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Protein

Ig kappa chain V-III region MOPC 63

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig kappa chain V-III region MOPC 63
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 131111Ig kappa chain V-III region MOPC 63PRO_0000015187Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 112PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP01661.

Structurei

Secondary structure

1
131
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 274Combined sources
Beta strandi29 – 313Combined sources
Beta strandi39 – 479Combined sources
Beta strandi57 – 626Combined sources
Beta strandi68 – 736Combined sources
Turni74 – 763Combined sources
Beta strandi86 – 905Combined sources
Beta strandi92 – 10110Combined sources
Beta strandi108 – 1147Combined sources
Beta strandi116 – 1194Combined sources
Beta strandi126 – 1283Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EGJX-ray2.80L21-131[»]
ProteinModelPortaliP01661.
SMRiP01661. Positions 22-131.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01661.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 4323Framework-1Add
BLAST
Regioni44 – 5815Complementarity-determining-1Add
BLAST
Regioni59 – 7315Framework-2Add
BLAST
Regioni74 – 807Complementarity-determining-2
Regioni81 – 11232Framework-3Add
BLAST
Regioni113 – 1219Complementarity-determining-3
Regioni122 – 13110Framework-4

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

eggNOGiNOG76434.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
PhylomeDBiP01661.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METDTLLLWV LLLWVPGSTG NIVLTQSPAS LAVSLGQRAT ISCRASESVD
60 70 80 90 100
SYGNSFMHWY QQKPGQPPKL LIYLASNLES GVPARFSGSG SRTDFTLTID
110 120 130
PVEADDAATY YCQQNNEDPW TFGGGTKLEI K
Length:131
Mass (Da):14,291
Last modified:July 21, 1986 - v1
Checksum:iD212EC9F08DC880A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei131 – 1311

Sequence databases

PIRiB90412. KVMSM6.
D45722.

Cross-referencesi

Sequence databases

PIRiB90412. KVMSM6.
D45722.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EGJX-ray2.80L21-131[»]
ProteinModelPortaliP01661.
SMRiP01661. Positions 22-131.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI43.001.

Proteomic databases

PRIDEiP01661.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG76434.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
PhylomeDBiP01661.

Miscellaneous databases

EvolutionaryTraceiP01661.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primary structures of N-terminal extra peptide segments linked to the variable and constant regions of immunoglobulin light chain precursors: implications on the organization and controlled expression of immunoglobulin genes."
    Burstein Y., Schechter I.
    Biochemistry 17:2392-2400(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-35.
  2. "Mouse immunoglobulin chains. Pattern of sequence variation among kappa chains with limited sequence differences."
    McKean D.J., Potter M., Hood L.E.
    Biochemistry 12:760-771(1973) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-131.
  3. "Mechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions."
    McKean D.J., Bell M., Potter M.
    Proc. Natl. Acad. Sci. U.S.A. 75:3913-3917(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiKV3A9_MOUSE
AccessioniPrimary (citable) accession number: P01661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 24, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.