P01606 (KV114_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig kappa chain V-I region OU
Organism	Homo sapiens (Human) [Reference proteome]
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous

The C region of this chain has the INV (3) marker. This chain was isolated from a Waldenstrom's macroglobulin.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	Fc-gamma receptor signaling pathway involved in phagocytosis Traceable author statement. Source: Reactome complement activation, classical pathway Traceable author statement. Source: Reactome innate immune response Traceable author statement. Source: Reactome
Cellular_component	extracellular region Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	antigen binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›108	›108	Ig kappa chain V-I region OU		PRO_0000059748
Regions
	Region	1 – 23	23	Framework-1
	Region	24 – 34	11	Complementarity-determining-1
	Region	35 – 49	15	Framework-2
	Region	50 – 56	7	Complementarity-determining-2
	Region	57 – 88	32	Framework-3
	Region	89 – 97	9	Complementarity-determining-3
	Region	98 – 107	10	Framework-4
Amino acid modifications
	Disulfide bond	23 ↔ 88		By similarity
Experimental info
	Non-terminal residue	108	1

Sequences

	Sequence		Length	Mass (Da)
	P01606 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 8283D4A24105827E	FASTA	108	11,779
	10 20 30 40 50 60 DIQMTZSPSS LSASVGBRVT ITCRASZTIS SYLBWYZZKP GKAPBLLIYA ASBLHSGVPS 70 80 90 100 RFSGSGSGTB FTFTISSLZP ZBFATYYCZZ SYSSPTTFGZ GTRLZIKR

References

[1]	"Macroglobulin structure: variable sequence of light and heavy chains." Kohler H., Shimizu A., Paul C., Putnam F.W. Science 169:56-59(1970) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
IPI	IPI00387098.
PIR	K1HUOU. A01872.
3D structure databases
ProteinModelPortal	P01606.
ModBase	Search...
Polymorphism databases
DMDM	125770.
Proteomic databases
PeptideAtlas	P01606.
PRIDE	P01606.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG018013.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Genevestigator	P01606.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_subgr. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35537648.

Entry information

Entry name

KV114_HUMAN

Accession

Primary (citable) accession number: P01606

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 29, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.