P01673 (KV3AL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig kappa chain V-III region PC 2485/PC 4039
Organism	Mus musculus (Mouse) [Reference proteome]
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous

The PC 4285 and PC 4039 sequences are identical.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Molecular_function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›111	›111	Ig kappa chain V-III region PC 2485/PC 4039		PRO_0000059795
Regions
	Region	1 – 23	23	Framework-1
	Region	24 – 38	15	Complementarity-determining-1
	Region	39 – 53	15	Framework-2
	Region	54 – 60	7	Complementarity-determining-2
	Region	61 – 92	32	Framework-3
	Region	93 – 101	9	Complementarity-determining-3
	Region	102 – 111	10	Framework-4
Amino acid modifications
	Disulfide bond	23 ↔ 92		By similarity
Experimental info
	Non-terminal residue	111	1

Sequences

	Sequence		Length	Mass (Da)
	P01673 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: BF38C59AA7858467	FASTA	111	11,987
	10 20 30 40 50 60 DIVLTQSPAS LAVSLGQRAT ISCRASKSVS TSGYSYMHWY QQKPGQPPKL LIYLASSLES 70 80 90 100 110 GVPARFSGSG SGTDFTLNIQ PVEEEDAAIY YCQHSRELPL TFGAGTKLEL K

References

[1]	"Rearrangement of genetic information may produce immunoglobulin diversity." Weigert M., Gatmaitan L., Loh E., Schilling J., Hood L.E. Nature 276:785-790(1978) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
IPI	IPI00464411.
PIR	KVMS85. A01939.
3D structure databases
ProteinModelPortal	P01673.
SMR	P01673. Positions 1-111.
ModBase	Search...
Proteomic databases
PRIDE	P01673.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG018013.
Gene expression databases
Genevestigator	P01673.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_subgr. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35563477.

Entry information

Entry name

KV3AL_MOUSE

Accession

Primary (citable) accession number: P01673

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program