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Protein

Ig heavy chain V-I region 5

Gene

IGKV1-5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

V segment of the variable region of immunoglobulins light chain that participates to the antigen recognition. Immunoglobulins (Igs), also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound Igs serve as receptors which, upon binding of a specific antigen (Ag), trigger the clonal expansion and differentiation of B lymphocytes into Ig-secreting plasma cells. Secreted Igs mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable region of one heavy chain, together with that of its associated light chain. Thus, each Ig has two antigen binding sites with remarkable affinity for a particular antigen. The variable regions are assembled by a process called V(D)J recombination and can then be subjected to somatic hypermutation after exposure to antigen to allow affinity maturation for a particular Ag (PubMed:20176268, PubMed:17576170).3 Publications

GO - Molecular functioni

  • antigen binding Source: UniProtKB
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-2168880. Scavenging of heme from plasma.
R-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-5690714. CD22 mediated BCR regulation.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain V-I region 5Curated
Alternative name(s):
Ig kappa chain V-I region CAR1 Publication
Ig kappa chain V-I region EU1 Publication
Ig kappa chain V-I region HK1021 Publication
Ig kappa chain V-I region Kue1 Publication
Immunoglobulin kappa variable 1-5Imported
Gene namesi
Name:IGKV1-5Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componentsi: Chromosome 2, Unplaced

Organism-specific databases

HGNCiHGNC:5741. IGKV1-5.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi125760.
125762.
125766.
125768.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22223 PublicationsAdd
BLAST
Chaini23 – 11795Ig heavy chain V-I region 5PRO_0000015169Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 110PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PeptideAtlasiP01602.
PRIDEiP01602.

PTM databases

iPTMnetiP01598.

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds.1 Publication

Protein-protein interaction databases

IntActiP01602. 3 interactions.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – ›117›94Ig-likePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 4523Framework-11 PublicationAdd
BLAST
Regioni46 – 5611Complementarity-determining-11 PublicationAdd
BLAST
Regioni57 – 7115Framework-21 PublicationAdd
BLAST
Regioni72 – 787Complementarity-determining-21 Publication
Regioni79 – 11032Framework-31 PublicationAdd
BLAST
Regioni111 – ›117›7Complementarity-determining-31 Publication

Sequence similaritiesi

Contains 1 Ig-like (immunoglobulin-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

GeneTreeiENSGT00780000121852.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
InParanoidiP01602.
OMAiTITINCQ.
PhylomeDBiP01602.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMRVPAQLL GLLLLWLPGA KCDIQMTQSP STLSASVGDR VTITCRASQS
60 70 80 90 100
ISSWLAWYQQ KPGKAPKLLI YKASSLESGV PSRFSGSGSG TEFTLTISSL
110
QPDDFATYYC QQYNSYS
Length:117
Mass (Da):12,782
Last modified:June 24, 2015 - v2
Checksum:i1BCDF3A40AFD9868
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 342LS → QP AA sequence (PubMed:112021).Curated
Sequence conflicti42 – 421T → A AA sequence (PubMed:4216454).Curated
Sequence conflicti50 – 501S → N AA sequence (PubMed:4216454).Curated
Sequence conflicti52 – 532SS → NI AA sequence (PubMed:112021).Curated
Sequence conflicti52 – 532SS → NT AA sequence (PubMed:5489770).Curated
Sequence conflicti63 – 631G → E AA sequence (PubMed:112021).Curated
Sequence conflicti68 – 681L → V AA sequence (PubMed:4216454).Curated
Sequence conflicti70 – 701I → M AA sequence (PubMed:5489770).Curated
Sequence conflicti73 – 731A → S AA sequence (PubMed:4216454).Curated
Sequence conflicti75 – 784SLES → TLET AA sequence (PubMed:112021).Curated
Sequence conflicti85 – 851S → I AA sequence (PubMed:5489770).Curated
Sequence conflicti92 – 921E → D AA sequence (PubMed:4216454).Curated
Sequence conflicti98 – 981S → N AA sequence (PubMed:112021).Curated
Sequence conflicti114 – 1174NSYS → SRYP AA sequence (PubMed:112021).Curated
Sequence conflicti115 – 1173SYS → TFF AA sequence (PubMed:4216454).Curated
Sequence conflicti116 – 1172YS → DS AA sequence (PubMed:5489770).Curated
Non-terminal residuei117 – 1171

Polymorphismi

There are several alleles. The sequence shown is that of allele IGKV1-5*03.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721K → D in allele IGKV1-5*01; requires 2 nucleotide substitutions. 1 Publication
VAR_073349

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00245 Genomic DNA. Translation: AAA59087.1.
Z00001 Genomic DNA. Translation: CAA77292.1.
AC243970 Genomic DNA. No translation available.
PIRiA01864. K1HUAR.
A01870. K1HUKU.
A01882. K1HU12.
A90562. K1HUEU.
UniGeneiHs.449609.

Genome annotation databases

EnsembliENST00000496168; ENSP00000420436; ENSG00000243466.
ENST00000632205; ENSP00000488639; ENSG00000282801.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00245 Genomic DNA. Translation: AAA59087.1.
Z00001 Genomic DNA. Translation: CAA77292.1.
AC243970 Genomic DNA. No translation available.
PIRiA01864. K1HUAR.
A01870. K1HUKU.
A01882. K1HU12.
A90562. K1HUEU.
UniGeneiHs.449609.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01602. 3 interactions.

Protein family/group databases

IMGTiSearch...
Search...
Search...

PTM databases

iPTMnetiP01598.

Polymorphism and mutation databases

DMDMi125760.
125762.
125766.
125768.

Proteomic databases

PeptideAtlasiP01602.
PRIDEiP01602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000496168; ENSP00000420436; ENSG00000243466.
ENST00000632205; ENSP00000488639; ENSG00000282801.

Organism-specific databases

GeneCardsiIGKV1-5.
HGNCiHGNC:5741. IGKV1-5.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00780000121852.
HOGENOMiHOG000059537.
HOVERGENiHBG018013.
InParanoidiP01602.
OMAiTITINCQ.
PhylomeDBiP01602.

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-2168880. Scavenging of heme from plasma.
R-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-5690714. CD22 mediated BCR regulation.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKV110_HUMAN
AccessioniPrimary (citable) accession number: P01602
Secondary accession number(s): A0A075B6S8
, P01596, P01598, P01604
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 24, 2015
Last modified: September 7, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.