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P01661 (KV3A9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig kappa chain V-III region MOPC 63
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.2
Chain21 – 131111Ig kappa chain V-III region MOPC 63
PRO_0000015187

Regions

Region21 – 4323Framework-1
Region44 – 5815Complementarity-determining-1
Region59 – 7315Framework-2
Region74 – 807Complementarity-determining-2
Region81 – 11232Framework-3
Region113 – 1219Complementarity-determining-3
Region122 – 13110Framework-4

Amino acid modifications

Disulfide bond43 ↔ 112 By similarity

Experimental info

Non-terminal residue1311

Secondary structure

...................... 131
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01661 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: D212EC9F08DC880A

FASTA13114,291
        10         20         30         40         50         60 
METDTLLLWV LLLWVPGSTG NIVLTQSPAS LAVSLGQRAT ISCRASESVD SYGNSFMHWY 

        70         80         90        100        110        120 
QQKPGQPPKL LIYLASNLES GVPARFSGSG SRTDFTLTID PVEADDAATY YCQQNNEDPW 

       130 
TFGGGTKLEI K 

« Hide

References

[1]"Primary structures of N-terminal extra peptide segments linked to the variable and constant regions of immunoglobulin light chain precursors: implications on the organization and controlled expression of immunoglobulin genes."
Burstein Y., Schechter I.
Biochemistry 17:2392-2400(1978) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-35.
[2]"Mouse immunoglobulin chains. Pattern of sequence variation among kappa chains with limited sequence differences."
McKean D.J., Potter M., Hood L.E.
Biochemistry 12:760-771(1973) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-131.
[3]"Mechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions."
McKean D.J., Bell M., Potter M.
Proc. Natl. Acad. Sci. U.S.A. 75:3913-3917(1978) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRKVMSM6. B90412.
D45722.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1EGJX-ray2.80L21-131[»]
ProteinModelPortalP01661.
SMRP01661. Positions 22-131.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI43.001.

Proteomic databases

PRIDEP01661.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG76434.
HOGENOMHOG000059537.
HOVERGENHBG018013.
InParanoidP01661.
PhylomeDBP01661.

Gene expression databases

GenevestigatorP01661.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01661.

Entry information

Entry nameKV3A9_MOUSE
AccessionPrimary (citable) accession number: P01661
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references