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Protein

Immunoglobulin J chain

Gene

Jchain

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.1 Publication

GO - Molecular functioni

  • antigen binding Source: MGI
  • IgA binding Source: UniProtKB
  • peptidoglycan binding Source: Ensembl
  • phosphatidylcholine binding Source: Ensembl
  • protein homodimerization activity Source: MGI
  • single-stranded DNA binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin J chainImported
Gene namesi
Name:JchainImported
Synonyms:Igj
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:96493. Jchain.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000002148622 – 159Immunoglobulin J chainAdd BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 123By similarity
Disulfide bondi36Interchain (with heavy chain)By similarity
Glycosylationi70N-linked (GlcNAc...) (complex)By similarity1
Disulfide bondi90Interchain (with heavy chain)By similarity
Disulfide bondi93 ↔ 113By similarity
Disulfide bondi131 ↔ 156By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP01592.
MaxQBiP01592.
PaxDbiP01592.
PeptideAtlasiP01592.
PRIDEiP01592.

PTM databases

iPTMnetiP01592.
PhosphoSitePlusiP01592.

Expressioni

Gene expression databases

BgeeiENSMUSG00000067149.
CleanExiMM_IGJ.
GenevisibleiP01592. MM.

Interactioni

GO - Molecular functioni

  • IgA binding Source: UniProtKB
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084259.

Structurei

3D structure databases

ProteinModelPortaliP01592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYAZ. Eukaryota.
ENOG410YX96. LUCA.
GeneTreeiENSGT00390000012791.
HOGENOMiHOG000113012.
HOVERGENiHBG006138.
InParanoidiP01592.
OMAiKCYTNRV.
OrthoDBiEOG091G0RP0.
PhylomeDBiP01592.
TreeFamiTF335878.

Family and domain databases

InterProiIPR024110. Ig_J.
[Graphical view]
PANTHERiPTHR10070. PTHR10070. 1 hit.
PfamiPF15097. Ig_J_chain. 1 hit.
[Graphical view]
ProDomiPD021296. PD021296. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTHLLLWGV LAIFVKAVLV TGDDEATILA DNKCMCTRVT SRIIPSTEDP
60 70 80 90 100
NEDIVERNIR IVVPLNNREN ISDPTSPLRR NFVYHLSDVC KKCDPVEVEL
110 120 130 140 150
EDQVVTATQS NICNEDDGVP ETCYMYDRNK CYTTMVPLRY HGETKMVQAA

LTPDSCYPD
Length:159
Mass (Da):18,014
Last modified:February 1, 2005 - v4
Checksum:iB75269C634470384
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17A → V in AAA38674 (PubMed:3079912).Curated1
Sequence conflicti42R → K in AAA38674 (PubMed:3079912).Curated1
Sequence conflicti89V → L in AAA38673 (PubMed:6815655).Curated1
Sequence conflicti138 – 139LR → PG in AAA38673 (PubMed:6815655).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12557, M12555, M12556 Genomic DNA. Translation: AAA38674.1.
J00544 mRNA. Translation: AAA38673.1. Sequence problems.
M90766 mRNA. Translation: AAA37918.1.
CCDSiCCDS19401.1.
PIRiA25963. JIMS.
RefSeqiNP_690052.2. NM_152839.3.
UniGeneiMm.1192.

Genome annotation databases

EnsembliENSMUST00000087033; ENSMUSP00000084259; ENSMUSG00000067149.
GeneIDi16069.
KEGGimmu:16069.
UCSCiuc008xzu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12557, M12555, M12556 Genomic DNA. Translation: AAA38674.1.
J00544 mRNA. Translation: AAA38673.1. Sequence problems.
M90766 mRNA. Translation: AAA37918.1.
CCDSiCCDS19401.1.
PIRiA25963. JIMS.
RefSeqiNP_690052.2. NM_152839.3.
UniGeneiMm.1192.

3D structure databases

ProteinModelPortaliP01592.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084259.

PTM databases

iPTMnetiP01592.
PhosphoSitePlusiP01592.

Proteomic databases

EPDiP01592.
MaxQBiP01592.
PaxDbiP01592.
PeptideAtlasiP01592.
PRIDEiP01592.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087033; ENSMUSP00000084259; ENSMUSG00000067149.
GeneIDi16069.
KEGGimmu:16069.
UCSCiuc008xzu.2. mouse.

Organism-specific databases

CTDi3512.
MGIiMGI:96493. Jchain.

Phylogenomic databases

eggNOGiENOG410IYAZ. Eukaryota.
ENOG410YX96. LUCA.
GeneTreeiENSGT00390000012791.
HOGENOMiHOG000113012.
HOVERGENiHBG006138.
InParanoidiP01592.
OMAiKCYTNRV.
OrthoDBiEOG091G0RP0.
PhylomeDBiP01592.
TreeFamiTF335878.

Miscellaneous databases

PROiP01592.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067149.
CleanExiMM_IGJ.
GenevisibleiP01592. MM.

Family and domain databases

InterProiIPR024110. Ig_J.
[Graphical view]
PANTHERiPTHR10070. PTHR10070. 1 hit.
PfamiPF15097. Ig_J_chain. 1 hit.
[Graphical view]
ProDomiPD021296. PD021296. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiIGJ_MOUSE
AccessioniPrimary (citable) accession number: P01592
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 109 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.