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P01582 (IL1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-1 alpha

Short name=IL-1 alpha
Gene names
Name:Il1a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Subunit structure

Monomer.

Subcellular location

Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Domain

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similarities

Belongs to the IL-1 family.

Ontologies

Keywords
   Biological processInflammatory response
   Cellular componentSecreted
   Molecular functionCytokine
Mitogen
Pyrogen
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to heat

Inferred from sequence or structural similarity. Source: UniProtKB

cytokine-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

ectopic germ cell programmed cell death

Inferred from genetic interaction PubMed 11536012. Source: MGI

extrinsic apoptotic signaling pathway in absence of ligand

Inferred from mutant phenotype PubMed 11536012. Source: MGI

fever generation

Inferred from electronic annotation. Source: UniProtKB-KW

immune response

Inferred from electronic annotation. Source: InterPro

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of angiogenesis

Inferred from mutant phenotype PubMed 12598651. Source: BHF-UCL

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of cytokine secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-2 biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of mitosis

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 19666510. Source: MGI

positive regulation vascular endothelial growth factor production

Inferred from mutant phenotype PubMed 12598651. Source: BHF-UCL

response to copper ion

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytosol

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular space

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functioncopper ion binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 114114
PRO_0000015273
Chain115 – 270156Interleukin-1 alpha
PRO_0000015274

Amino acid modifications

Modified residue901Phosphoserine Ref.4
Glycosylation641N-linked (GlcNAc...) Potential
Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P01582 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 7F60AC4F330D5B11

FASTA27031,023
        10         20         30         40         50         60 
MAKVPDLFED LKNCYSENED YSSAIDHLSL NQKSFYDASY GSLHETCTDQ FVSLRTSETS 

        70         80         90        100        110        120 
KMSNFTFKES RVTVSATSSN GKILKKRRLS FSETFTEDDL QSITHDLEET IQPRSAPYTY 

       130        140        150        160        170        180 
QSDLRYKLMK LVRQKFVMND SLNQTIYQDV DKHYLSTTWL NDLQQEVKFD MYAYSSGGDD 

       190        200        210        220        230        240 
SKYPVTLKIS DSQLFVSAQG EDQPVLLKEL PETPKLITGS ETDLIFFWKS INSKNYFTSA 

       250        260        270 
AYPELFIATK EQSRVHLARG LPSMTDFQIS 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of murine interleukin-1 cDNA in Escherichia coli."
Lomedico P.T., Gubler U., Hellmann C.P., Dukovich M., Giri J.G., Pan Y.-C.E., Collier K., Semionow R., Chua A.O., Mizel S.B.
Nature 312:458-462(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete nucleotide sequence of the murine interleukin-1 alpha gene."
Kastelic T., Wanner A., Mackenzie A., Cheneval D.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
[4]"The precursor of interleukin-1 alpha is phosphorylated at residue serine 90."
Beuscher H.U., Nickells M.W., Colten H.R.
J. Biol. Chem. 263:4023-4028(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-90.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X01450 mRNA. Translation: CAA25682.1.
AF010237 Genomic DNA. Translation: AAC28999.1.
BC003727 mRNA. Translation: AAH03727.1.
PIRICMS1. A01846.
RefSeqNP_034684.2. NM_010554.4.
XP_006498855.1. XM_006498792.1.
XP_006498856.1. XM_006498793.1.
UniGeneMm.15534.

3D structure databases

ProteinModelPortalP01582.
SMRP01582. Positions 123-269.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200623. 1 interaction.
STRING10090.ENSMUSP00000028882.

PTM databases

PhosphoSiteP01582.

Proteomic databases

PRIDEP01582.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028882; ENSMUSP00000028882; ENSMUSG00000027399.
GeneID16175.
KEGGmmu:16175.
UCSCuc008mhr.1. mouse.

Organism-specific databases

CTD3552.
MGIMGI:96542. Il1a.

Phylogenomic databases

eggNOGNOG39906.
HOGENOMHOG000113034.
HOVERGENHBG002432.
InParanoidP01582.
KOK04383.
OMANQKSFYD.
OrthoDBEOG76473H.
PhylomeDBP01582.
TreeFamTF300203.

Gene expression databases

ArrayExpressP01582.
BgeeP01582.
CleanExMM_IL1A.
GenevestigatorP01582.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR000975. IL-1.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR003502. IL-1_propep.
[Graphical view]
PANTHERPTHR11420. PTHR11420. 1 hit.
PfamPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SMARTSM00125. IL1. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio289033.
PROP01582.
SOURCESearch...

Entry information

Entry nameIL1A_MOUSE
AccessionPrimary (citable) accession number: P01582
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot