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P01580

- IFNG_MOUSE

UniProt

P01580 - IFNG_MOUSE

Protein

Interferon gamma

Gene

Ifng

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

    GO - Molecular functioni

    1. cytokine activity Source: MGI
    2. protein binding Source: IntAct

    GO - Biological processi

    1. adaptive immune response Source: MGI
    2. antigen processing and presentation Source: MGI
    3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: MGI
    4. cell cycle arrest Source: Ensembl
    5. cellular response to interleukin-18 Source: MGI
    6. cellular response to lipopolysaccharide Source: MGI
    7. defense response to bacterium Source: MGI
    8. defense response to protozoan Source: MGI
    9. defense response to virus Source: MGI
    10. endoplasmic reticulum unfolded protein response Source: MGI
    11. extrinsic apoptotic signaling pathway Source: Ensembl
    12. humoral immune response Source: MGI
    13. inflammatory cell apoptotic process Source: MGI
    14. negative regulation of growth of symbiont in host Source: MGI
    15. negative regulation of growth of symbiont involved in interaction with host Source: MGI
    16. negative regulation of interleukin-17 production Source: Ensembl
    17. negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
    18. negative regulation of metanephric nephron tubule epithelial cell differentiation Source: Ensembl
    19. negative regulation of myelination Source: MGI
    20. negative regulation of smooth muscle cell proliferation Source: Ensembl
    21. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    22. neutrophil apoptotic process Source: MGI
    23. neutrophil chemotaxis Source: MGI
    24. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
    25. positive regulation of cell adhesion Source: Ensembl
    26. positive regulation of chemokine biosynthetic process Source: MGI
    27. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
    28. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
    29. positive regulation of interleukin-12 biosynthetic process Source: MGI
    30. positive regulation of interleukin-12 production Source: MGI
    31. positive regulation of interleukin-1 beta secretion Source: MGI
    32. positive regulation of interleukin-23 production Source: Ensembl
    33. positive regulation of interleukin-6 biosynthetic process Source: MGI
    34. positive regulation of isotype switching to IgG isotypes Source: MGI
    35. positive regulation of killing of cells of other organism Source: Ensembl
    36. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
    37. positive regulation of mesenchymal cell proliferation Source: Ensembl
    38. positive regulation of MHC class II biosynthetic process Source: BHF-UCL
    39. positive regulation of neuron differentiation Source: Ensembl
    40. positive regulation of nitric oxide biosynthetic process Source: MGI
    41. positive regulation of osteoclast differentiation Source: Ensembl
    42. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: MGI
    43. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
    44. positive regulation of synaptic transmission, cholinergic Source: Ensembl
    45. positive regulation of T cell proliferation Source: MGI
    46. positive regulation of transcription, DNA-templated Source: MGI
    47. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    48. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
    49. positive regulation of tumor necrosis factor production Source: BHF-UCL
    50. positive regulation of tyrosine phosphorylation of Stat1 protein Source: MGI
    51. positive regulation of vitamin D biosynthetic process Source: Ensembl
    52. protein import into nucleus, translocation Source: Ensembl
    53. regulation of immune response Source: MGI
    54. regulation of insulin secretion Source: Ensembl
    55. regulation of the force of heart contraction Source: Ensembl
    56. regulation of transcription, DNA-templated Source: MGI
    57. response to drug Source: Ensembl
    58. response to virus Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense, Growth regulation

    Enzyme and pathway databases

    ReactomeiREACT_198645. Regulation of IFNG signaling.
    REACT_198660. Interferon gamma signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon gamma
    Short name:
    IFN-gamma
    Gene namesi
    Name:Ifng
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:107656. Ifng.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 155133Interferon gammaPRO_0000016453Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)By similarity
    Glycosylationi90 – 901N-linked (GlcNAc...)By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP01580.

    PTM databases

    PhosphoSiteiP01580.

    Expressioni

    Tissue specificityi

    Released primarily from activated T lymphocytes.

    Gene expression databases

    ArrayExpressiP01580.
    BgeeiP01580.
    CleanExiMM_IFNG.
    GenevestigatoriP01580.

    Interactioni

    Subunit structurei

    Homodimer.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Kpna2P522935EBI-7892102,EBI-3043908

    Protein-protein interaction databases

    IntActiP01580. 2 interactions.
    STRINGi10090.ENSMUSP00000063800.

    Structurei

    3D structure databases

    ProteinModelPortaliP01580.
    SMRiP01580. Positions 30-141.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45353.
    GeneTreeiENSGT00390000007831.
    HOGENOMiHOG000254784.
    HOVERGENiHBG056912.
    InParanoidiP01580.
    KOiK04687.
    OMAiKEYFNAS.
    OrthoDBiEOG7VHSZM.
    PhylomeDBiP01580.
    TreeFamiTF336308.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view]
    PANTHERiPTHR11419. PTHR11419. 1 hit.
    PfamiPF00714. IFN-gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001936. IFN-gamma. 1 hit.
    ProDomiPD002435. Interferon_gamma. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01580-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNATHCILAL QLFLMAVSGC YCHGTVIESL ESLNNYFNSS GIDVEEKSLF    50
    LDIWRNWQKD GDMKILQSQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT 100
    TFFSNSKAKK DAFMSIAKFE VNNPQVQRQA FNELIRVVHQ LLPESSLRKR 150
    KRSRC 155
    Length:155
    Mass (Da):17,907
    Last modified:July 21, 1986 - v1
    Checksum:i7EE80BAECB42071A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K00083 mRNA. Translation: AAA37894.1.
    AK089574 mRNA. Translation: BAC40926.1.
    BC119063 mRNA. Translation: AAI19064.1.
    BC119065 mRNA. Translation: AAI19066.1.
    CCDSiCCDS24200.1.
    PIRiA01844. IVMSG.
    RefSeqiNP_032363.1. NM_008337.3.
    UniGeneiMm.240327.

    Genome annotation databases

    EnsembliENSMUST00000068592; ENSMUSP00000063800; ENSMUSG00000055170.
    GeneIDi15978.
    KEGGimmu:15978.
    UCSCiuc007hdy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K00083 mRNA. Translation: AAA37894.1 .
    AK089574 mRNA. Translation: BAC40926.1 .
    BC119063 mRNA. Translation: AAI19064.1 .
    BC119065 mRNA. Translation: AAI19066.1 .
    CCDSi CCDS24200.1.
    PIRi A01844. IVMSG.
    RefSeqi NP_032363.1. NM_008337.3.
    UniGenei Mm.240327.

    3D structure databases

    ProteinModelPortali P01580.
    SMRi P01580. Positions 30-141.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P01580. 2 interactions.
    STRINGi 10090.ENSMUSP00000063800.

    PTM databases

    PhosphoSitei P01580.

    Proteomic databases

    PRIDEi P01580.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068592 ; ENSMUSP00000063800 ; ENSMUSG00000055170 .
    GeneIDi 15978.
    KEGGi mmu:15978.
    UCSCi uc007hdy.1. mouse.

    Organism-specific databases

    CTDi 3458.
    MGIi MGI:107656. Ifng.

    Phylogenomic databases

    eggNOGi NOG45353.
    GeneTreei ENSGT00390000007831.
    HOGENOMi HOG000254784.
    HOVERGENi HBG056912.
    InParanoidi P01580.
    KOi K04687.
    OMAi KEYFNAS.
    OrthoDBi EOG7VHSZM.
    PhylomeDBi P01580.
    TreeFami TF336308.

    Enzyme and pathway databases

    Reactomei REACT_198645. Regulation of IFNG signaling.
    REACT_198660. Interferon gamma signaling.

    Miscellaneous databases

    NextBioi 288760.
    PROi P01580.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01580.
    Bgeei P01580.
    CleanExi MM_IFNG.
    Genevestigatori P01580.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view ]
    PANTHERi PTHR11419. PTHR11419. 1 hit.
    Pfami PF00714. IFN-gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001936. IFN-gamma. 1 hit.
    ProDomi PD002435. Interferon_gamma. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of murine immune interferon cDNA."
      Gray P.W., Goeddel D.V.
      Proc. Natl. Acad. Sci. U.S.A. 80:5842-5846(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Spleen.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiIFNG_MOUSE
    AccessioniPrimary (citable) accession number: P01580
    Secondary accession number(s): Q542B8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3