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P01622

- KV304_HUMAN

UniProt

P01622 - KV304_HUMAN

Protein

Ig kappa chain V-III region Ti

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB

    GO - Biological processi

    1. complement activation Source: Reactome
    2. complement activation, classical pathway Source: Reactome
    3. Fc-epsilon receptor signaling pathway Source: Reactome
    4. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
    5. immune response Source: UniProtKB
    6. innate immune response Source: Reactome
    7. regulation of immune response Source: Reactome

    Keywords - Molecular functioni

    Bence-Jones protein

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_160163. Scavenging of heme from plasma.
    REACT_160274. FCGR activation.
    REACT_163701. FCERI mediated MAPK activation.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_163936. Fc epsilon receptor (FCERI) signaling.
    REACT_163994. FCERI mediated NF-kB activation.
    REACT_7956. Classical antibody-mediated complement activation.
    REACT_8024. Initial triggering of complement.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ig kappa chain V-III region Ti
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. plasma membrane Source: Reactome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›109›109Ig kappa chain V-III region TiPRO_0000059764Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi23 ↔ 89PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP01622.

    Expressioni

    Gene expression databases

    GenevestigatoriP01622.

    Structurei

    3D structure databases

    ProteinModelPortaliP01622.
    SMRiP01622. Positions 1-109.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Immunoglobulin domain, Immunoglobulin V region

    Phylogenomic databases

    HOVERGENiHBG018013.
    PhylomeDBiP01622.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P01622-1 [UniParc]FASTAAdd to Basket

    « Hide

    EIVLTQSPGT LSLSPGERAT LSCRASQSVS NSFLAWYQQK PGQAPRLLIY    50
    VASSRATGIP DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYGSSPSTFG 100
    QGTKVELKR 109
    Length:109
    Mass (Da):11,788
    Last modified:July 21, 1986 - v1
    Checksum:i8C35058CDC7749BC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei109 – 1091

    Sequence databases

    PIRiA01895. K3HUTI.

    Polymorphism databases

    DMDMi125801.

    Cross-referencesi

    Sequence databases

    PIRi A01895. K3HUTI.

    3D structure databases

    ProteinModelPortali P01622.
    SMRi P01622. Positions 1-109.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 125801.

    Proteomic databases

    PRIDEi P01622.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG018013.
    PhylomeDBi P01622.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_160163. Scavenging of heme from plasma.
    REACT_160274. FCGR activation.
    REACT_163701. FCERI mediated MAPK activation.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_163936. Fc epsilon receptor (FCERI) signaling.
    REACT_163994. FCERI mediated NF-kB activation.
    REACT_7956. Classical antibody-mediated complement activation.
    REACT_8024. Initial triggering of complement.

    Gene expression databases

    Genevestigatori P01622.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The complete amino acid sequence and its significance for the mechanism of antibody production."
      Suter L., Barnikol H.U., Watanabe S., Hilschmann N.
      Hoppe-Seyler's Z. Physiol. Chem. 353:189-208(1972) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiKV304_HUMAN
    AccessioniPrimary (citable) accession number: P01622
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The C region of this chain has the INV (3) marker.
    This is a Bence-Jones protein.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    External Data

    Dasty 3