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Protein

Interferon gamma

Gene

Ifng

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

  • cytokine activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiR-RNO-877300. Interferon gamma signaling.
R-RNO-877312. Regulation of IFNG signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:Ifng
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi2866. Ifng.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • external side of plasma membrane Source: Ensembl
  • extracellular space Source: RGD
  • neuron projection Source: RGD
  • perikaryon Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001645723 – 156Interferon gammaAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Pyrrolidone carboxylic acidBy similarity1
Glycosylationi38N-linked (GlcNAc...)By similarity1
Glycosylationi91N-linked (GlcNAc...)By similarity1

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP01581.
PRIDEiP01581.

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Gene expression databases

BgeeiENSRNOG00000007468.
GenevisibleiP01581. RN.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • cytokine activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009917.

Structurei

3D structure databases

ProteinModelPortaliP01581.
SMRiP01581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWSY. Eukaryota.
ENOG410Z8I5. LUCA.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP01581.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG091G0ZH0.
PhylomeDBiP01581.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATRRVLVL QLCLMALSGC YCQGTLIESL ESLKNYFNSS SMDAMEGKSL
60 70 80 90 100
LLDIWRNWQK DGNTKILESQ IISFYLRLFE VLKDNQAISN NISVIESHLI
110 120 130 140 150
TNFFSNSKAK KDAFMSIAKF EVNNPQIQHK AVNELIRVIH QLSPESSLRK

RKRSRC
Length:156
Mass (Da):17,918
Last modified:July 21, 1986 - v1
Checksum:iBC0B433D2CE1E3F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02325 Genomic DNA. Translation: CAA26185.1.
X02326 Genomic DNA. Translation: CAA26186.1.
X02326 Genomic DNA. Translation: CAA26187.1.
X02327 Genomic DNA. Translation: CAA26188.1.
M29317, M29315, M29316 Genomic DNA. Translation: AAA41362.1.
AF010466 mRNA. Translation: AAB66352.1.
PIRiA01845. IVRTG.
RefSeqiNP_620235.1. NM_138880.2.
UniGeneiRn.10795.

Genome annotation databases

EnsembliENSRNOT00000009919; ENSRNOP00000009917; ENSRNOG00000007468.
GeneIDi25712.
KEGGirno:25712.
UCSCiRGD:2866. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02325 Genomic DNA. Translation: CAA26185.1.
X02326 Genomic DNA. Translation: CAA26186.1.
X02326 Genomic DNA. Translation: CAA26187.1.
X02327 Genomic DNA. Translation: CAA26188.1.
M29317, M29315, M29316 Genomic DNA. Translation: AAA41362.1.
AF010466 mRNA. Translation: AAB66352.1.
PIRiA01845. IVRTG.
RefSeqiNP_620235.1. NM_138880.2.
UniGeneiRn.10795.

3D structure databases

ProteinModelPortaliP01581.
SMRiP01581.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009917.

Proteomic databases

PaxDbiP01581.
PRIDEiP01581.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009919; ENSRNOP00000009917; ENSRNOG00000007468.
GeneIDi25712.
KEGGirno:25712.
UCSCiRGD:2866. rat.

Organism-specific databases

CTDi3458.
RGDi2866. Ifng.

Phylogenomic databases

eggNOGiENOG410IWSY. Eukaryota.
ENOG410Z8I5. LUCA.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP01581.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG091G0ZH0.
PhylomeDBiP01581.
TreeFamiTF336308.

Enzyme and pathway databases

ReactomeiR-RNO-877300. Interferon gamma signaling.
R-RNO-877312. Regulation of IFNG signaling.

Miscellaneous databases

PROiP01581.

Gene expression databases

BgeeiENSRNOG00000007468.
GenevisibleiP01581. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIFNG_RAT
AccessioniPrimary (citable) accession number: P01581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.