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P01574

- IFNB_HUMAN

UniProt

P01574 - IFNB_HUMAN

Protein

Interferon beta

Gene

IFNB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 165 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Has antiviral, antibacterial and anticancer activities.

    GO - Molecular functioni

    1. cytokine activity Source: BHF-UCL
    2. type I interferon receptor binding Source: UniProtKB

    GO - Biological processi

    1. adaptive immune response Source: Ensembl
    2. B cell activation involved in immune response Source: UniProtKB
    3. B cell differentiation Source: RefGenome
    4. B cell proliferation Source: UniProtKB
    5. blood coagulation Source: Reactome
    6. cell surface receptor signaling pathway Source: ProtInc
    7. cellular response to exogenous dsRNA Source: BHF-UCL
    8. cellular response to interferon-beta Source: BHF-UCL
    9. cytokine-mediated signaling pathway Source: RefGenome
    10. defense response to bacterium Source: Ensembl
    11. defense response to virus Source: BHF-UCL
    12. humoral immune response Source: RefGenome
    13. innate immune response Source: Reactome
    14. natural killer cell activation Source: UniProtKB
    15. natural killer cell activation involved in immune response Source: RefGenome
    16. negative regulation of T cell differentiation Source: UniProtKB
    17. negative regulation of T-helper 2 cell cytokine production Source: UniProtKB
    18. negative regulation of viral genome replication Source: BHF-UCL
    19. positive regulation of apoptotic signaling pathway Source: UniProtKB
    20. positive regulation of innate immune response Source: UniProtKB
    21. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: BHF-UCL
    22. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    23. regulation of MHC class I biosynthetic process Source: UniProtKB
    24. regulation of type I interferon-mediated signaling pathway Source: Reactome
    25. response to exogenous dsRNA Source: MGI
    26. response to virus Source: UniProtKB
    27. T cell activation involved in immune response Source: RefGenome
    28. type I interferon signaling pathway Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Enzyme and pathway databases

    ReactomeiREACT_169436. Oxidative Stress Induced Senescence.
    REACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25026. TRAF3-dependent IRF activation pathway.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.
    SignaLinkiP01574.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon beta
    Short name:
    IFN-beta
    Alternative name(s):
    Fibroblast interferon
    Gene namesi
    Name:IFNB1
    Synonyms:IFB, IFNB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:5434. IFNB1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Pharmaceutical usei

    Available under the names Avonex (Biogen), Betaseron (Berlex) and Rebif (Serono). Used in the treatment of multiple sclerosis (MS). Betaseron is a slightly modified form of IFNB1 with two residue substitutions.

    Organism-specific databases

    PharmGKBiPA29672.

    Protein family/group databases

    Allergomei9875. Hom s IFN beta.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Add
    BLAST
    Chaini22 – 187166Interferon betaPRO_0000016400Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241PhosphotyrosineBy similarity
    Disulfide bondi52 ↔ 1621 Publication
    Glycosylationi101 – 1011N-linked (GlcNAc...)

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP01574.
    PRIDEiP01574.

    PTM databases

    PhosphoSiteiP01574.

    Miscellaneous databases

    PMAP-CutDBP01574.

    Expressioni

    Gene expression databases

    ArrayExpressiP01574.
    CleanExiHS_IFNB1.
    GenevestigatoriP01574.

    Organism-specific databases

    HPAiCAB009386.

    Interactioni

    Subunit structurei

    Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.

    Protein-protein interaction databases

    BioGridi109678. 1 interaction.
    DIPiDIP-6018N.
    STRINGi9606.ENSP00000369581.

    Structurei

    Secondary structure

    1
    187
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi24 – 4219
    Helixi51 – 555
    Helixi63 – 675
    Helixi73 – 9119
    Helixi96 – 983
    Helixi102 – 12726
    Turni137 – 1393
    Helixi140 – 15617
    Turni157 – 1593
    Helixi161 – 18222

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AU1X-ray2.20A/B22-187[»]
    ProteinModelPortaliP01574.
    SMRiP01574. Positions 22-187.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01574.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43895.
    HOGENOMiHOG000230501.
    HOVERGENiHBG052086.
    InParanoidiP01574.
    KOiK05415.
    OMAiNGRLEYC.
    OrthoDBiEOG7J9VRD.
    PhylomeDBiP01574.
    TreeFamiTF336177.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    IPR015588. Interferon_beta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PTHR11691:SF7. PTHR11691:SF7. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01574-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNKCLLQIA LLLCFSTTAL SMSYNLLGFL QRSSNFQCQK LLWQLNGRLE    50
    YCLKDRMNFD IPEEIKQLQQ FQKEDAALTI YEMLQNIFAI FRQDSSSTGW 100
    NETIVENLLA NVYHQINHLK TVLEEKLEKE DFTRGKLMSS LHLKRYYGRI 150
    LHYLKAKEYS HCAWTIVRVE ILRNFYFINR LTGYLRN 187
    Length:187
    Mass (Da):22,294
    Last modified:July 21, 1986 - v1
    Checksum:i0B013D4087723CEC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti162 – 1621C → Y in clone PF526, loss of ability to form the essential disulfide bond, loss of antiviral activity.
    VAR_004016
    Natural varianti164 – 1641W → C in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036330

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00534 Genomic DNA. Translation: CAA23795.1.
    V00535 Genomic DNA. Translation: CAA23796.1.
    V00546 mRNA. Translation: CAA23807.1.
    V00547 mRNA. Translation: CAA23808.1.
    M28622 mRNA. Translation: AAA36040.1.
    EF064725 Genomic DNA. Translation: ABK41908.1.
    AB451323 mRNA. Translation: BAG70137.1.
    AB451452 mRNA. Translation: BAG70266.1.
    CH471071 Genomic DNA. Translation: EAW58625.1.
    BC069314 mRNA. Translation: AAH69314.1.
    BC096150 mRNA. Translation: AAH96150.1.
    BC096151 mRNA. Translation: AAH96151.1.
    BC096152 mRNA. Translation: AAH96152.1.
    BC096153 mRNA. Translation: AAH96153.1.
    CCDSiCCDS6495.1.
    PIRiA93721. IVHUB1.
    RefSeqiNP_002167.1. NM_002176.2.
    UniGeneiHs.93177.

    Genome annotation databases

    EnsembliENST00000380232; ENSP00000369581; ENSG00000171855.
    GeneIDi3456.
    KEGGihsa:3456.
    UCSCiuc003zok.3. human.

    Polymorphism databases

    DMDMi124469.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Avonex

    Clinical information on Avonex

    Betaseron

    Clinical information on Betaseron

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00534 Genomic DNA. Translation: CAA23795.1 .
    V00535 Genomic DNA. Translation: CAA23796.1 .
    V00546 mRNA. Translation: CAA23807.1 .
    V00547 mRNA. Translation: CAA23808.1 .
    M28622 mRNA. Translation: AAA36040.1 .
    EF064725 Genomic DNA. Translation: ABK41908.1 .
    AB451323 mRNA. Translation: BAG70137.1 .
    AB451452 mRNA. Translation: BAG70266.1 .
    CH471071 Genomic DNA. Translation: EAW58625.1 .
    BC069314 mRNA. Translation: AAH69314.1 .
    BC096150 mRNA. Translation: AAH96150.1 .
    BC096151 mRNA. Translation: AAH96151.1 .
    BC096152 mRNA. Translation: AAH96152.1 .
    BC096153 mRNA. Translation: AAH96153.1 .
    CCDSi CCDS6495.1.
    PIRi A93721. IVHUB1.
    RefSeqi NP_002167.1. NM_002176.2.
    UniGenei Hs.93177.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AU1 X-ray 2.20 A/B 22-187 [» ]
    ProteinModelPortali P01574.
    SMRi P01574. Positions 22-187.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109678. 1 interaction.
    DIPi DIP-6018N.
    STRINGi 9606.ENSP00000369581.

    Chemistry

    DrugBanki DB00060. Interferon beta-1a.
    DB00068. Interferon beta-1b.

    Protein family/group databases

    Allergomei 9875. Hom s IFN beta.

    PTM databases

    PhosphoSitei P01574.

    Polymorphism databases

    DMDMi 124469.

    Proteomic databases

    PaxDbi P01574.
    PRIDEi P01574.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380232 ; ENSP00000369581 ; ENSG00000171855 .
    GeneIDi 3456.
    KEGGi hsa:3456.
    UCSCi uc003zok.3. human.

    Organism-specific databases

    CTDi 3456.
    GeneCardsi GC09M021077.
    HGNCi HGNC:5434. IFNB1.
    HPAi CAB009386.
    MIMi 147640. gene.
    neXtProti NX_P01574.
    PharmGKBi PA29672.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43895.
    HOGENOMi HOG000230501.
    HOVERGENi HBG052086.
    InParanoidi P01574.
    KOi K05415.
    OMAi NGRLEYC.
    OrthoDBi EOG7J9VRD.
    PhylomeDBi P01574.
    TreeFami TF336177.

    Enzyme and pathway databases

    Reactomei REACT_169436. Oxidative Stress Induced Senescence.
    REACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25026. TRAF3-dependent IRF activation pathway.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.
    SignaLinki P01574.

    Miscellaneous databases

    EvolutionaryTracei P01574.
    GeneWikii IFNB1.
    GenomeRNAii 3456.
    NextBioi 13618.
    PMAP-CutDB P01574.
    PROi P01574.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01574.
    CleanExi HS_IFNB1.
    Genevestigatori P01574.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    IPR015588. Interferon_beta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    PTHR11691:SF7. PTHR11691:SF7. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Structure of a chromosomal gene for human interferon beta."
      Ohno S., Taniguchi T.
      Proc. Natl. Acad. Sci. U.S.A. 78:5305-5309(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The nucleotide sequence of human fibroblast interferon cDNA."
      Taniguchi T., Ohno S., Fujii-Kuriyama Y., Muramatsu M.
      Gene 10:11-15(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Isolation and structure of a human fibroblast interferon gene."
      Derynck R., Content J., Declercq E., Volckaert G., Tavernier J., Devos R., Fiers W.
      Nature 285:542-547(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase."
      Houghton M., Eaton M.A.W., Stewart A.G., Smith J.C., Doel S.M., Cartlin G.H., Lewis H.M., Patel T.P., Emtage J.S., Carey N.H., Porter A.G.
      Nucleic Acids Res. 8:2885-2894(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    7. "On the relationship between human interferon alpha 1 and beta 1 genes."
      May L.T., Sehgal P.B.
      J. Interferon Res. 5:521-526(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    9. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
      Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
      , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
      Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    12. "The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers."
      Houghton M., Stewart A.G., Doel S.M., Emtage J.S., Eaton M.A.W., Smith J.C., Patel T.P., Lewis H.M., Porter A.G., Birch J.R., Cartwright T., Carey N.H.
      Nucleic Acids Res. 8:1913-1931(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-68.
    13. "Assignment of the disulphide bonds of leukocyte interferon."
      Wetzel R.
      Nature 289:606-607(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BOND.
    14. "A single amino acid change in IFN-beta1 abolishes its antiviral activity."
      Shepard H.M., Leung D., Stebbing N., Goeddel D.V.
      Nature 294:563-565(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 71-187 (VARIANT CLONE PF526).
    15. Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
    16. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-164.

    Entry informationi

    Entry nameiIFNB_HUMAN
    AccessioniPrimary (citable) accession number: P01574
    Secondary accession number(s): Q5VWC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 165 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Pharmaceutical, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3