P01661 (KV3A9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig kappa chain V-III region MOPC 63
Organism	Mus musculus (Mouse) [Reference proteome]
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain Signal
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Molecular_function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Ref.2
	Chain	21 – 131	111	Ig kappa chain V-III region MOPC 63		PRO_0000015187
Regions
	Region	21 – 43	23	Framework-1
	Region	44 – 58	15	Complementarity-determining-1
	Region	59 – 73	15	Framework-2
	Region	74 – 80	7	Complementarity-determining-2
	Region	81 – 112	32	Framework-3
	Region	113 – 121	9	Complementarity-determining-3
	Region	122 – 131	10	Framework-4
Amino acid modifications
	Disulfide bond	43 ↔ 112		By similarity
Experimental info
	Non-terminal residue	131	1

Sequences

	Sequence		Length	Mass (Da)
	P01661 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: D212EC9F08DC880A	FASTA	131	14,291
	10 20 30 40 50 60 METDTLLLWV LLLWVPGSTG NIVLTQSPAS LAVSLGQRAT ISCRASESVD SYGNSFMHWY 70 80 90 100 110 120 QQKPGQPPKL LIYLASNLES GVPARFSGSG SRTDFTLTID PVEADDAATY YCQQNNEDPW 130 TFGGGTKLEI K

References

[1]	"Primary structures of N-terminal extra peptide segments linked to the variable and constant regions of immunoglobulin light chain precursors: implications on the organization and controlled expression of immunoglobulin genes." Burstein Y., Schechter I. Biochemistry 17:2392-2400(1978) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-35.
[2]	"Mouse immunoglobulin chains. Pattern of sequence variation among kappa chains with limited sequence differences." McKean D.J., Potter M., Hood L.E. Biochemistry 12:760-771(1973) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 21-131.
[3]	"Mechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions." McKean D.J., Bell M., Potter M. Proc. Natl. Acad. Sci. U.S.A. 75:3913-3917(1978) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

IPI

IPI00138144.

PIR

KVMSM6. B90412.
D45722.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1EGJ	X-ray	2.80	L	21-131	[»]

ProteinModelPortal

P01661.

SMR

P01661. Positions 21-131.

ModBase

Search...

Protein family/group databases

MEROPS

I43.001.

Proteomic databases

PRIDE

P01661.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

eggNOG

NOG76434.

HOGENOM

HOG000059537.

HOVERGEN

HBG018013.

InParanoid

P01661.

OrthoDB

EOG4XSKRF.

Gene expression databases

Genevestigator

P01661.

GermOnline

ENSMUSG00000061260. Mus musculus.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]

Pfam

PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00406. IGv. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P01661.

Entry information

Entry name

KV3A9_MOUSE

Accession

Primary (citable) accession number: P01661

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program