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Protein

Interleukin-2 receptor subunit alpha

Gene

Il2ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.By similarity

GO - Molecular functioni

  • drug binding Source: Ensembl
  • interleukin-2 receptor activity Source: MGI

GO - Biological processi

  • activation-induced cell death of T cells Source: MGI
  • inflammatory response to antigenic stimulus Source: Ensembl
  • interleukin-2-mediated signaling pathway Source: GOC
  • negative regulation of defense response to virus Source: Ensembl
  • negative regulation of immune response Source: Ensembl
  • negative regulation of inflammatory response Source: MGI
  • negative regulation of lymphocyte proliferation Source: MGI
  • negative regulation of T cell proliferation Source: MGI
  • Notch signaling pathway Source: MGI
  • positive regulation of activated T cell proliferation Source: MGI
  • positive regulation of T cell differentiation Source: Ensembl
  • regulation of T cell homeostatic proliferation Source: MGI
  • regulation of T cell tolerance induction Source: MGI
  • T cell homeostasis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-451927. Interleukin-2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-912526. Interleukin receptor SHC signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit alpha
Short name:
IL-2 receptor subunit alpha
Short name:
IL-2-RA
Short name:
IL-2R subunit alpha
Short name:
IL2-RA
Alternative name(s):
p55
CD_antigen: CD25
Gene namesi
Name:Il2ra
Synonyms:Il2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96549. Il2ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 236215ExtracellularSequence analysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence analysisAdd
BLAST
Topological domaini258 – 26811CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3287.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 268247Interleukin-2 receptor subunit alphaPRO_0000011026Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 66PROSITE-ProRule annotation
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi49 ↔ 75PROSITE-ProRule annotation
Disulfide bondi51 ↔ 77PROSITE-ProRule annotation
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence analysis
Disulfide bondi121 ↔ 164PROSITE-ProRule annotation
Disulfide bondi148 ↔ 180PROSITE-ProRule annotation
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP01590.
PaxDbiP01590.
PRIDEiP01590.

PTM databases

PhosphoSiteiP01590.

Expressioni

Gene expression databases

BgeeiP01590.
CleanExiMM_IL2RA.
ExpressionAtlasiP01590. baseline and differential.
GenevisibleiP01590. MM.

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028111.

Chemistry

BindingDBiP01590.

Structurei

3D structure databases

ProteinModelPortaliP01590.
SMRiP01590. Positions 22-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 7958Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini119 – 18264Sushi 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J24B. Eukaryota.
ENOG41116U7. LUCA.
HOGENOMiHOG000113044.
HOVERGENiHBG052109.
InParanoidiP01590.
KOiK05068.
OMAiCQAELCD.
OrthoDBiEOG7S21ZH.
PhylomeDBiP01590.
TreeFamiTF337408.

Family and domain databases

InterProiIPR015486. IL-2_rcpt_alpha.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR10573. PTHR10573. 1 hit.
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 2 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 2 hits.
PROSITEiPS50923. SUSHI. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPRLLMLGF LSLTIVPSCR AELCLYDPPE VPNATFKALS YKNGTILNCE
60 70 80 90 100
CKRGFRRLKE LVYMRCLGNS WSSNCQCTSN SHDKSRKQVT AQLEHQKEQQ
110 120 130 140 150
TTTDMQKPTQ SMHQENLTGH CREPPPWKHE DSKRIYHFVE GQSVHYECIP
160 170 180 190 200
GYKALQRGPA ISICKMKCGK TGWTQPQLTC VDEREHHRFL ASEESQGSRN
210 220 230 240 250
SSPESETSCP ITTTDFPQPT ETTAMTETFV LTMEYKVAVA SCLFLLISIL
260
LLSGLTWQHR WRKSRRTI
Length:268
Mass (Da):30,723
Last modified:July 21, 1986 - v1
Checksum:i20C8F712B719192D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 44MEPR → MCQEDGAT in AAA39290 (Ref. 3) Curated
Sequence conflicti7 – 71M → T in AAA39282 (PubMed:2987826).Curated
Sequence conflicti118 – 1181T → A in AAA39282 (PubMed:2987826).Curated
Sequence conflicti140 – 1401E → V in AAA39282 (PubMed:2987826).Curated
Sequence conflicti216 – 2161F → L in AAA39282 (PubMed:2987826).Curated
Sequence conflicti227 – 2271E → V in AAA39282 (PubMed:2987826).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02891 mRNA. Translation: AAA39285.1.
M30856 mRNA. Translation: AAA39282.1.
M54934 mRNA. Translation: AAA39290.1.
M21977 mRNA. Translation: AAA39288.1.
M21978 mRNA. Translation: AAA39287.1.
CCDSiCCDS15685.1.
PIRiA01857. UHMS2.
RefSeqiNP_032393.3. NM_008367.3.
UniGeneiMm.915.

Genome annotation databases

EnsembliENSMUST00000028111; ENSMUSP00000028111; ENSMUSG00000026770.
GeneIDi16184.
KEGGimmu:16184.
UCSCiuc008iiq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02891 mRNA. Translation: AAA39285.1.
M30856 mRNA. Translation: AAA39282.1.
M54934 mRNA. Translation: AAA39290.1.
M21977 mRNA. Translation: AAA39288.1.
M21978 mRNA. Translation: AAA39287.1.
CCDSiCCDS15685.1.
PIRiA01857. UHMS2.
RefSeqiNP_032393.3. NM_008367.3.
UniGeneiMm.915.

3D structure databases

ProteinModelPortaliP01590.
SMRiP01590. Positions 22-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028111.

Chemistry

BindingDBiP01590.
ChEMBLiCHEMBL3287.

PTM databases

PhosphoSiteiP01590.

Proteomic databases

EPDiP01590.
PaxDbiP01590.
PRIDEiP01590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028111; ENSMUSP00000028111; ENSMUSG00000026770.
GeneIDi16184.
KEGGimmu:16184.
UCSCiuc008iiq.2. mouse.

Organism-specific databases

CTDi3559.
MGIiMGI:96549. Il2ra.

Phylogenomic databases

eggNOGiENOG410J24B. Eukaryota.
ENOG41116U7. LUCA.
HOGENOMiHOG000113044.
HOVERGENiHBG052109.
InParanoidiP01590.
KOiK05068.
OMAiCQAELCD.
OrthoDBiEOG7S21ZH.
PhylomeDBiP01590.
TreeFamiTF337408.

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-451927. Interleukin-2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-912526. Interleukin receptor SHC signaling.

Miscellaneous databases

ChiTaRSiIl2ra. mouse.
NextBioi289073.
PROiP01590.
SOURCEiSearch...

Gene expression databases

BgeeiP01590.
CleanExiMM_IL2RA.
ExpressionAtlasiP01590. baseline and differential.
GenevisibleiP01590. MM.

Family and domain databases

InterProiIPR015486. IL-2_rcpt_alpha.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR10573. PTHR10573. 1 hit.
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 2 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 2 hits.
PROSITEiPS50923. SUSHI. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA."
    Miller J., Malek T.R., Leonard W.J., Greene W.C., Shevach E.M., Germain R.N.
    J. Immunol. 134:4212-4217(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence."
    Shimuzu A., Kondo S., Takeda S., Yodoi J., Ishida N., Sabe H., Osawa H., Diamantstein T., Nikaido T., Honjo T.
    Nucleic Acids Res. 13:1505-1516(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Recombinant lymphokines and their receptors: molecular analysis for the murine interleukin-2 receptor."
    McKereghan K.N., Alpert A.R., Grabstein K.H., Cosman D., Cerretti D.P.
    Immunol. Ser. 35:109-123(1987)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "p55 IL-2 receptor mRNA precursors in murine T lymphocyte nuclei."
    Froussard P., Chastagner P., Somme G., Abadie A., Greene W., Theze J., Longacre S.
    J. Immunol. 141:1358-1364(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-21.

Entry informationi

Entry nameiIL2RA_MOUSE
AccessioniPrimary (citable) accession number: P01590
Secondary accession number(s): Q61731
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 11, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.