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P01583

- IL1A_HUMAN

UniProt

P01583 - IL1A_HUMAN

Protein

Interleukin-1 alpha

Gene

IL1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 165 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

    GO - Molecular functioni

    1. copper ion binding Source: UniProtKB
    2. cytokine activity Source: BHF-UCL
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: ProtInc
    2. cell proliferation Source: ProtInc
    3. cellular response to heat Source: UniProtKB
    4. cytokine-mediated signaling pathway Source: BHF-UCL
    5. ectopic germ cell programmed cell death Source: Ensembl
    6. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    7. fever generation Source: UniProtKB-KW
    8. immune response Source: InterPro
    9. inflammatory response Source: ProtInc
    10. negative regulation of cell proliferation Source: BHF-UCL
    11. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
    12. positive regulation of angiogenesis Source: BHF-UCL
    13. positive regulation of cell division Source: UniProtKB-KW
    14. positive regulation of cytokine secretion Source: BHF-UCL
    15. positive regulation of interleukin-2 biosynthetic process Source: BHF-UCL
    16. positive regulation of mitosis Source: BHF-UCL
    17. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    18. positive regulation vascular endothelial growth factor production Source: BHF-UCL
    19. response to copper ion Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Mitogen, Pyrogen

    Keywords - Biological processi

    Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_169168. Senescence-Associated Secretory Phenotype (SASP).
    REACT_22442. Interleukin-1 signaling.
    REACT_23950. Interleukin-1 processing.
    SignaLinkiP01583.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-1 alpha
    Short name:
    IL-1 alpha
    Alternative name(s):
    Hematopoietin-1
    Gene namesi
    Name:IL1A
    Synonyms:IL1F1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:5991. IL1A.

    Subcellular locationi

    Secreted
    Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. extracellular region Source: Reactome
    3. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29807.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 1121121 PublicationPRO_0000015265Add
    BLAST
    Chaini113 – 271159Interleukin-1 alphaPRO_0000015266Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi82 – 821N6-myristoyl lysine1 Publication
    Lipidationi83 – 831N6-myristoyl lysine1 Publication
    Modified residuei87 – 871PhosphoserineBy similarity
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Myristate, Phosphoprotein

    Proteomic databases

    MaxQBiP01583.
    PaxDbiP01583.
    PRIDEiP01583.

    PTM databases

    PhosphoSiteiP01583.

    Miscellaneous databases

    PMAP-CutDBP01583.

    Expressioni

    Gene expression databases

    BgeeiP01583.
    CleanExiHS_IL1A.
    GenevestigatoriP01583.

    Organism-specific databases

    HPAiHPA048546.

    Interactioni

    Subunit structurei

    Monomer.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CASP1P294663EBI-1749782,EBI-516667

    Protein-protein interaction databases

    BioGridi109768. 11 interactions.
    IntActiP01583. 3 interactions.
    MINTiMINT-1534764.
    STRINGi9606.ENSP00000263339.

    Structurei

    Secondary structure

    1
    271
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi124 – 13714
    Beta strandi143 – 1508
    Beta strandi152 – 1554
    Beta strandi158 – 1603
    Beta strandi165 – 1728
    Beta strandi176 – 1783
    Beta strandi181 – 1899
    Beta strandi192 – 1943
    Beta strandi198 – 2003
    Beta strandi203 – 2053
    Beta strandi212 – 2143
    Helixi216 – 2216
    Beta strandi223 – 2286
    Beta strandi231 – 2355
    Beta strandi242 – 2443
    Beta strandi248 – 2514
    Beta strandi259 – 2613
    Beta strandi264 – 2674

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ITAmodel-A121-271[»]
    2ILAX-ray2.30A117-271[»]
    2KKINMR-A121-271[»]
    2L5XNMR-A/D121-271[»]
    ProteinModelPortaliP01583.
    SMRiP01583. Positions 121-271.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01583.

    Family & Domainsi

    Domaini

    The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

    Sequence similaritiesi

    Belongs to the IL-1 family.Curated

    Phylogenomic databases

    eggNOGiNOG39906.
    HOGENOMiHOG000113034.
    HOVERGENiHBG002432.
    InParanoidiP01583.
    KOiK04383.
    OMAiNQKSFYD.
    OrthoDBiEOG76473H.
    PhylomeDBiP01583.
    TreeFamiTF300203.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR003295. IL-1_alpha.
    IPR003294. IL-1_alpha/beta.
    IPR020877. IL-1_CS.
    IPR000975. IL-1_fam.
    IPR003502. IL-1_propep.
    [Graphical view]
    PANTHERiPTHR11420. PTHR11420. 1 hit.
    PfamiPF00340. IL1. 1 hit.
    PF02394. IL1_propep. 1 hit.
    [Graphical view]
    PRINTSiPR00264. INTERLEUKIN1.
    PR01358. INTRLEUKIN1A.
    PR01357. INTRLEUKN1AB.
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01583-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYHVSY GPLHEGCMDQ    50
    SVSLSISETS KTSKLTFKES MVVVATNGKV LKKRRLSLSQ SITDDDLEAI 100
    ANDSEEEIIK PRSAPFSFLS NVKYNFMRII KYEFILNDAL NQSIIRANDQ 150
    YLTAAALHNL DEAVKFDMGA YKSSKDDAKI TVILRISKTQ LYVTAQDEDQ 200
    PVLLKEMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP NLFIATKQDY 250
    WVCLAGGPPS ITDFQILENQ A 271
    Length:271
    Mass (Da):30,607
    Last modified:July 21, 1986 - v1
    Checksum:iCBCCC49569D9ED40
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti85 – 851R → Q.1 Publication
    Corresponds to variant rs3783531 [ dbSNP | Ensembl ].
    VAR_014304
    Natural varianti114 – 1141A → S.3 Publications
    Corresponds to variant rs17561 [ dbSNP | Ensembl ].
    VAR_014305
    Natural varianti125 – 1251N → D.
    Corresponds to variant rs17562 [ dbSNP | Ensembl ].
    VAR_014600
    Natural varianti138 – 1381D → N.1 Publication
    Corresponds to variant rs3783581 [ dbSNP | Ensembl ].
    VAR_014306
    Natural varianti176 – 1761D → H.
    Corresponds to variant rs1801715 [ dbSNP | Ensembl ].
    VAR_014601

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02531 mRNA. Translation: CAA26371.1.
    X03833 Genomic DNA. Translation: CAA27448.1.
    X02851 mRNA. Translation: CAA26604.1.
    X56086 mRNA. Translation: CAA39566.1.
    M28983 mRNA. Translation: AAA59134.1.
    M15329 mRNA. Translation: AAA59133.1.
    BN000002 Genomic DNA. Translation: CAD29871.1.
    BT007014 mRNA. Translation: AAP35660.1.
    CR457414 mRNA. Translation: CAG33695.1.
    AF536338 Genomic DNA. Translation: AAM96189.1.
    AK314850 mRNA. Translation: BAG37367.1.
    AC112235 Genomic DNA. Translation: AAX93054.1.
    CH471217 Genomic DNA. Translation: EAW73604.1.
    BC013142 mRNA. Translation: AAH13142.1.
    CCDSiCCDS2101.1.
    PIRiA23385. ICHU1A.
    RefSeqiNP_000566.3. NM_000575.3.
    UniGeneiHs.1722.

    Genome annotation databases

    EnsembliENST00000263339; ENSP00000263339; ENSG00000115008.
    GeneIDi3552.
    KEGGihsa:3552.
    UCSCiuc002tig.3. human.

    Polymorphism databases

    DMDMi124297.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Interleukin-1 entry

    SeattleSNPs
    SHMPD

    The Singapore human mutation and polymorphism database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02531 mRNA. Translation: CAA26371.1 .
    X03833 Genomic DNA. Translation: CAA27448.1 .
    X02851 mRNA. Translation: CAA26604.1 .
    X56086 mRNA. Translation: CAA39566.1 .
    M28983 mRNA. Translation: AAA59134.1 .
    M15329 mRNA. Translation: AAA59133.1 .
    BN000002 Genomic DNA. Translation: CAD29871.1 .
    BT007014 mRNA. Translation: AAP35660.1 .
    CR457414 mRNA. Translation: CAG33695.1 .
    AF536338 Genomic DNA. Translation: AAM96189.1 .
    AK314850 mRNA. Translation: BAG37367.1 .
    AC112235 Genomic DNA. Translation: AAX93054.1 .
    CH471217 Genomic DNA. Translation: EAW73604.1 .
    BC013142 mRNA. Translation: AAH13142.1 .
    CCDSi CCDS2101.1.
    PIRi A23385. ICHU1A.
    RefSeqi NP_000566.3. NM_000575.3.
    UniGenei Hs.1722.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ITA model - A 121-271 [» ]
    2ILA X-ray 2.30 A 117-271 [» ]
    2KKI NMR - A 121-271 [» ]
    2L5X NMR - A/D 121-271 [» ]
    ProteinModelPortali P01583.
    SMRi P01583. Positions 121-271.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109768. 11 interactions.
    IntActi P01583. 3 interactions.
    MINTi MINT-1534764.
    STRINGi 9606.ENSP00000263339.

    PTM databases

    PhosphoSitei P01583.

    Polymorphism databases

    DMDMi 124297.

    Proteomic databases

    MaxQBi P01583.
    PaxDbi P01583.
    PRIDEi P01583.

    Protocols and materials databases

    DNASUi 3552.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263339 ; ENSP00000263339 ; ENSG00000115008 .
    GeneIDi 3552.
    KEGGi hsa:3552.
    UCSCi uc002tig.3. human.

    Organism-specific databases

    CTDi 3552.
    GeneCardsi GC02M113531.
    HGNCi HGNC:5991. IL1A.
    HPAi HPA048546.
    MIMi 147760. gene.
    neXtProti NX_P01583.
    PharmGKBi PA29807.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39906.
    HOGENOMi HOG000113034.
    HOVERGENi HBG002432.
    InParanoidi P01583.
    KOi K04383.
    OMAi NQKSFYD.
    OrthoDBi EOG76473H.
    PhylomeDBi P01583.
    TreeFami TF300203.

    Enzyme and pathway databases

    Reactomei REACT_169168. Senescence-Associated Secretory Phenotype (SASP).
    REACT_22442. Interleukin-1 signaling.
    REACT_23950. Interleukin-1 processing.
    SignaLinki P01583.

    Miscellaneous databases

    EvolutionaryTracei P01583.
    GeneWikii IL1A.
    GenomeRNAii 3552.
    NextBioi 13868.
    PMAP-CutDB P01583.
    PROi P01583.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01583.
    CleanExi HS_IL1A.
    Genevestigatori P01583.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR003295. IL-1_alpha.
    IPR003294. IL-1_alpha/beta.
    IPR020877. IL-1_CS.
    IPR000975. IL-1_fam.
    IPR003502. IL-1_propep.
    [Graphical view ]
    PANTHERi PTHR11420. PTHR11420. 1 hit.
    Pfami PF00340. IL1. 1 hit.
    PF02394. IL1_propep. 1 hit.
    [Graphical view ]
    PRINTSi PR00264. INTERLEUKIN1.
    PR01358. INTRLEUKIN1A.
    PR01357. INTRLEUKN1AB.
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00253. INTERLEUKIN_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs."
      March C.J., Mosley B., Larsen A., Cerretti D.P., Braedt G., Price V., Gillis S., Henney C.S., Kronheim S.R., Grabstein K., Conlon P.J., Hopp T.P., Cosman D.
      Nature 315:641-647(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete nucleotide sequence of the gene for human interleukin 1 alpha."
      Furutani Y., Notake M., Fukui T., Ohue M., Nomura H., Yamada M., Nakamura S.
      Nucleic Acids Res. 14:3167-3179(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor."
      Furutani Y., Notake M., Yamayoshi M., Yamagishi J., Nomura H., Ohue M., Furuta R., Fukui T., Yamada M., Nakamura S.
      Nucleic Acids Res. 13:5869-5882(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-114.
    4. "Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta."
      Kotenko S.V., Bulenkov M.T., Veiko V.P., Epishin S.M., Lomakin I.B., Emel'Yanov A.V., Kozlov A.P., Konusova V.G., Kotov A.Y., Kurbatova T.V., Reshetnikov V.L., Simbirtsev A.S., Ketlinskii S.A., Vinetskii Y.P.
      Dokl. Akad. Nauk SSSR 309:1005-1008(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-114.
    5. "Recombinant human interleukin 1 alpha: purification and biological characterization."
      Gubler U., Chua A.O., Stern A.S., Hellmann C.P., Vitek M.P., Dechiara T.M., Benjamin W.R., Collier K.J., Dukovich M., Familletti P.C., Fiedler-Nagy C., Jenson J., Kaffka K., Kilian P.L., Stremlo D., Wittreich B.H., Woehle D., Mizel S.B., Lomedico P.T.
      J. Immunol. 136:2492-2497(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    6. "cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line."
      Nishida T., Nishino N., Takano M., Kawai K., Bando K., Masui Y., Nakai S., Hirai Y.
      Biochem. Biophys. Res. Commun. 143:345-352(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    7. "A sequence-based map of the nine genes of the human interleukin-1 cluster."
      Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K.
      Genomics 79:718-725(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    8. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    9. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    10. SeattleSNPs variation discovery resource
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-85; SER-114 AND ASN-138.
    11. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    12. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    14. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    15. "Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow."
      Zsebo K.M., Wypych J., Yuschenkoff V.N., Lu H., Hunt P., Dukes P.P., Langley K.E.
      Blood 71:962-968(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 113-132.
    16. "The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece."
      Stevenson F.T., Bursten S.L., Fanton C., Locksley R.M., Lovett D.H.
      Proc. Natl. Acad. Sci. U.S.A. 90:7245-7249(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: MYRISTOYLATION AT LYS-82 AND LYS-83.
    17. Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).

    Entry informationi

    Entry nameiIL1A_HUMAN
    AccessioniPrimary (citable) accession number: P01583
    Secondary accession number(s): Q53QF9, Q7RU02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 165 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3