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Protein

Interferon gamma

Gene

Ifng

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiR-RNO-877300 Interferon gamma signaling
R-RNO-877312 Regulation of IFNG signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:Ifng
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi2866 Ifng

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001645723 – 156Interferon gammaAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Pyrrolidone carboxylic acidBy similarity1
Glycosylationi38N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi91N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP01581
PRIDEiP01581

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Gene expression databases

BgeeiENSRNOG00000007468
GenevisibleiP01581 RN

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009917

Structurei

3D structure databases

ProteinModelPortaliP01581
SMRiP01581
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWSY Eukaryota
ENOG410Z8I5 LUCA
GeneTreeiENSGT00390000007831
HOGENOMiHOG000254784
HOVERGENiHBG056912
InParanoidiP01581
KOiK04687
OMAiWKEESDK
OrthoDBiEOG091G0ZH0
PhylomeDBiP01581
TreeFamiTF336308

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002069 Interferon_gamma
PANTHERiPTHR11419 PTHR11419, 1 hit
PfamiView protein in Pfam
PF00714 IFN-gamma, 1 hit
PIRSFiPIRSF001936 IFN-gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002435 Interferon_gamma, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATRRVLVL QLCLMALSGC YCQGTLIESL ESLKNYFNSS SMDAMEGKSL
60 70 80 90 100
LLDIWRNWQK DGNTKILESQ IISFYLRLFE VLKDNQAISN NISVIESHLI
110 120 130 140 150
TNFFSNSKAK KDAFMSIAKF EVNNPQIQHK AVNELIRVIH QLSPESSLRK

RKRSRC
Length:156
Mass (Da):17,918
Last modified:July 21, 1986 - v1
Checksum:iBC0B433D2CE1E3F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02325 Genomic DNA Translation: CAA26185.1
X02326 Genomic DNA Translation: CAA26186.1
X02326 Genomic DNA Translation: CAA26187.1
X02327 Genomic DNA Translation: CAA26188.1
M29317, M29315, M29316 Genomic DNA Translation: AAA41362.1
AF010466 mRNA Translation: AAB66352.1
PIRiA01845 IVRTG
RefSeqiNP_620235.1, NM_138880.2
UniGeneiRn.10795

Genome annotation databases

EnsembliENSRNOT00000009919; ENSRNOP00000009917; ENSRNOG00000007468
GeneIDi25712
KEGGirno:25712
UCSCiRGD:2866 rat

Similar proteinsi

Entry informationi

Entry nameiIFNG_RAT
AccessioniPrimary (citable) accession number: P01581
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health