Reviewed,
UniProtKB/Swiss-Prot P01581 (IFNG_RAT)
Last modified
November 3, 2009.
Version 77.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Interferon gamma Short name=IFN-gamma | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 156 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. |
| Subunit structure | Homodimer. |
| Subcellular location | |
| Tissue specificity | Released primarily from activated T lymphocytes. |
| Sequence similarities | Belongs to the type II (or gamma) interferon family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | By similarity | ||||||
| Chain | 23 – 156 | 134 | Interferon gamma | PRO_0000016457 | |||||
Amino acid modifications | |||||||||
| Modified residue | 23 | 1 | Pyrrolidone carboxylic acid By similarity | ||||||
| Glycosylation | 38 | 1 | N-linked (GlcNAc...) By similarity | ||||||
| Glycosylation | 91 | 1 | N-linked (GlcNAc...) By similarity | ||||||
Sequences
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References
| [1] | "Cloning and expression of the chromosomal immune interferon gene of the rat." Dijkema R., van der Meide P.H., Pouwels P.H., Caspers M., Dubbeld M., Schellekens H. EMBO J. 4:761-767(1985) [PubMed: 3924594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Cloning, expression, and purification of rat IFN-gamma." Dijkema R., der Meide P.H., Dubbeld M., Caspers M., Wubben J., Schellekens H. Methods Enzymol. 119:453-463(1986) [PubMed: 3093809] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | Widegren B., Visse E., Sjogren H.O. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Fischer. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X02325 Genomic DNA. Translation: CAA26185.1. X02326 Genomic DNA. Translation: CAA26186.1. X02326 Genomic DNA. Translation: CAA26187.1. X02327 Genomic DNA. Translation: CAA26188.1. M29317, M29315, M29316 Genomic DNA. Translation: AAA41362.1. AF010466 mRNA. Translation: AAB66352.1. | |
| IPI | IPI00214504. |
| PIR | IVRTG. A01845. |
| RefSeq | NP_620235.1. |
| UniGene | Rn.10795 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1D9C based on UniProtKB P07353. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P01581. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000009919; ENSRNOP00000009917; ENSRNOG00000007468; Rattus norvegicus. [Genome view] |
| GeneID | 25712. |
| KEGG | rno:25712. |
| UCSC | NM_138880. rat. |
Organism-specific databases | |
| CTD | 25712. |
| RGD | 2866. Ifng. |
Phylogenomic databases | |
| HOVERGEN | P01581. |
| OMA | NWKEESD. |
Gene expression databases | |
| ArrayExpress | P01581. |
| Genevestigator | P01581. |
| GermOnline | ENSRNOG00000007468. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR002069. Interferon_gamma. [Graphical view] |
| PANTHER | PTHR11419. IFN-gamma. 1 hit. |
| Pfam | PF00714. IFN-gamma. 1 hit. [Graphical view] |
| PIRSF | PIRSF001936. IFN-gamma. 1 hit. |
| ProDom | PD002435. IFN-gamma. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 607779. |
Entry information
| Entry name | IFNG_RAT | ||||||||
| Accession | Primary (citable) accession number: P01581 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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