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P01621

- KV303_HUMAN

UniProt

P01621 - KV303_HUMAN

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Protein
Ig kappa chain V-III region NG9
Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB

GO - Biological processi

  1. Fc-epsilon receptor signaling pathway Source: Reactome
  2. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  3. complement activation Source: Reactome
  4. complement activation, classical pathway Source: Reactome
  5. immune response Source: UniProtKB
  6. innate immune response Source: Reactome
  7. regulation of immune response Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_160163. Scavenging of heme from plasma.
REACT_160274. FCGR activation.
REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_7956. Classical antibody-mediated complement activation.
REACT_8024. Initial triggering of complement.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig kappa chain V-III region NG9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: UniProt
  2. extracellular region Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. plasma membrane Source: Reactome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 4›4
Chaini5 – 10096Ig kappa chain V-III region NG9
PRO_0000015174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 93 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01621.
PeptideAtlasiP01621.
PRIDEiP01621.

Expressioni

Gene expression databases

GenevestigatoriP01621.

Structurei

3D structure databases

ProteinModelPortaliP01621.
SMRiP01621. Positions 5-99.

Family & Domainsi

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

eggNOGiNOG315653.
HOVERGENiHBG018013.
InParanoidiP01621.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01621-1 [UniParc]FASTAAdd to Basket

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VPSGEIVLTQ SPGTLSLSPG ERATLSCRAS QSVSSSYLAW YQQKPGQAPR    50
LLIYGATSRA TGIPDRFSGS ASGTDFTLTI SRLEPEDFAV YYCQQYGNSQ 100
Length:100
Mass (Da):10,729
Last modified:July 21, 1986 - v1
Checksum:i5D9AF363CC52632F
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei100 – 1001

Sequence databases

PIRiA01894. K3HUNG.

Polymorphism databases

DMDMi125799.

Cross-referencesi

Sequence databases

PIRi A01894. K3HUNG.

3D structure databases

ProteinModelPortali P01621.
SMRi P01621. Positions 5-99.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 125799.

Proteomic databases

PaxDbi P01621.
PeptideAtlasi P01621.
PRIDEi P01621.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG315653.
HOVERGENi HBG018013.
InParanoidi P01621.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_160163. Scavenging of heme from plasma.
REACT_160274. FCGR activation.
REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_7956. Classical antibody-mediated complement activation.
REACT_8024. Initial triggering of complement.

Miscellaneous databases

NextBioi 35537660.

Gene expression databases

Genevestigatori P01621.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Most kappa immunoglobulin mRNA in human lymphocytes is homologous to a small family of germ-line V genes."
    Bentley D.L.
    Nature 307:77-80(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKV303_HUMAN
AccessioniPrimary (citable) accession number: P01621
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene was isolated from the NG9/9.1 hybridoma.

Keywords - Technical termi

Complete proteome, Hybridoma, Reference proteome

External Data

Dasty 3

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