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Protein

Ig kappa chain V-V region L7

Gene

Gm10881

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB-KW
Complete GO annotation...

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig kappa chain V-V region L7
Gene namesi
Name:Gm10881
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:3642817. Gm10881.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – ›115›95Ig kappa chain V-V region L7PRO_0000015196Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 108PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP01642.
PRIDEiP01642.

Expressioni

Gene expression databases

BgeeiP01642.
GenevestigatoriP01642.

Structurei

Secondary structure

1
115
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 274Combined sources
Beta strandi29 – 335Combined sources
Beta strandi39 – 479Combined sources
Beta strandi53 – 586Combined sources
Beta strandi65 – 695Combined sources
Turni70 – 723Combined sources
Beta strandi82 – 876Combined sources
Beta strandi90 – 978Combined sources
Helixi100 – 1023Combined sources
Beta strandi104 – 1107Combined sources
Beta strandi112 – 1154Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1C08X-ray2.30A21-115[»]
1IC4X-ray2.50L21-115[»]
1IC5X-ray2.30L21-115[»]
1IC7X-ray2.10L21-115[»]
1J1OX-ray1.80L21-115[»]
1J1PX-ray1.80L21-115[»]
1J1XX-ray1.80L21-115[»]
2OZ4X-ray2.70L21-115[»]
4CKDelectron microscopy13.00L/M/N/O21-115[»]
ProteinModelPortaliP01642.
SMRiP01642. Positions 21-115.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01642.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 4323Framework-1Add
BLAST
Regioni44 – 5411Complementarity-determining-1Add
BLAST
Regioni55 – 6915Framework-2Add
BLAST
Regioni70 – 767Complementarity-determining-2
Regioni77 – 10832Framework-3Add
BLAST
Regioni109 – ›115›7Complementarity-determining-3

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

eggNOGiNOG270118.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
InParanoidiP01642.
OMAiTKTSSAW.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01642-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSTPQFLVF LLFWIPASRG DILLTQSPAI LSVSPGERVS FSCRASQSIG
60 70 80 90 100
TSIHWYQQRT NGSPRLLIKY ASESISGIPS RFSGSGSGTD FTLSINSVES
110
EDIADYYCQQ SNSWP
Length:115
Mass (Da):12,615
Last modified:July 20, 1986 - v1
Checksum:iC17BEC758C577E00
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei115 – 1151

Sequence databases

PIRiA01925. KVMSL7.

Genome annotation databases

EnsembliENSMUST00000103364; ENSMUSP00000100165; ENSMUSG00000076563.

Cross-referencesi

Sequence databases

PIRiA01925. KVMSL7.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1C08X-ray2.30A21-115[»]
1IC4X-ray2.50L21-115[»]
1IC5X-ray2.30L21-115[»]
1IC7X-ray2.10L21-115[»]
1J1OX-ray1.80L21-115[»]
1J1PX-ray1.80L21-115[»]
1J1XX-ray1.80L21-115[»]
2OZ4X-ray2.70L21-115[»]
4CKDelectron microscopy13.00L/M/N/O21-115[»]
ProteinModelPortaliP01642.
SMRiP01642. Positions 21-115.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI43.001.

Proteomic databases

MaxQBiP01642.
PRIDEiP01642.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103364; ENSMUSP00000100165; ENSMUSG00000076563.

Organism-specific databases

MGIiMGI:3642817. Gm10881.

Phylogenomic databases

eggNOGiNOG270118.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
InParanoidiP01642.
OMAiTKTSSAW.

Miscellaneous databases

EvolutionaryTraceiP01642.
SOURCEiSearch...

Gene expression databases

BgeeiP01642.
GenevestigatoriP01642.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Differences between germ-line and rearranged immunoglobulin V kappa coding sequences suggest a localized mutation mechanism."
    Pech M., Hochtl J., Schnell H., Zachau H.G.
    Nature 291:668-670(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiKV5A9_MOUSE
AccessioniPrimary (citable) accession number: P01642
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 20, 1986
Last sequence update: July 20, 1986
Last modified: March 31, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There appears to be two possible splice junctions at the 3' end of the intron. The alternate would code for a protein lacking residues 17-19.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.