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P01574

- IFNB_HUMAN

UniProt

P01574 - IFNB_HUMAN

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Protein

Interferon beta

Gene

IFNB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has antiviral, antibacterial and anticancer activities.

GO - Molecular functioni

  1. cytokine activity Source: BHF-UCL
  2. type I interferon receptor binding Source: UniProtKB

GO - Biological processi

  1. adaptive immune response Source: Ensembl
  2. B cell activation involved in immune response Source: UniProtKB
  3. B cell differentiation Source: RefGenome
  4. B cell proliferation Source: UniProtKB
  5. blood coagulation Source: Reactome
  6. cell surface receptor signaling pathway Source: ProtInc
  7. cellular response to exogenous dsRNA Source: BHF-UCL
  8. cellular response to interferon-beta Source: BHF-UCL
  9. cytokine-mediated signaling pathway Source: RefGenome
  10. defense response to bacterium Source: Ensembl
  11. defense response to virus Source: BHF-UCL
  12. humoral immune response Source: RefGenome
  13. innate immune response Source: Reactome
  14. natural killer cell activation Source: UniProtKB
  15. natural killer cell activation involved in immune response Source: RefGenome
  16. negative regulation of T cell differentiation Source: UniProtKB
  17. negative regulation of T-helper 2 cell cytokine production Source: UniProtKB
  18. negative regulation of viral genome replication Source: BHF-UCL
  19. positive regulation of apoptotic signaling pathway Source: UniProtKB
  20. positive regulation of innate immune response Source: UniProtKB
  21. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: BHF-UCL
  22. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  23. regulation of MHC class I biosynthetic process Source: UniProtKB
  24. regulation of type I interferon-mediated signaling pathway Source: Reactome
  25. response to exogenous dsRNA Source: MGI
  26. response to virus Source: UniProtKB
  27. T cell activation involved in immune response Source: RefGenome
  28. type I interferon signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiREACT_169436. Oxidative Stress Induced Senescence.
REACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25026. TRAF3-dependent IRF activation pathway.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.
SignaLinkiP01574.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon beta
Short name:
IFN-beta
Alternative name(s):
Fibroblast interferon
Gene namesi
Name:IFNB1
Synonyms:IFB, IFNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:5434. IFNB1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Available under the names Avonex (Biogen), Betaseron (Berlex) and Rebif (Serono). Used in the treatment of multiple sclerosis (MS). Betaseron is a slightly modified form of IFNB1 with two residue substitutions.

Organism-specific databases

PharmGKBiPA29672.

Protein family/group databases

Allergomei9875. Hom s IFN beta.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 187166Interferon betaPRO_0000016400Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241PhosphotyrosineBy similarity
Disulfide bondi52 ↔ 1621 Publication
Glycosylationi101 – 1011N-linked (GlcNAc...)

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01574.
PRIDEiP01574.

PTM databases

PhosphoSiteiP01574.

Miscellaneous databases

PMAP-CutDBP01574.

Expressioni

Gene expression databases

CleanExiHS_IFNB1.
ExpressionAtlasiP01574. differential.
GenevestigatoriP01574.

Organism-specific databases

HPAiCAB009386.

Interactioni

Subunit structurei

Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.

Protein-protein interaction databases

BioGridi109678. 1 interaction.
DIPiDIP-6018N.
STRINGi9606.ENSP00000369581.

Structurei

Secondary structure

1
187
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi24 – 4219Combined sources
Helixi51 – 555Combined sources
Helixi63 – 675Combined sources
Helixi73 – 9119Combined sources
Helixi96 – 983Combined sources
Helixi102 – 12726Combined sources
Turni137 – 1393Combined sources
Helixi140 – 15617Combined sources
Turni157 – 1593Combined sources
Helixi161 – 18222Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AU1X-ray2.20A/B22-187[»]
ProteinModelPortaliP01574.
SMRiP01574. Positions 22-187.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01574.

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43895.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230501.
HOVERGENiHBG052086.
InParanoidiP01574.
KOiK05415.
OMAiNGRLEYC.
OrthoDBiEOG7J9VRD.
PhylomeDBiP01574.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
IPR015588. Interferon_beta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PTHR11691:SF7. PTHR11691:SF7. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01574-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNKCLLQIA LLLCFSTTAL SMSYNLLGFL QRSSNFQCQK LLWQLNGRLE
60 70 80 90 100
YCLKDRMNFD IPEEIKQLQQ FQKEDAALTI YEMLQNIFAI FRQDSSSTGW
110 120 130 140 150
NETIVENLLA NVYHQINHLK TVLEEKLEKE DFTRGKLMSS LHLKRYYGRI
160 170 180
LHYLKAKEYS HCAWTIVRVE ILRNFYFINR LTGYLRN
Length:187
Mass (Da):22,294
Last modified:July 21, 1986 - v1
Checksum:i0B013D4087723CEC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti162 – 1621C → Y in clone PF526, loss of ability to form the essential disulfide bond, loss of antiviral activity.
VAR_004016
Natural varianti164 – 1641W → C in a breast cancer sample; somatic mutation. 1 Publication
VAR_036330

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00534 Genomic DNA. Translation: CAA23795.1.
V00535 Genomic DNA. Translation: CAA23796.1.
V00546 mRNA. Translation: CAA23807.1.
V00547 mRNA. Translation: CAA23808.1.
M28622 mRNA. Translation: AAA36040.1.
EF064725 Genomic DNA. Translation: ABK41908.1.
AB451323 mRNA. Translation: BAG70137.1.
AB451452 mRNA. Translation: BAG70266.1.
CH471071 Genomic DNA. Translation: EAW58625.1.
BC069314 mRNA. Translation: AAH69314.1.
BC096150 mRNA. Translation: AAH96150.1.
BC096151 mRNA. Translation: AAH96151.1.
BC096152 mRNA. Translation: AAH96152.1.
BC096153 mRNA. Translation: AAH96153.1.
CCDSiCCDS6495.1.
PIRiA93721. IVHUB1.
RefSeqiNP_002167.1. NM_002176.2.
UniGeneiHs.93177.

Genome annotation databases

EnsembliENST00000380232; ENSP00000369581; ENSG00000171855.
GeneIDi3456.
KEGGihsa:3456.
UCSCiuc003zok.3. human.

Polymorphism databases

DMDMi124469.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Avonex

Clinical information on Avonex

Betaseron

Clinical information on Betaseron

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00534 Genomic DNA. Translation: CAA23795.1 .
V00535 Genomic DNA. Translation: CAA23796.1 .
V00546 mRNA. Translation: CAA23807.1 .
V00547 mRNA. Translation: CAA23808.1 .
M28622 mRNA. Translation: AAA36040.1 .
EF064725 Genomic DNA. Translation: ABK41908.1 .
AB451323 mRNA. Translation: BAG70137.1 .
AB451452 mRNA. Translation: BAG70266.1 .
CH471071 Genomic DNA. Translation: EAW58625.1 .
BC069314 mRNA. Translation: AAH69314.1 .
BC096150 mRNA. Translation: AAH96150.1 .
BC096151 mRNA. Translation: AAH96151.1 .
BC096152 mRNA. Translation: AAH96152.1 .
BC096153 mRNA. Translation: AAH96153.1 .
CCDSi CCDS6495.1.
PIRi A93721. IVHUB1.
RefSeqi NP_002167.1. NM_002176.2.
UniGenei Hs.93177.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AU1 X-ray 2.20 A/B 22-187 [» ]
ProteinModelPortali P01574.
SMRi P01574. Positions 22-187.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109678. 1 interaction.
DIPi DIP-6018N.
STRINGi 9606.ENSP00000369581.

Protein family/group databases

Allergomei 9875. Hom s IFN beta.

PTM databases

PhosphoSitei P01574.

Polymorphism databases

DMDMi 124469.

Proteomic databases

PaxDbi P01574.
PRIDEi P01574.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380232 ; ENSP00000369581 ; ENSG00000171855 .
GeneIDi 3456.
KEGGi hsa:3456.
UCSCi uc003zok.3. human.

Organism-specific databases

CTDi 3456.
GeneCardsi GC09M021077.
HGNCi HGNC:5434. IFNB1.
HPAi CAB009386.
MIMi 147640. gene.
neXtProti NX_P01574.
PharmGKBi PA29672.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43895.
GeneTreei ENSGT00760000119150.
HOGENOMi HOG000230501.
HOVERGENi HBG052086.
InParanoidi P01574.
KOi K05415.
OMAi NGRLEYC.
OrthoDBi EOG7J9VRD.
PhylomeDBi P01574.
TreeFami TF336177.

Enzyme and pathway databases

Reactomei REACT_169436. Oxidative Stress Induced Senescence.
REACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25026. TRAF3-dependent IRF activation pathway.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.
SignaLinki P01574.

Miscellaneous databases

EvolutionaryTracei P01574.
GeneWikii IFNB1.
GenomeRNAii 3456.
NextBioi 13618.
PMAP-CutDB P01574.
PROi P01574.
SOURCEi Search...

Gene expression databases

CleanExi HS_IFNB1.
ExpressionAtlasi P01574. differential.
Genevestigatori P01574.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
IPR015588. Interferon_beta.
[Graphical view ]
PANTHERi PTHR11691. PTHR11691. 1 hit.
PTHR11691:SF7. PTHR11691:SF7. 1 hit.
Pfami PF00143. Interferon. 1 hit.
[Graphical view ]
PRINTSi PR00266. INTERFERONAB.
SMARTi SM00076. IFabd. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Structure of a chromosomal gene for human interferon beta."
    Ohno S., Taniguchi T.
    Proc. Natl. Acad. Sci. U.S.A. 78:5305-5309(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of human fibroblast interferon cDNA."
    Taniguchi T., Ohno S., Fujii-Kuriyama Y., Muramatsu M.
    Gene 10:11-15(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Isolation and structure of a human fibroblast interferon gene."
    Derynck R., Content J., Declercq E., Volckaert G., Tavernier J., Devos R., Fiers W.
    Nature 285:542-547(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase."
    Houghton M., Eaton M.A.W., Stewart A.G., Smith J.C., Doel S.M., Cartlin G.H., Lewis H.M., Patel T.P., Emtage J.S., Carey N.H., Porter A.G.
    Nucleic Acids Res. 8:2885-2894(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  7. "On the relationship between human interferon alpha 1 and beta 1 genes."
    May L.T., Sehgal P.B.
    J. Interferon Res. 5:521-526(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  9. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
    Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
    , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
    Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  12. "The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers."
    Houghton M., Stewart A.G., Doel S.M., Emtage J.S., Eaton M.A.W., Smith J.C., Patel T.P., Lewis H.M., Porter A.G., Birch J.R., Cartwright T., Carey N.H.
    Nucleic Acids Res. 8:1913-1931(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-68.
  13. "Assignment of the disulphide bonds of leukocyte interferon."
    Wetzel R.
    Nature 289:606-607(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BOND.
  14. "A single amino acid change in IFN-beta1 abolishes its antiviral activity."
    Shepard H.M., Leung D., Stebbing N., Goeddel D.V.
    Nature 294:563-565(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 71-187 (VARIANT CLONE PF526).
  15. Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
  16. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-164.

Entry informationi

Entry nameiIFNB_HUMAN
AccessioniPrimary (citable) accession number: P01574
Secondary accession number(s): Q5VWC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3