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Protein

Immunoglobulin J chain

Gene

Igj

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

GO - Molecular functioni

  1. antigen binding Source: MGI
  2. IgA binding Source: UniProtKB
  3. peptidoglycan binding Source: Ensembl
  4. phosphatidylcholine binding Source: Ensembl
  5. protein homodimerization activity Source: MGI
  6. single-stranded DNA binding Source: Ensembl

GO - Biological processi

  1. adaptive immune response Source: MGI
  2. antibacterial humoral response Source: MGI
  3. glomerular filtration Source: MGI
  4. humoral immune response Source: GO_Central
  5. innate immune response Source: MGI
  6. positive regulation of protein oligomerization Source: UniProtKB
  7. positive regulation of respiratory burst Source: MGI
  8. retina homeostasis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin J chain
Gene namesi
Name:Igj
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:96493. Igj.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: MGI
  2. dimeric IgA immunoglobulin complex Source: UniProtKB
  3. extracellular space Source: MGI
  4. extracellular vesicular exosome Source: MGI
  5. monomeric IgA immunoglobulin complex Source: MGI
  6. pentameric IgM immunoglobulin complex Source: MGI
  7. secretory dimeric IgA immunoglobulin complex Source: MGI
  8. secretory IgA immunoglobulin complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 159138Immunoglobulin J chainPRO_0000021486Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 123By similarity
Disulfide bondi36 – 36Interchain (with heavy chain)By similarity
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi90 – 90Interchain (with heavy chain)By similarity
Disulfide bondi93 ↔ 113By similarity
Disulfide bondi131 ↔ 156By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01592.
PaxDbiP01592.
PRIDEiP01592.

PTM databases

PhosphoSiteiP01592.

Expressioni

Gene expression databases

BgeeiP01592.
CleanExiMM_IGJ.
ExpressionAtlasiP01592. baseline and differential.
GenevestigatoriP01592.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084259.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43056.
GeneTreeiENSGT00390000012791.
HOGENOMiHOG000113012.
HOVERGENiHBG006138.
InParanoidiP01592.
OMAiRITSRII.
OrthoDBiEOG7G1V7R.
PhylomeDBiP01592.
TreeFamiTF335878.

Family and domain databases

InterProiIPR024110. Ig_J.
[Graphical view]
PANTHERiPTHR10070. PTHR10070. 1 hit.
PfamiPF15097. Ig_J_chain. 1 hit.
[Graphical view]
ProDomiPD021296. PD021296. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTHLLLWGV LAIFVKAVLV TGDDEATILA DNKCMCTRVT SRIIPSTEDP
60 70 80 90 100
NEDIVERNIR IVVPLNNREN ISDPTSPLRR NFVYHLSDVC KKCDPVEVEL
110 120 130 140 150
EDQVVTATQS NICNEDDGVP ETCYMYDRNK CYTTMVPLRY HGETKMVQAA

LTPDSCYPD
Length:159
Mass (Da):18,014
Last modified:January 31, 2005 - v4
Checksum:iB75269C634470384
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171A → V in AAA38674 (PubMed:3079912).Curated
Sequence conflicti42 – 421R → K in AAA38674 (PubMed:3079912).Curated
Sequence conflicti89 – 891V → L in AAA38673 (PubMed:6815655).Curated
Sequence conflicti138 – 1392LR → PG in AAA38673 (PubMed:6815655).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12557, M12555, M12556 Genomic DNA. Translation: AAA38674.1.
J00544 mRNA. Translation: AAA38673.1. Sequence problems.
M90766 mRNA. Translation: AAA37918.1.
CCDSiCCDS19401.1.
PIRiA25963. JIMS.
RefSeqiNP_690052.2. NM_152839.3.
UniGeneiMm.1192.

Genome annotation databases

EnsembliENSMUST00000087033; ENSMUSP00000084259; ENSMUSG00000067149.
GeneIDi16069.
KEGGimmu:16069.
UCSCiuc008xzu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12557, M12555, M12556 Genomic DNA. Translation: AAA38674.1.
J00544 mRNA. Translation: AAA38673.1. Sequence problems.
M90766 mRNA. Translation: AAA37918.1.
CCDSiCCDS19401.1.
PIRiA25963. JIMS.
RefSeqiNP_690052.2. NM_152839.3.
UniGeneiMm.1192.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084259.

PTM databases

PhosphoSiteiP01592.

Proteomic databases

MaxQBiP01592.
PaxDbiP01592.
PRIDEiP01592.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087033; ENSMUSP00000084259; ENSMUSG00000067149.
GeneIDi16069.
KEGGimmu:16069.
UCSCiuc008xzu.2. mouse.

Organism-specific databases

CTDi3512.
MGIiMGI:96493. Igj.

Phylogenomic databases

eggNOGiNOG43056.
GeneTreeiENSGT00390000012791.
HOGENOMiHOG000113012.
HOVERGENiHBG006138.
InParanoidiP01592.
OMAiRITSRII.
OrthoDBiEOG7G1V7R.
PhylomeDBiP01592.
TreeFamiTF335878.

Miscellaneous databases

NextBioi288876.
PROiP01592.
SOURCEiSearch...

Gene expression databases

BgeeiP01592.
CleanExiMM_IGJ.
ExpressionAtlasiP01592. baseline and differential.
GenevestigatoriP01592.

Family and domain databases

InterProiIPR024110. Ig_J.
[Graphical view]
PANTHERiPTHR10070. PTHR10070. 1 hit.
PfamiPF15097. Ig_J_chain. 1 hit.
[Graphical view]
ProDomiPD021296. PD021296. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Direct evidence that J chain regulates the polymeric structure of IgM in antibody-secreting B cells."
    Randall T.D., Brewer J.W., Corley R.B.
    J. Biol. Chem. 267:18002-18007(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/10.
  3. "Primary structure of the immunoglobulin J chain from the mouse."
    Cann G.M., Zaritsky A., Koshland M.E.
    Proc. Natl. Acad. Sci. U.S.A. 79:6656-6660(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-159.

Entry informationi

Entry nameiIGJ_MOUSE
AccessioniPrimary (citable) accession number: P01592
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 20, 1986
Last sequence update: January 31, 2005
Last modified: February 3, 2015
This is version 96 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.