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Protein

Immunoglobulin kappa variable 1-5

Gene

IGKV1-5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).4 Publications

GO - Molecular functioni

  • antigen binding Source: UniProtKB
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-2168880. Scavenging of heme from plasma.
R-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-5690714. CD22 mediated BCR regulation.
R-HSA-977606. Regulation of Complement cascade.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Protein family/group databases

IMGT/GENE-DBIGKV1-5.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin kappa variable 1-52 Publications
Alternative name(s):
Ig kappa chain V-I region CAR1 Publication
Ig kappa chain V-I region EU1 Publication
Ig kappa chain V-I region HK1021 Publication
Ig kappa chain V-I region Kue1 Publication
Gene namesi
Name:IGKV1-52 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5741. IGKV1-5.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • plasma membrane Source: Reactome

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi28299.
OpenTargetsiENSG00000243466.

Polymorphism and mutation databases

DMDMi125760.
125762.
125766.
125768.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 223 PublicationsAdd BLAST22
ChainiPRO_000001516923 – 117Immunoglobulin kappa variable 1-53 PublicationsAdd BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 110PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PeptideAtlasiP01602.
PRIDEiP01602.

PTM databases

iPTMnetiP01598.

Expressioni

Gene expression databases

BgeeiENSG00000243466.

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Protein-protein interaction databases

IntActiP01602. 4 interactors.

Structurei

3D structure databases

ProteinModelPortaliP01602.
SMRiP01602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – ›117Ig-likePROSITE-ProRule annotationAdd BLAST›94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 45Framework-11 PublicationAdd BLAST23
Regioni46 – 56Complementarity-determining-11 PublicationAdd BLAST11
Regioni57 – 71Framework-21 PublicationAdd BLAST15
Regioni72 – 78Complementarity-determining-21 Publication7
Regioni79 – 110Framework-31 PublicationAdd BLAST32
Regioni111 – ›117Complementarity-determining-31 Publication›7

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

GeneTreeiENSGT00780000121852.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
InParanoidiP01602.
OMAiIYWASTL.
PhylomeDBiP01602.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMRVPAQLL GLLLLWLPGA KCDIQMTQSP STLSASVGDR VTITCRASQS
60 70 80 90 100
ISSWLAWYQQ KPGKAPKLLI YKASSLESGV PSRFSGSGSG TEFTLTISSL
110
QPDDFATYYC QQYNSYS
Length:117
Mass (Da):12,782
Last modified:June 24, 2015 - v2
Checksum:i1BCDF3A40AFD9868
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33 – 34LS → QP AA sequence (PubMed:112021).Curated2
Sequence conflicti42T → A AA sequence (PubMed:4216454).Curated1
Sequence conflicti50S → N AA sequence (PubMed:4216454).Curated1
Sequence conflicti52 – 53SS → NI AA sequence (PubMed:112021).Curated2
Sequence conflicti52 – 53SS → NT AA sequence (PubMed:5489770).Curated2
Sequence conflicti63G → E AA sequence (PubMed:112021).Curated1
Sequence conflicti68L → V AA sequence (PubMed:4216454).Curated1
Sequence conflicti70I → M AA sequence (PubMed:5489770).Curated1
Sequence conflicti73A → S AA sequence (PubMed:4216454).Curated1
Sequence conflicti75 – 78SLES → TLET AA sequence (PubMed:112021).Curated4
Sequence conflicti85S → I AA sequence (PubMed:5489770).Curated1
Sequence conflicti92E → D AA sequence (PubMed:4216454).Curated1
Sequence conflicti98S → N AA sequence (PubMed:112021).Curated1
Sequence conflicti114 – 117NSYS → SRYP AA sequence (PubMed:112021).Curated4
Sequence conflicti115 – 117SYS → TFF AA sequence (PubMed:4216454).Curated3
Sequence conflicti116Y → D AA sequence (PubMed:5489770).Curated1
Non-terminal residuei1171

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGKV1-5*03.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07334972K → D in IMGT allele IGKV1-5*01; requires 2 nucleotide substitutions. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00245 Genomic DNA. Translation: AAA59087.1.
Z00001 Genomic DNA. Translation: CAA77292.1.
AC243970 Genomic DNA. No translation available.
PIRiA01864. K1HUAR.
A01870. K1HUKU.
A01882. K1HU12.
A90562. K1HUEU.
UniGeneiHs.449609.

Genome annotation databases

EnsembliENST00000496168; ENSP00000420436; ENSG00000243466.
ENST00000632205; ENSP00000488639; ENSG00000282801.
UCSCiuc061lqk.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKV105_HUMAN
AccessioniPrimary (citable) accession number: P01602
Secondary accession number(s): A0A075B6S8
, P01596, P01598, P01604
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 24, 2015
Last modified: August 30, 2017
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

For an example of a full length immunoglobulin kappa light chain see AC P0DOX7.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations