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Protein

Ig kappa chain V-III region PC 3741/TEPC 111

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB-KW
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig kappa chain V-III region PC 3741/TEPC 111
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›111›111Ig kappa chain V-III region PC 3741/TEPC 111PRO_0000059783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 92PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP01660.
PaxDbiP01660.
PRIDEiP01660.

Expressioni

Gene expression databases

GenevestigatoriP01660.

Interactioni

Protein-protein interaction databases

MINTiMINT-132875.
STRINGi10090.ENSMUSP00000100201.

Structurei

Secondary structure

1
111
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 74Combined sources
Beta strandi9 – 124Combined sources
Beta strandi19 – 279Combined sources
Beta strandi37 – 426Combined sources
Beta strandi44 – 463Combined sources
Beta strandi48 – 536Combined sources
Turni54 – 563Combined sources
Beta strandi66 – 716Combined sources
Beta strandi74 – 818Combined sources
Helixi84 – 863Combined sources
Beta strandi88 – 947Combined sources
Beta strandi96 – 994Combined sources
Beta strandi106 – 1094Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EJOX-ray2.30L1-111[»]
1I8IX-ray2.40A4-111[»]
1I8KX-ray1.80A4-111[»]
1J05X-ray1.50A/L1-111[»]
1MOEX-ray2.60A/B2-111[»]
1QFWX-ray3.50L1-111[»]
M1-111[»]
2R29X-ray3.00L1-111[»]
2R69X-ray3.80L1-111[»]
2R6Pelectron microscopy24.00E/G1-111[»]
2VL5X-ray2.10B/D1-111[»]
3BSZX-ray3.38L/M1-111[»]
4NJAX-ray2.20L1-111[»]
ProteinModelPortaliP01660.
SMRiP01660. Positions 1-111.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01660.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2323Framework-1Add
BLAST
Regioni24 – 3815Complementarity-determining-1Add
BLAST
Regioni39 – 5315Framework-2Add
BLAST
Regioni54 – 607Complementarity-determining-2
Regioni61 – 9232Framework-3Add
BLAST
Regioni93 – 1019Complementarity-determining-3
Regioni102 – 11110Framework-4

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region

Phylogenomic databases

eggNOGiNOG76434.
HOVERGENiHBG018013.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DIVLTQSPAS LAVSLGQRAT ISCRASESVD SYGNSFMHWY QQKPGQPPKL
60 70 80 90 100
LIYRASNLES GIPARFSGSG SRTDFTLTIN PVEADDVATY YCQQSNEDPY
110
TFGGGTKLEI K
Length:111
Mass (Da):12,099
Last modified:July 21, 1986 - v1
Checksum:iEC46C9D259213BE4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei111 – 1111

Sequence databases

PIRiA93204. KVMS37.

Cross-referencesi

Sequence databases

PIRiA93204. KVMS37.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EJOX-ray2.30L1-111[»]
1I8IX-ray2.40A4-111[»]
1I8KX-ray1.80A4-111[»]
1J05X-ray1.50A/L1-111[»]
1MOEX-ray2.60A/B2-111[»]
1QFWX-ray3.50L1-111[»]
M1-111[»]
2R29X-ray3.00L1-111[»]
2R69X-ray3.80L1-111[»]
2R6Pelectron microscopy24.00E/G1-111[»]
2VL5X-ray2.10B/D1-111[»]
3BSZX-ray3.38L/M1-111[»]
4NJAX-ray2.20L1-111[»]
ProteinModelPortaliP01660.
SMRiP01660. Positions 1-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-132875.
STRINGi10090.ENSMUSP00000100201.

Proteomic databases

MaxQBiP01660.
PaxDbiP01660.
PRIDEiP01660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG76434.
HOVERGENiHBG018013.

Miscellaneous databases

EvolutionaryTraceiP01660.

Gene expression databases

GenevestigatoriP01660.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rearrangement of genetic information may produce immunoglobulin diversity."
    Weigert M., Gatmaitan L., Loh E., Schilling J., Hood L.E.
    Nature 276:785-790(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (PC 3741).
  2. "Mechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions."
    McKean D.J., Bell M., Potter M.
    Proc. Natl. Acad. Sci. U.S.A. 75:3913-3917(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (TEPC 111).

Entry informationi

Entry nameiKV3A8_MOUSE
AccessioniPrimary (citable) accession number: P01660
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 1, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The PC 3741 and TEPC 111 sequences are identical.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.