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Protein

Interferon gamma

Gene

Ifng

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiR-MMU-877300 Interferon gamma signaling
R-MMU-877312 Regulation of IFNG signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:Ifng
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:107656 Ifng

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001645323 – 155Interferon gammaAdd BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi90N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP01580
PaxDbiP01580
PRIDEiP01580

PTM databases

PhosphoSitePlusiP01580

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Gene expression databases

BgeeiENSMUSG00000055170
CleanExiMM_IFNG
GenevisibleiP01580 MM

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
Kpna2P522935EBI-7892102,EBI-3043908

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01580, 2 interactors
MINTiP01580
STRINGi10090.ENSMUSP00000063800

Structurei

3D structure databases

ProteinModelPortaliP01580
SMRiP01580
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWSY Eukaryota
ENOG410Z8I5 LUCA
GeneTreeiENSGT00390000007831
HOGENOMiHOG000254784
HOVERGENiHBG056912
InParanoidiP01580
KOiK04687
OMAiWKEESDK
OrthoDBiEOG091G0ZH0
PhylomeDBiP01580
TreeFamiTF336308

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002069 Interferon_gamma
PANTHERiPTHR11419 PTHR11419, 1 hit
PfamiView protein in Pfam
PF00714 IFN-gamma, 1 hit
PIRSFiPIRSF001936 IFN-gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002435 Interferon_gamma, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNATHCILAL QLFLMAVSGC YCHGTVIESL ESLNNYFNSS GIDVEEKSLF
60 70 80 90 100
LDIWRNWQKD GDMKILQSQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT
110 120 130 140 150
TFFSNSKAKK DAFMSIAKFE VNNPQVQRQA FNELIRVVHQ LLPESSLRKR

KRSRC
Length:155
Mass (Da):17,907
Last modified:July 21, 1986 - v1
Checksum:i7EE80BAECB42071A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00083 mRNA Translation: AAA37894.1
AK089574 mRNA Translation: BAC40926.1
BC119063 mRNA Translation: AAI19064.1
BC119065 mRNA Translation: AAI19066.1
CCDSiCCDS24200.1
PIRiA01844 IVMSG
RefSeqiNP_032363.1, NM_008337.4
UniGeneiMm.240327

Genome annotation databases

EnsembliENSMUST00000068592; ENSMUSP00000063800; ENSMUSG00000055170
GeneIDi15978
KEGGimmu:15978
UCSCiuc007hdy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIFNG_MOUSE
AccessioniPrimary (citable) accession number: P01580
Secondary accession number(s): Q542B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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