Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interferon beta

Gene

IFNB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has antiviral, antibacterial and anticancer activities.

GO - Molecular functioni

  • chloramphenicol O-acetyltransferase activity Source: AgBase
  • cytokine activity Source: BHF-UCL
  • type I interferon receptor binding Source: GO_Central

GO - Biological processi

  • B cell activation involved in immune response Source: UniProtKB
  • B cell differentiation Source: GO_Central
  • B cell proliferation Source: GO_Central
  • blood coagulation Source: Reactome
  • cell surface receptor signaling pathway Source: ProtInc
  • cellular response to exogenous dsRNA Source: BHF-UCL
  • cellular response to interferon-beta Source: BHF-UCL
  • defense response to virus Source: BHF-UCL
  • humoral immune response Source: GO_Central
  • natural killer cell activation Source: UniProtKB
  • natural killer cell activation involved in immune response Source: GO_Central
  • negative regulation of T cell differentiation Source: UniProtKB
  • negative regulation of T-helper 2 cell cytokine production Source: UniProtKB
  • negative regulation of viral genome replication Source: BHF-UCL
  • positive regulation of apoptotic signaling pathway Source: UniProtKB
  • positive regulation of innate immune response Source: UniProtKB
  • positive regulation of peptidyl-serine phosphorylation of STAT protein Source: BHF-UCL
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • regulation of MHC class I biosynthetic process Source: UniProtKB
  • response to exogenous dsRNA Source: MGI
  • response to virus Source: UniProtKB
  • T cell activation involved in immune response Source: GO_Central
  • type I interferon signaling pathway Source: BHF-UCL

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-918233 TRAF3-dependent IRF activation pathway
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiP01574
SIGNORiP01574

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon beta
Short name:
IFN-beta
Alternative name(s):
Fibroblast interferon
Gene namesi
Name:IFNB1
Synonyms:IFB, IFNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000171855.6
HGNCiHGNC:5434 IFNB1
MIMi147640 gene
neXtProtiNX_P01574

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Available under the names Avonex (Biogen), Betaseron (Berlex) and Rebif (Serono). Used in the treatment of multiple sclerosis (MS). Betaseron is a slightly modified form of IFNB1 with two residue substitutions.

Organism-specific databases

DisGeNETi3456
OpenTargetsiENSG00000171855
PharmGKBiPA29672

Protein family/group databases

Allergomei9875 Hom s IFN beta

Chemistry databases

DrugBankiDB02379 Beta-D-Glucose

Polymorphism and mutation databases

BioMutaiIFNB1
DMDMi124469

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001640022 – 187Interferon betaAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphotyrosineBy similarity1
Disulfide bondi52 ↔ 1621 Publication
Glycosylationi101N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01574
PeptideAtlasiP01574
PRIDEiP01574
TopDownProteomicsiP01574

PTM databases

GlyConnecti291
iPTMnetiP01574
PhosphoSitePlusiP01574
UniCarbKBiP01574

Miscellaneous databases

PMAP-CutDBiP01574

Expressioni

Gene expression databases

BgeeiENSG00000171855
CleanExiHS_IFNB1
GenevisibleiP01574 HS

Organism-specific databases

HPAiCAB009386

Interactioni

Subunit structurei

Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.

GO - Molecular functioni

  • cytokine activity Source: BHF-UCL
  • type I interferon receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi109678, 2 interactors
CORUMiP01574
DIPiDIP-6018N
IntActiP01574, 1 interactor
STRINGi9606.ENSP00000369581

Structurei

Secondary structure

1187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 42Combined sources19
Helixi51 – 55Combined sources5
Helixi63 – 67Combined sources5
Helixi73 – 91Combined sources19
Helixi96 – 98Combined sources3
Helixi102 – 127Combined sources26
Turni137 – 139Combined sources3
Helixi140 – 156Combined sources17
Turni157 – 159Combined sources3
Helixi161 – 182Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AU1X-ray2.20A/B22-187[»]
ProteinModelPortaliP01574
SMRiP01574
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01574

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0RY Eukaryota
ENOG41113EJ LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230501
HOVERGENiHBG052086
InParanoidiP01574
KOiK05415
OMAiCLKDRMN
OrthoDBiEOG091G0V76
PhylomeDBiP01574
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
IPR015588 Interferon_beta
PANTHERiPTHR11691 PTHR11691, 1 hit
PTHR11691:SF43 PTHR11691:SF43, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNKCLLQIA LLLCFSTTAL SMSYNLLGFL QRSSNFQCQK LLWQLNGRLE
60 70 80 90 100
YCLKDRMNFD IPEEIKQLQQ FQKEDAALTI YEMLQNIFAI FRQDSSSTGW
110 120 130 140 150
NETIVENLLA NVYHQINHLK TVLEEKLEKE DFTRGKLMSS LHLKRYYGRI
160 170 180
LHYLKAKEYS HCAWTIVRVE ILRNFYFINR LTGYLRN
Length:187
Mass (Da):22,294
Last modified:July 21, 1986 - v1
Checksum:i0B013D4087723CEC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004016162C → Y Variant found in a clone obtained from a fibroblast cell line; does not form the essential disulfide bond; results in loss of antiviral activity. 1 Publication1
Natural variantiVAR_036330164W → C in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00534 Genomic DNA Translation: CAA23795.1
V00535 Genomic DNA Translation: CAA23796.1
V00546 mRNA Translation: CAA23807.1
V00547 mRNA Translation: CAA23808.1
M28622 mRNA Translation: AAA36040.1
EF064725 Genomic DNA Translation: ABK41908.1
AB451323 mRNA Translation: BAG70137.1
AB451452 mRNA Translation: BAG70266.1
CH471071 Genomic DNA Translation: EAW58625.1
BC069314 mRNA Translation: AAH69314.1
BC096150 mRNA Translation: AAH96150.1
BC096151 mRNA Translation: AAH96151.1
BC096152 mRNA Translation: AAH96152.1
BC096153 mRNA Translation: AAH96153.1
CCDSiCCDS6495.1
PIRiA93721 IVHUB1
RefSeqiNP_002167.1, NM_002176.3
UniGeneiHs.93177

Genome annotation databases

EnsembliENST00000380232; ENSP00000369581; ENSG00000171855
GeneIDi3456
KEGGihsa:3456
UCSCiuc003zok.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIFNB_HUMAN
AccessioniPrimary (citable) accession number: P01574
Secondary accession number(s): Q5VWC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 198 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health