Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P01592 (IGJ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunoglobulin J chain
Gene names
Name:Igj
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Subcellular location

Secreted.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121
Chain22 – 159138Immunoglobulin J chain
PRO_0000021486

Amino acid modifications

Glycosylation701N-linked (GlcNAc...) Potential
Disulfide bond34 ↔ 123 By similarity
Disulfide bond36Interchain (with heavy chain) By similarity
Disulfide bond90Interchain (with heavy chain) By similarity
Disulfide bond93 ↔ 113 By similarity
Disulfide bond131 ↔ 156 By similarity

Experimental info

Sequence conflict171A → V in AAA38674. Ref.1
Sequence conflict421R → K in AAA38674. Ref.1
Sequence conflict891V → L in AAA38673. Ref.3
Sequence conflict138 – 1392LR → PG in AAA38673. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P01592 [UniParc].

Last modified February 1, 2005. Version 4.
Checksum: B75269C634470384

FASTA15918,014
        10         20         30         40         50         60 
MKTHLLLWGV LAIFVKAVLV TGDDEATILA DNKCMCTRVT SRIIPSTEDP NEDIVERNIR 

        70         80         90        100        110        120 
IVVPLNNREN ISDPTSPLRR NFVYHLSDVC KKCDPVEVEL EDQVVTATQS NICNEDDGVP 

       130        140        150 
ETCYMYDRNK CYTTMVPLRY HGETKMVQAA LTPDSCYPD 

« Hide

References

[1]"Immunoglobulin J chain gene from the mouse."
Matsuuchi L., Cann G.M., Koshland M.E.
Proc. Natl. Acad. Sci. U.S.A. 83:456-460(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Direct evidence that J chain regulates the polymeric structure of IgM in antibody-secreting B cells."
Randall T.D., Brewer J.W., Corley R.B.
J. Biol. Chem. 267:18002-18007(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/10.
[3]"Primary structure of the immunoglobulin J chain from the mouse."
Cann G.M., Zaritsky A., Koshland M.E.
Proc. Natl. Acad. Sci. U.S.A. 79:6656-6660(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-159.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M12557, M12555, M12556 Genomic DNA. Translation: AAA38674.1.
J00544 mRNA. Translation: AAA38673.1. Sequence problems.
M90766 mRNA. Translation: AAA37918.1.
CCDSCCDS19401.1.
PIRJIMS. A25963.
RefSeqNP_690052.2. NM_152839.3.
UniGeneMm.1192.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000084259.

PTM databases

PhosphoSiteP01592.

Proteomic databases

MaxQBP01592.
PaxDbP01592.
PRIDEP01592.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000087033; ENSMUSP00000084259; ENSMUSG00000067149.
GeneID16069.
KEGGmmu:16069.
UCSCuc008xzu.2. mouse.

Organism-specific databases

CTD3512.
MGIMGI:96493. Igj.

Phylogenomic databases

eggNOGNOG43056.
GeneTreeENSGT00390000012791.
HOGENOMHOG000113012.
HOVERGENHBG006138.
InParanoidP01592.
OMATIRRHEI.
OrthoDBEOG7G1V7R.
PhylomeDBP01592.
TreeFamTF335878.

Gene expression databases

ArrayExpressP01592.
BgeeP01592.
CleanExMM_IGJ.
GenevestigatorP01592.

Family and domain databases

InterProIPR024110. Ig_J.
[Graphical view]
PANTHERPTHR10070. PTHR10070. 1 hit.
PfamPF15097. Ig_J_chain. 1 hit.
[Graphical view]
ProDomPD021296. PD021296. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

NextBio288876.
PROP01592.
SOURCESearch...

Entry information

Entry nameIGJ_MOUSE
AccessionPrimary (citable) accession number: P01592
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 92 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot