Experimental info

Non-terminal residue1111

Secondary structure

............................ 111
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01709 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 7CC1D6E2FA3377BA

FASTA11111,558
        10         20         30         40         50         60 
QSALTQPPSA SGSLGQSVTI SCTGTSSDVG GYNYVSWYQQ HAGKAPKVII YEVNKRPSGV 

        70         80         90        100        110 
PDRFSGSKSG NTASLTVSGL QAEDEADYYC SSYEGSDNFV FGTGTKVTVL G 

« Hide

References

[1]"Primary structure of the Mcg lambda chain."
Fett J.W., Deutsch H.F.
Biochemistry 13:4102-4114(1974) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
[2]"A new lambda-chain gene."
Fett J.W., Deutsch H.F.
Immunochemistry 12:643-652(1975) [PubMed] [Europe PMC] [Abstract]
Cited for: LAMBDA CHAIN GENES.
[3]"Rotational allomerism and divergent evolution of domains in immunoglobulin light chains."
Edmundson A.B., Ely K.R., Abola E.E., Schiffer M., Panagiotopoulos N.
Biochemistry 14:3953-3961(1975)
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
[4]"Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms."
Ely K.R., Herron J.N., Harker M., Edmundson A.B.
J. Mol. Biol. 210:601-615(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRL2HUMC. A90381.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1A8JX-ray2.70H/L2-111[»]
1DCLX-ray2.30A/B2-111[»]
2MCGX-ray2.001/22-111[»]
ProteinModelPortalP01709.
SMRP01709. Positions 2-111.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1504417.

Protein family/group databases

MEROPSI43.001.

Polymorphism databases

DMDM126559.

Proteomic databases

PaxDbP01709.
PRIDEP01709.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG278894.
HOVERGENHBG018013.
PhylomeDBP01709.

Enzyme and pathway databases

ReactomeREACT_160300. Binding and Uptake of Ligands by Scavenger Receptors.
REACT_6900. Immune System.

Gene expression databases

GenevestigatorP01709.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01709.
NextBio35537674.

Entry information

Entry nameLV206_HUMAN
AccessionPrimary (citable) accession number: P01709
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references