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P01582

- IL1A_MOUSE

UniProt

P01582 - IL1A_MOUSE

Protein

Interleukin-1 alpha

Gene

Il1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

    GO - Molecular functioni

    1. copper ion binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to heat Source: UniProtKB
    2. cytokine-mediated signaling pathway Source: Ensembl
    3. ectopic germ cell programmed cell death Source: MGI
    4. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    5. fever generation Source: UniProtKB-KW
    6. immune response Source: InterPro
    7. negative regulation of cell proliferation Source: Ensembl
    8. positive regulation of angiogenesis Source: BHF-UCL
    9. positive regulation of cell division Source: UniProtKB-KW
    10. positive regulation of cytokine secretion Source: Ensembl
    11. positive regulation of interleukin-2 biosynthetic process Source: Ensembl
    12. positive regulation of mitosis Source: Ensembl
    13. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    14. positive regulation vascular endothelial growth factor production Source: BHF-UCL
    15. response to copper ion Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Mitogen, Pyrogen

    Keywords - Biological processi

    Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_224208. Interleukin-1 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-1 alpha
    Short name:
    IL-1 alpha
    Gene namesi
    Name:Il1a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:96542. Il1a.

    Subcellular locationi

    Secreted
    Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 114114PRO_0000015273Add
    BLAST
    Chaini115 – 270156Interleukin-1 alphaPRO_0000015274Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Modified residuei90 – 901Phosphoserine1 Publication
    Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP01582.

    PTM databases

    PhosphoSiteiP01582.

    Expressioni

    Gene expression databases

    ArrayExpressiP01582.
    BgeeiP01582.
    CleanExiMM_IL1A.
    GenevestigatoriP01582.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi200623. 1 interaction.
    STRINGi10090.ENSMUSP00000028882.

    Structurei

    3D structure databases

    ProteinModelPortaliP01582.
    SMRiP01582. Positions 123-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

    Sequence similaritiesi

    Belongs to the IL-1 family.Curated

    Phylogenomic databases

    eggNOGiNOG39906.
    HOGENOMiHOG000113034.
    HOVERGENiHBG002432.
    InParanoidiP01582.
    KOiK04383.
    OMAiNQKSFYD.
    OrthoDBiEOG76473H.
    PhylomeDBiP01582.
    TreeFamiTF300203.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR003295. IL-1_alpha.
    IPR003294. IL-1_alpha/beta.
    IPR020877. IL-1_CS.
    IPR000975. IL-1_fam.
    IPR003502. IL-1_propep.
    [Graphical view]
    PANTHERiPTHR11420. PTHR11420. 1 hit.
    PfamiPF00340. IL1. 1 hit.
    PF02394. IL1_propep. 1 hit.
    [Graphical view]
    PRINTSiPR00264. INTERLEUKIN1.
    PR01358. INTRLEUKIN1A.
    PR01357. INTRLEUKN1AB.
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01582-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKVPDLFED LKNCYSENED YSSAIDHLSL NQKSFYDASY GSLHETCTDQ    50
    FVSLRTSETS KMSNFTFKES RVTVSATSSN GKILKKRRLS FSETFTEDDL 100
    QSITHDLEET IQPRSAPYTY QSDLRYKLMK LVRQKFVMND SLNQTIYQDV 150
    DKHYLSTTWL NDLQQEVKFD MYAYSSGGDD SKYPVTLKIS DSQLFVSAQG 200
    EDQPVLLKEL PETPKLITGS ETDLIFFWKS INSKNYFTSA AYPELFIATK 250
    EQSRVHLARG LPSMTDFQIS 270
    Length:270
    Mass (Da):31,023
    Last modified:July 21, 1986 - v1
    Checksum:i7F60AC4F330D5B11
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01450 mRNA. Translation: CAA25682.1.
    AF010237 Genomic DNA. Translation: AAC28999.1.
    BC003727 mRNA. Translation: AAH03727.1.
    CCDSiCCDS16725.1.
    PIRiA01846. ICMS1.
    RefSeqiNP_034684.2. NM_010554.4.
    XP_006498855.1. XM_006498792.1.
    XP_006498856.1. XM_006498793.1.
    UniGeneiMm.15534.

    Genome annotation databases

    EnsembliENSMUST00000028882; ENSMUSP00000028882; ENSMUSG00000027399.
    GeneIDi16175.
    KEGGimmu:16175.
    UCSCiuc008mhr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01450 mRNA. Translation: CAA25682.1 .
    AF010237 Genomic DNA. Translation: AAC28999.1 .
    BC003727 mRNA. Translation: AAH03727.1 .
    CCDSi CCDS16725.1.
    PIRi A01846. ICMS1.
    RefSeqi NP_034684.2. NM_010554.4.
    XP_006498855.1. XM_006498792.1.
    XP_006498856.1. XM_006498793.1.
    UniGenei Mm.15534.

    3D structure databases

    ProteinModelPortali P01582.
    SMRi P01582. Positions 123-269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200623. 1 interaction.
    STRINGi 10090.ENSMUSP00000028882.

    PTM databases

    PhosphoSitei P01582.

    Proteomic databases

    PRIDEi P01582.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028882 ; ENSMUSP00000028882 ; ENSMUSG00000027399 .
    GeneIDi 16175.
    KEGGi mmu:16175.
    UCSCi uc008mhr.1. mouse.

    Organism-specific databases

    CTDi 3552.
    MGIi MGI:96542. Il1a.

    Phylogenomic databases

    eggNOGi NOG39906.
    HOGENOMi HOG000113034.
    HOVERGENi HBG002432.
    InParanoidi P01582.
    KOi K04383.
    OMAi NQKSFYD.
    OrthoDBi EOG76473H.
    PhylomeDBi P01582.
    TreeFami TF300203.

    Enzyme and pathway databases

    Reactomei REACT_224208. Interleukin-1 signaling.

    Miscellaneous databases

    NextBioi 289033.
    PROi P01582.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01582.
    Bgeei P01582.
    CleanExi MM_IL1A.
    Genevestigatori P01582.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR003295. IL-1_alpha.
    IPR003294. IL-1_alpha/beta.
    IPR020877. IL-1_CS.
    IPR000975. IL-1_fam.
    IPR003502. IL-1_propep.
    [Graphical view ]
    PANTHERi PTHR11420. PTHR11420. 1 hit.
    Pfami PF00340. IL1. 1 hit.
    PF02394. IL1_propep. 1 hit.
    [Graphical view ]
    PRINTSi PR00264. INTERLEUKIN1.
    PR01358. INTRLEUKIN1A.
    PR01357. INTRLEUKN1AB.
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00253. INTERLEUKIN_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete nucleotide sequence of the murine interleukin-1 alpha gene."
      Kastelic T., Wanner A., Mackenzie A., Cheneval D.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    4. "The precursor of interleukin-1 alpha is phosphorylated at residue serine 90."
      Beuscher H.U., Nickells M.W., Colten H.R.
      J. Biol. Chem. 263:4023-4028(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-90.

    Entry informationi

    Entry nameiIL1A_MOUSE
    AccessioniPrimary (citable) accession number: P01582
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3