Reviewed, UniProtKB/Swiss-Prot P01589 (IL2RA_HUMAN)

Names and origin

Protein names

Recommended name:
    Interleukin-2 receptor alpha chain
      Short name=IL-2 receptor alpha subunit
      Short name=IL-2-RA
      Short name=IL2-RA
Alternative name(s):
    p55
    TAC antigen
    CD_antigen=CD25

Gene names

Name:

IL2RA

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor for interleukin-2.
Subunit structure	Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain.
Subcellular location	Membrane; Single-pass type I membrane protein.
Involvement in disease	Genetic variations in IL2RA are associated with susceptibility to insulin-dependent diabetes mellitus type 10 (IDDM10) [MIM:601942].
Sequence similarities	Contains 2 Sushi (CCP/SCR) domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Sushi Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	cell proliferation Traceable author statement. Source: ProtInc cell surface receptor linked signal transduction Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	interleukin-2 receptor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

21

Chain

22 – 272

251

Interleukin-2 receptor alpha chain

PRO_0000011024

Regions

Topological domain

22 – 240

219

Extracellular Potential

Transmembrane

241 – 259

19

Potential

Topological domain

260 – 272

13

Cytoplasmic Potential

Domain

22 – 84

63

Sushi 1

Domain

123 – 186

64

Sushi 2

Amino acid modifications

Glycosylation

70

1

N-linked (GlcNAc...) Ref.9

Glycosylation

89

1

N-linked (GlcNAc...) Ref.9

Glycosylation

218

1

O-linked (GalNAc...) Ref.9

Glycosylation

224

1

O-linked (GalNAc...) Ref.9

Glycosylation

229

1

O-linked (GalNAc...) Ref.9

Glycosylation

237

1

O-linked (GalNAc...) Ref.9

Disulfide bond

24 ↔ 168

Ref.9 Ref.11 Ref.12

Disulfide bond

49 ↔ 80

Ref.9 Ref.11 Ref.12

Disulfide bond

51 ↔ 82

Ref.9 Ref.11 Ref.12

Disulfide bond

67 ↔ 125

Ref.9 Ref.11 Ref.12

Disulfide bond

152 ↔ 184

Ref.9 Ref.11 Ref.12

Natural variations

Natural variant

272

1

I → T: dbSNP rs12722712. Ref.5

VAR_019280

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

272

Helix Strand Turn

Details...

Beta strand

34 – 37

4

Beta strand

39 – 41

3

Beta strand

46 – 48

3

Beta strand

55 – 57

3

Beta strand

63 – 67

5

Beta strand

82 – 84

3

Beta strand

147 – 152

6

Beta strand

157 – 162

6

Beta strand

164 – 170

7

Beta strand

175 – 177

3

Beta strand

182 – 185

4

Sequences

	Sequence		Length	Mass (Da)
	P01589-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 83D907C8C81D2C0E	FASTA	272	30,819
	10 20 30 40 50 60 MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE CKRGFRRIKS 70 80 90 100 110 120 GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE QKERKTTEMQ SPMQPVDQAS 130 140 150 160 170 180 LPGHCREPPP WENEATERIY HFVVGQMVYY QCVQGYRALH RGPAESVCKM THGKTRWTQP 190 200 210 220 230 240 QLICTGEMET SQFPGEEKPQ ASPEGRPESE TSCLVTTTDF QIQTEMAATM ETSIFTTEYQ 250 260 270 VAVAGCVFLL ISVLLLSGLT WQRRQRKSRR TI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of cDNA encoding human interleukin-2 receptor." Nikaido T., Shimizu A., Ishida N., Sabe H., Teshigawara K., Maeda M., Uchiyama T., Yodoi J., Honjo T. Nature 311:631-635(1984) [PubMed: 6090949] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning and expression of cDNAs for the human interleukin-2 receptor." Leonard W.J., Depper J.M., Crabtree G.R., Rudikoff S., Pumphrey J., Robb R.J., Kroenke M., Svetlik P.B., Peffer N.J., Waldmann T.A., Greene W.C. Nature 311:626-631(1984) [PubMed: 6090948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Molecular cloning and structure of the human interleukin 2 receptor gene." Ishida N., Kanamori H., Noma T., Nikaido T., Sabe H., Suzuki N., Shimizu A., Honjo T. Nucleic Acids Res. 13:7579-7589(1985) [PubMed: 2999698] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Structure of the human interleukin-2 receptor gene." Leonard W.J., Depper J.M., Kanehisa M., Kroenke M., Peffer N.J., Svetlik P.B., Sullivan M., Greene W.C. Science 230:633-639(1985) [PubMed: 2996141] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	SeattleSNPs variation discovery resource Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-272.
[6]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I." Cross S.L., Feinberg M.B., Wolf J.B., Holbrook N.J., Wong-Stall F., Leonard W.J. Cell 49:47-56(1987) [PubMed: 3030566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
[9]	"Structural analysis of recombinant soluble human interleukin-2 receptor. Primary structure, assignment of disulfide bonds and core IL-2 binding structure." Miedel M.C., Hulmes J.D., Weber D.V., Bailon P., Pan Y.C. Biochem. Biophys. Res. Commun. 154:372-379(1988) [PubMed: 3134887] [Abstract] Cited for: DISULFIDE BONDS, GLYCOSYLATION AT ASN-70; ASN-89; THR-218; THR-224; THR-229 AND THR-237.
[10]	"The interleukin-2 and interleukin-4 receptors studied by molecular modelling." Bamborough P., Hedgecock C.J., Richards W.G. Structure 2:839-851(1994) [PubMed: 7529123] [Abstract] Cited for: 3D-STRUCTURE MODELING OF 23-83.
[11]	"Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors." Wang X., Rickert M., Garcia K.C. Science 310:1159-1163(2005) [PubMed: 16293754] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 22-238 IN COMPLEX WITH IL2; IL2RB AND IL2RC, DISULFIDE BONDS.
[12]	"Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor." Stauber D.J., Debler E.W., Horton P.A., Smith K.A., Wilson I.A. Proc. Natl. Acad. Sci. U.S.A. 103:2788-2793(2006) [PubMed: 16477002] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-233 IN COMPLEX WITH IL2; IL2RB AND IL2RC, DISULFIDE BONDS.
[13]	"Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes." Lowe C.E., Cooper J.D., Brusko T., Walker N.M., Smyth D.J., Bailey R., Bourget K., Plagnol V., Field S., Atkinson M., Clayton D.G., Wicker L.S., Todd J.A. Nat. Genet. 39:1074-1082(2007) [PubMed: 17676041] [Abstract] Cited for: INVOLVEMENT IN NIDDM10.
+	Additional computationally mapped references.

Web resources

IL2RAbase

IL2RA mutation db

SeattleSNPs

Cross-references

Sequence databases

EMBLGenBankDDBJ

X01057 mRNA. Translation: CAA25525.1.
X03131 , X03132, X03133, X03134, X03135, X03136, X03137, X03138 Genomic DNA. Translation: CAA26906.1.
K03122 mRNA. Translation: AAB59535.1. Sequence problems.
M11066 , M10322, M11060, M11061, M11062, M11063, M11064, M11065 Genomic DNA. Translation: AAA67527.1.
AY563103 Genomic DNA. Translation: AAS55572.1.
AL157395, AL137186 Genomic DNA. Translation: CAH73595.1.
AL137186, AL157395 Genomic DNA. Translation: CAI41069.1.
CH471072 Genomic DNA. Translation: EAW86414.1.
M15864 Genomic DNA. Translation: AAA59162.1.
BN000945 Genomic DNA. Translation: CAK26553.1.

IPI

IPI00003101.

PIR

UHHU2. A44186.

RefSeq

NP_000408.1.

UniGene

Hs.231367

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ILM	model	-	A	23-83	[»]
1ILN	model	-	A	23-83	[»]
1Z92	X-ray	2.80	B	22-238	[»]
2B5I	X-ray	2.30	D	22-238	[»]
2ERJ	X-ray	3.00	A/E	22-233	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-1080N.

STRING

P01589.

PTM databases

PhosphoSite

P01589.

Proteomic databases

PRIDE

P01589.

Genome annotation databases

Ensembl

ENST00000379959; ENSP00000369293; ENSG00000134460; Homo sapiens. [Genome view]

GeneID

3559.

KEGG

hsa:3559.

UCSC

uc001iiz.1. human.

Organism-specific databases

CTD

3559.

GeneCards

GC10M006093.

H-InvDB

HIX0035309.

HGNC

HGNC:6008. IL2RA.

HPA

CAB002419.

MIM

147730. gene.
601942. phenotype.
606367. phenotype.

Orphanet

101972. Combined T and B cell immunodeficiency.

PharmGKB

PA29828.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

HBG125998.

HOVERGEN

P01589.

InParanoid

P01589.

OMA

TMLNCEC.

Enzyme and pathway databases

Pathway_Interaction_DB

arf6_traffickingpathway. Arf6 trafficking events.
nfat_tfpathway. Calcineurin-regulated NFAT-dependent transcription in lymphocytes.
tcrcalciumpathway. Calcium signaling in the CD4+ TCR pathway.
cd8tcrdownstreampathway. Downstream signaling in naive CD8+ T cells.
il12_stat4pathway. IL12 signaling mediated by STAT4.
il12_2pathway. IL12-mediated signaling events.
il2_pi3kpathway. IL2 signaling events mediated by PI3K.
il2_stat5pathway. IL2 signaling events mediated by STAT5.
il2_1pathway. IL2-mediated signaling events.

Gene expression databases

ArrayExpress

P01589.

Bgee

P01589.

CleanEx

HS_IL2RA.

Genevestigator

P01589.

GermOnline

ENSG00000134460. Homo sapiens.

Family and domain databases

InterPro

IPR016060. Complement_control_module.
IPR015486. IL-2_recpt_a.
IPR000436. Sushi_SCR_CCP.
[Graphical view]

Gene3D

G3DSA:2.10.70.10. Complement_control_module. 1 hit.

PANTHER

PTHR10573. IL-2_recpt_a. 1 hit.

Pfam

PF00084. Sushi. 2 hits.
[Graphical view]

SMART

SM00032. CCP. 2 hits.
[Graphical view]

PROSITE

PS50923. SUSHI. 2 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

DrugBank

DB00041. Aldesleukin.
DB00074. Basiliximab.
DB00111. Daclizumab.
DB00004. Denileukin diftitox.

NextBio

13900.

SOURCE

Search...

Entry information

Entry name

IL2RA_HUMAN

Accession

Primary (citable) accession number: P01589
Secondary accession number(s): Q5W007

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	December 15, 2009
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.