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P01580

- IFNG_MOUSE

UniProt

P01580 - IFNG_MOUSE

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Protein

Interferon gamma

Gene
Ifng
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

  1. cytokine activity Source: MGI
  2. protein binding Source: IntAct

GO - Biological processi

  1. adaptive immune response Source: MGI
  2. antigen processing and presentation Source: MGI
  3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: MGI
  4. cell cycle arrest Source: Ensembl
  5. cellular response to interleukin-18 Source: MGI
  6. cellular response to lipopolysaccharide Source: MGI
  7. defense response to bacterium Source: MGI
  8. defense response to protozoan Source: MGI
  9. defense response to virus Source: MGI
  10. endoplasmic reticulum unfolded protein response Source: MGI
  11. extrinsic apoptotic signaling pathway Source: Ensembl
  12. humoral immune response Source: MGI
  13. inflammatory cell apoptotic process Source: MGI
  14. negative regulation of growth of symbiont in host Source: MGI
  15. negative regulation of growth of symbiont involved in interaction with host Source: MGI
  16. negative regulation of interleukin-17 production Source: Ensembl
  17. negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
  18. negative regulation of metanephric nephron tubule epithelial cell differentiation Source: Ensembl
  19. negative regulation of myelination Source: MGI
  20. negative regulation of smooth muscle cell proliferation Source: Ensembl
  21. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  22. neutrophil apoptotic process Source: MGI
  23. neutrophil chemotaxis Source: MGI
  24. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
  25. positive regulation of cell adhesion Source: Ensembl
  26. positive regulation of chemokine biosynthetic process Source: MGI
  27. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
  28. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
  29. positive regulation of interleukin-12 biosynthetic process Source: MGI
  30. positive regulation of interleukin-12 production Source: MGI
  31. positive regulation of interleukin-1 beta secretion Source: MGI
  32. positive regulation of interleukin-23 production Source: Ensembl
  33. positive regulation of interleukin-6 biosynthetic process Source: MGI
  34. positive regulation of isotype switching to IgG isotypes Source: MGI
  35. positive regulation of killing of cells of other organism Source: Ensembl
  36. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  37. positive regulation of mesenchymal cell proliferation Source: Ensembl
  38. positive regulation of MHC class II biosynthetic process Source: BHF-UCL
  39. positive regulation of neuron differentiation Source: Ensembl
  40. positive regulation of nitric oxide biosynthetic process Source: MGI
  41. positive regulation of osteoclast differentiation Source: Ensembl
  42. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: MGI
  43. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
  44. positive regulation of synaptic transmission, cholinergic Source: Ensembl
  45. positive regulation of T cell proliferation Source: MGI
  46. positive regulation of transcription, DNA-templated Source: MGI
  47. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  48. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
  49. positive regulation of tumor necrosis factor production Source: BHF-UCL
  50. positive regulation of tyrosine phosphorylation of Stat1 protein Source: MGI
  51. positive regulation of vitamin D biosynthetic process Source: Ensembl
  52. protein import into nucleus, translocation Source: Ensembl
  53. regulation of immune response Source: MGI
  54. regulation of insulin secretion Source: Ensembl
  55. regulation of the force of heart contraction Source: Ensembl
  56. regulation of transcription, DNA-templated Source: MGI
  57. response to drug Source: Ensembl
  58. response to virus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiREACT_198645. Regulation of IFNG signaling.
REACT_198660. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:Ifng
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:107656. Ifng.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 155133Interferon gammaPRO_0000016453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...) By similarity
Glycosylationi90 – 901N-linked (GlcNAc...) By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP01580.

PTM databases

PhosphoSiteiP01580.

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Gene expression databases

ArrayExpressiP01580.
BgeeiP01580.
CleanExiMM_IFNG.
GenevestigatoriP01580.

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
Kpna2P522935EBI-7892102,EBI-3043908

Protein-protein interaction databases

IntActiP01580. 2 interactions.
STRINGi10090.ENSMUSP00000063800.

Structurei

3D structure databases

ProteinModelPortaliP01580.
SMRiP01580. Positions 30-141.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP01580.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
PhylomeDBiP01580.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01580-1 [UniParc]FASTAAdd to Basket

« Hide

MNATHCILAL QLFLMAVSGC YCHGTVIESL ESLNNYFNSS GIDVEEKSLF    50
LDIWRNWQKD GDMKILQSQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT 100
TFFSNSKAKK DAFMSIAKFE VNNPQVQRQA FNELIRVVHQ LLPESSLRKR 150
KRSRC 155
Length:155
Mass (Da):17,907
Last modified:July 21, 1986 - v1
Checksum:i7EE80BAECB42071A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K00083 mRNA. Translation: AAA37894.1.
AK089574 mRNA. Translation: BAC40926.1.
BC119063 mRNA. Translation: AAI19064.1.
BC119065 mRNA. Translation: AAI19066.1.
CCDSiCCDS24200.1.
PIRiA01844. IVMSG.
RefSeqiNP_032363.1. NM_008337.3.
UniGeneiMm.240327.

Genome annotation databases

EnsembliENSMUST00000068592; ENSMUSP00000063800; ENSMUSG00000055170.
GeneIDi15978.
KEGGimmu:15978.
UCSCiuc007hdy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K00083 mRNA. Translation: AAA37894.1 .
AK089574 mRNA. Translation: BAC40926.1 .
BC119063 mRNA. Translation: AAI19064.1 .
BC119065 mRNA. Translation: AAI19066.1 .
CCDSi CCDS24200.1.
PIRi A01844. IVMSG.
RefSeqi NP_032363.1. NM_008337.3.
UniGenei Mm.240327.

3D structure databases

ProteinModelPortali P01580.
SMRi P01580. Positions 30-141.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P01580. 2 interactions.
STRINGi 10090.ENSMUSP00000063800.

PTM databases

PhosphoSitei P01580.

Proteomic databases

PRIDEi P01580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000068592 ; ENSMUSP00000063800 ; ENSMUSG00000055170 .
GeneIDi 15978.
KEGGi mmu:15978.
UCSCi uc007hdy.1. mouse.

Organism-specific databases

CTDi 3458.
MGIi MGI:107656. Ifng.

Phylogenomic databases

eggNOGi NOG45353.
GeneTreei ENSGT00390000007831.
HOGENOMi HOG000254784.
HOVERGENi HBG056912.
InParanoidi P01580.
KOi K04687.
OMAi KEYFNAS.
OrthoDBi EOG7VHSZM.
PhylomeDBi P01580.
TreeFami TF336308.

Enzyme and pathway databases

Reactomei REACT_198645. Regulation of IFNG signaling.
REACT_198660. Interferon gamma signaling.

Miscellaneous databases

NextBioi 288760.
PROi P01580.
SOURCEi Search...

Gene expression databases

ArrayExpressi P01580.
Bgeei P01580.
CleanExi MM_IFNG.
Genevestigatori P01580.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view ]
PANTHERi PTHR11419. PTHR11419. 1 hit.
Pfami PF00714. IFN-gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF001936. IFN-gamma. 1 hit.
ProDomi PD002435. Interferon_gamma. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of murine immune interferon cDNA."
    Gray P.W., Goeddel D.V.
    Proc. Natl. Acad. Sci. U.S.A. 80:5842-5846(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiIFNG_MOUSE
AccessioniPrimary (citable) accession number: P01580
Secondary accession number(s): Q542B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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