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P01591

- IGJ_HUMAN

UniProt

P01591 - IGJ_HUMAN

Protein

Immunoglobulin J chain

Gene

IGJ

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB
    2. IgA binding Source: UniProt
    3. protein homodimerization activity Source: UniProt

    GO - Biological processi

    1. adaptive immune response Source: UniProt
    2. antibacterial humoral response Source: UniProt
    3. glomerular filtration Source: UniProt
    4. immune response Source: UniProtKB
    5. innate immune response Source: UniProt
    6. positive regulation of protein oligomerization Source: UniProt
    7. positive regulation of respiratory burst Source: UniProt
    8. retina homeostasis Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Immunoglobulin J chain
    Gene namesi
    Name:IGJ
    Synonyms:IGCJ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:5713. IGJ.

    Subcellular locationi

    GO - Cellular componenti

    1. blood microparticle Source: UniProt
    2. dimeric IgA immunoglobulin complex Source: UniProt
    3. extracellular region Source: UniProtKB
    4. extracellular space Source: UniProt
    5. extracellular vesicular exosome Source: UniProt
    6. monomeric IgA immunoglobulin complex Source: UniProt
    7. pentameric IgM immunoglobulin complex Source: UniProt
    8. secretory dimeric IgA immunoglobulin complex Source: UniProt
    9. secretory IgA immunoglobulin complex Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29733.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Add
    BLAST
    Chaini23 – 159137Immunoglobulin J chainPRO_0000084174Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231Pyrrolidone carboxylic acid1 Publication
    Disulfide bondi35 ↔ 1231 Publication
    Disulfide bondi37 – 37Interchain (with heavy chain)1 Publication
    Glycosylationi71 – 711N-linked (GlcNAc...) (complex)6 PublicationsCAR_000167
    Disulfide bondi91 – 91Interchain (with heavy chain)1 Publication
    Disulfide bondi94 ↔ 1141 Publication
    Disulfide bondi131 ↔ 1561 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    MaxQBiP01591.
    PaxDbiP01591.
    PRIDEiP01591.

    2D gel databases

    SWISS-2DPAGEP01591.

    PTM databases

    PhosphoSiteiP01591.
    UniCarbKBiP01591.

    Expressioni

    Gene expression databases

    ArrayExpressiP01591.
    BgeeiP01591.
    CleanExiHS_IGJ.
    GenevestigatoriP01591.

    Organism-specific databases

    HPAiCAB034436.

    Interactioni

    Protein-protein interaction databases

    BioGridi109732. 1 interaction.
    IntActiP01591. 2 interactions.
    STRINGi9606.ENSP00000254801.

    Structurei

    3D structure databases

    ProteinModelPortaliP01591.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43056.
    HOGENOMiHOG000113012.
    HOVERGENiHBG006138.
    InParanoidiP01591.
    OrthoDBiEOG7G1V7R.
    PhylomeDBiP01591.
    TreeFamiTF335878.

    Family and domain databases

    InterProiIPR024110. Ig_J.
    [Graphical view]
    PANTHERiPTHR10070. PTHR10070. 1 hit.
    PfamiPF15097. Ig_J_chain. 1 hit.
    [Graphical view]
    ProDomiPD021296. PD021296. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01591-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNHLLFWGV LAVFIKAVHV KAQEDERIVL VDNKCKCARI TSRIIRSSED    50
    PNEDIVERNI RIIVPLNNRE NISDPTSPLR TRFVYHLSDL CKKCDPTEVE 100
    LDNQIVTATQ SNICDEDSAT ETCYTYDRNK CYTAVVPLVY GGETKMVETA 150
    LTPDACYPD 159
    Length:159
    Mass (Da):18,099
    Last modified:October 13, 2009 - v4
    Checksum:iB7835C02CCC0CB05
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK312014 mRNA. Translation: BAG34952.1.
    M12759, M12378 Genomic DNA. Translation: AAA58902.1.
    CCDSiCCDS3545.1.
    PIRiA01859. JIHU.
    RefSeqiNP_653247.1. NM_144646.3.
    XP_006714274.1. XM_006714211.1.
    XP_006714275.1. XM_006714212.1.
    UniGeneiHs.643431.

    Genome annotation databases

    EnsembliENST00000254801; ENSP00000254801; ENSG00000132465.
    ENST00000510437; ENSP00000426687; ENSG00000132465.
    GeneIDi3512.
    KEGGihsa:3512.
    UCSCiuc003hfn.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK312014 mRNA. Translation: BAG34952.1 .
    M12759 , M12378 Genomic DNA. Translation: AAA58902.1 .
    CCDSi CCDS3545.1.
    PIRi A01859. JIHU.
    RefSeqi NP_653247.1. NM_144646.3.
    XP_006714274.1. XM_006714211.1.
    XP_006714275.1. XM_006714212.1.
    UniGenei Hs.643431.

    3D structure databases

    ProteinModelPortali P01591.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109732. 1 interaction.
    IntActi P01591. 2 interactions.
    STRINGi 9606.ENSP00000254801.

    PTM databases

    PhosphoSitei P01591.
    UniCarbKBi P01591.

    2D gel databases

    SWISS-2DPAGE P01591.

    Proteomic databases

    MaxQBi P01591.
    PaxDbi P01591.
    PRIDEi P01591.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254801 ; ENSP00000254801 ; ENSG00000132465 .
    ENST00000510437 ; ENSP00000426687 ; ENSG00000132465 .
    GeneIDi 3512.
    KEGGi hsa:3512.
    UCSCi uc003hfn.4. human.

    Organism-specific databases

    CTDi 3512.
    GeneCardsi GC04M071478.
    HGNCi HGNC:5713. IGJ.
    HPAi CAB034436.
    MIMi 147790. gene.
    neXtProti NX_P01591.
    PharmGKBi PA29733.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43056.
    HOGENOMi HOG000113012.
    HOVERGENi HBG006138.
    InParanoidi P01591.
    OrthoDBi EOG7G1V7R.
    PhylomeDBi P01591.
    TreeFami TF335878.

    Miscellaneous databases

    ChiTaRSi IGJ. human.
    GeneWikii IGJ.
    GenomeRNAii 3512.
    NextBioi 13774.
    PROi P01591.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01591.
    Bgeei P01591.
    CleanExi HS_IGJ.
    Genevestigatori P01591.

    Family and domain databases

    InterProi IPR024110. Ig_J.
    [Graphical view ]
    PANTHERi PTHR10070. PTHR10070. 1 hit.
    Pfami PF15097. Ig_J_chain. 1 hit.
    [Graphical view ]
    ProDomi PD021296. PD021296. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Small intestine.
    2. "Primary structure of human J chain: alignment of peptides from chemical and enzymatic hydrolyses."
      Mole J.E., Bhown A.S., Bennett J.C.
      Biochemistry 16:3507-3513(1977) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY PROTEIN SEQUENCE OF 23-159, PYROGLUTAMATE FORMATION AT GLN-23.
    3. "Human J chain gene. Structure and expression in B lymphoid cells."
      Max E.E., Korsmeyer S.J.
      J. Exp. Med. 161:832-849(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-159.
    4. "Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M."
      Frutiger S., Hughes G.J., Paquet N., Luethy R., Jaton J.-C.
      Biochemistry 31:12643-12647(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS, PARTIAL PROTEIN SEQUENCE.
    5. Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
      Tissue: Bile.
    6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
      Tissue: Plasma.
    7. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
      Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
      J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
      Tissue: Saliva.
    8. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
      Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
      Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
      Tissue: Milk.
    9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
      Tissue: Liver.
    10. Cited for: GLYCOSYLATION AT ASN-71.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIGJ_HUMAN
    AccessioniPrimary (citable) accession number: P01591
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 128 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3