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P01608

- KV116_HUMAN

UniProt

P01608 - KV116_HUMAN

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Protein
Ig kappa chain V-I region Roy
Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB

GO - Biological processi

  1. Fc-epsilon receptor signaling pathway Source: Reactome
  2. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  3. complement activation Source: Reactome
  4. complement activation, classical pathway Source: Reactome
  5. immune response Source: UniProtKB
  6. innate immune response Source: Reactome
  7. regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Bence-Jones protein

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_160163. Scavenging of heme from plasma.
REACT_160274. FCGR activation.
REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_7956. Classical antibody-mediated complement activation.
REACT_8024. Initial triggering of complement.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig kappa chain V-I region Roy
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: UniProt
  2. extracellular region Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›108›108Ig kappa chain V-I region Roy
PRO_0000059750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 88 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP01608.

Expressioni

Gene expression databases

GenevestigatoriP01608.

Structurei

3D structure databases

ProteinModelPortaliP01608.
SMRiP01608. Positions 1-107.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2323Framework-1
Add
BLAST
Regioni24 – 3411Complementarity-determining-1
Add
BLAST
Regioni35 – 4915Framework-2
Add
BLAST
Regioni50 – 567Complementarity-determining-2
Regioni57 – 8832Framework-3
Add
BLAST
Regioni89 – 979Complementarity-determining-3
Regioni98 – 10710Framework-4

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region

Phylogenomic databases

HOVERGENiHBG018013.
PhylomeDBiP01608.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01608-1 [UniParc]FASTAAdd to Basket

« Hide

DIQMTQSPSS LSASVGDRVT ITCQASQDIS IFLNWYQQKP GKAPKLLIYD    50
ASKLEAGVPS RFSGTGSGTD FTFTISSLQP EDIATYYCQQ FDNLPLTFGG 100
GTKVDFKR 108
Length:108
Mass (Da):11,782
Last modified:July 21, 1986 - v1
Checksum:iF5ACEDE5A313DF3A
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei108 – 1081

Sequence databases

PIRiA91638. K1HURY.

Polymorphism databases

DMDMi125772.

Cross-referencesi

Sequence databases

PIRi A91638. K1HURY.

3D structure databases

ProteinModelPortali P01608.
SMRi P01608. Positions 1-107.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I43.001.

Polymorphism databases

DMDMi 125772.

Proteomic databases

PRIDEi P01608.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG018013.
PhylomeDBi P01608.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_160163. Scavenging of heme from plasma.
REACT_160274. FCGR activation.
REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_7956. Classical antibody-mediated complement activation.
REACT_8024. Initial triggering of complement.

Miscellaneous databases

NextBioi 35537650.

Gene expression databases

Genevestigatori P01608.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Chemical structure of 2 kappa-type Bence Jones proteins (Roy and Cum.)."
    Hilschmann N.
    Hoppe-Seyler's Z. Physiol. Chem. 348:1077-1080(1967) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
  2. Hilschmann N., Barnikol H.U., Hess M., Langer B., Ponstingl H., Steinmetz-Kayne M., Suter L., Watanabe S.
    (In) Franek F., Shugar D. (eds.); Gamma globulins: structure and function, pp.57-74, Academic Press, New York (1969)
    Cited for: SEQUENCE REVISION TO 39 AND 41.

Entry informationi

Entry nameiKV116_HUMAN
AccessioniPrimary (citable) accession number: P01608
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The C region of this chain has the INV (1,2) marker.
This is a Bence-Jones protein.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

External Data

Dasty 3

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