P01621 (KV303_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig kappa chain V-III region NG9
Organism	Homo sapiens (Human) [Reference proteome]
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	100 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous

This gene was isolated from the NG9/9.1 hybridoma.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain Signal
PTM	Disulfide bond
Technical term	Complete proteome Hybridoma Reference proteome
Gene Ontology (GO)
Biological_process	complement activation, classical pathway Traceable author statement. Source: Reactome innate immune response Traceable author statement. Source: Reactome
Cellular_component	extracellular region Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	antigen binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	‹1 – 4	›4
	Chain	5 – 100	96	Ig kappa chain V-III region NG9		PRO_0000015174
Amino acid modifications
	Disulfide bond	27 ↔ 93		By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	100	1

Sequences

	Sequence		Length	Mass (Da)
	P01621 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 5D9AF363CC52632F	FASTA	100	10,729
	10 20 30 40 50 60 VPSGEIVLTQ SPGTLSLSPG ERATLSCRAS QSVSSSYLAW YQQKPGQAPR LLIYGATSRA 70 80 90 100 TGIPDRFSGS ASGTDFTLTI SRLEPEDFAV YYCQQYGNSQ

References

[1]	"Most kappa immunoglobulin mRNA in human lymphocytes is homologous to a small family of germ-line V genes." Bentley D.L. Nature 307:77-80(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
IPI	IPI00387116.
PIR	K3HUNG. A01894.
3D structure databases
ProteinModelPortal	P01621.
SMR	P01621. Positions 5-99.
ModBase	Search...
Polymorphism databases
DMDM	125799.
Proteomic databases
PaxDb	P01621.
PeptideAtlas	P01621.
PRIDE	P01621.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG315653.
HOVERGEN	HBG018013.
InParanoid	P01621.
OrthoDB	EOG444KMZ.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Genevestigator	P01621.
GermOnline	ENSG00000169769. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_subgr. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35537660.

Entry information

Entry name

KV303_HUMAN

Accession

Primary (citable) accession number: P01621

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.