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Protein

Ig kappa chain V-V region K2

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig kappa chain V-V region K2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – ›115›95Ig kappa chain V-V region K2PRO_0000015191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 108PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP01635.
PaxDbiP01635.
PRIDEiP01635.

Expressioni

Gene expression databases

BgeeiP01635.
GenevestigatoriP01635.

Interactioni

Protein-protein interaction databases

MINTiMINT-1512510.
STRINGi10090.ENSMUSP00000100170.

Structurei

Secondary structure

1
115
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 274Combined sources
Beta strandi29 – 335Combined sources
Beta strandi39 – 479Combined sources
Beta strandi53 – 586Combined sources
Beta strandi65 – 695Combined sources
Turni70 – 723Combined sources
Beta strandi82 – 876Combined sources
Beta strandi90 – 978Combined sources
Helixi100 – 1023Combined sources
Beta strandi104 – 1107Combined sources
Beta strandi112 – 1154Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A2YX-ray1.50A21-115[»]
1A7NX-ray2.01L21-115[»]
1A7OX-ray2.00L21-115[»]
1A7PX-ray2.01L21-115[»]
1A7QX-ray2.00L21-115[»]
1A7RX-ray2.01L21-115[»]
1DVFX-ray1.90A21-115[»]
1KIPX-ray2.10A21-115[»]
1KIQX-ray1.85A21-115[»]
1QBLX-ray2.26L21-115[»]
1QBMX-ray2.37L21-115[»]
1VFAX-ray1.80A21-115[»]
1VFBX-ray1.80A21-115[»]
1WEJX-ray1.80L21-115[»]
ProteinModelPortaliP01635.
SMRiP01635. Positions 21-115.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01635.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 4323Framework-1Add
BLAST
Regioni44 – 5411Complementarity-determining-1Add
BLAST
Regioni55 – 6915Framework-2Add
BLAST
Regioni70 – 767Complementarity-determining-2
Regioni77 – 10832Framework-3Add
BLAST
Regioni109 – ›115›7Complementarity-determining-3

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

eggNOGiNOG72718.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
OMAiPISGARC.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLTQVLAL LLLWLTGARC DIQMTQSPAS LSASVGETVT ITCRASGNIH
60 70 80 90 100
NYLAWYQQKQ GKSPQLLVYN AKTLADGVPS RFSGSGSGTQ YSLKINSLQP
110
EDFGSYYCQH FWSTP
Length:115
Mass (Da):12,581
Last modified:July 21, 1986 - v1
Checksum:i4F41E3D40C539DEC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei115 – 1151

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00778 Genomic DNA. Translation: CAA24155.1.
PIRiA01918. KVMSK2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00778 Genomic DNA. Translation: CAA24155.1.
PIRiA01918. KVMSK2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A2YX-ray1.50A21-115[»]
1A7NX-ray2.01L21-115[»]
1A7OX-ray2.00L21-115[»]
1A7PX-ray2.01L21-115[»]
1A7QX-ray2.00L21-115[»]
1A7RX-ray2.01L21-115[»]
1DVFX-ray1.90A21-115[»]
1KIPX-ray2.10A21-115[»]
1KIQX-ray1.85A21-115[»]
1QBLX-ray2.26L21-115[»]
1QBMX-ray2.37L21-115[»]
1VFAX-ray1.80A21-115[»]
1VFBX-ray1.80A21-115[»]
1WEJX-ray1.80L21-115[»]
ProteinModelPortaliP01635.
SMRiP01635. Positions 21-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1512510.
STRINGi10090.ENSMUSP00000100170.

Protein family/group databases

IMGTiSearch...

Proteomic databases

MaxQBiP01635.
PaxDbiP01635.
PRIDEiP01635.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG72718.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
OMAiPISGARC.

Miscellaneous databases

EvolutionaryTraceiP01635.

Gene expression databases

BgeeiP01635.
GenevestigatoriP01635.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes."
    Nishioka Y., Leder P.
    J. Biol. Chem. 255:3691-3694(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKV5A3_MOUSE
AccessioniPrimary (citable) accession number: P01635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 27, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The gene was isolated and sequenced separately from two different sources, embryos and cultured plasmacytoma cells that secrete the similar kappa chain MOPC 149.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.