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Reviewed, UniProtKB/Swiss-Prot P01574 (IFNB_HUMAN)

Last modified July 22, 2008. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Interferon beta
      Short name(s)=IFN-beta
Alternative name(s):
    Fibroblast interferon
Gene names
Name: IFNB1
Synonyms: IFB, IFNB
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Has antiviral, antibacterial and anticancer activities.

Subunit structure

Monomer.

Subcellular location

Secreted.

Pharmaceutical use

Available under the names Avonex (Biogen), Betaseron (Berlex) and Rebif (Serono). Used in the treatment of multiple sclerosis (MS). Betaseron is a slightly modified form of IFNB1 with two residue substitutions.

Sequence similarities

Belongs to the alpha/beta interferon family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 2121
Chain22 – 187166Interferon beta

Amino acid modifications

Modified residue1401Phosphoserine
Glycosylation1011N-linked (GlcNAc...)
Disulfide bond52 ↔ 162

Natural variations

Natural variant1621C → Y in clone PF526, loss of ability to form the essential disulfide bond, loss of antiviral activity.
Natural variant1641W → C in a breast cancer sample; somatic mutation.

Secondary structure

................... 187
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01574-1 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 0B013D4087723CEC

FASTA18722,294
        10         20         30         40         50         60 
MTNKCLLQIA LLLCFSTTAL SMSYNLLGFL QRSSNFQCQK LLWQLNGRLE YCLKDRMNFD 

        70         80         90        100        110        120 
IPEEIKQLQQ FQKEDAALTI YEMLQNIFAI FRQDSSSTGW NETIVENLLA NVYHQINHLK 

       130        140        150        160        170        180 
TVLEEKLEKE DFTRGKLMSS LHLKRYYGRI LHYLKAKEYS HCAWTIVRVE ILRNFYFINR 


LTGYLRN 

« Hide

References

« Hide 'large scale' references
[1]"Human fibroblast interferon gene lacks introns."
Lawn R.M., Adelman J., Franke A.E., Houck C.M., Gross M., Najarian R., Goeddel D.V.
Nucleic Acids Res. 9:1045-1052(1981) [PubMed: 6164984] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Structure of a chromosomal gene for human interferon beta."
Ohno S., Taniguchi T.
Proc. Natl. Acad. Sci. U.S.A. 78:5305-5309(1981) [PubMed: 16593086] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]"The nucleotide sequence of human fibroblast interferon cDNA."
Taniguchi T., Ohno S., Fujii-Kuriyama Y., Muramatsu M.
Gene 10:11-15(1980) [PubMed: 6157601] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[4]"Isolation and structure of a human fibroblast interferon gene."
Derynck R., Content J., Declercq E., Volckaert G., Tavernier J., Devos R., Fiers W.
Nature 285:542-547(1980) [PubMed: 6157094] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[5]"The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase."
Houghton M., Eaton M.A.W., Stewart A.G., Smith J.C., Doel S.M., Cartlin G.H., Lewis H.M., Patel T.P., Emtage J.S., Carey N.H., Porter A.G.
Nucleic Acids Res. 8:2885-2894(1980) [PubMed: 6159580] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[6]"Synthesis of human fibroblast interferon by E. coli."
Goeddel D.V., Shepard H.M., Yelverton E., Leung D., Crea R., Sloma A., Pestka S.
Nucleic Acids Res. 8:4057-4074(1980) [PubMed: 6159584] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[7]"On the relationship between human interferon alpha 1 and beta 1 genes."
May L.T., Sehgal P.B.
J. Interferon Res. 5:521-526(1985) [PubMed: 2414376] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[9]"The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers."
Houghton M., Stewart A.G., Doel S.M., Emtage J.S., Eaton M.A.W., Smith J.C., Patel T.P., Lewis H.M., Porter A.G., Birch J.R., Cartwright T., Carey N.H.
Nucleic Acids Res. 8:1913-1931(1980) [PubMed: 6159597] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-68.
[10]"Assignment of the disulphide bonds of leukocyte interferon."
Wetzel R.
Nature 289:606-607(1981) [PubMed: 6162107] [Abstract]
Cited for: DISULFIDE BOND.
[11]"A single amino acid change in IFN-beta1 abolishes its antiviral activity."
Shepard H.M., Leung D., Stebbing N., Goeddel D.V.
Nature 294:563-565(1981) [PubMed: 6171735] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 71-187 (VARIANT CLONE PF526).
[12]"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.
Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140, MASS SPECTROMETRY.
[13]"The crystal structure of human interferon beta at 2.2-A resolution."
Karpusas M., Nolte M., Benton C.B., Meier W., Lipscomb W.N., Goelz S.
Proc. Natl. Acad. Sci. U.S.A. 94:11813-11818(1997) [PubMed: 9342320] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
[14]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed: 16959974] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-164.

Web resources

Avonex

Clinical information on Avonex

Betaseron

Clinical information on Betaseron

Cross-references

Sequence databases

V00534 Genomic DNA. Translation: CAA23795.1.
V00535 Genomic DNA. Translation: CAA23796.1.
V00546 mRNA. Translation: CAA23807.1.
V00547 mRNA. Translation: CAA23808.1.
BC069314 mRNA. Translation: AAH69314.1.
M28622 mRNA. Translation: AAA36040.1.
PIRIVHUB1. A93721.
RefSeqNP_002167.1.
UniGeneHs.93177

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1AU1X-ray2.20A/B22-187[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:6018N.

PTM databases

PhosphoSiteP01574.

Genome annotation databases

EnsemblENSG00000171855. Homo sapiens. [Contig view]
GeneID3456.
KEGGhsa:3456.

Organism-specific databases

H-InvDBHIX0034856.
HGNCHGNC:5434. IFNB1.
HPACAB009386.
MIM147640. gene.
PharmGKBPA29672.
GenAtlasSearch...
GeneCardsSearch...
GeneLynxSearch...

Phylogenomic databases

HOGENOMP01574.
HOVERGENP01574.

Gene expression databases

ArrayExpressP01574.
CleanExHS_IFNB1.
GermOnlineENSG00000171855. Homo sapiens.

Family and domain databases

InterProIPR012351. 4_helix_cytokine_core.
IPR015588. IFNb.
IPR000471. Interferon_abd.
[Graphical view]
Gene3DG3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit.
PANTHERPTHR11691:SF7. IFNb. 1 hit.
PTHR11691. Interferon_abd. 1 hit.
PfamPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSPR00266. INTERFERONAB.
ProDomPD000550. Interferon_abd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00076. IFabd. 1 hit.
[Graphical view]
PROSITEPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

DrugBankDB00060. Interferon beta-1a.
DB00068. Interferon beta-1b.
LinkHubP01574.
SOURCESearch...
ProtoNetSearch...

Entry information

Entry nameIFNB_HUMAN
AccessionPrimary (citable) accession number: P01574
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 22, 2008
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents