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Protein

Immunoglobulin J chain

Gene

JCHAIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.By similarity

GO - Molecular functioni

  • antigen binding Source: UniProtKB
  • IgA binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • adaptive immune response Source: UniProtKB
  • antibacterial humoral response Source: UniProtKB
  • glomerular filtration Source: UniProtKB
  • immune response Source: UniProtKB
  • innate immune response Source: UniProtKB
  • positive regulation of protein oligomerization Source: UniProtKB
  • positive regulation of respiratory burst Source: UniProtKB
  • receptor-mediated endocytosis Source: Reactome
  • retina homeostasis Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132465-MONOMER.
ReactomeiR-HSA-2168880. Scavenging of heme from plasma.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin J chain
Alternative name(s):
Joining chain of multimeric IgA and IgMImported
Gene namesi
Name:JCHAINImported
Synonyms:IGCJ, IGJ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:5713. JCHAIN.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • dimeric IgA immunoglobulin complex Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
  • monomeric IgA immunoglobulin complex Source: UniProtKB
  • pentameric IgM immunoglobulin complex Source: UniProtKB
  • secretory dimeric IgA immunoglobulin complex Source: UniProtKB
  • secretory IgA immunoglobulin complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3512.
OpenTargetsiENSG00000132465.
PharmGKBiPA29733.

Polymorphism and mutation databases

BioMutaiIGJ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000008417423 – 159Immunoglobulin J chainAdd BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Pyrrolidone carboxylic acid2 Publications1
Disulfide bondi35 ↔ 1231 Publication
Disulfide bondi37Interchain (with heavy chain)1 Publication
GlycosylationiCAR_00016771N-linked (GlcNAc...) (complex)6 Publications1
Disulfide bondi91Interchain (with heavy chain)1 Publication
Disulfide bondi94 ↔ 1141 Publication
Disulfide bondi131 ↔ 1561 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP01591.
MaxQBiP01591.
PaxDbiP01591.
PeptideAtlasiP01591.
PRIDEiP01591.

2D gel databases

SWISS-2DPAGEP01591.

PTM databases

iPTMnetiP01591.
PhosphoSitePlusiP01591.
UniCarbKBiP01591.

Expressioni

Gene expression databases

BgeeiENSG00000132465.
CleanExiHS_IGJ.
ExpressionAtlasiP01591. baseline and differential.
GenevisibleiP01591. HS.

Organism-specific databases

HPAiCAB034436.
HPA044132.

Interactioni

GO - Molecular functioni

  • IgA binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi109732. 19 interactors.
IntActiP01591. 4 interactors.
STRINGi9606.ENSP00000254801.

Structurei

3D structure databases

ProteinModelPortaliP01591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYAZ. Eukaryota.
ENOG410YX96. LUCA.
GeneTreeiENSGT00390000012791.
HOGENOMiHOG000113012.
HOVERGENiHBG006138.
InParanoidiP01591.
OMAiKCYTNRV.
OrthoDBiEOG091G0RP0.
PhylomeDBiP01591.
TreeFamiTF335878.

Family and domain databases

InterProiIPR024110. Ig_J.
[Graphical view]
PANTHERiPTHR10070. PTHR10070. 1 hit.
PfamiPF15097. Ig_J_chain. 1 hit.
[Graphical view]
ProDomiPD021296. PD021296. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNHLLFWGV LAVFIKAVHV KAQEDERIVL VDNKCKCARI TSRIIRSSED
60 70 80 90 100
PNEDIVERNI RIIVPLNNRE NISDPTSPLR TRFVYHLSDL CKKCDPTEVE
110 120 130 140 150
LDNQIVTATQ SNICDEDSAT ETCYTYDRNK CYTAVVPLVY GGETKMVETA

LTPDACYPD
Length:159
Mass (Da):18,099
Last modified:October 13, 2009 - v4
Checksum:iB7835C02CCC0CB05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312014 mRNA. Translation: BAG34952.1.
M12759, M12378 Genomic DNA. Translation: AAA58902.1.
CCDSiCCDS3545.1.
PIRiA01859. JIHU.
RefSeqiNP_653247.1. NM_144646.3.
XP_006714274.1. XM_006714211.2.
XP_006714275.1. XM_006714212.2.
XP_011530227.1. XM_011531925.1.
XP_011530228.1. XM_011531926.1.
UniGeneiHs.643431.

Genome annotation databases

EnsembliENST00000254801; ENSP00000254801; ENSG00000132465.
ENST00000510437; ENSP00000426687; ENSG00000132465.
ENST00000543780; ENSP00000440066; ENSG00000132465.
GeneIDi3512.
KEGGihsa:3512.
UCSCiuc003hfn.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312014 mRNA. Translation: BAG34952.1.
M12759, M12378 Genomic DNA. Translation: AAA58902.1.
CCDSiCCDS3545.1.
PIRiA01859. JIHU.
RefSeqiNP_653247.1. NM_144646.3.
XP_006714274.1. XM_006714211.2.
XP_006714275.1. XM_006714212.2.
XP_011530227.1. XM_011531925.1.
XP_011530228.1. XM_011531926.1.
UniGeneiHs.643431.

3D structure databases

ProteinModelPortaliP01591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109732. 19 interactors.
IntActiP01591. 4 interactors.
STRINGi9606.ENSP00000254801.

PTM databases

iPTMnetiP01591.
PhosphoSitePlusiP01591.
UniCarbKBiP01591.

Polymorphism and mutation databases

BioMutaiIGJ.

2D gel databases

SWISS-2DPAGEP01591.

Proteomic databases

EPDiP01591.
MaxQBiP01591.
PaxDbiP01591.
PeptideAtlasiP01591.
PRIDEiP01591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254801; ENSP00000254801; ENSG00000132465.
ENST00000510437; ENSP00000426687; ENSG00000132465.
ENST00000543780; ENSP00000440066; ENSG00000132465.
GeneIDi3512.
KEGGihsa:3512.
UCSCiuc003hfn.5. human.

Organism-specific databases

CTDi3512.
DisGeNETi3512.
GeneCardsiJCHAIN.
HGNCiHGNC:5713. JCHAIN.
HPAiCAB034436.
HPA044132.
MIMi147790. gene.
neXtProtiNX_P01591.
OpenTargetsiENSG00000132465.
PharmGKBiPA29733.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYAZ. Eukaryota.
ENOG410YX96. LUCA.
GeneTreeiENSGT00390000012791.
HOGENOMiHOG000113012.
HOVERGENiHBG006138.
InParanoidiP01591.
OMAiKCYTNRV.
OrthoDBiEOG091G0RP0.
PhylomeDBiP01591.
TreeFamiTF335878.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132465-MONOMER.
ReactomeiR-HSA-2168880. Scavenging of heme from plasma.

Miscellaneous databases

ChiTaRSiIGJ. human.
GeneWikiiIGJ.
GenomeRNAii3512.
PROiP01591.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132465.
CleanExiHS_IGJ.
ExpressionAtlasiP01591. baseline and differential.
GenevisibleiP01591. HS.

Family and domain databases

InterProiIPR024110. Ig_J.
[Graphical view]
PANTHERiPTHR10070. PTHR10070. 1 hit.
PfamiPF15097. Ig_J_chain. 1 hit.
[Graphical view]
ProDomiPD021296. PD021296. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiIGJ_HUMAN
AccessioniPrimary (citable) accession number: P01591
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 13, 2009
Last modified: November 2, 2016
This is version 145 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.