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P01581 (IFNG_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon gamma

Short name=IFN-gamma
Gene names
Name:Ifng
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length156 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

Subunit structure

Homodimer.

Subcellular location

Secreted.

Tissue specificity

Released primarily from activated T lymphocytes.

Sequence similarities

Belongs to the type II (or gamma) interferon family.

Ontologies

Keywords
   Biological processAntiviral defense
Growth regulation
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
Pyrrolidone carboxylic acid
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processCD8-positive, alpha-beta T cell differentiation involved in immune response

Inferred from electronic annotation. Source: Ensembl

adaptive immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

antigen processing and presentation

Inferred from electronic annotation. Source: Ensembl

cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-18

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

defense response to bacterium

Inferred from electronic annotation. Source: Ensembl

defense response to protozoan

Inferred from electronic annotation. Source: Ensembl

defense response to virus

Inferred from electronic annotation. Source: UniProtKB-KW

endoplasmic reticulum unfolded protein response

Inferred from electronic annotation. Source: Ensembl

extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

humoral immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of cell proliferation

Inferred from direct assay PubMed 11940252. Source: RGD

negative regulation of growth of symbiont in host

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from direct assay PubMed 20624457. Source: BHF-UCL

negative regulation of metanephric nephron tubule epithelial cell differentiation

Inferred from direct assay PubMed 20624457. Source: BHF-UCL

negative regulation of myelination

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 20624457. Source: BHF-UCL

neutrophil apoptotic process

Inferred from electronic annotation. Source: Ensembl

neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of MHC class II biosynthetic process

Inferred from expression pattern PubMed 3127329. Source: RGD

positive regulation of T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of calcidiol 1-monooxygenase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell adhesion

Inferred from direct assay PubMed 2509328. Source: RGD

positive regulation of chemokine biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of fructose 1,6-bisphosphate metabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-1 beta secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-12 biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-12 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-23 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of isotype switching to IgG isotypes

Inferred from electronic annotation. Source: Ensembl

positive regulation of killing of cells of other organism

Inferred from electronic annotation. Source: Ensembl

positive regulation of membrane protein ectodomain proteolysis

Inferred from electronic annotation. Source: Ensembl

positive regulation of mesenchymal cell proliferation

Inferred from direct assay PubMed 20624457. Source: BHF-UCL

positive regulation of neuron differentiation

Inferred from direct assay PubMed 19355840. Source: RGD

positive regulation of nitric oxide biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoclast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation of STAT protein

Inferred from direct assay PubMed 20624457. Source: BHF-UCL

positive regulation of smooth muscle cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of synaptic transmission, cholinergic

Inferred from direct assay PubMed 1900518. Source: RGD

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor (ligand) superfamily member 11 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat1 protein

Inferred from direct assay PubMed 20624457. Source: BHF-UCL

positive regulation of vitamin D biosynthetic process

Inferred from electronic annotation. Source: Ensembl

protein import into nucleus, translocation

Inferred from electronic annotation. Source: Ensembl

regulation of hepatocyte proliferation

Inferred from direct assay PubMed 15799032. Source: RGD

regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

regulation of neuronal action potential

Inferred from direct assay PubMed 7715823. Source: RGD

regulation of the force of heart contraction

Inferred from direct assay PubMed 1900518. Source: RGD

response to drug

Inferred from expression pattern PubMed 19439114. Source: RGD

sensory perception of mechanical stimulus

Inferred from direct assay PubMed 7715823. Source: RGD

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from direct assay PubMed 2474612Ref.1. Source: RGD

   Molecular_functioncytokine activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 156134Interferon gamma
PRO_0000016457

Amino acid modifications

Modified residue231Pyrrolidone carboxylic acid By similarity
Glycosylation381N-linked (GlcNAc...) By similarity
Glycosylation911N-linked (GlcNAc...) By similarity

Sequences

Sequence LengthMass (Da)Tools
P01581 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: BC0B433D2CE1E3F2

FASTA15617,918
        10         20         30         40         50         60 
MSATRRVLVL QLCLMALSGC YCQGTLIESL ESLKNYFNSS SMDAMEGKSL LLDIWRNWQK 

        70         80         90        100        110        120 
DGNTKILESQ IISFYLRLFE VLKDNQAISN NISVIESHLI TNFFSNSKAK KDAFMSIAKF 

       130        140        150 
EVNNPQIQHK AVNELIRVIH QLSPESSLRK RKRSRC 

« Hide

References

[1]"Cloning and expression of the chromosomal immune interferon gene of the rat."
Dijkema R., van der Meide P.H., Pouwels P.H., Caspers M., Dubbeld M., Schellekens H.
EMBO J. 4:761-767(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cloning, expression, and purification of rat IFN-gamma."
Dijkema R., der Meide P.H., Dubbeld M., Caspers M., Wubben J., Schellekens H.
Methods Enzymol. 119:453-463(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]Widegren B., Visse E., Sjogren H.O.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Fischer.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X02325 Genomic DNA. Translation: CAA26185.1.
X02326 Genomic DNA. Translation: CAA26186.1.
X02326 Genomic DNA. Translation: CAA26187.1.
X02327 Genomic DNA. Translation: CAA26188.1.
M29317, M29315, M29316 Genomic DNA. Translation: AAA41362.1.
AF010466 mRNA. Translation: AAB66352.1.
PIRIVRTG. A01845.
RefSeqNP_620235.1. NM_138880.2.
UniGeneRn.10795.

3D structure databases

ProteinModelPortalP01581.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000009917.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000009919; ENSRNOP00000009917; ENSRNOG00000007468.
GeneID25712.
KEGGrno:25712.
UCSCRGD:2866. rat.

Organism-specific databases

CTD3458.
RGD2866. Ifng.

Phylogenomic databases

eggNOGNOG45353.
GeneTreeENSGT00390000007831.
HOGENOMHOG000254784.
HOVERGENHBG056912.
InParanoidP01581.
KOK04687.
OMAKEYFNAS.
OrthoDBEOG7VHSZM.
PhylomeDBP01581.
TreeFamTF336308.

Gene expression databases

GenevestigatorP01581.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERPTHR11419. PTHR11419. 1 hit.
PfamPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFPIRSF001936. IFN-gamma. 1 hit.
ProDomPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

NextBio607779.
PROP01581.

Entry information

Entry nameIFNG_RAT
AccessionPrimary (citable) accession number: P01581
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 14, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families