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P01608 (KV116_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ig kappa chain V-I region Roy
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length108 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Miscellaneous

The C region of this chain has the INV (1,2) marker.

This is a Bence-Jones protein.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›108›108Ig kappa chain V-I region Roy
PRO_0000059750

Regions

Region1 – 2323Framework-1
Region24 – 3411Complementarity-determining-1
Region35 – 4915Framework-2
Region50 – 567Complementarity-determining-2
Region57 – 8832Framework-3
Region89 – 979Complementarity-determining-3
Region98 – 10710Framework-4

Amino acid modifications

Disulfide bond23 ↔ 88 By similarity

Experimental info

Non-terminal residue1081

Sequences

Sequence LengthMass (Da)Tools
P01608 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: F5ACEDE5A313DF3A

FASTA10811,782
        10         20         30         40         50         60 
DIQMTQSPSS LSASVGDRVT ITCQASQDIS IFLNWYQQKP GKAPKLLIYD ASKLEAGVPS 

        70         80         90        100 
RFSGTGSGTD FTFTISSLQP EDIATYYCQQ FDNLPLTFGG GTKVDFKR 

« Hide

References

[1]"Chemical structure of 2 kappa-type Bence Jones proteins (Roy and Cum.)."
Hilschmann N.
Hoppe-Seyler's Z. Physiol. Chem. 348:1077-1080(1967) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
[2]Hilschmann N., Barnikol H.U., Hess M., Langer B., Ponstingl H., Steinmetz-Kayne M., Suter L., Watanabe S.
(In) Franek F., Shugar D. (eds.); Gamma globulins: structure and function, pp.57-74, Academic Press, New York (1969)
Cited for: SEQUENCE REVISION TO 39 AND 41.

Cross-references

Sequence databases

PIRK1HURY. A91638.

3D structure databases

ProteinModelPortalP01608.
SMRP01608. Positions 1-107.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI43.001.

Polymorphism databases

DMDM125772.

Proteomic databases

PRIDEP01608.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG018013.
PhylomeDBP01608.

Enzyme and pathway databases

ReactomeREACT_160300. Binding and Uptake of Ligands by Scavenger Receptors.
REACT_6900. Immune System.

Gene expression databases

GenevestigatorP01608.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35537650.

Entry information

Entry nameKV116_HUMAN
AccessionPrimary (citable) accession number: P01608
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.