Reviewed, UniProtKB/Swiss-Prot P01616 (KV203_HUMAN)

Names and origin

Protein names	Recommended name:     Ig kappa chain V-II region MIL
Organism	Homo sapiens (Human)
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	112 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Miscellaneous

The C region of this chain has the INV (3) marker. This is a Bence-Jones protein.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain
Molecular function	Bence-Jones protein
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NME2	P22392	1	EBI-1053880,EBI-713693

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›112	›112	Ig kappa chain V-II region MIL		PRO_0000059760
Regions
	Region	1 – 23	23	Framework-1
	Region	24 – 38	15	Complementarity-determining-1
	Region	39 – 53	15	Framework-2
	Region	54 – 60	7	Complementarity-determining-2
	Region	61 – 92	32	Framework-3
	Region	93 – 101	9	Complementarity-determining-3
	Region	102 – 111	10	Framework-4
Amino acid modifications
	Disulfide bond	23 ↔ 92		By similarity
Experimental info
	Non-terminal residue	112	1

Sequences

	Sequence		Length	Mass (Da)
	P01616-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: E5B22E2FA7ABE481	FASTA	112	12,057
	10 20 30 40 50 60 DIVLTQSPLS LPVTPGEPAS ISCRSSQNLL ZSBGBYLDWY LZKPGZSPZL LIYLGSNRAS 70 80 90 100 110 GVPNRFSGSG SGTBFTLKIS RVZAZBVGVY YCMQALQTPL TFGGGTNVEI KR

References

[1]	"The genetic, molecular, and cellular basis of antibody formation: some facts and a unifying hypothesis." Dreyer W.J., Gray W.R., Hood L.E. Cold Spring Harb. Symp. Quant. Biol. 32:353-367(1967) Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
IPI	IPI00387110.
PIR	K2HUML. A01887.
3D structure databases
HSSP	HSSP built from PDB template 1I9I based on UniProtKB Q99M37.
SMR	P01616. Positions 1-110.
ModBase	Search...
Protein-protein interaction databases
IntAct	P01616. 3 interactions.
Proteomic databases
PeptideAtlas	P01616.
PRIDE	P01616.
Phylogenomic databases
HOVERGEN	P01616.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_sub. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KV203_HUMAN

Accession

Primary (citable) accession number: P01616

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	March 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)