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Protein

Interleukin-1 alpha

Gene

Il1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

GO - Molecular functioni

  • copper ion binding Source: UniProtKB
  • cytokine activity Source: MGI
  • interleukin-1 receptor binding Source: MGI

GO - Biological processi

  • cellular response to heat Source: UniProtKB
  • connective tissue replacement involved in inflammatory response wound healing Source: MGI
  • cytokine-mediated signaling pathway Source: MGI
  • ectopic germ cell programmed cell death Source: MGI
  • extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  • fever generation Source: UniProtKB-KW
  • immune response Source: InterPro
  • inflammatory response Source: MGI
  • interleukin-1-mediated signaling pathway Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • positive regulation of angiogenesis Source: BHF-UCL
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cytokine secretion Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of interleukin-2 biosynthetic process Source: MGI
  • positive regulation of interleukin-6 production Source: MGI
  • positive regulation of mitotic nuclear division Source: MGI
  • positive regulation of monocyte chemotactic protein-1 production Source: MGI
  • positive regulation of neutrophil extravasation Source: MGI
  • positive regulation of protein secretion Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of vascular endothelial growth factor production Source: BHF-UCL
  • response to copper ion Source: UniProtKB

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-448706 Interleukin-1 processing
R-MMU-9020702 Interleukin-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Gene namesi
Name:Il1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96542 Il1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152731 – 114Add BLAST114
ChainiPRO_0000015274115 – 270Interleukin-1 alphaAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei90Phosphoserine1 Publication1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01582
PRIDEiP01582

PTM databases

iPTMnetiP01582
PhosphoSitePlusiP01582

Expressioni

Gene expression databases

BgeeiENSMUSG00000027399
CleanExiMM_IL1A
ExpressionAtlasiP01582 baseline and differential

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-1 receptor binding Source: MGI

Protein-protein interaction databases

BioGridi2006231 interactor.
STRINGi10090.ENSMUSP00000028882

Structurei

3D structure databases

ProteinModelPortaliP01582
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JAAI Eukaryota
ENOG411151X LUCA
GeneTreeiENSGT00390000013353
HOGENOMiHOG000113034
HOVERGENiHBG002432
InParanoidiP01582
KOiK04383
OMAiNQKSFYD
OrthoDBiEOG091G0MAP
PhylomeDBiP01582
TreeFamiTF300203

Family and domain databases

InterProiView protein in InterPro
IPR003295 IL-1_alpha
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR45409 PTHR45409, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01358 INTRLEUKIN1A
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPDLFED LKNCYSENED YSSAIDHLSL NQKSFYDASY GSLHETCTDQ
60 70 80 90 100
FVSLRTSETS KMSNFTFKES RVTVSATSSN GKILKKRRLS FSETFTEDDL
110 120 130 140 150
QSITHDLEET IQPRSAPYTY QSDLRYKLMK LVRQKFVMND SLNQTIYQDV
160 170 180 190 200
DKHYLSTTWL NDLQQEVKFD MYAYSSGGDD SKYPVTLKIS DSQLFVSAQG
210 220 230 240 250
EDQPVLLKEL PETPKLITGS ETDLIFFWKS INSKNYFTSA AYPELFIATK
260 270
EQSRVHLARG LPSMTDFQIS
Length:270
Mass (Da):31,023
Last modified:July 21, 1986 - v1
Checksum:i7F60AC4F330D5B11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01450 mRNA Translation: CAA25682.1
AF010237 Genomic DNA Translation: AAC28999.1
BC003727 mRNA Translation: AAH03727.1
CCDSiCCDS16725.1
PIRiA01846 ICMS1
RefSeqiNP_034684.2, NM_010554.4
XP_006498856.1, XM_006498793.3
UniGeneiMm.15534

Genome annotation databases

EnsembliENSMUST00000028882; ENSMUSP00000028882; ENSMUSG00000027399
GeneIDi16175
KEGGimmu:16175
UCSCiuc008mhr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIL1A_MOUSE
AccessioniPrimary (citable) accession number: P01582
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome