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P01581

- IFNG_RAT

UniProt

P01581 - IFNG_RAT

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Protein

Interferon gamma

Gene
Ifng
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

  1. cytokine activity Source: RefGenome

GO - Biological processi

  1. adaptive immune response Source: RefGenome
  2. antigen processing and presentation Source: Ensembl
  3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: Ensembl
  4. cell cycle arrest Source: Ensembl
  5. cellular response to interleukin-18 Source: Ensembl
  6. cellular response to lipopolysaccharide Source: Ensembl
  7. defense response to bacterium Source: Ensembl
  8. defense response to protozoan Source: Ensembl
  9. defense response to virus Source: UniProtKB-KW
  10. endoplasmic reticulum unfolded protein response Source: Ensembl
  11. extrinsic apoptotic signaling pathway Source: Ensembl
  12. humoral immune response Source: RefGenome
  13. negative regulation of cell proliferation Source: RGD
  14. negative regulation of growth of symbiont in host Source: Ensembl
  15. negative regulation of interleukin-17 production Source: Ensembl
  16. negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: BHF-UCL
  17. negative regulation of metanephric nephron tubule epithelial cell differentiation Source: BHF-UCL
  18. negative regulation of myelination Source: Ensembl
  19. negative regulation of smooth muscle cell proliferation Source: Ensembl
  20. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  21. neutrophil apoptotic process Source: Ensembl
  22. neutrophil chemotaxis Source: Ensembl
  23. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
  24. positive regulation of cell adhesion Source: RGD
  25. positive regulation of chemokine biosynthetic process Source: Ensembl
  26. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
  27. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
  28. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
  29. positive regulation of interleukin-12 production Source: Ensembl
  30. positive regulation of interleukin-1 beta secretion Source: Ensembl
  31. positive regulation of interleukin-23 production Source: Ensembl
  32. positive regulation of interleukin-6 biosynthetic process Source: Ensembl
  33. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  34. positive regulation of killing of cells of other organism Source: Ensembl
  35. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  36. positive regulation of mesenchymal cell proliferation Source: BHF-UCL
  37. positive regulation of MHC class II biosynthetic process Source: RGD
  38. positive regulation of neuron differentiation Source: RGD
  39. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  40. positive regulation of osteoclast differentiation Source: Ensembl
  41. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: BHF-UCL
  42. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
  43. positive regulation of synaptic transmission, cholinergic Source: RGD
  44. positive regulation of T cell proliferation Source: Ensembl
  45. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  46. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
  47. positive regulation of tumor necrosis factor production Source: Ensembl
  48. positive regulation of tyrosine phosphorylation of Stat1 protein Source: BHF-UCL
  49. positive regulation of vitamin D biosynthetic process Source: Ensembl
  50. protein import into nucleus, translocation Source: Ensembl
  51. regulation of hepatocyte proliferation Source: RGD
  52. regulation of insulin secretion Source: Ensembl
  53. regulation of neuronal action potential Source: RGD
  54. regulation of the force of heart contraction Source: RGD
  55. response to drug Source: RGD
  56. sensory perception of mechanical stimulus Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiREACT_196446. Interferon gamma signaling.
REACT_196448. Regulation of IFNG signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:Ifng
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi2866. Ifng.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarityAdd
BLAST
Chaini23 – 156134Interferon gammaPRO_0000016457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231Pyrrolidone carboxylic acid By similarity
Glycosylationi38 – 381N-linked (GlcNAc...) By similarity
Glycosylationi91 – 911N-linked (GlcNAc...) By similarity

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Gene expression databases

GenevestigatoriP01581.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009917.

Structurei

3D structure databases

ProteinModelPortaliP01581.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP01581.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
PhylomeDBiP01581.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01581-1 [UniParc]FASTAAdd to Basket

« Hide

MSATRRVLVL QLCLMALSGC YCQGTLIESL ESLKNYFNSS SMDAMEGKSL    50
LLDIWRNWQK DGNTKILESQ IISFYLRLFE VLKDNQAISN NISVIESHLI 100
TNFFSNSKAK KDAFMSIAKF EVNNPQIQHK AVNELIRVIH QLSPESSLRK 150
RKRSRC 156
Length:156
Mass (Da):17,918
Last modified:July 21, 1986 - v1
Checksum:iBC0B433D2CE1E3F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02325 Genomic DNA. Translation: CAA26185.1.
X02326 Genomic DNA. Translation: CAA26186.1.
X02326 Genomic DNA. Translation: CAA26187.1.
X02327 Genomic DNA. Translation: CAA26188.1.
M29317, M29315, M29316 Genomic DNA. Translation: AAA41362.1.
AF010466 mRNA. Translation: AAB66352.1.
PIRiA01845. IVRTG.
RefSeqiNP_620235.1. NM_138880.2.
UniGeneiRn.10795.

Genome annotation databases

EnsembliENSRNOT00000009919; ENSRNOP00000009917; ENSRNOG00000007468.
GeneIDi25712.
KEGGirno:25712.
UCSCiRGD:2866. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02325 Genomic DNA. Translation: CAA26185.1 .
X02326 Genomic DNA. Translation: CAA26186.1 .
X02326 Genomic DNA. Translation: CAA26187.1 .
X02327 Genomic DNA. Translation: CAA26188.1 .
M29317 , M29315 , M29316 Genomic DNA. Translation: AAA41362.1 .
AF010466 mRNA. Translation: AAB66352.1 .
PIRi A01845. IVRTG.
RefSeqi NP_620235.1. NM_138880.2.
UniGenei Rn.10795.

3D structure databases

ProteinModelPortali P01581.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000009917.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000009919 ; ENSRNOP00000009917 ; ENSRNOG00000007468 .
GeneIDi 25712.
KEGGi rno:25712.
UCSCi RGD:2866. rat.

Organism-specific databases

CTDi 3458.
RGDi 2866. Ifng.

Phylogenomic databases

eggNOGi NOG45353.
GeneTreei ENSGT00390000007831.
HOGENOMi HOG000254784.
HOVERGENi HBG056912.
InParanoidi P01581.
KOi K04687.
OMAi KEYFNAS.
OrthoDBi EOG7VHSZM.
PhylomeDBi P01581.
TreeFami TF336308.

Enzyme and pathway databases

Reactomei REACT_196446. Interferon gamma signaling.
REACT_196448. Regulation of IFNG signaling.

Miscellaneous databases

NextBioi 607779.
PROi P01581.

Gene expression databases

Genevestigatori P01581.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view ]
PANTHERi PTHR11419. PTHR11419. 1 hit.
Pfami PF00714. IFN-gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF001936. IFN-gamma. 1 hit.
ProDomi PD002435. Interferon_gamma. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of the chromosomal immune interferon gene of the rat."
    Dijkema R., van der Meide P.H., Pouwels P.H., Caspers M., Dubbeld M., Schellekens H.
    EMBO J. 4:761-767(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Widegren B., Visse E., Sjogren H.O.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer.

Entry informationi

Entry nameiIFNG_RAT
AccessioniPrimary (citable) accession number: P01581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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