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Protein

Ig kappa chain V-II region 26-10

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monoclonal antibody

Names & Taxonomyi

Protein namesi
Recommended name:
Ig kappa chain V-II region 26-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›113›113Ig kappa chain V-II region 26-10PRO_0000059776Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 93PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP01631.
MaxQBiP01631.
PeptideAtlasiP01631.
PRIDEiP01631.

Interactioni

Protein-protein interaction databases

IntActiP01631. 1 interaction.
MINTiMINT-1505910.

Structurei

Secondary structure

1
113
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 74Combined sources
Beta strandi9 – 135Combined sources
Beta strandi19 – 279Combined sources
Beta strandi31 – 344Combined sources
Beta strandi38 – 436Combined sources
Beta strandi50 – 545Combined sources
Turni55 – 573Combined sources
Beta strandi67 – 726Combined sources
Beta strandi75 – 806Combined sources
Helixi85 – 873Combined sources
Beta strandi89 – 957Combined sources
Beta strandi97 – 1004Combined sources
Beta strandi107 – 1115Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BFVX-ray2.10L5-113[»]
1CFVX-ray2.10L5-113[»]
1DLFX-ray1.45L1-113[»]
1MAJNMR-A1-113[»]
1MAKNMR-A1-113[»]
1N4XX-ray1.70L/M4-110[»]
1SVZX-ray1.89A/B1-112[»]
1WZ1X-ray1.85L1-113[»]
2BFVX-ray2.50L5-113[»]
2DLFX-ray1.55L1-113[»]
2HKFX-ray2.01L1-113[»]
2HKHX-ray2.10L1-113[»]
2IPTX-ray2.00L1-113[»]
2IQAX-ray2.00A/L1-113[»]
2O5XX-ray2.05L1-113[»]
2O5YX-ray2.85L1-113[»]
2O5ZX-ray2.40L1-113[»]
2R0WX-ray2.50L1-113[»]
2VQ1X-ray2.50A/E1-113[»]
ProteinModelPortaliP01631.
SMRiP01631. Positions 1-113.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01631.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2323Framework-1Add
BLAST
Regioni24 – 3916Complementarity-determining-1Add
BLAST
Regioni40 – 5415Framework-2Add
BLAST
Regioni55 – 617Complementarity-determining-2
Regioni62 – 9332Framework-3Add
BLAST
Regioni94 – 1029Complementarity-determining-3
Regioni103 – 11210Framework-4

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region

Phylogenomic databases

HOVERGENiHBG018013.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DVVMTQTPLS LPVSLGDQAS ISCRSSQSLV HSNGNTYLNW YLQKAGQSPK
60 70 80 90 100
LLIYKVSNRF SGVPDRFSGS GSGTDFTLKI SRVEAEDLGI YFCSQTTHVP
110
PTFGGGTKLE IKR
Length:113
Mass (Da):12,273
Last modified:July 21, 1986 - v1
Checksum:iF9F39CE949A84C2A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei113 – 1131

Sequence databases

PIRiA01914. KVMS26.
A32248.
B32248.
C32248.
F32530.
H31485.
PH1030.
PH1031.
S53750.
UniGeneiMm.333124.
Mm.489779.

Cross-referencesi

Sequence databases

PIRiA01914. KVMS26.
A32248.
B32248.
C32248.
F32530.
H31485.
PH1030.
PH1031.
S53750.
UniGeneiMm.333124.
Mm.489779.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BFVX-ray2.10L5-113[»]
1CFVX-ray2.10L5-113[»]
1DLFX-ray1.45L1-113[»]
1MAJNMR-A1-113[»]
1MAKNMR-A1-113[»]
1N4XX-ray1.70L/M4-110[»]
1SVZX-ray1.89A/B1-112[»]
1WZ1X-ray1.85L1-113[»]
2BFVX-ray2.50L5-113[»]
2DLFX-ray1.55L1-113[»]
2HKFX-ray2.01L1-113[»]
2HKHX-ray2.10L1-113[»]
2IPTX-ray2.00L1-113[»]
2IQAX-ray2.00A/L1-113[»]
2O5XX-ray2.05L1-113[»]
2O5YX-ray2.85L1-113[»]
2O5ZX-ray2.40L1-113[»]
2R0WX-ray2.50L1-113[»]
2VQ1X-ray2.50A/E1-113[»]
ProteinModelPortaliP01631.
SMRiP01631. Positions 1-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01631. 1 interaction.
MINTiMINT-1505910.

Proteomic databases

EPDiP01631.
MaxQBiP01631.
PeptideAtlasiP01631.
PRIDEiP01631.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG018013.

Miscellaneous databases

EvolutionaryTraceiP01631.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKV2A7_MOUSE
AccessioniPrimary (citable) accession number: P01631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This chain was isolated from an IgG2a hybridoma protein that binds digoxin.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Hybridoma, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.