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Protein

Ig kappa chain V-II region 26-10

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This chain was isolated from an IgG2a hybridoma protein that binds digoxin.

GO - Molecular functioni

Keywordsi

Molecular functionMonoclonal antibody

Names & Taxonomyi

Protein namesi
Recommended name:
Ig kappa chain V-II region 26-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000597761 – ›113Ig kappa chain V-II region 26-10Add BLAST›113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 93PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP01631
MaxQBiP01631
PeptideAtlasiP01631
PRIDEiP01631

Interactioni

Protein-protein interaction databases

IntActiP01631, 1 interactor
MINTiP01631

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Beta strandi9 – 13Combined sources5
Beta strandi19 – 27Combined sources9
Beta strandi31 – 34Combined sources4
Beta strandi38 – 43Combined sources6
Beta strandi50 – 54Combined sources5
Turni55 – 57Combined sources3
Beta strandi67 – 72Combined sources6
Beta strandi75 – 80Combined sources6
Helixi85 – 87Combined sources3
Beta strandi89 – 95Combined sources7
Beta strandi97 – 100Combined sources4
Beta strandi107 – 111Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BFVX-ray2.10L5-113[»]
1CFVX-ray2.10L5-113[»]
1DLFX-ray1.45L1-113[»]
1MAJNMR-A1-113[»]
1MAKNMR-A1-113[»]
1N4XX-ray1.70L/M4-110[»]
1SVZX-ray1.89A/B1-112[»]
1WZ1X-ray1.85L1-113[»]
2BFVX-ray2.50L5-113[»]
2DLFX-ray1.55L1-113[»]
2HKFX-ray2.01L1-113[»]
2HKHX-ray2.10L1-113[»]
2IPTX-ray2.00L1-113[»]
2IQAX-ray2.00A/L1-113[»]
2O5XX-ray2.05L1-113[»]
2O5YX-ray2.85L1-113[»]
2O5ZX-ray2.40L1-113[»]
2R0WX-ray2.50L1-113[»]
2VQ1X-ray2.50A/E1-113[»]
ProteinModelPortaliP01631
SMRiP01631
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01631

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 23Framework-1Add BLAST23
Regioni24 – 39Complementarity-determining-1Add BLAST16
Regioni40 – 54Framework-2Add BLAST15
Regioni55 – 61Complementarity-determining-27
Regioni62 – 93Framework-3Add BLAST32
Regioni94 – 102Complementarity-determining-39
Regioni103 – 112Framework-410

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region

Phylogenomic databases

HOVERGENiHBG018013

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P01631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DVVMTQTPLS LPVSLGDQAS ISCRSSQSLV HSNGNTYLNW YLQKAGQSPK
60 70 80 90 100
LLIYKVSNRF SGVPDRFSGS GSGTDFTLKI SRVEAEDLGI YFCSQTTHVP
110
PTFGGGTKLE IKR
Length:113
Mass (Da):12,273
Last modified:July 21, 1986 - v1
Checksum:iF9F39CE949A84C2A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1131

Sequence databases

PIRiA01914 KVMS26
A32248
B32248
C32248
F32530
H31485
PH1030
PH1031
S53750
UniGeneiMm.333124
Mm.489779

Similar proteinsi

Entry informationi

Entry nameiKV2A7_MOUSE
AccessioniPrimary (citable) accession number: P01631
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Hybridoma, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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