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Protein

Interferon beta

Gene

Ifnb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has antiviral, antibacterial and anticancer activities.

GO - Molecular functioni

  • chloramphenicol O-acetyltransferase activity Source: MGI
  • cytokine activity Source: MGI
  • type I interferon receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiR-MMU-909733. Interferon alpha/beta signaling.
R-MMU-912694. Regulation of IFNA signaling.
R-MMU-918233. TRAF3-dependent IRF activation pathway.
R-MMU-933541. TRAF6 mediated IRF7 activation.
R-MMU-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon beta
Short name:
IFN-beta
Gene namesi
Name:Ifnb1
Synonyms:Ifb, Ifnb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:107657. Ifnb1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001640322 – 182Interferon betaAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphotyrosineBy similarity1
Glycosylationi50N-linked (GlcNAc...)1
Glycosylationi90N-linked (GlcNAc...)1
Glycosylationi97N-linked (GlcNAc...)1

Post-translational modificationi

This beta interferon does not have a disulfide bond.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01575.
PRIDEiP01575.

PTM databases

PhosphoSitePlusiP01575.
UniCarbKBiP01575.

Miscellaneous databases

PMAP-CutDBP01575.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048806.
CleanExiMM_IFNB1.
ExpressionAtlasiP01575. baseline and differential.
GenevisibleiP01575. MM.

Interactioni

Subunit structurei

Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.1 Publication

GO - Molecular functioni

  • cytokine activity Source: MGI
  • type I interferon receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056720.

Structurei

Secondary structure

1182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 43Combined sources20
Helixi61 – 64Combined sources4
Helixi69 – 86Combined sources18
Helixi92 – 94Combined sources3
Helixi98 – 118Combined sources21
Helixi119 – 122Combined sources4
Helixi123 – 129Combined sources7
Helixi133 – 151Combined sources19
Turni152 – 154Combined sources3
Helixi156 – 176Combined sources21
Helixi177 – 180Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IFAX-ray2.60A24-181[»]
1WU3X-ray2.15I22-182[»]
2HIFmodel-A24-182[»]
3WCYX-ray2.90I22-182[»]
ProteinModelPortaliP01575.
SMRiP01575.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01575.

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0RY. Eukaryota.
ENOG41113EJ. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230501.
HOVERGENiHBG052086.
InParanoidiP01575.
KOiK05415.
OMAiNGRLEYC.
OrthoDBiEOG091G0V76.
PhylomeDBiP01575.
TreeFamiTF336177.

Family and domain databases

CDDicd00095. IFab. 1 hit.
Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
IPR015588. Interferon_beta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PTHR11691:SF40. PTHR11691:SF40. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNRWILHAA FLLCFSTTAL SINYKQLQLQ ERTNIRKCQE LLEQLNGKIN
60 70 80 90 100
LTYRADFKIP MEMTEKMQKS YTAFAIQEML QNVFLVFRNN FSSTGWNETI
110 120 130 140 150
VVRLLDELHQ QTVFLKTVLE EKQEERLTWE MSSTALHLKS YYWRVQRYLK
160 170 180
LMKYNSYAWM VVRAEIFRNF LIIRRLTRNF QN
Length:182
Mass (Da):22,127
Last modified:July 21, 1986 - v1
Checksum:i8C4C32947FD1B917
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00020 mRNA. Translation: AAA37891.1.
X14455 Genomic DNA. Translation: CAA32625.1.
X14029 Genomic DNA. Translation: CAA32190.1.
CCDSiCCDS18318.1.
PIRiS02020. IVMSB.
RefSeqiNP_034640.1. NM_010510.1.
UniGeneiMm.1245.

Genome annotation databases

EnsembliENSMUST00000055671; ENSMUSP00000056720; ENSMUSG00000048806.
GeneIDi15977.
KEGGimmu:15977.
UCSCiuc008tmz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00020 mRNA. Translation: AAA37891.1.
X14455 Genomic DNA. Translation: CAA32625.1.
X14029 Genomic DNA. Translation: CAA32190.1.
CCDSiCCDS18318.1.
PIRiS02020. IVMSB.
RefSeqiNP_034640.1. NM_010510.1.
UniGeneiMm.1245.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IFAX-ray2.60A24-181[»]
1WU3X-ray2.15I22-182[»]
2HIFmodel-A24-182[»]
3WCYX-ray2.90I22-182[»]
ProteinModelPortaliP01575.
SMRiP01575.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056720.

PTM databases

PhosphoSitePlusiP01575.
UniCarbKBiP01575.

Proteomic databases

PaxDbiP01575.
PRIDEiP01575.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055671; ENSMUSP00000056720; ENSMUSG00000048806.
GeneIDi15977.
KEGGimmu:15977.
UCSCiuc008tmz.1. mouse.

Organism-specific databases

CTDi3456.
MGIiMGI:107657. Ifnb1.

Phylogenomic databases

eggNOGiENOG410J0RY. Eukaryota.
ENOG41113EJ. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230501.
HOVERGENiHBG052086.
InParanoidiP01575.
KOiK05415.
OMAiNGRLEYC.
OrthoDBiEOG091G0V76.
PhylomeDBiP01575.
TreeFamiTF336177.

Enzyme and pathway databases

ReactomeiR-MMU-909733. Interferon alpha/beta signaling.
R-MMU-912694. Regulation of IFNA signaling.
R-MMU-918233. TRAF3-dependent IRF activation pathway.
R-MMU-933541. TRAF6 mediated IRF7 activation.
R-MMU-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

EvolutionaryTraceiP01575.
PMAP-CutDBP01575.
PROiP01575.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048806.
CleanExiMM_IFNB1.
ExpressionAtlasiP01575. baseline and differential.
GenevisibleiP01575. MM.

Family and domain databases

CDDicd00095. IFab. 1 hit.
Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
IPR015588. Interferon_beta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PTHR11691:SF40. PTHR11691:SF40. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFNB_MOUSE
AccessioniPrimary (citable) accession number: P01575
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.