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P01660

- KV3A8_MOUSE

UniProt

P01660 - KV3A8_MOUSE

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Protein

Ig kappa chain V-III region PC 3741/TEPC 111

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB-KW
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig kappa chain V-III region PC 3741/TEPC 111
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›111›111Ig kappa chain V-III region PC 3741/TEPC 111PRO_0000059783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 92PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01660.
PRIDEiP01660.

Expressioni

Gene expression databases

GenevestigatoriP01660.

Interactioni

Protein-protein interaction databases

MINTiMINT-132875.
STRINGi10090.ENSMUSP00000100201.

Structurei

Secondary structure

1
111
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 74Combined sources
Beta strandi9 – 124Combined sources
Beta strandi19 – 279Combined sources
Beta strandi37 – 426Combined sources
Beta strandi44 – 463Combined sources
Beta strandi48 – 536Combined sources
Turni54 – 563Combined sources
Beta strandi66 – 716Combined sources
Beta strandi74 – 818Combined sources
Helixi84 – 863Combined sources
Beta strandi88 – 947Combined sources
Beta strandi96 – 994Combined sources
Beta strandi106 – 1094Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EJOX-ray2.30L1-111[»]
1I8IX-ray2.40A4-111[»]
1I8KX-ray1.80A4-111[»]
1J05X-ray1.50A/L1-111[»]
1MOEX-ray2.60A/B2-111[»]
1QFWX-ray3.50L1-111[»]
M1-111[»]
2R29X-ray3.00L1-111[»]
2R69X-ray3.80L1-111[»]
2R6Pelectron microscopy24.00E/G1-111[»]
2VL5X-ray2.10B/D1-111[»]
3BSZX-ray3.38L/M1-111[»]
ProteinModelPortaliP01660.
SMRiP01660. Positions 1-111.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01660.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2323Framework-1Add
BLAST
Regioni24 – 3815Complementarity-determining-1Add
BLAST
Regioni39 – 5315Framework-2Add
BLAST
Regioni54 – 607Complementarity-determining-2
Regioni61 – 9232Framework-3Add
BLAST
Regioni93 – 1019Complementarity-determining-3
Regioni102 – 11110Framework-4

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region

Phylogenomic databases

eggNOGiNOG76434.
HOVERGENiHBG018013.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01660-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
DIVLTQSPAS LAVSLGQRAT ISCRASESVD SYGNSFMHWY QQKPGQPPKL
60 70 80 90 100
LIYRASNLES GIPARFSGSG SRTDFTLTIN PVEADDVATY YCQQSNEDPY
110
TFGGGTKLEI K
Length:111
Mass (Da):12,099
Last modified:July 21, 1986 - v1
Checksum:iEC46C9D259213BE4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei111 – 1111

Sequence databases

PIRiA93204. KVMS37.

Cross-referencesi

Sequence databases

PIRi A93204. KVMS37.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EJO X-ray 2.30 L 1-111 [» ]
1I8I X-ray 2.40 A 4-111 [» ]
1I8K X-ray 1.80 A 4-111 [» ]
1J05 X-ray 1.50 A/L 1-111 [» ]
1MOE X-ray 2.60 A/B 2-111 [» ]
1QFW X-ray 3.50 L 1-111 [» ]
M 1-111 [» ]
2R29 X-ray 3.00 L 1-111 [» ]
2R69 X-ray 3.80 L 1-111 [» ]
2R6P electron microscopy 24.00 E/G 1-111 [» ]
2VL5 X-ray 2.10 B/D 1-111 [» ]
3BSZ X-ray 3.38 L/M 1-111 [» ]
ProteinModelPortali P01660.
SMRi P01660. Positions 1-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-132875.
STRINGi 10090.ENSMUSP00000100201.

Proteomic databases

PaxDbi P01660.
PRIDEi P01660.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG76434.
HOVERGENi HBG018013.

Miscellaneous databases

EvolutionaryTracei P01660.

Gene expression databases

Genevestigatori P01660.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rearrangement of genetic information may produce immunoglobulin diversity."
    Weigert M., Gatmaitan L., Loh E., Schilling J., Hood L.E.
    Nature 276:785-790(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (PC 3741).
  2. "Mechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions."
    McKean D.J., Bell M., Potter M.
    Proc. Natl. Acad. Sci. U.S.A. 75:3913-3917(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (TEPC 111).

Entry informationi

Entry nameiKV3A8_MOUSE
AccessioniPrimary (citable) accession number: P01660
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The PC 3741 and TEPC 111 sequences are identical.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3