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Protein

Interleukin-1 alpha

Gene

IL1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

GO - Molecular functioni

  • copper ion binding Source: UniProtKB
  • cytokine activity Source: BHF-UCL
  • interleukin-1 receptor binding Source: GO_Central

GO - Biological processi

  • apoptotic process Source: ProtInc
  • cell proliferation Source: ProtInc
  • cellular response to heat Source: UniProtKB
  • connective tissue replacement involved in inflammatory response wound healing Source: Ensembl
  • cytokine-mediated signaling pathway Source: BHF-UCL
  • ectopic germ cell programmed cell death Source: Ensembl
  • extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  • fever generation Source: UniProtKB-KW
  • immune response Source: InterPro
  • inflammatory response Source: ProtInc
  • interleukin-1-mediated signaling pathway Source: Ensembl
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
  • positive regulation of angiogenesis Source: BHF-UCL
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cytokine secretion Source: BHF-UCL
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
  • positive regulation of interleukin-2 biosynthetic process Source: BHF-UCL
  • positive regulation of interleukin-6 production Source: Ensembl
  • positive regulation of JNK cascade Source: GO_Central
  • positive regulation of mitotic nuclear division Source: BHF-UCL
  • positive regulation of monocyte chemotactic protein-1 production Source: Ensembl
  • positive regulation of neutrophil extravasation Source: Ensembl
  • positive regulation of protein secretion Source: AgBase
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • positive regulation of vascular endothelial growth factor production Source: BHF-UCL
  • response to copper ion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Mitogen, Pyrogen

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115008-MONOMER.
ReactomeiR-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-HSA-446652. Interleukin-1 signaling.
R-HSA-448706. Interleukin-1 processing.
SignaLinkiP01583.
SIGNORiP01583.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Alternative name(s):
Hematopoietin-1
Gene namesi
Name:IL1A
Synonyms:IL1F1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5991. IL1A.

Subcellular locationi

  • Secreted

  • Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3552.
OpenTargetsiENSG00000115008.
PharmGKBiPA29807.

Chemistry databases

ChEMBLiCHEMBL3580496.
DrugBankiDB06372. Rilonacept.

Polymorphism and mutation databases

BioMutaiIL1A.
DMDMi124297.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152651 – 1121 PublicationAdd BLAST112
ChainiPRO_0000015266113 – 271Interleukin-1 alphaAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi82N6-myristoyl lysine1 Publication1
Lipidationi83N6-myristoyl lysine1 Publication1
Modified residuei87PhosphoserineBy similarity1
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiP01583.
PeptideAtlasiP01583.
PRIDEiP01583.

PTM databases

iPTMnetiP01583.
PhosphoSitePlusiP01583.

Miscellaneous databases

PMAP-CutDBP01583.

Expressioni

Gene expression databases

BgeeiENSG00000115008.
CleanExiHS_IL1A.
GenevisibleiP01583. HS.

Organism-specific databases

HPAiHPA048546.

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
CASP1P294663EBI-1749782,EBI-516667

GO - Molecular functioni

  • cytokine activity Source: BHF-UCL
  • interleukin-1 receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi109768. 13 interactors.
DIPiDIP-40550N.
IntActiP01583. 4 interactors.
MINTiMINT-1534764.
STRINGi9606.ENSP00000263339.

Structurei

Secondary structure

1271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi124 – 137Combined sources14
Beta strandi143 – 150Combined sources8
Beta strandi152 – 155Combined sources4
Beta strandi158 – 160Combined sources3
Beta strandi165 – 172Combined sources8
Beta strandi176 – 178Combined sources3
Beta strandi181 – 189Combined sources9
Beta strandi192 – 194Combined sources3
Beta strandi198 – 200Combined sources3
Beta strandi203 – 205Combined sources3
Beta strandi212 – 214Combined sources3
Helixi216 – 221Combined sources6
Beta strandi223 – 228Combined sources6
Beta strandi231 – 235Combined sources5
Beta strandi242 – 244Combined sources3
Beta strandi248 – 251Combined sources4
Beta strandi259 – 261Combined sources3
Beta strandi264 – 267Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ITAmodel-A121-271[»]
2ILAX-ray2.30A117-271[»]
2KKINMR-A121-271[»]
2L5XNMR-A/D121-271[»]
ProteinModelPortaliP01583.
SMRiP01583.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01583.

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JAAI. Eukaryota.
ENOG411151X. LUCA.
GeneTreeiENSGT00390000013353.
HOGENOMiHOG000113034.
HOVERGENiHBG002432.
InParanoidiP01583.
KOiK04383.
OMAiNQKSFYD.
OrthoDBiEOG091G0MAP.
PhylomeDBiP01583.
TreeFamiTF300203.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYHVSY GPLHEGCMDQ
60 70 80 90 100
SVSLSISETS KTSKLTFKES MVVVATNGKV LKKRRLSLSQ SITDDDLEAI
110 120 130 140 150
ANDSEEEIIK PRSAPFSFLS NVKYNFMRII KYEFILNDAL NQSIIRANDQ
160 170 180 190 200
YLTAAALHNL DEAVKFDMGA YKSSKDDAKI TVILRISKTQ LYVTAQDEDQ
210 220 230 240 250
PVLLKEMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP NLFIATKQDY
260 270
WVCLAGGPPS ITDFQILENQ A
Length:271
Mass (Da):30,607
Last modified:July 21, 1986 - v1
Checksum:iCBCCC49569D9ED40
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01430485R → Q.1 PublicationCorresponds to variant rs3783531dbSNPEnsembl.1
Natural variantiVAR_014305114A → S.3 PublicationsCorresponds to variant rs17561dbSNPEnsembl.1
Natural variantiVAR_014600125N → D.Corresponds to variant rs17562dbSNPEnsembl.1
Natural variantiVAR_014306138D → N.1 PublicationCorresponds to variant rs3783581dbSNPEnsembl.1
Natural variantiVAR_014601176D → H.Corresponds to variant rs1801715dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02531 mRNA. Translation: CAA26371.1.
X03833 Genomic DNA. Translation: CAA27448.1.
X02851 mRNA. Translation: CAA26604.1.
X56086 mRNA. Translation: CAA39566.1.
M28983 mRNA. Translation: AAA59134.1.
M15329 mRNA. Translation: AAA59133.1.
BN000002 Genomic DNA. Translation: CAD29871.1.
BT007014 mRNA. Translation: AAP35660.1.
CR457414 mRNA. Translation: CAG33695.1.
AF536338 Genomic DNA. Translation: AAM96189.1.
AK314850 mRNA. Translation: BAG37367.1.
AC112235 Genomic DNA. Translation: AAX93054.1.
CH471217 Genomic DNA. Translation: EAW73604.1.
BC013142 mRNA. Translation: AAH13142.1.
CCDSiCCDS2101.1.
PIRiA23385. ICHU1A.
RefSeqiNP_000566.3. NM_000575.4.
UniGeneiHs.1722.

Genome annotation databases

EnsembliENST00000263339; ENSP00000263339; ENSG00000115008.
GeneIDi3552.
KEGGihsa:3552.
UCSCiuc002tig.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-1 entry

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02531 mRNA. Translation: CAA26371.1.
X03833 Genomic DNA. Translation: CAA27448.1.
X02851 mRNA. Translation: CAA26604.1.
X56086 mRNA. Translation: CAA39566.1.
M28983 mRNA. Translation: AAA59134.1.
M15329 mRNA. Translation: AAA59133.1.
BN000002 Genomic DNA. Translation: CAD29871.1.
BT007014 mRNA. Translation: AAP35660.1.
CR457414 mRNA. Translation: CAG33695.1.
AF536338 Genomic DNA. Translation: AAM96189.1.
AK314850 mRNA. Translation: BAG37367.1.
AC112235 Genomic DNA. Translation: AAX93054.1.
CH471217 Genomic DNA. Translation: EAW73604.1.
BC013142 mRNA. Translation: AAH13142.1.
CCDSiCCDS2101.1.
PIRiA23385. ICHU1A.
RefSeqiNP_000566.3. NM_000575.4.
UniGeneiHs.1722.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ITAmodel-A121-271[»]
2ILAX-ray2.30A117-271[»]
2KKINMR-A121-271[»]
2L5XNMR-A/D121-271[»]
ProteinModelPortaliP01583.
SMRiP01583.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109768. 13 interactors.
DIPiDIP-40550N.
IntActiP01583. 4 interactors.
MINTiMINT-1534764.
STRINGi9606.ENSP00000263339.

Chemistry databases

ChEMBLiCHEMBL3580496.
DrugBankiDB06372. Rilonacept.

PTM databases

iPTMnetiP01583.
PhosphoSitePlusiP01583.

Polymorphism and mutation databases

BioMutaiIL1A.
DMDMi124297.

Proteomic databases

PaxDbiP01583.
PeptideAtlasiP01583.
PRIDEiP01583.

Protocols and materials databases

DNASUi3552.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263339; ENSP00000263339; ENSG00000115008.
GeneIDi3552.
KEGGihsa:3552.
UCSCiuc002tig.4. human.

Organism-specific databases

CTDi3552.
DisGeNETi3552.
GeneCardsiIL1A.
HGNCiHGNC:5991. IL1A.
HPAiHPA048546.
MIMi147760. gene.
neXtProtiNX_P01583.
OpenTargetsiENSG00000115008.
PharmGKBiPA29807.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAAI. Eukaryota.
ENOG411151X. LUCA.
GeneTreeiENSGT00390000013353.
HOGENOMiHOG000113034.
HOVERGENiHBG002432.
InParanoidiP01583.
KOiK04383.
OMAiNQKSFYD.
OrthoDBiEOG091G0MAP.
PhylomeDBiP01583.
TreeFamiTF300203.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115008-MONOMER.
ReactomeiR-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-HSA-446652. Interleukin-1 signaling.
R-HSA-448706. Interleukin-1 processing.
SignaLinkiP01583.
SIGNORiP01583.

Miscellaneous databases

ChiTaRSiIL1A. human.
EvolutionaryTraceiP01583.
GeneWikiiIL1A.
GenomeRNAii3552.
PMAP-CutDBP01583.
PROiP01583.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115008.
CleanExiHS_IL1A.
GenevisibleiP01583. HS.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL1A_HUMAN
AccessioniPrimary (citable) accession number: P01583
Secondary accession number(s): Q53QF9, Q7RU02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 188 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.