P01591 (IGJ_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Immunoglobulin J chain

Gene names

Name:	IGJ
Synonyms:	IGCJ

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
Subcellular location	Secreted.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Disulfide bond Glycoprotein Pyrrolidone carboxylic acid
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	immune response Non-traceable author statement Ref.3. Source: UniProtKB
Cellular_component	extracellular region Non-traceable author statement PubMed 14718574Ref.3. Source: UniProtKB
Molecular_function	antigen binding Non-traceable author statement Ref.3. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Ref.2
	Chain	23 – 159	137	Immunoglobulin J chain		PRO_0000084174
Amino acid modifications
	Modified residue	23	1	Pyrrolidone carboxylic acid
	Glycosylation	71	1	N-linked (GlcNAc...) Ref.5 Ref.6 Ref.7 Ref.8 Ref.9		CAR_000167
	Disulfide bond	35 ↔ 123		Ref.4
	Disulfide bond	37		Interchain (with heavy chain) Ref.4
	Disulfide bond	91		Interchain (with heavy chain) Ref.4
	Disulfide bond	94 ↔ 114		Ref.4
	Disulfide bond	131 ↔ 156		Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P01591 [UniParc]. Last modified October 13, 2009. Version 4. Checksum: B7835C02CCC0CB05	FASTA	159	18,099
	10 20 30 40 50 60 MKNHLLFWGV LAVFIKAVHV KAQEDERIVL VDNKCKCARI TSRIIRSSED PNEDIVERNI 70 80 90 100 110 120 RIIVPLNNRE NISDPTSPLR TRFVYHLSDL CKKCDPTEVE LDNQIVTATQ SNICDEDSAT 130 140 150 ETCYTYDRNK CYTAVVPLVY GGETKMVETA LTPDACYPD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine.
[2]	"Primary structure of human J chain: alignment of peptides from chemical and enzymatic hydrolyses." Mole J.E., Bhown A.S., Bennett J.C. Biochemistry 16:3507-3513(1977) [PubMed] [Europe PMC] [Abstract] Cited for: PRELIMINARY PROTEIN SEQUENCE OF 23-159.
[3]	"Human J chain gene. Structure and expression in B lymphoid cells." Max E.E., Korsmeyer S.J. J. Exp. Med. 161:832-849(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-159.
[4]	"Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M." Frutiger S., Hughes G.J., Paquet N., Luethy R., Jaton J.-C. Biochemistry 31:12643-12647(1992) [PubMed] [Europe PMC] [Abstract] Cited for: DISULFIDE BONDS, PARTIAL PROTEIN SEQUENCE.
[5]	"A proteomic analysis of human bile." Kristiansen T.Z., Bunkenborg J., Gronborg M., Molina H., Thuluvath P.J., Argani P., Goggins M.G., Maitra A., Pandey A. Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71, MASS SPECTROMETRY. Tissue: Bile.
[6]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71, MASS SPECTROMETRY. Tissue: Plasma.
[7]	"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry." Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A. J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71, MASS SPECTROMETRY. Tissue: Saliva.
[8]	"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry." Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F. Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71, MASS SPECTROMETRY. Tissue: Milk.
[9]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71, MASS SPECTROMETRY. Tissue: Liver.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK312014 mRNA. Translation: BAG34952.1. M12759, M12378 Genomic DNA. Translation: AAA58902.1.
IPI	IPI00178926.
PIR	JIHU. A01859.
RefSeq	NP_653247.1. NM_144646.3.
UniGene	Hs.643431. Hs.715953.
3D structure databases
ProteinModelPortal	P01591.
ModBase	Search...
Protein-protein interaction databases
IntAct	P01591. 2 interactions.
STRING	9606.ENSP00000254801.
PTM databases
GlycoSuiteDB	P01591.
PhosphoSite	P01591.
2D gel databases
SWISS-2DPAGE	P01591.
Proteomic databases
PaxDb	P01591.
PRIDE	P01591.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000254801; ENSP00000254801; ENSG00000132465. ENST00000510437; ENSP00000426687; ENSG00000132465.
GeneID	3512.
KEGG	hsa:3512.
UCSC	uc003hfn.4. human.
Organism-specific databases
CTD	3512.
GeneCards	GC04M071478.
HGNC	HGNC:5713. IGJ.
HPA	CAB034436.
MIM	147790. gene.
neXtProt	NX_P01591.
PharmGKB	PA29733.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43056.
HOGENOM	HOG000113012.
HOVERGEN	HBG006138.
InParanoid	P01591.
OrthoDB	EOG42V8HH.
PhylomeDB	P01591.
Gene expression databases
ArrayExpress	P01591.
Bgee	P01591.
CleanEx	HS_IGJ.
Genevestigator	P01591.
GermOnline	ENSG00000132465. Homo sapiens.
Family and domain databases
InterPro	IPR024110. Ig_J. [Graphical view]
PANTHER	PTHR10070. PTHR10070. 1 hit.
ProDom	PD021296. PD021296. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
ChiTaRS	IGJ. human.
GenomeRNAi	3512.
NextBio	13774.
SOURCE	Search...

Entry information

Entry name

IGJ_HUMAN

Accession

Primary (citable) accession number: P01591

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	October 13, 2009
Last modified:	May 29, 2013
This is version 117 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.