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P01581

- IFNG_RAT

UniProt

P01581 - IFNG_RAT

Protein

Interferon gamma

Gene

Ifng

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. antigen processing and presentation Source: Ensembl
    3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: Ensembl
    4. cell cycle arrest Source: Ensembl
    5. cellular response to interleukin-18 Source: Ensembl
    6. cellular response to lipopolysaccharide Source: Ensembl
    7. defense response to bacterium Source: Ensembl
    8. defense response to protozoan Source: Ensembl
    9. defense response to virus Source: UniProtKB-KW
    10. endoplasmic reticulum unfolded protein response Source: Ensembl
    11. extrinsic apoptotic signaling pathway Source: Ensembl
    12. humoral immune response Source: RefGenome
    13. negative regulation of cell proliferation Source: RGD
    14. negative regulation of growth of symbiont in host Source: Ensembl
    15. negative regulation of interleukin-17 production Source: Ensembl
    16. negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: BHF-UCL
    17. negative regulation of metanephric nephron tubule epithelial cell differentiation Source: BHF-UCL
    18. negative regulation of myelination Source: Ensembl
    19. negative regulation of smooth muscle cell proliferation Source: Ensembl
    20. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    21. neutrophil apoptotic process Source: Ensembl
    22. neutrophil chemotaxis Source: Ensembl
    23. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
    24. positive regulation of cell adhesion Source: RGD
    25. positive regulation of chemokine biosynthetic process Source: Ensembl
    26. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
    27. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
    28. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
    29. positive regulation of interleukin-12 production Source: Ensembl
    30. positive regulation of interleukin-1 beta secretion Source: Ensembl
    31. positive regulation of interleukin-23 production Source: Ensembl
    32. positive regulation of interleukin-6 biosynthetic process Source: Ensembl
    33. positive regulation of isotype switching to IgG isotypes Source: Ensembl
    34. positive regulation of killing of cells of other organism Source: Ensembl
    35. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
    36. positive regulation of mesenchymal cell proliferation Source: BHF-UCL
    37. positive regulation of MHC class II biosynthetic process Source: RGD
    38. positive regulation of neuron differentiation Source: RGD
    39. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    40. positive regulation of osteoclast differentiation Source: Ensembl
    41. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: BHF-UCL
    42. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
    43. positive regulation of synaptic transmission, cholinergic Source: RGD
    44. positive regulation of T cell proliferation Source: Ensembl
    45. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    46. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
    47. positive regulation of tumor necrosis factor production Source: Ensembl
    48. positive regulation of tyrosine phosphorylation of Stat1 protein Source: BHF-UCL
    49. positive regulation of vitamin D biosynthetic process Source: Ensembl
    50. protein import into nucleus, translocation Source: Ensembl
    51. regulation of hepatocyte proliferation Source: RGD
    52. regulation of insulin secretion Source: Ensembl
    53. regulation of neuronal action potential Source: RGD
    54. regulation of the force of heart contraction Source: RGD
    55. response to drug Source: RGD
    56. sensory perception of mechanical stimulus Source: RGD

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense, Growth regulation

    Enzyme and pathway databases

    ReactomeiREACT_196446. Interferon gamma signaling.
    REACT_196448. Regulation of IFNG signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon gamma
    Short name:
    IFN-gamma
    Gene namesi
    Name:Ifng
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi2866. Ifng.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 156134Interferon gammaPRO_0000016457Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231Pyrrolidone carboxylic acidBy similarity
    Glycosylationi38 – 381N-linked (GlcNAc...)By similarity
    Glycosylationi91 – 911N-linked (GlcNAc...)By similarity

    Keywords - PTMi

    Glycoprotein, Pyrrolidone carboxylic acid

    Expressioni

    Tissue specificityi

    Released primarily from activated T lymphocytes.

    Gene expression databases

    GenevestigatoriP01581.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000009917.

    Structurei

    3D structure databases

    ProteinModelPortaliP01581.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45353.
    GeneTreeiENSGT00390000007831.
    HOGENOMiHOG000254784.
    HOVERGENiHBG056912.
    InParanoidiP01581.
    KOiK04687.
    OMAiKEYFNAS.
    OrthoDBiEOG7VHSZM.
    PhylomeDBiP01581.
    TreeFamiTF336308.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view]
    PANTHERiPTHR11419. PTHR11419. 1 hit.
    PfamiPF00714. IFN-gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001936. IFN-gamma. 1 hit.
    ProDomiPD002435. Interferon_gamma. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01581-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSATRRVLVL QLCLMALSGC YCQGTLIESL ESLKNYFNSS SMDAMEGKSL    50
    LLDIWRNWQK DGNTKILESQ IISFYLRLFE VLKDNQAISN NISVIESHLI 100
    TNFFSNSKAK KDAFMSIAKF EVNNPQIQHK AVNELIRVIH QLSPESSLRK 150
    RKRSRC 156
    Length:156
    Mass (Da):17,918
    Last modified:July 21, 1986 - v1
    Checksum:iBC0B433D2CE1E3F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02325 Genomic DNA. Translation: CAA26185.1.
    X02326 Genomic DNA. Translation: CAA26186.1.
    X02326 Genomic DNA. Translation: CAA26187.1.
    X02327 Genomic DNA. Translation: CAA26188.1.
    M29317, M29315, M29316 Genomic DNA. Translation: AAA41362.1.
    AF010466 mRNA. Translation: AAB66352.1.
    PIRiA01845. IVRTG.
    RefSeqiNP_620235.1. NM_138880.2.
    UniGeneiRn.10795.

    Genome annotation databases

    EnsembliENSRNOT00000009919; ENSRNOP00000009917; ENSRNOG00000007468.
    GeneIDi25712.
    KEGGirno:25712.
    UCSCiRGD:2866. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02325 Genomic DNA. Translation: CAA26185.1 .
    X02326 Genomic DNA. Translation: CAA26186.1 .
    X02326 Genomic DNA. Translation: CAA26187.1 .
    X02327 Genomic DNA. Translation: CAA26188.1 .
    M29317 , M29315 , M29316 Genomic DNA. Translation: AAA41362.1 .
    AF010466 mRNA. Translation: AAB66352.1 .
    PIRi A01845. IVRTG.
    RefSeqi NP_620235.1. NM_138880.2.
    UniGenei Rn.10795.

    3D structure databases

    ProteinModelPortali P01581.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000009917.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009919 ; ENSRNOP00000009917 ; ENSRNOG00000007468 .
    GeneIDi 25712.
    KEGGi rno:25712.
    UCSCi RGD:2866. rat.

    Organism-specific databases

    CTDi 3458.
    RGDi 2866. Ifng.

    Phylogenomic databases

    eggNOGi NOG45353.
    GeneTreei ENSGT00390000007831.
    HOGENOMi HOG000254784.
    HOVERGENi HBG056912.
    InParanoidi P01581.
    KOi K04687.
    OMAi KEYFNAS.
    OrthoDBi EOG7VHSZM.
    PhylomeDBi P01581.
    TreeFami TF336308.

    Enzyme and pathway databases

    Reactomei REACT_196446. Interferon gamma signaling.
    REACT_196448. Regulation of IFNG signaling.

    Miscellaneous databases

    NextBioi 607779.
    PROi P01581.

    Gene expression databases

    Genevestigatori P01581.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view ]
    PANTHERi PTHR11419. PTHR11419. 1 hit.
    Pfami PF00714. IFN-gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001936. IFN-gamma. 1 hit.
    ProDomi PD002435. Interferon_gamma. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of the chromosomal immune interferon gene of the rat."
      Dijkema R., van der Meide P.H., Pouwels P.H., Caspers M., Dubbeld M., Schellekens H.
      EMBO J. 4:761-767(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Widegren B., Visse E., Sjogren H.O.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Fischer.

    Entry informationi

    Entry nameiIFNG_RAT
    AccessioniPrimary (citable) accession number: P01581
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3