P01616 (KV203_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig kappa chain V-II region MIL
Organism	Homo sapiens (Human)
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	112 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous

The C region of this chain has the INV (3) marker. This is a Bence-Jones protein.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain
Molecular function	Bence-Jones protein
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	complement activation, classical pathway Traceable author statement. Source: Reactome innate immune response Traceable author statement. Source: Reactome
Cellular component	extracellular region Traceable author statement. Source: Reactome
Molecular function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NME2	P22392	1	EBI-1053880,EBI-713693

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›112	›112	Ig kappa chain V-II region MIL		PRO_0000059760
Regions
	Region	1 – 23	23	Framework-1
	Region	24 – 38	15	Complementarity-determining-1
	Region	39 – 53	15	Framework-2
	Region	54 – 60	7	Complementarity-determining-2
	Region	61 – 92	32	Framework-3
	Region	93 – 101	9	Complementarity-determining-3
	Region	102 – 111	10	Framework-4
Amino acid modifications
	Disulfide bond	23 ↔ 92		By similarity
Experimental info
	Non-terminal residue	112	1

Sequences

	Sequence		Length	Mass (Da)
	P01616 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: E5B22E2FA7ABE481	FASTA	112	12,057
	10 20 30 40 50 60 DIVLTQSPLS LPVTPGEPAS ISCRSSQNLL ZSBGBYLDWY LZKPGZSPZL LIYLGSNRAS 70 80 90 100 110 GVPNRFSGSG SGTBFTLKIS RVZAZBVGVY YCMQALQTPL TFGGGTNVEI KR

References

[1]	"The genetic, molecular, and cellular basis of antibody formation: some facts and a unifying hypothesis." Dreyer W.J., Gray W.R., Hood L.E. Cold Spring Harb. Symp. Quant. Biol. 32:353-367(1967) Cited for: PROTEIN SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
IPI	IPI00387110.
PIR	K2HUML. A01887.
3D structure databases
ProteinModelPortal	P01616.
ModBase	Search...
Polymorphism databases
DMDM	125786.
Proteomic databases
PeptideAtlas	P01616.
PRIDE	P01616.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG018013.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Genevestigator	P01616.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_subgr. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KV203_HUMAN

Accession

Primary (citable) accession number: P01616

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.