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P01591

- IGJ_HUMAN

UniProt

P01591 - IGJ_HUMAN

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Protein

Immunoglobulin J chain

Gene
IGJ, IGCJ
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

GO - Molecular functioni

  1. antigen binding Source: UniProtKB
  2. IgA binding Source: UniProt
  3. protein homodimerization activity Source: UniProt

GO - Biological processi

  1. adaptive immune response Source: UniProt
  2. antibacterial humoral response Source: UniProt
  3. glomerular filtration Source: UniProt
  4. immune response Source: UniProtKB
  5. innate immune response Source: UniProt
  6. positive regulation of protein oligomerization Source: UniProt
  7. positive regulation of respiratory burst Source: UniProt
  8. retina homeostasis Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin J chain
Gene namesi
Name:IGJ
Synonyms:IGCJ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:5713. IGJ.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: UniProt
  2. dimeric IgA immunoglobulin complex Source: UniProt
  3. extracellular region Source: UniProtKB
  4. extracellular space Source: UniProt
  5. extracellular vesicular exosome Source: UniProt
  6. monomeric IgA immunoglobulin complex Source: UniProt
  7. pentameric IgM immunoglobulin complex Source: UniProt
  8. secretory dimeric IgA immunoglobulin complex Source: UniProt
  9. secretory IgA immunoglobulin complex Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29733.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 159137Immunoglobulin J chainPRO_0000084174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231Pyrrolidone carboxylic acid
Disulfide bondi35 ↔ 1231 Publication
Disulfide bondi37 – 37Interchain (with heavy chain)1 Publication
Glycosylationi71 – 711N-linked (GlcNAc...) (complex)6 PublicationsCAR_000167
Disulfide bondi91 – 91Interchain (with heavy chain)1 Publication
Disulfide bondi94 ↔ 1141 Publication
Disulfide bondi131 ↔ 1561 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP01591.
PaxDbiP01591.
PRIDEiP01591.

2D gel databases

SWISS-2DPAGEP01591.

PTM databases

PhosphoSiteiP01591.
UniCarbKBiP01591.

Expressioni

Gene expression databases

ArrayExpressiP01591.
BgeeiP01591.
CleanExiHS_IGJ.
GenevestigatoriP01591.

Organism-specific databases

HPAiCAB034436.

Interactioni

Protein-protein interaction databases

BioGridi109732. 1 interaction.
IntActiP01591. 2 interactions.
STRINGi9606.ENSP00000254801.

Structurei

3D structure databases

ProteinModelPortaliP01591.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43056.
HOGENOMiHOG000113012.
HOVERGENiHBG006138.
InParanoidiP01591.
OrthoDBiEOG7G1V7R.
PhylomeDBiP01591.
TreeFamiTF335878.

Family and domain databases

InterProiIPR024110. Ig_J.
[Graphical view]
PANTHERiPTHR10070. PTHR10070. 1 hit.
PfamiPF15097. Ig_J_chain. 1 hit.
[Graphical view]
ProDomiPD021296. PD021296. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01591-1 [UniParc]FASTAAdd to Basket

« Hide

MKNHLLFWGV LAVFIKAVHV KAQEDERIVL VDNKCKCARI TSRIIRSSED    50
PNEDIVERNI RIIVPLNNRE NISDPTSPLR TRFVYHLSDL CKKCDPTEVE 100
LDNQIVTATQ SNICDEDSAT ETCYTYDRNK CYTAVVPLVY GGETKMVETA 150
LTPDACYPD 159
Length:159
Mass (Da):18,099
Last modified:October 13, 2009 - v4
Checksum:iB7835C02CCC0CB05
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK312014 mRNA. Translation: BAG34952.1.
M12759, M12378 Genomic DNA. Translation: AAA58902.1.
CCDSiCCDS3545.1.
PIRiA01859. JIHU.
RefSeqiNP_653247.1. NM_144646.3.
XP_006714274.1. XM_006714211.1.
XP_006714275.1. XM_006714212.1.
UniGeneiHs.643431.

Genome annotation databases

EnsembliENST00000254801; ENSP00000254801; ENSG00000132465.
ENST00000510437; ENSP00000426687; ENSG00000132465.
GeneIDi3512.
KEGGihsa:3512.
UCSCiuc003hfn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK312014 mRNA. Translation: BAG34952.1 .
M12759 , M12378 Genomic DNA. Translation: AAA58902.1 .
CCDSi CCDS3545.1.
PIRi A01859. JIHU.
RefSeqi NP_653247.1. NM_144646.3.
XP_006714274.1. XM_006714211.1.
XP_006714275.1. XM_006714212.1.
UniGenei Hs.643431.

3D structure databases

ProteinModelPortali P01591.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109732. 1 interaction.
IntActi P01591. 2 interactions.
STRINGi 9606.ENSP00000254801.

PTM databases

PhosphoSitei P01591.
UniCarbKBi P01591.

2D gel databases

SWISS-2DPAGE P01591.

Proteomic databases

MaxQBi P01591.
PaxDbi P01591.
PRIDEi P01591.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254801 ; ENSP00000254801 ; ENSG00000132465 .
ENST00000510437 ; ENSP00000426687 ; ENSG00000132465 .
GeneIDi 3512.
KEGGi hsa:3512.
UCSCi uc003hfn.4. human.

Organism-specific databases

CTDi 3512.
GeneCardsi GC04M071478.
HGNCi HGNC:5713. IGJ.
HPAi CAB034436.
MIMi 147790. gene.
neXtProti NX_P01591.
PharmGKBi PA29733.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43056.
HOGENOMi HOG000113012.
HOVERGENi HBG006138.
InParanoidi P01591.
OrthoDBi EOG7G1V7R.
PhylomeDBi P01591.
TreeFami TF335878.

Miscellaneous databases

ChiTaRSi IGJ. human.
GeneWikii IGJ.
GenomeRNAii 3512.
NextBioi 13774.
PROi P01591.
SOURCEi Search...

Gene expression databases

ArrayExpressi P01591.
Bgeei P01591.
CleanExi HS_IGJ.
Genevestigatori P01591.

Family and domain databases

InterProi IPR024110. Ig_J.
[Graphical view ]
PANTHERi PTHR10070. PTHR10070. 1 hit.
Pfami PF15097. Ig_J_chain. 1 hit.
[Graphical view ]
ProDomi PD021296. PD021296. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  2. "Primary structure of human J chain: alignment of peptides from chemical and enzymatic hydrolyses."
    Mole J.E., Bhown A.S., Bennett J.C.
    Biochemistry 16:3507-3513(1977) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PROTEIN SEQUENCE OF 23-159, PYROGLUTAMATE FORMATION AT GLN-23.
  3. "Human J chain gene. Structure and expression in B lymphoid cells."
    Max E.E., Korsmeyer S.J.
    J. Exp. Med. 161:832-849(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-159.
  4. "Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M."
    Frutiger S., Hughes G.J., Paquet N., Luethy R., Jaton J.-C.
    Biochemistry 31:12643-12647(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS, PARTIAL PROTEIN SEQUENCE.
  5. Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
    Tissue: Bile.
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
    Tissue: Plasma.
  7. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
    Tissue: Saliva.
  8. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
    Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
    Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
    Tissue: Milk.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71.
    Tissue: Liver.
  10. Cited for: GLYCOSYLATION AT ASN-71.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIGJ_HUMAN
AccessioniPrimary (citable) accession number: P01591
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 13, 2009
Last modified: July 9, 2014
This is version 127 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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