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Reviewed, UniProtKB/Swiss-Prot P01631 (KV2A7_MOUSE)

Last modified October 13, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ig kappa chain V-II region 26-10
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length113 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Miscellaneous

This chain was isolated from an IgG2a hybridoma protein that binds digoxin.

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Ontologies

Keywords
   DomainImmunoglobulin V region
Immunoglobulin domain
   Molecular functionMonoclonal antibody
   PTMDisulfide bond
   Technical term3D-structure
Direct protein sequencing
Hybridoma
Gene Ontology (GO)
   Molecular functionantigen binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›113›113Ig kappa chain V-II region 26-10
PRO_0000059776

Regions

Region1 – 2323Framework-1
Region24 – 3916Complementarity-determining-1
Region40 – 5415Framework-2
Region55 – 617Complementarity-determining-2
Region62 – 9332Framework-3
Region94 – 1029Complementarity-determining-3
Region103 – 11210Framework-4

Amino acid modifications

Disulfide bond23 ↔ 93 By similarity

Experimental info

Non-terminal residue1131

Secondary structure

1 ........................ 113
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P01631-1 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: F9F39CE949A84C2A

FASTA11312,273
        10         20         30         40         50         60 
DVVMTQTPLS LPVSLGDQAS ISCRSSQSLV HSNGNTYLNW YLQKAGQSPK LLIYKVSNRF 

        70         80         90        100        110 
SGVPDRFSGS GSGTDFTLKI SRVEAEDLGI YFCSQTTHVP PTFGGGTKLE IKR

« Hide

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References

[1]"Amino acid sequence of the light chain variable region from a mouse anti-digoxin hybridoma antibody."
Novotny J., Margolies M.N.
Biochemistry 22:1153-1158(1983) [PubMed: 6404298] [Abstract]
Cited for: PROTEIN SEQUENCE.
Strain: A/J.
+Additional computationally mapped references.

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Cross-references

Sequence databases

IPIIPI00464378.
PIRKVMS26. A01914.
A32248.
B32248.
C32248.
F32530.
H31485.
PH1030.
PH1031.
S53750.
UniGeneMm.304143
Mm.333124
Mm.389773

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BFVX-ray2.10L5-113[»]
1CFVX-ray2.10L5-113[»]
1MAJNMR-A1-113[»]
1MAKNMR-A1-113[»]
1SVZX-ray1.89A/B4-112[»]
2BFVX-ray2.50L5-113[»]
2DLFX-ray1.55L1-113[»]
2HKFX-ray2.01L1-113[»]
2HKHX-ray2.10L1-113[»]
2IPTX-ray2.00L1-113[»]
2IQAX-ray2.00A/L1-113[»]
2O5XX-ray2.05L1-113[»]
2O5YX-ray2.85L1-113[»]
2O5ZX-ray2.40L1-113[»]
2R0WX-ray2.50L1-113[»]
2VQ1X-ray2.50A/E1-113[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGP01631.

Proteomic databases

PRIDEP01631.

Phylogenomic databases

HOVERGENP01631.

Gene expression databases

GenevestigatorP01631.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_sub.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00693. Fluorescein.

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Entry information

Entry nameKV2A7_MOUSE
AccessionPrimary (citable) accession number: P01631
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 13, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents