Reviewed, UniProtKB/Swiss-Prot P01607 (KV115_HUMAN)

Names and origin

Protein names	Recommended name:     Ig kappa chain V-I region Rei
Organism	Homo sapiens (Human) [Complete proteome]
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Miscellaneous

The C region of this chain has the INV (1,2) marker. This is a Bence-Jones protein.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain
Molecular function	Bence-Jones protein
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	immune response Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	extracellular region Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	antigen binding Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – ›108

›108

Ig kappa chain V-I region Rei

PRO_0000059749

Regions

Region

1 – 23

23

Framework-1

Region

24 – 34

11

Complementarity-determining-1

Region

35 – 49

15

Framework-2

Region

50 – 56

7

Complementarity-determining-2

Region

57 – 88

32

Framework-3

Region

89 – 97

9

Complementarity-determining-3

Region

98 – 107

10

Framework-4

Amino acid modifications

Disulfide bond

23 ↔ 88

Ref.2

Experimental info

Non-terminal residue

108

1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

108

Helix Strand Turn

Details...

Beta strand

4 – 7

4

Beta strand

9 – 13

5

Beta strand

19 – 27

9

Beta strand

33 – 38

6

Beta strand

45 – 49

5

Turn

50 – 52

3

Beta strand

62 – 67

6

Beta strand

70 – 77

8

Helix

80 – 82

3

Beta strand

84 – 90

7

Beta strand

92 – 95

4

Beta strand

102 – 106

5

Sequences

	Sequence		Length	Mass (Da)
	P01607-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 9E8143E1188BCE2A	FASTA	108	11,902
	10 20 30 40 50 60 DIQMTQSPSS LSASVGDRVT ITCQASQDII KYLNWYQQTP GKAPKLLIYE ASNLQAGVPS 70 80 90 100 RFSGSGSGTD YTFTISSLQP EDIATYYCQQ YQSLPYTFGQ GTKLQITR

References

[1]	"The primary structure of a crystalline monoclonal immunoglobulin kappa-type L-chain, subgroup I (Bence-Jones protein Rei); isolation and characterization of the tryptic peptides; the complete amino acid sequence of the protein; a contribution to the elucidation of the three-dimensional structure of antibodies, in particular their combining site." Palm W., Hilschmann N. Hoppe-Seyler's Z. Physiol. Chem. 356:167-191(1975) [PubMed: 809329] [Abstract] Cited for: PROTEIN SEQUENCE.
[2]	"The molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0-A resolution." Epp O., Lattman E.E., Schiffer M., Huber R., Palm W. Biochemistry 14:4943-4952(1975) [PubMed: 1182131] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

IPI

IPI00387099.

PIR

K1HURE. A91663.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1AR2	X-ray	2.80	A	1-107	[»]
1BWW	X-ray	1.70	A/B	1-107	[»]
1REI	X-ray	2.00	A/B	1-107	[»]

ModBase

Search...

Proteomic databases

PRIDE

P01607.

Phylogenomic databases

HOVERGEN

P01607.

Gene expression databases

Genevestigator

P01607.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_sub.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

Pfam

PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00406. IGv. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

KV115_HUMAN

Accession

Primary (citable) accession number: P01607

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	October 13, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.