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P01642

- KV5A9_MOUSE

UniProt

P01642 - KV5A9_MOUSE

Protein

Ig kappa chain V-V region L7

Gene

Gm10881

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB-KW

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ig kappa chain V-V region L7
    Gene namesi
    Name:Gm10881
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:3642817. Gm10881.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – ›115›95Ig kappa chain V-V region L7PRO_0000015196Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 108PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP01642.

    Expressioni

    Gene expression databases

    BgeeiP01642.
    GenevestigatoriP01642.

    Structurei

    Secondary structure

    1
    115
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi24 – 274
    Beta strandi29 – 335
    Beta strandi39 – 479
    Beta strandi53 – 586
    Beta strandi65 – 695
    Turni70 – 723
    Beta strandi82 – 876
    Beta strandi90 – 978
    Helixi100 – 1023
    Beta strandi104 – 1107
    Beta strandi112 – 1154

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1C08X-ray2.30A21-115[»]
    1IC4X-ray2.50L21-115[»]
    1IC5X-ray2.30L21-115[»]
    1IC7X-ray2.10L21-115[»]
    1J1OX-ray1.80L21-115[»]
    1J1PX-ray1.80L21-115[»]
    1J1XX-ray1.80L21-115[»]
    2OZ4X-ray2.70L21-115[»]
    4CKDelectron microscopy13.00L/M/N/O21-115[»]
    ProteinModelPortaliP01642.
    SMRiP01642. Positions 21-115.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01642.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 4323Framework-1Add
    BLAST
    Regioni44 – 5411Complementarity-determining-1Add
    BLAST
    Regioni55 – 6915Framework-2Add
    BLAST
    Regioni70 – 767Complementarity-determining-2
    Regioni77 – 10832Framework-3Add
    BLAST
    Regioni109 – ›115›7Complementarity-determining-3

    Keywords - Domaini

    Immunoglobulin domain, Immunoglobulin V region, Signal

    Phylogenomic databases

    eggNOGiNOG270118.
    HOGENOMiHOG000059537.
    HOVERGENiHBG018013.
    InParanoidiP01642.
    OMAiTKTSSAW.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01642-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSTPQFLVF LLFWIPASRG DILLTQSPAI LSVSPGERVS FSCRASQSIG    50
    TSIHWYQQRT NGSPRLLIKY ASESISGIPS RFSGSGSGTD FTLSINSVES 100
    EDIADYYCQQ SNSWP 115
    Length:115
    Mass (Da):12,615
    Last modified:July 21, 1986 - v1
    Checksum:iC17BEC758C577E00
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei115 – 1151

    Sequence databases

    PIRiA01925. KVMSL7.

    Genome annotation databases

    EnsembliENSMUST00000103364; ENSMUSP00000100165; ENSMUSG00000076563.

    Cross-referencesi

    Sequence databases

    PIRi A01925. KVMSL7.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1C08 X-ray 2.30 A 21-115 [» ]
    1IC4 X-ray 2.50 L 21-115 [» ]
    1IC5 X-ray 2.30 L 21-115 [» ]
    1IC7 X-ray 2.10 L 21-115 [» ]
    1J1O X-ray 1.80 L 21-115 [» ]
    1J1P X-ray 1.80 L 21-115 [» ]
    1J1X X-ray 1.80 L 21-115 [» ]
    2OZ4 X-ray 2.70 L 21-115 [» ]
    4CKD electron microscopy 13.00 L/M/N/O 21-115 [» ]
    ProteinModelPortali P01642.
    SMRi P01642. Positions 21-115.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I43.001.

    Proteomic databases

    PRIDEi P01642.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000103364 ; ENSMUSP00000100165 ; ENSMUSG00000076563 .

    Organism-specific databases

    MGIi MGI:3642817. Gm10881.

    Phylogenomic databases

    eggNOGi NOG270118.
    HOGENOMi HOG000059537.
    HOVERGENi HBG018013.
    InParanoidi P01642.
    OMAi TKTSSAW.

    Miscellaneous databases

    EvolutionaryTracei P01642.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01642.
    Genevestigatori P01642.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differences between germ-line and rearranged immunoglobulin V kappa coding sequences suggest a localized mutation mechanism."
      Pech M., Hochtl J., Schnell H., Zachau H.G.
      Nature 291:668-670(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiKV5A9_MOUSE
    AccessioniPrimary (citable) accession number: P01642
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There appears to be two possible splice junctions at the 3' end of the intron. The alternate would code for a protein lacking residues 17-19.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3