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P01591 (IGJ_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunoglobulin J chain
Gene names
Name:IGJ
Synonyms:IGCJ
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Subcellular location

Secreted.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.2
Chain23 – 159137Immunoglobulin J chain
PRO_0000084174

Amino acid modifications

Modified residue231Pyrrolidone carboxylic acid
Glycosylation711N-linked (GlcNAc...) (complex) Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10
CAR_000167
Disulfide bond35 ↔ 123 Ref.4
Disulfide bond37Interchain (with heavy chain) Ref.4
Disulfide bond91Interchain (with heavy chain) Ref.4
Disulfide bond94 ↔ 114 Ref.4
Disulfide bond131 ↔ 156 Ref.4

Sequences

Sequence LengthMass (Da)Tools
P01591 [UniParc].

Last modified October 13, 2009. Version 4.
Checksum: B7835C02CCC0CB05

FASTA15918,099
        10         20         30         40         50         60 
MKNHLLFWGV LAVFIKAVHV KAQEDERIVL VDNKCKCARI TSRIIRSSED PNEDIVERNI 

        70         80         90        100        110        120 
RIIVPLNNRE NISDPTSPLR TRFVYHLSDL CKKCDPTEVE LDNQIVTATQ SNICDEDSAT 

       130        140        150 
ETCYTYDRNK CYTAVVPLVY GGETKMVETA LTPDACYPD 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Small intestine.
[2]"Primary structure of human J chain: alignment of peptides from chemical and enzymatic hydrolyses."
Mole J.E., Bhown A.S., Bennett J.C.
Biochemistry 16:3507-3513(1977) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY PROTEIN SEQUENCE OF 23-159, PYROGLUTAMATE FORMATION AT GLN-23.
[3]"Human J chain gene. Structure and expression in B lymphoid cells."
Max E.E., Korsmeyer S.J.
J. Exp. Med. 161:832-849(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-159.
[4]"Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M."
Frutiger S., Hughes G.J., Paquet N., Luethy R., Jaton J.-C.
Biochemistry 31:12643-12647(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BONDS, PARTIAL PROTEIN SEQUENCE.
[5]"A proteomic analysis of human bile."
Kristiansen T.Z., Bunkenborg J., Gronborg M., Molina H., Thuluvath P.J., Argani P., Goggins M.G., Maitra A., Pandey A.
Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
Tissue: Bile.
[6]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
Tissue: Plasma.
[7]"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
Tissue: Saliva.
[8]"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
Tissue: Milk.
[9]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
Tissue: Liver.
[10]"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-71.
[11]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK312014 mRNA. Translation: BAG34952.1.
M12759, M12378 Genomic DNA. Translation: AAA58902.1.
PIRJIHU. A01859.
RefSeqNP_653247.1. NM_144646.3.
UniGeneHs.643431.

3D structure databases

ProteinModelPortalP01591.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109732. 1 interaction.
IntActP01591. 2 interactions.
STRING9606.ENSP00000254801.

PTM databases

PhosphoSiteP01591.
UniCarbKBP01591.

2D gel databases

SWISS-2DPAGEP01591.

Proteomic databases

PaxDbP01591.
PRIDEP01591.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254801; ENSP00000254801; ENSG00000132465.
ENST00000510437; ENSP00000426687; ENSG00000132465.
GeneID3512.
KEGGhsa:3512.
UCSCuc003hfn.4. human.

Organism-specific databases

CTD3512.
GeneCardsGC04M071478.
HGNCHGNC:5713. IGJ.
HPACAB034436.
MIM147790. gene.
neXtProtNX_P01591.
PharmGKBPA29733.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43056.
HOGENOMHOG000113012.
HOVERGENHBG006138.
InParanoidP01591.
OrthoDBEOG7G1V7R.
PhylomeDBP01591.
TreeFamTF335878.

Gene expression databases

ArrayExpressP01591.
BgeeP01591.
CleanExHS_IGJ.
GenevestigatorP01591.

Family and domain databases

InterProIPR024110. Ig_J.
[Graphical view]
PANTHERPTHR10070. PTHR10070. 1 hit.
PfamPF15097. Ig_J_chain. 1 hit.
[Graphical view]
ProDomPD021296. PD021296. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

ChiTaRSIGJ. human.
GeneWikiIGJ.
GenomeRNAi3512.
NextBio13774.
PROP01591.
SOURCESearch...

Entry information

Entry nameIGJ_HUMAN
AccessionPrimary (citable) accession number: P01591
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 13, 2009
Last modified: April 16, 2014
This is version 125 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM