Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-2 receptor subunit alpha

Gene

IL2RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134460-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-451927. Interleukin-2 signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-912526. Interleukin receptor SHC signaling.
SIGNORiP01589.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit alpha
Short name:
IL-2 receptor subunit alpha
Short name:
IL-2-RA
Short name:
IL-2R subunit alpha
Short name:
IL2-RA
Alternative name(s):
TAC antigen
p55
CD_antigen: CD25
Gene namesi
Name:IL2RA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:6008. IL2RA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 240ExtracellularSequence analysisAdd BLAST219
Transmembranei241 – 259HelicalSequence analysisAdd BLAST19
Topological domaini260 – 272CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Diabetes mellitus, insulin-dependent, 10 (IDDM10)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:601942
Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions.
See also OMIM:606367
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07464141Y → S in IMD41. 1 PublicationCorresponds to variant rs796051888dbSNPEnsembl.1
Natural variantiVAR_074642166S → N in IMD41; the receptor does not localize to the plasma membrane. 1 PublicationCorresponds to variant rs796051887dbSNPEnsembl.1

Keywords - Diseasei

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNETi3559.
MalaCardsiIL2RA.
MIMi601942. phenotype.
606367. phenotype.
OpenTargetsiENSG00000134460.
Orphaneti169100. Immunodeficiency due to CD25 deficiency.
85408. Juvenile rheumatoid factor-negative polyarthritis.
85410. Oligoarticular juvenile arthritis.
PharmGKBiPA29828.

Chemistry databases

ChEMBLiCHEMBL1778.
DrugBankiDB00041. Aldesleukin.
DB00074. Basiliximab.
DB00111. Daclizumab.
DB00004. Denileukin diftitox.
GuidetoPHARMACOLOGYi1695.

Polymorphism and mutation databases

BioMutaiIL2RA.
DMDMi124317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001102422 – 272Interleukin-2 receptor subunit alphaAdd BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 168
Disulfide bondi49 ↔ 80
Disulfide bondi51 ↔ 82
Disulfide bondi67 ↔ 125
Glycosylationi70N-linked (GlcNAc...)1 Publication1
Glycosylationi89N-linked (GlcNAc...)1 Publication1
Disulfide bondi152 ↔ 184
Glycosylationi218O-linked (GalNAc...)1 Publication1
Glycosylationi224O-linked (GalNAc...)1 Publication1
Glycosylationi229O-linked (GalNAc...)1 Publication1
Glycosylationi237O-linked (GalNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01589.
PeptideAtlasiP01589.
PRIDEiP01589.

PTM databases

iPTMnetiP01589.
PhosphoSitePlusiP01589.

Expressioni

Gene expression databases

BgeeiENSG00000134460.
CleanExiHS_IL2RA.
ExpressionAtlasiP01589. baseline and differential.
GenevisibleiP01589. HS.

Organism-specific databases

HPAiCAB002419.
HPA054622.

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109774. 4 interactors.
DIPiDIP-1080N.
IntActiP01589. 2 interactors.
MINTiMINT-8146732.
STRINGi9606.ENSP00000369293.

Chemistry databases

BindingDBiP01589.

Structurei

Secondary structure

1272
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 37Combined sources4
Beta strandi39 – 41Combined sources3
Beta strandi46 – 48Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi63 – 67Combined sources5
Beta strandi74 – 77Combined sources4
Beta strandi82 – 84Combined sources3
Beta strandi135 – 137Combined sources3
Beta strandi143 – 145Combined sources3
Beta strandi147 – 152Combined sources6
Beta strandi157 – 162Combined sources6
Beta strandi164 – 170Combined sources7
Beta strandi172 – 174Combined sources3
Beta strandi175 – 177Combined sources3
Beta strandi182 – 185Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILMmodel-A23-83[»]
1ILNmodel-A23-83[»]
1Z92X-ray2.80B22-238[»]
2B5IX-ray2.30D22-238[»]
2ERJX-ray3.00A/E22-233[»]
3IU3X-ray2.90I/J/K22-238[»]
3NFPX-ray2.86I/K22-238[»]
ProteinModelPortaliP01589.
SMRiP01589.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01589.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 84Sushi 1PROSITE-ProRule annotationAdd BLAST63
Domaini123 – 186Sushi 2PROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J24B. Eukaryota.
ENOG41116U7. LUCA.
GeneTreeiENSGT00390000018872.
HOGENOMiHOG000113044.
HOVERGENiHBG052109.
InParanoidiP01589.
KOiK05068.
OMAiCQAELCD.
OrthoDBiEOG091G0NHH.
PhylomeDBiP01589.
TreeFamiTF337408.

Family and domain databases

CDDicd00033. CCP. 1 hit.
InterProiIPR015486. IL-2_rcpt_alpha.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR10573. PTHR10573. 1 hit.
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 2 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 2 hits.
PROSITEiPS50923. SUSHI. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE
60 70 80 90 100
CKRGFRRIKS GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE
110 120 130 140 150
QKERKTTEMQ SPMQPVDQAS LPGHCREPPP WENEATERIY HFVVGQMVYY
160 170 180 190 200
QCVQGYRALH RGPAESVCKM THGKTRWTQP QLICTGEMET SQFPGEEKPQ
210 220 230 240 250
ASPEGRPESE TSCLVTTTDF QIQTEMAATM ETSIFTTEYQ VAVAGCVFLL
260 270
ISVLLLSGLT WQRRQRKSRR TI
Length:272
Mass (Da):30,819
Last modified:July 21, 1986 - v1
Checksum:i83D907C8C81D2C0E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07464141Y → S in IMD41. 1 PublicationCorresponds to variant rs796051888dbSNPEnsembl.1
Natural variantiVAR_074642166S → N in IMD41; the receptor does not localize to the plasma membrane. 1 PublicationCorresponds to variant rs796051887dbSNPEnsembl.1
Natural variantiVAR_019280272I → T.1 PublicationCorresponds to variant rs12722712dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01057 mRNA. Translation: CAA25525.1.
X03131
, X03132, X03133, X03134, X03135, X03136, X03137, X03138 Genomic DNA. Translation: CAA26906.1.
K03122 mRNA. Translation: AAB59535.1. Sequence problems.
M11066
, M10322, M11060, M11061, M11062, M11063, M11064, M11065 Genomic DNA. Translation: AAA67527.1.
AY563103 Genomic DNA. Translation: AAS55572.1.
AL157395, AL137186 Genomic DNA. Translation: CAH73595.1.
AL137186, AL157395 Genomic DNA. Translation: CAI41069.1.
CH471072 Genomic DNA. Translation: EAW86414.1.
M15864 Genomic DNA. Translation: AAA59162.1.
BN000945 Genomic DNA. Translation: CAK26553.1.
CCDSiCCDS7076.1.
PIRiA44186. UHHU2.
RefSeqiNP_000408.1. NM_000417.2.
NP_001295171.1. NM_001308242.1.
NP_001295172.1. NM_001308243.1.
UniGeneiHs.231367.

Genome annotation databases

EnsembliENST00000379959; ENSP00000369293; ENSG00000134460.
GeneIDi3559.
KEGGihsa:3559.
UCSCiuc001iiz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

IL2RAbase

IL2RA mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01057 mRNA. Translation: CAA25525.1.
X03131
, X03132, X03133, X03134, X03135, X03136, X03137, X03138 Genomic DNA. Translation: CAA26906.1.
K03122 mRNA. Translation: AAB59535.1. Sequence problems.
M11066
, M10322, M11060, M11061, M11062, M11063, M11064, M11065 Genomic DNA. Translation: AAA67527.1.
AY563103 Genomic DNA. Translation: AAS55572.1.
AL157395, AL137186 Genomic DNA. Translation: CAH73595.1.
AL137186, AL157395 Genomic DNA. Translation: CAI41069.1.
CH471072 Genomic DNA. Translation: EAW86414.1.
M15864 Genomic DNA. Translation: AAA59162.1.
BN000945 Genomic DNA. Translation: CAK26553.1.
CCDSiCCDS7076.1.
PIRiA44186. UHHU2.
RefSeqiNP_000408.1. NM_000417.2.
NP_001295171.1. NM_001308242.1.
NP_001295172.1. NM_001308243.1.
UniGeneiHs.231367.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILMmodel-A23-83[»]
1ILNmodel-A23-83[»]
1Z92X-ray2.80B22-238[»]
2B5IX-ray2.30D22-238[»]
2ERJX-ray3.00A/E22-233[»]
3IU3X-ray2.90I/J/K22-238[»]
3NFPX-ray2.86I/K22-238[»]
ProteinModelPortaliP01589.
SMRiP01589.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109774. 4 interactors.
DIPiDIP-1080N.
IntActiP01589. 2 interactors.
MINTiMINT-8146732.
STRINGi9606.ENSP00000369293.

Chemistry databases

BindingDBiP01589.
ChEMBLiCHEMBL1778.
DrugBankiDB00041. Aldesleukin.
DB00074. Basiliximab.
DB00111. Daclizumab.
DB00004. Denileukin diftitox.
GuidetoPHARMACOLOGYi1695.

PTM databases

iPTMnetiP01589.
PhosphoSitePlusiP01589.

Polymorphism and mutation databases

BioMutaiIL2RA.
DMDMi124317.

Proteomic databases

PaxDbiP01589.
PeptideAtlasiP01589.
PRIDEiP01589.

Protocols and materials databases

DNASUi3559.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379959; ENSP00000369293; ENSG00000134460.
GeneIDi3559.
KEGGihsa:3559.
UCSCiuc001iiz.3. human.

Organism-specific databases

CTDi3559.
DisGeNETi3559.
GeneCardsiIL2RA.
HGNCiHGNC:6008. IL2RA.
HPAiCAB002419.
HPA054622.
MalaCardsiIL2RA.
MIMi147730. gene.
601942. phenotype.
606367. phenotype.
neXtProtiNX_P01589.
OpenTargetsiENSG00000134460.
Orphaneti169100. Immunodeficiency due to CD25 deficiency.
85408. Juvenile rheumatoid factor-negative polyarthritis.
85410. Oligoarticular juvenile arthritis.
PharmGKBiPA29828.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J24B. Eukaryota.
ENOG41116U7. LUCA.
GeneTreeiENSGT00390000018872.
HOGENOMiHOG000113044.
HOVERGENiHBG052109.
InParanoidiP01589.
KOiK05068.
OMAiCQAELCD.
OrthoDBiEOG091G0NHH.
PhylomeDBiP01589.
TreeFamiTF337408.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134460-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-451927. Interleukin-2 signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-912526. Interleukin receptor SHC signaling.
SIGNORiP01589.

Miscellaneous databases

EvolutionaryTraceiP01589.
GeneWikiiIL2RA.
GenomeRNAii3559.
PROiP01589.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134460.
CleanExiHS_IL2RA.
ExpressionAtlasiP01589. baseline and differential.
GenevisibleiP01589. HS.

Family and domain databases

CDDicd00033. CCP. 1 hit.
InterProiIPR015486. IL-2_rcpt_alpha.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR10573. PTHR10573. 1 hit.
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 2 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 2 hits.
PROSITEiPS50923. SUSHI. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL2RA_HUMAN
AccessioniPrimary (citable) accession number: P01589
Secondary accession number(s): Q5W007
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 183 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.