P01582 (IL1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-1 alpha
Short name=IL-1 alpha

Gene names

Name:

Il1a

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Subunit structure	Monomer.
Subcellular location	Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
Domain	The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
Sequence similarities	Belongs to the IL-1 family.

Ontologies

Keywords
Biological process	Inflammatory response
Cellular component	Secreted
Molecular function	Cytokine Mitogen Pyrogen
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to heat Inferred from sequence or structural similarity. Source: UniProtKB cytokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara fever generation Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of angiogenesis Inferred from mutant phenotype PubMed 12598651. Source: BHF-UCL positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cytokine secretion Inferred from electronic annotation. Source: Compara positive regulation of interleukin-2 biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of mitosis Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction PubMed 19666510. Source: MGI positive regulation vascular endothelial growth factor production Inferred from mutant phenotype PubMed 12598651. Source: BHF-UCL response to copper ion Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB extracellular space Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	copper ion binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 114	114			PRO_0000015273
	Chain	115 – 270	156	Interleukin-1 alpha		PRO_0000015274
Amino acid modifications
	Modified residue	90	1	Phosphoserine Ref.4
	Glycosylation	64	1	N-linked (GlcNAc...) Potential
	Glycosylation	139	1	N-linked (GlcNAc...) Potential
	Glycosylation	143	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P01582 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 7F60AC4F330D5B11	FASTA	270	31,023
	10 20 30 40 50 60 MAKVPDLFED LKNCYSENED YSSAIDHLSL NQKSFYDASY GSLHETCTDQ FVSLRTSETS 70 80 90 100 110 120 KMSNFTFKES RVTVSATSSN GKILKKRRLS FSETFTEDDL QSITHDLEET IQPRSAPYTY 130 140 150 160 170 180 QSDLRYKLMK LVRQKFVMND SLNQTIYQDV DKHYLSTTWL NDLQQEVKFD MYAYSSGGDD 190 200 210 220 230 240 SKYPVTLKIS DSQLFVSAQG EDQPVLLKEL PETPKLITGS ETDLIFFWKS INSKNYFTSA 250 260 270 AYPELFIATK EQSRVHLARG LPSMTDFQIS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of murine interleukin-1 cDNA in Escherichia coli." Lomedico P.T., Gubler U., Hellmann C.P., Dukovich M., Giri J.G., Pan Y.-C.E., Collier K., Semionow R., Chua A.O., Mizel S.B. Nature 312:458-462(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete nucleotide sequence of the murine interleukin-1 alpha gene." Kastelic T., Wanner A., Mackenzie A., Cheneval D. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
[4]	"The precursor of interleukin-1 alpha is phosphorylated at residue serine 90." Beuscher H.U., Nickells M.W., Colten H.R. J. Biol. Chem. 263:4023-4028(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SER-90.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X01450 mRNA. Translation: CAA25682.1. AF010237 Genomic DNA. Translation: AAC28999.1. BC003727 mRNA. Translation: AAH03727.1.
IPI	IPI00136895.
PIR	ICMS1. A01846.
RefSeq	NP_034684.2. NM_010554.4.
UniGene	Mm.15534.
3D structure databases
ProteinModelPortal	P01582.
SMR	P01582. Positions 123-269.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000028882.
PTM databases
PhosphoSite	P01582.
Proteomic databases
PRIDE	P01582.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000028882; ENSMUSP00000028882; ENSMUSG00000027399.
GeneID	16175.
KEGG	mmu:16175.
Organism-specific databases
CTD	3552.
MGI	MGI:96542. Il1a.
Phylogenomic databases
eggNOG	NOG39906.
HOGENOM	HOG000113034.
HOVERGEN	HBG002432.
InParanoid	P01582.
KO	K04383.
OMA	NQKSFYD.
OrthoDB	EOG4XWFZQ.
Gene expression databases
ArrayExpress	P01582.
Bgee	P01582.
CleanEx	MM_IL1A.
Genevestigator	P01582.
GermOnline	ENSMUSG00000027399. Mus musculus.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR003502. IL1_propep. IPR020877. Interleukin-1_CS. IPR000975. Interleukin_1. IPR003295. InterleukinIL1A. IPR003294. InterleukinIL1AB. [Graphical view]
PANTHER	PTHR11420. PTHR11420. 1 hit.
Pfam	PF00340. IL1. 1 hit. PF02394. IL1_propep. 1 hit. [Graphical view]
PRINTS	PR00264. INTERLEUKIN1. PR01358. INTRLEUKIN1A. PR01357. INTRLEUKN1AB.
SMART	SM00125. IL1. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00253. INTERLEUKIN_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	289033.
SOURCE	Search...

Entry information

Entry name

IL1A_MOUSE

Accession

Primary (citable) accession number: P01582

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program