Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P01660

- KV3A8_MOUSE

UniProt

P01660 - KV3A8_MOUSE

Protein

Ig kappa chain V-III region PC 3741/TEPC 111

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB-KW

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ig kappa chain V-III region PC 3741/TEPC 111
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›111›111Ig kappa chain V-III region PC 3741/TEPC 111PRO_0000059783Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi23 ↔ 92PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP01660.
    PRIDEiP01660.

    Expressioni

    Gene expression databases

    GenevestigatoriP01660.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-132875.
    STRINGi10090.ENSMUSP00000100201.

    Structurei

    Secondary structure

    1
    111
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 74
    Beta strandi9 – 124
    Beta strandi19 – 279
    Beta strandi37 – 426
    Beta strandi44 – 463
    Beta strandi48 – 536
    Turni54 – 563
    Beta strandi66 – 716
    Beta strandi74 – 818
    Helixi84 – 863
    Beta strandi88 – 947
    Beta strandi96 – 994
    Beta strandi106 – 1094

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EJOX-ray2.30L1-111[»]
    1I8IX-ray2.40A4-111[»]
    1I8KX-ray1.80A4-111[»]
    1J05X-ray1.50A/L1-111[»]
    1MOEX-ray2.60A/B2-111[»]
    1QFWX-ray3.50L1-111[»]
    M1-111[»]
    2R29X-ray3.00L1-111[»]
    2R69X-ray3.80L1-111[»]
    2R6Pelectron microscopy24.00E/G1-111[»]
    2VL5X-ray2.10B/D1-111[»]
    3BSZX-ray3.38L/M1-111[»]
    ProteinModelPortaliP01660.
    SMRiP01660. Positions 1-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01660.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2323Framework-1Add
    BLAST
    Regioni24 – 3815Complementarity-determining-1Add
    BLAST
    Regioni39 – 5315Framework-2Add
    BLAST
    Regioni54 – 607Complementarity-determining-2
    Regioni61 – 9232Framework-3Add
    BLAST
    Regioni93 – 1019Complementarity-determining-3
    Regioni102 – 11110Framework-4

    Keywords - Domaini

    Immunoglobulin domain, Immunoglobulin V region

    Phylogenomic databases

    eggNOGiNOG76434.
    HOVERGENiHBG018013.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P01660-1 [UniParc]FASTAAdd to Basket

    « Hide

    DIVLTQSPAS LAVSLGQRAT ISCRASESVD SYGNSFMHWY QQKPGQPPKL    50
    LIYRASNLES GIPARFSGSG SRTDFTLTIN PVEADDVATY YCQQSNEDPY 100
    TFGGGTKLEI K 111
    Length:111
    Mass (Da):12,099
    Last modified:July 21, 1986 - v1
    Checksum:iEC46C9D259213BE4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei111 – 1111

    Sequence databases

    PIRiA93204. KVMS37.

    Cross-referencesi

    Sequence databases

    PIRi A93204. KVMS37.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EJO X-ray 2.30 L 1-111 [» ]
    1I8I X-ray 2.40 A 4-111 [» ]
    1I8K X-ray 1.80 A 4-111 [» ]
    1J05 X-ray 1.50 A/L 1-111 [» ]
    1MOE X-ray 2.60 A/B 2-111 [» ]
    1QFW X-ray 3.50 L 1-111 [» ]
    M 1-111 [» ]
    2R29 X-ray 3.00 L 1-111 [» ]
    2R69 X-ray 3.80 L 1-111 [» ]
    2R6P electron microscopy 24.00 E/G 1-111 [» ]
    2VL5 X-ray 2.10 B/D 1-111 [» ]
    3BSZ X-ray 3.38 L/M 1-111 [» ]
    ProteinModelPortali P01660.
    SMRi P01660. Positions 1-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-132875.
    STRINGi 10090.ENSMUSP00000100201.

    Proteomic databases

    PaxDbi P01660.
    PRIDEi P01660.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG76434.
    HOVERGENi HBG018013.

    Miscellaneous databases

    EvolutionaryTracei P01660.

    Gene expression databases

    Genevestigatori P01660.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rearrangement of genetic information may produce immunoglobulin diversity."
      Weigert M., Gatmaitan L., Loh E., Schilling J., Hood L.E.
      Nature 276:785-790(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE (PC 3741).
    2. "Mechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions."
      McKean D.J., Bell M., Potter M.
      Proc. Natl. Acad. Sci. U.S.A. 75:3913-3917(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE (TEPC 111).

    Entry informationi

    Entry nameiKV3A8_MOUSE
    AccessioniPrimary (citable) accession number: P01660
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The PC 3741 and TEPC 111 sequences are identical.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3