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Protein

Interferon gamma

Gene

Ifng

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

  1. cytokine activity Source: MGI

GO - Biological processi

  1. adaptive immune response Source: MGI
  2. antigen processing and presentation Source: MGI
  3. apoptotic process Source: MGI
  4. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: MGI
  5. cell cycle arrest Source: MGI
  6. cellular response to interleukin-18 Source: MGI
  7. cellular response to lipopolysaccharide Source: MGI
  8. defense response to bacterium Source: MGI
  9. defense response to protozoan Source: MGI
  10. defense response to virus Source: MGI
  11. endoplasmic reticulum unfolded protein response Source: MGI
  12. extrinsic apoptotic signaling pathway Source: MGI
  13. humoral immune response Source: MGI
  14. inflammatory cell apoptotic process Source: MGI
  15. negative regulation of growth of symbiont in host Source: MGI
  16. negative regulation of growth of symbiont involved in interaction with host Source: MGI
  17. negative regulation of interleukin-17 production Source: MGI
  18. negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
  19. negative regulation of metanephric nephron tubule epithelial cell differentiation Source: Ensembl
  20. negative regulation of myelination Source: MGI
  21. negative regulation of smooth muscle cell proliferation Source: MGI
  22. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  23. neutrophil apoptotic process Source: MGI
  24. neutrophil chemotaxis Source: MGI
  25. positive regulation of calcidiol 1-monooxygenase activity Source: MGI
  26. positive regulation of chemokine biosynthetic process Source: MGI
  27. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: MGI
  28. positive regulation of fructose 1,6-bisphosphate metabolic process Source: MGI
  29. positive regulation of interleukin-12 biosynthetic process Source: MGI
  30. positive regulation of interleukin-12 production Source: MGI
  31. positive regulation of interleukin-1 beta secretion Source: MGI
  32. positive regulation of interleukin-23 production Source: MGI
  33. positive regulation of interleukin-6 biosynthetic process Source: MGI
  34. positive regulation of isotype switching to IgG isotypes Source: MGI
  35. positive regulation of killing of cells of other organism Source: MGI
  36. positive regulation of membrane protein ectodomain proteolysis Source: MGI
  37. positive regulation of mesenchymal cell proliferation Source: Ensembl
  38. positive regulation of MHC class II biosynthetic process Source: BHF-UCL
  39. positive regulation of neuron differentiation Source: Ensembl
  40. positive regulation of nitric oxide biosynthetic process Source: MGI
  41. positive regulation of osteoclast differentiation Source: MGI
  42. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: MGI
  43. positive regulation of smooth muscle cell apoptotic process Source: MGI
  44. positive regulation of synaptic transmission, cholinergic Source: Ensembl
  45. positive regulation of T cell proliferation Source: MGI
  46. positive regulation of transcription, DNA-templated Source: MGI
  47. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  48. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: MGI
  49. positive regulation of tumor necrosis factor production Source: BHF-UCL
  50. positive regulation of tyrosine phosphorylation of Stat1 protein Source: MGI
  51. positive regulation of vitamin D biosynthetic process Source: MGI
  52. protein import into nucleus, translocation Source: MGI
  53. regulation of hepatocyte proliferation Source: Ensembl
  54. regulation of immune response Source: MGI
  55. regulation of insulin secretion Source: MGI
  56. regulation of neuronal action potential Source: Ensembl
  57. regulation of the force of heart contraction Source: Ensembl
  58. regulation of transcription, DNA-templated Source: MGI
  59. response to drug Source: Ensembl
  60. response to virus Source: MGI
  61. sensory perception of mechanical stimulus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiREACT_289967. Regulation of IFNG signaling.
REACT_349056. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:Ifng
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:107656. Ifng.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. extracellular region Source: MGI
  3. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 155133Interferon gammaPRO_0000016453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)By similarity
Glycosylationi90 – 901N-linked (GlcNAc...)By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP01580.

PTM databases

PhosphoSiteiP01580.

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Gene expression databases

BgeeiP01580.
CleanExiMM_IFNG.
ExpressionAtlasiP01580. baseline and differential.
GenevestigatoriP01580.

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
Kpna2P522935EBI-7892102,EBI-3043908

Protein-protein interaction databases

IntActiP01580. 2 interactions.
STRINGi10090.ENSMUSP00000063800.

Structurei

3D structure databases

ProteinModelPortaliP01580.
SMRiP01580. Positions 30-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP01580.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
PhylomeDBiP01580.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNATHCILAL QLFLMAVSGC YCHGTVIESL ESLNNYFNSS GIDVEEKSLF
60 70 80 90 100
LDIWRNWQKD GDMKILQSQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT
110 120 130 140 150
TFFSNSKAKK DAFMSIAKFE VNNPQVQRQA FNELIRVVHQ LLPESSLRKR

KRSRC
Length:155
Mass (Da):17,907
Last modified:July 21, 1986 - v1
Checksum:i7EE80BAECB42071A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00083 mRNA. Translation: AAA37894.1.
AK089574 mRNA. Translation: BAC40926.1.
BC119063 mRNA. Translation: AAI19064.1.
BC119065 mRNA. Translation: AAI19066.1.
CCDSiCCDS24200.1.
PIRiA01844. IVMSG.
RefSeqiNP_032363.1. NM_008337.3.
UniGeneiMm.240327.

Genome annotation databases

EnsembliENSMUST00000068592; ENSMUSP00000063800; ENSMUSG00000055170.
GeneIDi15978.
KEGGimmu:15978.
UCSCiuc007hdy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00083 mRNA. Translation: AAA37894.1.
AK089574 mRNA. Translation: BAC40926.1.
BC119063 mRNA. Translation: AAI19064.1.
BC119065 mRNA. Translation: AAI19066.1.
CCDSiCCDS24200.1.
PIRiA01844. IVMSG.
RefSeqiNP_032363.1. NM_008337.3.
UniGeneiMm.240327.

3D structure databases

ProteinModelPortaliP01580.
SMRiP01580. Positions 30-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01580. 2 interactions.
STRINGi10090.ENSMUSP00000063800.

PTM databases

PhosphoSiteiP01580.

Proteomic databases

PRIDEiP01580.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068592; ENSMUSP00000063800; ENSMUSG00000055170.
GeneIDi15978.
KEGGimmu:15978.
UCSCiuc007hdy.1. mouse.

Organism-specific databases

CTDi3458.
MGIiMGI:107656. Ifng.

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP01580.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
PhylomeDBiP01580.
TreeFamiTF336308.

Enzyme and pathway databases

ReactomeiREACT_289967. Regulation of IFNG signaling.
REACT_349056. Interferon gamma signaling.

Miscellaneous databases

NextBioi288760.
PROiP01580.
SOURCEiSearch...

Gene expression databases

BgeeiP01580.
CleanExiMM_IFNG.
ExpressionAtlasiP01580. baseline and differential.
GenevestigatoriP01580.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of murine immune interferon cDNA."
    Gray P.W., Goeddel D.V.
    Proc. Natl. Acad. Sci. U.S.A. 80:5842-5846(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiIFNG_MOUSE
AccessioniPrimary (citable) accession number: P01580
Secondary accession number(s): Q542B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 1, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.