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Protein

Interferon gamma

Gene

IFNG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interferon-gamma receptor binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiR-HSA-877300. Interferon gamma signaling.
R-HSA-877312. Regulation of IFNG signaling.
SignaLinkiP01579.
SIGNORiP01579.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Alternative name(s):
Immune interferon
Gene namesi
Name:IFNG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:5438. IFNG.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Aplastic anemia (AA)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia.
See also OMIM:609135

Pharmaceutical usei

Available under the name Actimmune (Genentech). Used for reducing the frequency and severity of serious infections associated with chronic granulomatous disease (CGD).

Organism-specific databases

MalaCardsiIFNG.
MIMi609135. phenotype.
Orphaneti88. Idiopathic aplastic anemia.
PharmGKBiPA29674.

Chemistry

ChEMBLiCHEMBL3286073.
DrugBankiDB05676. Apremilast.
DB01296. Glucosamine.
DB01250. Olsalazine.

Polymorphism and mutation databases

BioMutaiIFNG.
DMDMi124479.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23232 PublicationsAdd
BLAST
Chaini24 – 161138Interferon gammaPRO_0000016444Add
BLAST
Propeptidei162 – 1665PRO_0000259481

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid2 Publications
Glycosylationi48 – 481N-linked (GlcNAc...)1 Publication
Glycosylationi120 – 1201N-linked (GlcNAc...); in dimeric form1 Publication

Post-translational modificationi

Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP01579.
PeptideAtlasiP01579.
PRIDEiP01579.

PTM databases

iPTMnetiP01579.
PhosphoSiteiP01579.
UniCarbKBiP01579.

Miscellaneous databases

PMAP-CutDBP01579.

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Gene expression databases

BgeeiENSG00000111537.
CleanExiHS_IFNG.
GenevisibleiP01579. HS.

Organism-specific databases

HPAiCAB010344.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interferon-gamma receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi109680. 5 interactions.
DIPiDIP-483N.
IntActiP01579. 2 interactions.
MINTiMINT-1508034.
STRINGi9606.ENSP00000229135.

Chemistry

BindingDBiP01579.

Structurei

Secondary structure

1
166
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi28 – 3811Combined sources
Helixi43 – 464Combined sources
Helixi53 – 586Combined sources
Helixi62 – 8120Combined sources
Turni82 – 854Combined sources
Turni87 – 893Combined sources
Helixi90 – 10415Combined sources
Helixi109 – 11911Combined sources
Helixi126 – 14015Combined sources
Helixi146 – 1483Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EKUX-ray2.90A/B26-161[»]
1FG9X-ray2.90A/B24-156[»]
1FYHX-ray2.04A/D28-156[»]
1HIGX-ray3.50A/B/C/D24-161[»]
3BESX-ray2.20L24-161[»]
ProteinModelPortaliP01579.
SMRiP01579. Positions 24-155.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01579.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWSY. Eukaryota.
ENOG410Z8I5. LUCA.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP01579.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG091G0ZH0.
PhylomeDBiP01579.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYTSYILAF QLCIVLGSLG CYCQDPYVKE AENLKKYFNA GHSDVADNGT
60 70 80 90 100
LFLGILKNWK EESDRKIMQS QIVSFYFKLF KNFKDDQSIQ KSVETIKEDM
110 120 130 140 150
NVKFFNSNKK KRDDFEKLTN YSVTDLNVQR KAIHELIQVM AELSPAAKTG
160
KRKRSQMLFR GRRASQ
Length:166
Mass (Da):19,348
Last modified:April 1, 1988 - v1
Checksum:i1514E8F785FD81AA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291K → Q.
VAR_004017
Natural varianti160 – 1601R → Q.1 Publication
Corresponds to variant rs201359065 [ dbSNP | Ensembl ].
VAR_004018

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13274 mRNA. Translation: CAA31639.1.
J00219 Genomic DNA. Translation: AAB59534.1.
X01992 mRNA. Translation: CAA26022.1.
V00543 mRNA. Translation: CAA23804.1.
AY255837 mRNA. Translation: AAP20098.1.
AF375790 Genomic DNA. Translation: AAK53058.1.
AB451324 mRNA. Translation: BAG70138.1.
AB451453 mRNA. Translation: BAG70267.1.
CH471054 Genomic DNA. Translation: EAW97180.1.
BC070256 mRNA. Translation: AAH70256.1.
CCDSiCCDS8980.1.
PIRiA93284. IVHUG.
RefSeqiNP_000610.2. NM_000619.2.
UniGeneiHs.856.

Genome annotation databases

EnsembliENST00000229135; ENSP00000229135; ENSG00000111537.
GeneIDi3458.
KEGGihsa:3458.
UCSCiuc001stw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interferon gamma entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13274 mRNA. Translation: CAA31639.1.
J00219 Genomic DNA. Translation: AAB59534.1.
X01992 mRNA. Translation: CAA26022.1.
V00543 mRNA. Translation: CAA23804.1.
AY255837 mRNA. Translation: AAP20098.1.
AF375790 Genomic DNA. Translation: AAK53058.1.
AB451324 mRNA. Translation: BAG70138.1.
AB451453 mRNA. Translation: BAG70267.1.
CH471054 Genomic DNA. Translation: EAW97180.1.
BC070256 mRNA. Translation: AAH70256.1.
CCDSiCCDS8980.1.
PIRiA93284. IVHUG.
RefSeqiNP_000610.2. NM_000619.2.
UniGeneiHs.856.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EKUX-ray2.90A/B26-161[»]
1FG9X-ray2.90A/B24-156[»]
1FYHX-ray2.04A/D28-156[»]
1HIGX-ray3.50A/B/C/D24-161[»]
3BESX-ray2.20L24-161[»]
ProteinModelPortaliP01579.
SMRiP01579. Positions 24-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109680. 5 interactions.
DIPiDIP-483N.
IntActiP01579. 2 interactions.
MINTiMINT-1508034.
STRINGi9606.ENSP00000229135.

Chemistry

BindingDBiP01579.
ChEMBLiCHEMBL3286073.
DrugBankiDB05676. Apremilast.
DB01296. Glucosamine.
DB01250. Olsalazine.

PTM databases

iPTMnetiP01579.
PhosphoSiteiP01579.
UniCarbKBiP01579.

Polymorphism and mutation databases

BioMutaiIFNG.
DMDMi124479.

Proteomic databases

PaxDbiP01579.
PeptideAtlasiP01579.
PRIDEiP01579.

Protocols and materials databases

DNASUi3458.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229135; ENSP00000229135; ENSG00000111537.
GeneIDi3458.
KEGGihsa:3458.
UCSCiuc001stw.2. human.

Organism-specific databases

CTDi3458.
GeneCardsiIFNG.
HGNCiHGNC:5438. IFNG.
HPAiCAB010344.
MalaCardsiIFNG.
MIMi147570. gene.
609135. phenotype.
neXtProtiNX_P01579.
Orphaneti88. Idiopathic aplastic anemia.
PharmGKBiPA29674.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWSY. Eukaryota.
ENOG410Z8I5. LUCA.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP01579.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG091G0ZH0.
PhylomeDBiP01579.
TreeFamiTF336308.

Enzyme and pathway databases

ReactomeiR-HSA-877300. Interferon gamma signaling.
R-HSA-877312. Regulation of IFNG signaling.
SignaLinkiP01579.
SIGNORiP01579.

Miscellaneous databases

EvolutionaryTraceiP01579.
GeneWikiiInterferon-gamma.
GenomeRNAii3458.
PMAP-CutDBP01579.
PROiP01579.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111537.
CleanExiHS_IFNG.
GenevisibleiP01579. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIFNG_HUMAN
AccessioniPrimary (citable) accession number: P01579
Secondary accession number(s): B5BU88, Q53ZV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: September 7, 2016
This is version 191 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.