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P01580 (IFNG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon gamma

Short name=IFN-gamma
Gene names
Name:Ifng
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length155 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

Subunit structure

Homodimer.

Subcellular location

Secreted.

Tissue specificity

Released primarily from activated T lymphocytes.

Sequence similarities

Belongs to the type II (or gamma) interferon family.

Ontologies

Keywords
   Biological processAntiviral defense
Growth regulation
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processCD8-positive, alpha-beta T cell differentiation involved in immune response

Inferred from direct assay PubMed 17277142. Source: MGI

adaptive immune response

Inferred from direct assay PubMed 17277142. Source: MGI

antigen processing and presentation

Inferred from direct assay PubMed 15356141. Source: MGI

cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-18

Inferred from direct assay PubMed 19666510. Source: MGI

cellular response to lipopolysaccharide

Inferred from direct assay PubMed 18791161. Source: MGI

defense response to bacterium

Inferred from direct assay PubMed 15240719. Source: MGI

defense response to protozoan

Inferred from mutant phenotype PubMed 9348310. Source: MGI

defense response to virus

Inferred from direct assay PubMed 20064371. Source: MGI

endoplasmic reticulum unfolded protein response

Inferred from direct assay PubMed 15911877. Source: MGI

extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

humoral immune response

Inferred from direct assay PubMed 17277142. Source: MGI

inflammatory cell apoptotic process

Inferred from mutant phenotype PubMed 11457893. Source: MGI

negative regulation of growth of symbiont in host

Inferred from mutant phenotype PubMed 9348310. Source: MGI

negative regulation of growth of symbiont involved in interaction with host

Inferred from direct assay PubMed 9348310. Source: MGI

negative regulation of interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of metanephric nephron tubule epithelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of myelination

Inferred from direct assay PubMed 15911877. Source: MGI

negative regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

neutrophil apoptotic process

Inferred from mutant phenotype PubMed 12925700. Source: MGI

neutrophil chemotaxis

Inferred from direct assay PubMed 12925700. Source: MGI

positive regulation of MHC class II biosynthetic process

Inferred from direct assay PubMed 1845803PubMed 2493384PubMed 2502420. Source: BHF-UCL

positive regulation of T cell proliferation

Inferred from direct assay PubMed 16280321. Source: MGI

positive regulation of calcidiol 1-monooxygenase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of chemokine biosynthetic process

Inferred from direct assay PubMed 12925700. Source: MGI

positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of fructose 1,6-bisphosphate metabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-1 beta secretion

Inferred from mutant phenotype PubMed 12925700. Source: MGI

positive regulation of interleukin-12 biosynthetic process

Inferred from direct assay PubMed 14568984. Source: MGI

positive regulation of interleukin-12 production

Inferred from direct assay PubMed 9348310. Source: MGI

positive regulation of interleukin-23 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 biosynthetic process

Inferred from direct assay PubMed 12925700. Source: MGI

positive regulation of isotype switching to IgG isotypes

Inferred from direct assay PubMed 12882831. Source: MGI

positive regulation of killing of cells of other organism

Inferred from electronic annotation. Source: Ensembl

positive regulation of membrane protein ectodomain proteolysis

Inferred from electronic annotation. Source: Ensembl

positive regulation of mesenchymal cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric oxide biosynthetic process

Inferred from direct assay PubMed 11168643. Source: MGI

positive regulation of osteoclast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation of STAT protein

Inferred from sequence orthology PubMed 16280321. Source: MGI

positive regulation of smooth muscle cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of synaptic transmission, cholinergic

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 18025219. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 14568984. Source: MGI

positive regulation of tumor necrosis factor (ligand) superfamily member 11 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor production

Inferred from direct assay PubMed 1845803PubMed 2502420. Source: BHF-UCL

positive regulation of tyrosine phosphorylation of Stat1 protein

Inferred from sequence orthology PubMed 16280321. Source: MGI

positive regulation of vitamin D biosynthetic process

Inferred from electronic annotation. Source: Ensembl

protein import into nucleus, translocation

Inferred from electronic annotation. Source: Ensembl

regulation of immune response

Inferred from direct assay PubMed 12882831. Source: MGI

regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

regulation of the force of heart contraction

Inferred from electronic annotation. Source: Ensembl

regulation of transcription, DNA-templated

Inferred from direct assay PubMed 12050152. Source: MGI

response to drug

Inferred from electronic annotation. Source: Ensembl

response to virus

Inferred from sequence orthology PubMed 16280321. Source: MGI

   Cellular_componentexternal side of plasma membrane

Inferred from direct assay PubMed 16177108PubMed 17658279PubMed 19838199PubMed 20399120PubMed 20956546PubMed 21217760PubMed 21606376PubMed 21613615PubMed 21709260. Source: MGI

extracellular space

Inferred from direct assay PubMed 10072077PubMed 11057672PubMed 11728336PubMed 11894098PubMed 15220916PubMed 15240714PubMed 16275384PubMed 16769892PubMed 17082577PubMed 17277142PubMed 18997793PubMed 19139201PubMed 20706986PubMed 21460847PubMed 9348310. Source: MGI

   Molecular_functioncytokine activity

Inferred from direct assay PubMed 11027433PubMed 11911824PubMed 12925700PubMed 15240719. Source: MGI

protein binding

Inferred from physical interaction PubMed 18405666. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Kpna2P522935EBI-7892102,EBI-3043908

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 155133Interferon gamma
PRO_0000016453

Amino acid modifications

Glycosylation381N-linked (GlcNAc...) By similarity
Glycosylation901N-linked (GlcNAc...) By similarity

Sequences

Sequence LengthMass (Da)Tools
P01580 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 7EE80BAECB42071A

FASTA15517,907
        10         20         30         40         50         60 
MNATHCILAL QLFLMAVSGC YCHGTVIESL ESLNNYFNSS GIDVEEKSLF LDIWRNWQKD 

        70         80         90        100        110        120 
GDMKILQSQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT TFFSNSKAKK DAFMSIAKFE 

       130        140        150 
VNNPQVQRQA FNELIRVVHQ LLPESSLRKR KRSRC 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of murine immune interferon cDNA."
Gray P.W., Goeddel D.V.
Proc. Natl. Acad. Sci. U.S.A. 80:5842-5846(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
Tissue: Spleen.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K00083 mRNA. Translation: AAA37894.1.
AK089574 mRNA. Translation: BAC40926.1.
BC119063 mRNA. Translation: AAI19064.1.
BC119065 mRNA. Translation: AAI19066.1.
CCDSCCDS24200.1.
PIRIVMSG. A01844.
RefSeqNP_032363.1. NM_008337.3.
UniGeneMm.240327.

3D structure databases

ProteinModelPortalP01580.
SMRP01580. Positions 30-141.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP01580. 2 interactions.
STRING10090.ENSMUSP00000063800.

PTM databases

PhosphoSiteP01580.

Proteomic databases

PRIDEP01580.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000068592; ENSMUSP00000063800; ENSMUSG00000055170.
GeneID15978.
KEGGmmu:15978.
UCSCuc007hdy.1. mouse.

Organism-specific databases

CTD3458.
MGIMGI:107656. Ifng.

Phylogenomic databases

eggNOGNOG45353.
GeneTreeENSGT00390000007831.
HOGENOMHOG000254784.
HOVERGENHBG056912.
InParanoidP01580.
KOK04687.
OMAKEYFNAS.
OrthoDBEOG7VHSZM.
PhylomeDBP01580.
TreeFamTF336308.

Gene expression databases

ArrayExpressP01580.
BgeeP01580.
CleanExMM_IFNG.
GenevestigatorP01580.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERPTHR11419. PTHR11419. 1 hit.
PfamPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFPIRSF001936. IFN-gamma. 1 hit.
ProDomPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

NextBio288760.
PROP01580.
SOURCESearch...

Entry information

Entry nameIFNG_MOUSE
AccessionPrimary (citable) accession number: P01580
Secondary accession number(s): Q542B8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot