ID KV5A3_MOUSE Reviewed; 115 AA. AC P01635; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 27-MAR-2024, entry version 165. DE RecName: Full=Immunoglobulin kappa chain variable 12-41 {ECO:0000312|MGI:MGI:4439772}; DE AltName: Full=Ig kappa chain V-V region K2; DE Flags: Precursor; Fragment; GN Name=Igkv12-41 {ECO:0000312|MGI:MGI:4439772}; GN Synonyms=Gm16848 {ECO:0000312|MGI:MGI:4439772}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6767723; DOI=10.1016/s0021-9258(19)85759-9; RA Nishioka Y., Leder P.; RT "Organization and complete sequence of identical embryonic and plasmacytoma RT kappa V-region genes."; RL J. Biol. Chem. 255:3691-3694(1980). CC -!- MISCELLANEOUS: The gene was isolated and sequenced separately from two CC different sources, embryos and cultured plasmacytoma cells that secrete CC the similar kappa chain MOPC 149. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; V00778; CAA24155.1; -; Genomic_DNA. DR PIR; A01918; KVMSK2. DR PDB; 1A2Y; X-ray; 1.50 A; A=21-115. DR PDB; 1A7N; X-ray; 2.01 A; L=21-115. DR PDB; 1A7O; X-ray; 2.00 A; L=21-115. DR PDB; 1A7P; X-ray; 2.01 A; L=21-115. DR PDB; 1A7Q; X-ray; 2.00 A; L=21-115. DR PDB; 1A7R; X-ray; 2.01 A; L=21-115. DR PDB; 1DVF; X-ray; 1.90 A; A=21-115. DR PDB; 1KIP; X-ray; 2.10 A; A=21-115. DR PDB; 1KIQ; X-ray; 1.85 A; A=21-115. DR PDB; 1QBL; X-ray; 2.26 A; L=21-115. DR PDB; 1QBM; X-ray; 2.37 A; L=21-115. DR PDB; 1VFA; X-ray; 1.80 A; A=21-115. DR PDB; 1VFB; X-ray; 1.80 A; A=21-115. DR PDB; 1WEJ; X-ray; 1.80 A; L=21-115. DR PDBsum; 1A2Y; -. DR PDBsum; 1A7N; -. DR PDBsum; 1A7O; -. DR PDBsum; 1A7P; -. DR PDBsum; 1A7Q; -. DR PDBsum; 1A7R; -. DR PDBsum; 1DVF; -. DR PDBsum; 1KIP; -. DR PDBsum; 1KIQ; -. DR PDBsum; 1QBL; -. DR PDBsum; 1QBM; -. DR PDBsum; 1VFA; -. DR PDBsum; 1VFB; -. DR PDBsum; 1WEJ; -. DR AlphaFoldDB; P01635; -. DR EMDB; EMD-20584; -. DR EMDB; EMD-26660; -. DR EMDB; EMD-27541; -. DR EMDB; EMD-32967; -. DR EMDB; EMD-32968; -. DR EMDB; EMD-32969; -. DR EMDB; EMD-32980; -. DR EMDB; EMD-33000; -. DR EMDB; EMD-33001; -. DR EMDB; EMD-40935; -. DR EMDB; EMD-8754; -. DR EMDB; EMD-8761; -. DR EMDB; EMD-8762; -. DR EMDB; EMD-8763; -. DR SMR; P01635; -. DR MINT; P01635; -. DR CPTAC; non-CPTAC-3653; -. DR MaxQB; P01635; -. DR Ensembl; ENSMUST00000103369.2; ENSMUSP00000100170.2; ENSMUSG00000095007.2. DR AGR; MGI:4439772; -. DR MGI; MGI:4439772; Igkv12-41. DR VEuPathDB; HostDB:ENSMUSG00000095007; -. DR GeneTree; ENSGT00940000153924; -. DR HOGENOM; CLU_077975_4_1_1; -. DR InParanoid; P01635; -. DR OMA; VEDPGIY; -. DR EvolutionaryTrace; P01635; -. DR Proteomes; UP000000589; Chromosome 6. DR RNAct; P01635; Protein. DR Bgee; ENSMUSG00000095007; Expressed in colon and 24 other cell types or tissues. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IBA:GO_Central. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR013106; Ig_V-set. DR PANTHER; PTHR23267:SF520; IG KAPPA CHAIN V-V REGION MOPC 149-RELATED; 1. DR PANTHER; PTHR23267; IMMUNOGLOBULIN LIGHT CHAIN; 1. DR Pfam; PF07686; V-set; 1. DR SMART; SM00409; IG; 1. DR SMART; SM00406; IGv; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW 3D-structure; Adaptive immunity; Disulfide bond; Immunity; Immunoglobulin; KW Reference proteome; Signal. FT SIGNAL 1..20 FT CHAIN 21..>115 FT /note="Immunoglobulin kappa chain variable 12-41" FT /id="PRO_0000015191" FT REGION 21..43 FT /note="Framework-1" FT REGION 44..54 FT /note="Complementarity-determining-1" FT REGION 55..69 FT /note="Framework-2" FT REGION 70..76 FT /note="Complementarity-determining-2" FT REGION 77..108 FT /note="Framework-3" FT REGION 109..>115 FT /note="Complementarity-determining-3" FT DISULFID 43..108 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT NON_TER 115 FT STRAND 24..27 FT /evidence="ECO:0007829|PDB:1A2Y" FT STRAND 29..33 FT /evidence="ECO:0007829|PDB:1A2Y" FT STRAND 39..47 FT /evidence="ECO:0007829|PDB:1A2Y" FT STRAND 53..58 FT /evidence="ECO:0007829|PDB:1A2Y" FT STRAND 65..69 FT /evidence="ECO:0007829|PDB:1A2Y" FT TURN 70..72 FT /evidence="ECO:0007829|PDB:1A2Y" FT STRAND 82..87 FT /evidence="ECO:0007829|PDB:1A2Y" FT STRAND 90..97 FT /evidence="ECO:0007829|PDB:1A2Y" FT HELIX 100..102 FT /evidence="ECO:0007829|PDB:1A2Y" FT STRAND 104..110 FT /evidence="ECO:0007829|PDB:1A2Y" FT STRAND 112..115 FT /evidence="ECO:0007829|PDB:1A2Y" SQ SEQUENCE 115 AA; 12581 MW; 4F41E3D40C539DEC CRC64; MSVLTQVLAL LLLWLTGARC DIQMTQSPAS LSASVGETVT ITCRASGNIH NYLAWYQQKQ GKSPQLLVYN AKTLADGVPS RFSGSGSGTQ YSLKINSLQP EDFGSYYCQH FWSTP //