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P01582

- IL1A_MOUSE

UniProt

P01582 - IL1A_MOUSE

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Protein

Interleukin-1 alpha

Gene
Il1a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

GO - Molecular functioni

  1. copper ion binding Source: UniProtKB

GO - Biological processi

  1. cellular response to heat Source: UniProtKB
  2. cytokine-mediated signaling pathway Source: Ensembl
  3. ectopic germ cell programmed cell death Source: MGI
  4. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  5. fever generation Source: UniProtKB-KW
  6. immune response Source: InterPro
  7. negative regulation of cell proliferation Source: Ensembl
  8. positive regulation of angiogenesis Source: BHF-UCL
  9. positive regulation of cell division Source: UniProtKB-KW
  10. positive regulation of cytokine secretion Source: Ensembl
  11. positive regulation of interleukin-2 biosynthetic process Source: Ensembl
  12. positive regulation of mitosis Source: Ensembl
  13. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  14. positive regulation vascular endothelial growth factor production Source: BHF-UCL
  15. response to copper ion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Mitogen, Pyrogen

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_224208. Interleukin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Gene namesi
Name:Il1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96542. Il1a.

Subcellular locationi

Secreted
Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 114114PRO_0000015273Add
BLAST
Chaini115 – 270156Interleukin-1 alphaPRO_0000015274Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...) Reviewed prediction
Modified residuei90 – 901Phosphoserine1 Publication
Glycosylationi139 – 1391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi143 – 1431N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP01582.

PTM databases

PhosphoSiteiP01582.

Expressioni

Gene expression databases

ArrayExpressiP01582.
BgeeiP01582.
CleanExiMM_IL1A.
GenevestigatoriP01582.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi200623. 1 interaction.
STRINGi10090.ENSMUSP00000028882.

Structurei

3D structure databases

ProteinModelPortaliP01582.
SMRiP01582. Positions 123-269.

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.

Phylogenomic databases

eggNOGiNOG39906.
HOGENOMiHOG000113034.
HOVERGENiHBG002432.
InParanoidiP01582.
KOiK04383.
OMAiNQKSFYD.
OrthoDBiEOG76473H.
PhylomeDBiP01582.
TreeFamiTF300203.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PANTHERiPTHR11420. PTHR11420. 1 hit.
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01582-1 [UniParc]FASTAAdd to Basket

« Hide

MAKVPDLFED LKNCYSENED YSSAIDHLSL NQKSFYDASY GSLHETCTDQ    50
FVSLRTSETS KMSNFTFKES RVTVSATSSN GKILKKRRLS FSETFTEDDL 100
QSITHDLEET IQPRSAPYTY QSDLRYKLMK LVRQKFVMND SLNQTIYQDV 150
DKHYLSTTWL NDLQQEVKFD MYAYSSGGDD SKYPVTLKIS DSQLFVSAQG 200
EDQPVLLKEL PETPKLITGS ETDLIFFWKS INSKNYFTSA AYPELFIATK 250
EQSRVHLARG LPSMTDFQIS 270
Length:270
Mass (Da):31,023
Last modified:July 21, 1986 - v1
Checksum:i7F60AC4F330D5B11
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01450 mRNA. Translation: CAA25682.1.
AF010237 Genomic DNA. Translation: AAC28999.1.
BC003727 mRNA. Translation: AAH03727.1.
CCDSiCCDS16725.1.
PIRiA01846. ICMS1.
RefSeqiNP_034684.2. NM_010554.4.
XP_006498855.1. XM_006498792.1.
XP_006498856.1. XM_006498793.1.
UniGeneiMm.15534.

Genome annotation databases

EnsembliENSMUST00000028882; ENSMUSP00000028882; ENSMUSG00000027399.
GeneIDi16175.
KEGGimmu:16175.
UCSCiuc008mhr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01450 mRNA. Translation: CAA25682.1 .
AF010237 Genomic DNA. Translation: AAC28999.1 .
BC003727 mRNA. Translation: AAH03727.1 .
CCDSi CCDS16725.1.
PIRi A01846. ICMS1.
RefSeqi NP_034684.2. NM_010554.4.
XP_006498855.1. XM_006498792.1.
XP_006498856.1. XM_006498793.1.
UniGenei Mm.15534.

3D structure databases

ProteinModelPortali P01582.
SMRi P01582. Positions 123-269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200623. 1 interaction.
STRINGi 10090.ENSMUSP00000028882.

PTM databases

PhosphoSitei P01582.

Proteomic databases

PRIDEi P01582.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028882 ; ENSMUSP00000028882 ; ENSMUSG00000027399 .
GeneIDi 16175.
KEGGi mmu:16175.
UCSCi uc008mhr.1. mouse.

Organism-specific databases

CTDi 3552.
MGIi MGI:96542. Il1a.

Phylogenomic databases

eggNOGi NOG39906.
HOGENOMi HOG000113034.
HOVERGENi HBG002432.
InParanoidi P01582.
KOi K04383.
OMAi NQKSFYD.
OrthoDBi EOG76473H.
PhylomeDBi P01582.
TreeFami TF300203.

Enzyme and pathway databases

Reactomei REACT_224208. Interleukin-1 signaling.

Miscellaneous databases

NextBioi 289033.
PROi P01582.
SOURCEi Search...

Gene expression databases

ArrayExpressi P01582.
Bgeei P01582.
CleanExi MM_IL1A.
Genevestigatori P01582.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view ]
PANTHERi PTHR11420. PTHR11420. 1 hit.
Pfami PF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view ]
PRINTSi PR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00253. INTERLEUKIN_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete nucleotide sequence of the murine interleukin-1 alpha gene."
    Kastelic T., Wanner A., Mackenzie A., Cheneval D.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  4. "The precursor of interleukin-1 alpha is phosphorylated at residue serine 90."
    Beuscher H.U., Nickells M.W., Colten H.R.
    J. Biol. Chem. 263:4023-4028(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-90.

Entry informationi

Entry nameiIL1A_MOUSE
AccessioniPrimary (citable) accession number: P01582
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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