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P01660 (KV3A8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig kappa chain V-III region PC 3741/TEPC 111
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length111 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Miscellaneous

The PC 3741 and TEPC 111 sequences are identical.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›111›111Ig kappa chain V-III region PC 3741/TEPC 111
PRO_0000059783

Regions

Region1 – 2323Framework-1
Region24 – 3815Complementarity-determining-1
Region39 – 5315Framework-2
Region54 – 607Complementarity-determining-2
Region61 – 9232Framework-3
Region93 – 1019Complementarity-determining-3
Region102 – 11110Framework-4

Amino acid modifications

Disulfide bond23 ↔ 92 By similarity

Experimental info

Non-terminal residue1111

Secondary structure

.......................... 111
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01660 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: EC46C9D259213BE4

FASTA11112,099
        10         20         30         40         50         60 
DIVLTQSPAS LAVSLGQRAT ISCRASESVD SYGNSFMHWY QQKPGQPPKL LIYRASNLES 

        70         80         90        100        110 
GIPARFSGSG SRTDFTLTIN PVEADDVATY YCQQSNEDPY TFGGGTKLEI K 

« Hide

References

[1]"Rearrangement of genetic information may produce immunoglobulin diversity."
Weigert M., Gatmaitan L., Loh E., Schilling J., Hood L.E.
Nature 276:785-790(1978) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE (PC 3741).
[2]"Mechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions."
McKean D.J., Bell M., Potter M.
Proc. Natl. Acad. Sci. U.S.A. 75:3913-3917(1978) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE (TEPC 111).
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRKVMS37. A93204.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1EJOX-ray2.30L1-111[»]
1I8IX-ray2.40A4-111[»]
1I8KX-ray1.80A4-111[»]
1J05X-ray1.50A/L1-111[»]
1MOEX-ray2.60A/B2-111[»]
1QFWX-ray3.50L1-111[»]
M1-111[»]
2R29X-ray3.00L1-111[»]
2R69X-ray3.80L1-111[»]
2R6Pelectron microscopy24.00E/G1-111[»]
2VL5X-ray2.10B/D1-111[»]
3BSZX-ray3.38L/M1-111[»]
ProteinModelPortalP01660.
SMRP01660. Positions 1-111.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-132875.
STRING10090.ENSMUSP00000100201.

Proteomic databases

PaxDbP01660.
PRIDEP01660.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG76434.
HOVERGENHBG018013.

Gene expression databases

GenevestigatorP01660.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01660.

Entry information

Entry nameKV3A8_MOUSE
AccessionPrimary (citable) accession number: P01660
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references