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P01592

- IGJ_MOUSE

UniProt

P01592 - IGJ_MOUSE

Protein

Immunoglobulin J chain

Gene

Igj

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

    GO - Molecular functioni

    1. antigen binding Source: MGI
    2. IgA binding Source: UniProt

    GO - Biological processi

    1. humoral immune response Source: MGI
    2. positive regulation of protein oligomerization Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Immunoglobulin J chain
    Gene namesi
    Name:Igj
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:96493. Igj.

    Subcellular locationi

    GO - Cellular componenti

    1. dimeric IgA immunoglobulin complex Source: UniProt

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Add
    BLAST
    Chaini22 – 159138Immunoglobulin J chainPRO_0000021486Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 123By similarity
    Disulfide bondi36 – 36Interchain (with heavy chain)By similarity
    Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi90 – 90Interchain (with heavy chain)By similarity
    Disulfide bondi93 ↔ 113By similarity
    Disulfide bondi131 ↔ 156By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP01592.
    PaxDbiP01592.
    PRIDEiP01592.

    PTM databases

    PhosphoSiteiP01592.

    Expressioni

    Gene expression databases

    ArrayExpressiP01592.
    BgeeiP01592.
    CleanExiMM_IGJ.
    GenevestigatoriP01592.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000084259.

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43056.
    GeneTreeiENSGT00390000012791.
    HOGENOMiHOG000113012.
    HOVERGENiHBG006138.
    InParanoidiP01592.
    OMAiTIRRHEI.
    OrthoDBiEOG7G1V7R.
    PhylomeDBiP01592.
    TreeFamiTF335878.

    Family and domain databases

    InterProiIPR024110. Ig_J.
    [Graphical view]
    PANTHERiPTHR10070. PTHR10070. 1 hit.
    PfamiPF15097. Ig_J_chain. 1 hit.
    [Graphical view]
    ProDomiPD021296. PD021296. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01592-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTHLLLWGV LAIFVKAVLV TGDDEATILA DNKCMCTRVT SRIIPSTEDP    50
    NEDIVERNIR IVVPLNNREN ISDPTSPLRR NFVYHLSDVC KKCDPVEVEL 100
    EDQVVTATQS NICNEDDGVP ETCYMYDRNK CYTTMVPLRY HGETKMVQAA 150
    LTPDSCYPD 159
    Length:159
    Mass (Da):18,014
    Last modified:February 1, 2005 - v4
    Checksum:iB75269C634470384
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 171A → V in AAA38674. (PubMed:3079912)Curated
    Sequence conflicti42 – 421R → K in AAA38674. (PubMed:3079912)Curated
    Sequence conflicti89 – 891V → L in AAA38673. (PubMed:6815655)Curated
    Sequence conflicti138 – 1392LR → PG in AAA38673. (PubMed:6815655)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12557, M12555, M12556 Genomic DNA. Translation: AAA38674.1.
    J00544 mRNA. Translation: AAA38673.1. Sequence problems.
    M90766 mRNA. Translation: AAA37918.1.
    CCDSiCCDS19401.1.
    PIRiA25963. JIMS.
    RefSeqiNP_690052.2. NM_152839.3.
    UniGeneiMm.1192.

    Genome annotation databases

    EnsembliENSMUST00000087033; ENSMUSP00000084259; ENSMUSG00000067149.
    GeneIDi16069.
    KEGGimmu:16069.
    UCSCiuc008xzu.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12557 , M12555 , M12556 Genomic DNA. Translation: AAA38674.1 .
    J00544 mRNA. Translation: AAA38673.1 . Sequence problems.
    M90766 mRNA. Translation: AAA37918.1 .
    CCDSi CCDS19401.1.
    PIRi A25963. JIMS.
    RefSeqi NP_690052.2. NM_152839.3.
    UniGenei Mm.1192.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000084259.

    PTM databases

    PhosphoSitei P01592.

    Proteomic databases

    MaxQBi P01592.
    PaxDbi P01592.
    PRIDEi P01592.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000087033 ; ENSMUSP00000084259 ; ENSMUSG00000067149 .
    GeneIDi 16069.
    KEGGi mmu:16069.
    UCSCi uc008xzu.2. mouse.

    Organism-specific databases

    CTDi 3512.
    MGIi MGI:96493. Igj.

    Phylogenomic databases

    eggNOGi NOG43056.
    GeneTreei ENSGT00390000012791.
    HOGENOMi HOG000113012.
    HOVERGENi HBG006138.
    InParanoidi P01592.
    OMAi TIRRHEI.
    OrthoDBi EOG7G1V7R.
    PhylomeDBi P01592.
    TreeFami TF335878.

    Miscellaneous databases

    NextBioi 288876.
    PROi P01592.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01592.
    Bgeei P01592.
    CleanExi MM_IGJ.
    Genevestigatori P01592.

    Family and domain databases

    InterProi IPR024110. Ig_J.
    [Graphical view ]
    PANTHERi PTHR10070. PTHR10070. 1 hit.
    Pfami PF15097. Ig_J_chain. 1 hit.
    [Graphical view ]
    ProDomi PD021296. PD021296. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Direct evidence that J chain regulates the polymeric structure of IgM in antibody-secreting B cells."
      Randall T.D., Brewer J.W., Corley R.B.
      J. Biol. Chem. 267:18002-18007(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/10.
    3. "Primary structure of the immunoglobulin J chain from the mouse."
      Cann G.M., Zaritsky A., Koshland M.E.
      Proc. Natl. Acad. Sci. U.S.A. 79:6656-6660(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-159.

    Entry informationi

    Entry nameiIGJ_MOUSE
    AccessioniPrimary (citable) accession number: P01592
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 93 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3