##gff-version 3
P01588	UniProtKB	Signal peptide	1	27	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3949763;Dbxref=PMID:3949763	
P01588	UniProtKB	Chain	28	193	.	.	.	ID=PRO_0000008401;Note=Erythropoietin	
P01588	UniProtKB	Glycosylation	51	51	.	.	.	ID=CAR_000052;Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3949763;Dbxref=PMID:3949763	
P01588	UniProtKB	Glycosylation	65	65	.	.	.	ID=CAR_000166;Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3949763;Dbxref=PMID:3949763	
P01588	UniProtKB	Glycosylation	110	110	.	.	.	ID=CAR_000192;Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3949763;Dbxref=PMID:3949763	
P01588	UniProtKB	Glycosylation	153	153	.	.	.	Note=O-linked (GalNAc...) serine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3949763;Dbxref=PMID:3949763	
P01588	UniProtKB	Disulfide bond	34	188	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3949763;Dbxref=PMID:3949763	
P01588	UniProtKB	Disulfide bond	56	60	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3949763;Dbxref=PMID:3949763	
P01588	UniProtKB	Natural variant	70	70	.	.	.	ID=VAR_080573;Note=In ECYT5%3B uncertain significance. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27651169;Dbxref=dbSNP:rs62483572,PMID:27651169	
P01588	UniProtKB	Natural variant	84	84	.	.	.	ID=VAR_080574;Note=In ECYT5%3B uncertain significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27651169;Dbxref=dbSNP:rs137953994,PMID:27651169	
P01588	UniProtKB	Natural variant	99	99	.	.	.	ID=VAR_080575;Note=Found in a patient thought to have erythrocytosis%2C but had normal red cell mass%3B uncertain significance. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27651169;Dbxref=PMID:27651169	
P01588	UniProtKB	Natural variant	114	114	.	.	.	ID=VAR_080576;Note=In ECYT5%3B uncertain significance. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27651169;Dbxref=dbSNP:rs11976235,PMID:27651169	
P01588	UniProtKB	Natural variant	131	132	.	.	.	ID=VAR_009870;Note=In a hepatocellular carcinoma. SL->NF;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8396923;Dbxref=PMID:8396923	
P01588	UniProtKB	Natural variant	147	147	.	.	.	ID=VAR_080577;Note=In ECYT5%3B uncertain significance. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27651169;Dbxref=dbSNP:rs149431976,PMID:27651169	
P01588	UniProtKB	Natural variant	149	149	.	.	.	ID=VAR_009871;Note=In a hepatocellular carcinoma. P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8396923;Dbxref=PMID:8396923	
P01588	UniProtKB	Natural variant	177	177	.	.	.	ID=VAR_078447;Note=In DBAL%3B loss of support of normal erythroid expansion or differentiation%3B reduced ability to promote EPOR dimer formation upon binding%2C resulting in reduced JAK2 activation and decreased STAT1 and STAT3 phosphorylation%3B mild decrease in affinity for EPOR%3B no effect on STAT5A phosphorylation. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28283061;Dbxref=dbSNP:rs1358275550,PMID:28283061	
P01588	UniProtKB	Mutagenesis	127	127	.	.	.	Note=Decreased erythrocyte proliferation%3B impaired EPOR dimerization following binding. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28283061;Dbxref=PMID:28283061	
P01588	UniProtKB	Sequence conflict	40	40	.	.	.	Note=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P01588	UniProtKB	Sequence conflict	85	85	.	.	.	Note=Q->QQ;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P01588	UniProtKB	Sequence conflict	140	140	.	.	.	Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P01588	UniProtKB	Helix	32	34	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EER	
P01588	UniProtKB	Helix	36	52	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EER	
P01588	UniProtKB	Helix	53	55	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EER	
P01588	UniProtKB	Beta strand	57	60	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1BUY	
P01588	UniProtKB	Beta strand	61	68	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EER	
P01588	UniProtKB	Helix	75	78	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EER	
P01588	UniProtKB	Beta strand	79	81	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1BUY	
P01588	UniProtKB	Helix	83	109	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EER	
P01588	UniProtKB	Helix	118	138	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EER	
P01588	UniProtKB	Helix	141	147	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EER	
P01588	UniProtKB	Beta strand	160	164	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EER	
P01588	UniProtKB	Helix	165	177	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EER	
P01588	UniProtKB	Helix	179	188	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EER