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P01592

- IGJ_MOUSE

UniProt

P01592 - IGJ_MOUSE

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Protein
Immunoglobulin J chain
Gene
Igj
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

GO - Molecular functioni

  1. IgA binding Source: UniProt
  2. antigen binding Source: MGI

GO - Biological processi

  1. humoral immune response Source: MGI
  2. positive regulation of protein oligomerization Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin J chain
Gene namesi
Name:Igj
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:96493. Igj.

Subcellular locationi

GO - Cellular componenti

  1. dimeric IgA immunoglobulin complex Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121
Add
BLAST
Chaini22 – 159138Immunoglobulin J chain
PRO_0000021486Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 123 By similarity
Disulfide bondi36 – 36Interchain (with heavy chain) By similarity
Glycosylationi70 – 701N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi90 – 90Interchain (with heavy chain) By similarity
Disulfide bondi93 ↔ 113 By similarity
Disulfide bondi131 ↔ 156 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01592.
PaxDbiP01592.
PRIDEiP01592.

PTM databases

PhosphoSiteiP01592.

Expressioni

Gene expression databases

ArrayExpressiP01592.
BgeeiP01592.
CleanExiMM_IGJ.
GenevestigatoriP01592.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084259.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43056.
GeneTreeiENSGT00390000012791.
HOGENOMiHOG000113012.
HOVERGENiHBG006138.
InParanoidiP01592.
OMAiTIRRHEI.
OrthoDBiEOG7G1V7R.
PhylomeDBiP01592.
TreeFamiTF335878.

Family and domain databases

InterProiIPR024110. Ig_J.
[Graphical view]
PANTHERiPTHR10070. PTHR10070. 1 hit.
PfamiPF15097. Ig_J_chain. 1 hit.
[Graphical view]
ProDomiPD021296. PD021296. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01592-1 [UniParc]FASTAAdd to Basket

« Hide

MKTHLLLWGV LAIFVKAVLV TGDDEATILA DNKCMCTRVT SRIIPSTEDP    50
NEDIVERNIR IVVPLNNREN ISDPTSPLRR NFVYHLSDVC KKCDPVEVEL 100
EDQVVTATQS NICNEDDGVP ETCYMYDRNK CYTTMVPLRY HGETKMVQAA 150
LTPDSCYPD 159
Length:159
Mass (Da):18,014
Last modified:February 1, 2005 - v4
Checksum:iB75269C634470384
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171A → V in AAA38674. 1 Publication
Sequence conflicti42 – 421R → K in AAA38674. 1 Publication
Sequence conflicti89 – 891V → L in AAA38673. 1 Publication
Sequence conflicti138 – 1392LR → PG in AAA38673. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M12557, M12555, M12556 Genomic DNA. Translation: AAA38674.1.
J00544 mRNA. Translation: AAA38673.1. Sequence problems.
M90766 mRNA. Translation: AAA37918.1.
CCDSiCCDS19401.1.
PIRiA25963. JIMS.
RefSeqiNP_690052.2. NM_152839.3.
UniGeneiMm.1192.

Genome annotation databases

EnsembliENSMUST00000087033; ENSMUSP00000084259; ENSMUSG00000067149.
GeneIDi16069.
KEGGimmu:16069.
UCSCiuc008xzu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M12557 , M12555 , M12556 Genomic DNA. Translation: AAA38674.1 .
J00544 mRNA. Translation: AAA38673.1 . Sequence problems.
M90766 mRNA. Translation: AAA37918.1 .
CCDSi CCDS19401.1.
PIRi A25963. JIMS.
RefSeqi NP_690052.2. NM_152839.3.
UniGenei Mm.1192.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000084259.

PTM databases

PhosphoSitei P01592.

Proteomic databases

MaxQBi P01592.
PaxDbi P01592.
PRIDEi P01592.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087033 ; ENSMUSP00000084259 ; ENSMUSG00000067149 .
GeneIDi 16069.
KEGGi mmu:16069.
UCSCi uc008xzu.2. mouse.

Organism-specific databases

CTDi 3512.
MGIi MGI:96493. Igj.

Phylogenomic databases

eggNOGi NOG43056.
GeneTreei ENSGT00390000012791.
HOGENOMi HOG000113012.
HOVERGENi HBG006138.
InParanoidi P01592.
OMAi TIRRHEI.
OrthoDBi EOG7G1V7R.
PhylomeDBi P01592.
TreeFami TF335878.

Miscellaneous databases

NextBioi 288876.
PROi P01592.
SOURCEi Search...

Gene expression databases

ArrayExpressi P01592.
Bgeei P01592.
CleanExi MM_IGJ.
Genevestigatori P01592.

Family and domain databases

InterProi IPR024110. Ig_J.
[Graphical view ]
PANTHERi PTHR10070. PTHR10070. 1 hit.
Pfami PF15097. Ig_J_chain. 1 hit.
[Graphical view ]
ProDomi PD021296. PD021296. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Direct evidence that J chain regulates the polymeric structure of IgM in antibody-secreting B cells."
    Randall T.D., Brewer J.W., Corley R.B.
    J. Biol. Chem. 267:18002-18007(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/10.
  3. "Primary structure of the immunoglobulin J chain from the mouse."
    Cann G.M., Zaritsky A., Koshland M.E.
    Proc. Natl. Acad. Sci. U.S.A. 79:6656-6660(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-159.

Entry informationi

Entry nameiIGJ_MOUSE
AccessioniPrimary (citable) accession number: P01592
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 92 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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