Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interferon beta

Gene

Ifnb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has antiviral, antibacterial and anticancer activities.

GO - Molecular functioni

  • chloramphenicol O-acetyltransferase activity Source: MGI
  • cytokine activity Source: MGI
  • type I interferon receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-MMU-909733 Interferon alpha/beta signaling
R-MMU-912694 Regulation of IFNA signaling
R-MMU-918233 TRAF3-dependent IRF activation pathway
R-MMU-933541 TRAF6 mediated IRF7 activation
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon beta
Short name:
IFN-beta
Gene namesi
Name:Ifnb1
Synonyms:Ifb, Ifnb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:107657 Ifnb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001640322 – 182Interferon betaAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphotyrosineBy similarity1
Glycosylationi50N-linked (GlcNAc...) asparagine1
Glycosylationi90N-linked (GlcNAc...) asparagine1
Glycosylationi97N-linked (GlcNAc...) asparagine1

Post-translational modificationi

This beta interferon does not have a disulfide bond.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01575
PRIDEiP01575

PTM databases

GlyConnecti292
PhosphoSitePlusiP01575
UniCarbKBiP01575

Miscellaneous databases

PMAP-CutDBiP01575

Expressioni

Gene expression databases

BgeeiENSMUSG00000048806
CleanExiMM_IFNB1
ExpressionAtlasiP01575 baseline and differential
GenevisibleiP01575 MM

Interactioni

Subunit structurei

Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.1 Publication

GO - Molecular functioni

  • cytokine activity Source: MGI
  • type I interferon receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056720

Structurei

Secondary structure

1182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 43Combined sources20
Helixi61 – 64Combined sources4
Helixi69 – 86Combined sources18
Helixi92 – 94Combined sources3
Helixi98 – 118Combined sources21
Helixi119 – 122Combined sources4
Helixi123 – 129Combined sources7
Helixi133 – 151Combined sources19
Turni152 – 154Combined sources3
Helixi156 – 176Combined sources21
Helixi177 – 180Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IFAX-ray2.60A24-181[»]
1WU3X-ray2.15I22-182[»]
2HIFmodel-A24-182[»]
3WCYX-ray2.90I22-182[»]
ProteinModelPortaliP01575
SMRiP01575
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01575

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0RY Eukaryota
ENOG41113EJ LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230501
HOVERGENiHBG052086
InParanoidiP01575
KOiK05415
OMAiCLKDRMN
OrthoDBiEOG091G0V76
PhylomeDBiP01575
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
IPR015588 Interferon_beta
PANTHERiPTHR11691 PTHR11691, 1 hit
PTHR11691:SF43 PTHR11691:SF43, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNRWILHAA FLLCFSTTAL SINYKQLQLQ ERTNIRKCQE LLEQLNGKIN
60 70 80 90 100
LTYRADFKIP MEMTEKMQKS YTAFAIQEML QNVFLVFRNN FSSTGWNETI
110 120 130 140 150
VVRLLDELHQ QTVFLKTVLE EKQEERLTWE MSSTALHLKS YYWRVQRYLK
160 170 180
LMKYNSYAWM VVRAEIFRNF LIIRRLTRNF QN
Length:182
Mass (Da):22,127
Last modified:July 21, 1986 - v1
Checksum:i8C4C32947FD1B917
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00020 mRNA Translation: AAA37891.1
X14455 Genomic DNA Translation: CAA32625.1
X14029 Genomic DNA Translation: CAA32190.1
CCDSiCCDS18318.1
PIRiS02020 IVMSB
RefSeqiNP_034640.1, NM_010510.1
UniGeneiMm.1245

Genome annotation databases

EnsembliENSMUST00000055671; ENSMUSP00000056720; ENSMUSG00000048806
GeneIDi15977
KEGGimmu:15977
UCSCiuc008tmz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIFNB_MOUSE
AccessioniPrimary (citable) accession number: P01575
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health