P01583 (IL1A_HUMAN)
Reviewed,
UniProtKB/Swiss-Prot
Last modified
August 10, 2010.
Version 128.
History...
Names and origin
| Protein names | Recommended name: Interleukin-1 alpha Short name=IL-1 alpha Alternative name(s): Hematopoietin-1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 271 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. |
| Subunit structure | Monomer. |
| Subcellular location | Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. |
| Domain | The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. |
| Sequence similarities | Belongs to the IL-1 family. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CASP1 | P29466 | 3 | EBI-1749782,EBI-516667 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Propeptide | 1 – 112 | 112 | PRO_0000015265 | |||||||||||||||||||||||||||||||||
| Chain | 113 – 271 | 159 | Interleukin-1 alpha | PRO_0000015266 | ||||||||||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||||||||||
| Lipidation | 82 | 1 | N6-myristoyl lysine Ref.13 | |||||||||||||||||||||||||||||||||
| Lipidation | 83 | 1 | N6-myristoyl lysine Ref.13 | |||||||||||||||||||||||||||||||||
| Glycosylation | 102 | 1 | N-linked (GlcNAc...) Potential | |||||||||||||||||||||||||||||||||
| Glycosylation | 141 | 1 | N-linked (GlcNAc...) Potential | |||||||||||||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||||||||||||
| Natural variant | 85 | 1 | R → Q. [dbSNP:rs3783531] Ref.10 | VAR_014304 | ||||||||||||||||||||||||||||||||
| Natural variant | 114 | 1 | A → S. [dbSNP:rs17561] Ref.10 Ref.3 Ref.4 | VAR_014305 | ||||||||||||||||||||||||||||||||
| Natural variant | 125 | 1 | N → D. [dbSNP:rs17562] | VAR_014600 | ||||||||||||||||||||||||||||||||
| Natural variant | 138 | 1 | D → N. [dbSNP:rs3783581] Ref.10 | VAR_014306 | ||||||||||||||||||||||||||||||||
| Natural variant | 176 | 1 | D → H. [dbSNP:rs1801715] | VAR_014601 | ||||||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||||||
| Beta strand | 124 – 138 | 15 | ||||||||||||||||||||||||||||||||||
| Beta strand | 143 – 146 | 4 | ||||||||||||||||||||||||||||||||||
| Beta strand | 152 – 155 | 4 | ||||||||||||||||||||||||||||||||||
| Turn | 161 – 162 | 2 | ||||||||||||||||||||||||||||||||||
| Beta strand | 166 – 172 | 7 | ||||||||||||||||||||||||||||||||||
| Beta strand | 181 – 186 | 6 | ||||||||||||||||||||||||||||||||||
| Beta strand | 191 – 194 | 4 | ||||||||||||||||||||||||||||||||||
| Beta strand | 203 – 206 | 4 | ||||||||||||||||||||||||||||||||||
| Helix | 216 – 221 | 6 | ||||||||||||||||||||||||||||||||||
| Beta strand | 222 – 228 | 7 | ||||||||||||||||||||||||||||||||||
| Turn | 229 – 230 | 2 | ||||||||||||||||||||||||||||||||||
| Beta strand | 231 – 236 | 6 | ||||||||||||||||||||||||||||||||||
| Turn | 240 – 241 | 2 | ||||||||||||||||||||||||||||||||||
| Turn | 258 – 259 | 2 | ||||||||||||||||||||||||||||||||||
| Beta strand | 264 – 267 | 4 | ||||||||||||||||||||||||||||||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs." March C.J., Mosley B., Larsen A., Cerretti D.P., Braedt G., Price V., Gillis S., Henney C.S., Kronheim S.R., Grabstein K., Conlon P.J., Hopp T.P., Cosman D. Nature 315:641-647(1985) [PubMed: 2989698] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Complete nucleotide sequence of the gene for human interleukin 1 alpha." Furutani Y., Notake M., Fukui T., Ohue M., Nomura H., Yamada M., Nakamura S. Nucleic Acids Res. 14:3167-3179(1986) [PubMed: 3486405] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor." Furutani Y., Notake M., Yamayoshi M., Yamagishi J., Nomura H., Ohue M., Furuta R., Fukui T., Yamada M., Nakamura S. Nucleic Acids Res. 13:5869-5882(1985) [PubMed: 2994016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-114. |
| [4] | "Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta." Kotenko S.V., Bulenkov M.T., Veiko V.P., Epishin S.M., Lomakin I.B., Emel'Yanov A.V., Kozlov A.P., Konusova V.G., Kotov A.Y., Kurbatova T.V., Reshetnikov V.L., Simbirtsev A.S., Ketlinskii S.A., Vinetskii Y.P. Dokl. Akad. Nauk SSSR 309:1005-1008(1989) [PubMed: 2635664] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-114. |
| [5] | "Recombinant human interleukin 1 alpha: purification and biological characterization." Gubler U., Chua A.O., Stern A.S., Hellmann C.P., Vitek M.P., Dechiara T.M., Benjamin W.R., Collier K.J., Dukovich M., Familletti P.C., Fiedler-Nagy C., Jenson J., Kaffka K., Kilian P.L., Stremlo D., Wittreich B.H., Woehle D., Mizel S.B., Lomedico P.T. J. Immunol. 136:2492-2497(1986) [PubMed: 3485152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [6] | "cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line." Nishida T., Nishino N., Takano M., Kawai K., Bando K., Masui Y., Nakai S., Hirai Y. Biochem. Biophys. Res. Commun. 143:345-352(1987) [PubMed: 3493774] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [7] | "A sequence-based map of the nine genes of the human interleukin-1 cluster." Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K. Genomics 79:718-725(2002) [PubMed: 11991722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [8] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [9] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [10] | SeattleSNPs variation discovery resource Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-85; SER-114 AND ASN-138. |
| [11] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [12] | "Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow." Zsebo K.M., Wypych J., Yuschenkoff V.N., Lu H., Hunt P., Dukes P.P., Langley K.E. Blood 71:962-968(1988) [PubMed: 3281727] [Abstract] Cited for: PROTEIN SEQUENCE OF 113-132. |
| [13] | "The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece." Stevenson F.T., Bursten S.L., Fanton C., Locksley R.M., Lovett D.H. Proc. Natl. Acad. Sci. U.S.A. 90:7245-7249(1993) [PubMed: 8346241] [Abstract] Cited for: MYRISTOYLATION AT LYS-82 AND LYS-83. |
| [14] | "Structure of interleukin 1 alpha at 2.7-A resolution." Graves B.J., Hatada M.H., Hendrickson W.A., Miller J.K., Madison V.S., Satow Y. Biochemistry 29:2679-2684(1990) [PubMed: 2346741] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS). |
| + | Additional computationally mapped references. |
Web resources
| Wikipedia Interleukin-1 entry |
| SeattleSNPs |
| SHMPD The Singapore human mutation and polymorphism database |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | X02531 mRNA. Translation: CAA26371.1. X03833 Genomic DNA. Translation: CAA27448.1. X02851 mRNA. Translation: CAA26604.1. X56086 mRNA. Translation: CAA39566.1. M28983 mRNA. Translation: AAA59134.1. M15329 mRNA. Translation: AAA59133.1. BN000002 Genomic DNA. Translation: CAD29871.1. BT007014 mRNA. Translation: AAP35660.1. CR457414 mRNA. Translation: CAG33695.1. AF536338 Genomic DNA. Translation: AAM96189.1. BC013142 mRNA. Translation: AAH13142.1. | ||||||||||||||||||
| IPI | IPI00003096. | ||||||||||||||||||
| PIR | ICHU1A. A23385. | ||||||||||||||||||
| RefSeq | NP_000566.3. | ||||||||||||||||||
| UniGene | Hs.1722. | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||
| ProteinModelPortal | P01583. | ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| IntAct | P01583. 7 interactions. | ||||||||||||||||||
| STRING | P01583. | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | P01583. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | P01583. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENST00000263339; ENSP00000263339; ENSG00000115008; Homo sapiens. [Genome view] ENST00000409071; ENSP00000387167; ENSG00000115008; Homo sapiens. [Genome view] | ||||||||||||||||||
| GeneID | 3552. | ||||||||||||||||||
| KEGG | hsa:3552. | ||||||||||||||||||
| UCSC | uc002tig.1. human. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 3552. | ||||||||||||||||||
| GeneCards | GC02M113626. | ||||||||||||||||||
| H-InvDB | HIX0002385. | ||||||||||||||||||
| HGNC | HGNC:5991. IL1A. | ||||||||||||||||||
| HPA | CAB004449. | ||||||||||||||||||
| MIM | 147760. gene. | ||||||||||||||||||
| PharmGKB | PA29807. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| eggNOG | prNOG10963. | ||||||||||||||||||
| HOGENOM | HBG126005. | ||||||||||||||||||
| HOVERGEN | HBG002432. | ||||||||||||||||||
| InParanoid | P01583. | ||||||||||||||||||
| OMA | NQKSFYD. | ||||||||||||||||||
| OrthoDB | EOG9XH2JD. | ||||||||||||||||||
| PhylomeDB | P01583. | ||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||
| Pathway_Interaction_DB | a6b1_a6b4_integrin_pathway. a6b1 and a6b4 Integrin signaling. il1pathway. IL1-mediated signaling events. | ||||||||||||||||||
| Reactome | REACT_6900. Signaling in Immune system. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | P01583. | ||||||||||||||||||
| Bgee | P01583. | ||||||||||||||||||
| CleanEx | HS_IL1A. | ||||||||||||||||||
| Genevestigator | P01583. | ||||||||||||||||||
| GermOnline | ENSG00000115008. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR008996. Cytokine_IL1-like. IPR003502. IL1_propep. IPR020877. Interleukin-1_CS. IPR000975. Interleukin_1. IPR003295. InterleukinIL1A. IPR003294. InterleukinIL1AB. [Graphical view] | ||||||||||||||||||
| PANTHER | PTHR11420. InterleukinIL1A. 1 hit. | ||||||||||||||||||
| Pfam | PF00340. IL1. 1 hit. PF02394. IL1_propep. 1 hit. [Graphical view] | ||||||||||||||||||
| PRINTS | PR00264. INTERLEUKIN1. PR01358. INTRLEUKIN1A. PR01357. INTRLEUKN1AB. | ||||||||||||||||||
| SMART | SM00125. IL1. 1 hit. [Graphical view] | ||||||||||||||||||
| SUPFAM | SSF50353. Cytok_IL1_like. 1 hit. | ||||||||||||||||||
| PROSITE | PS00253. INTERLEUKIN_1. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| NextBio | 13868. | ||||||||||||||||||
| PMAP-CutDB | P01583. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | IL1A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P01583 Secondary accession number(s): Q7RU02 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


