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P01572 (IFNA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon alpha-1

Short name=IFN-alpha-1
Gene names
Name:Ifna1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Ref.3

Subcellular location

Secreted.

Post-translational modification

Glycosylated. Ref.3

Sequence similarities

Belongs to the alpha/beta interferon family.

Caution

Was named interferon alpha-E (embryonic) based on peptide sequencing (Ref.6). The differences found may be sequencing erros and have not been confirmed by other studies.

Ontologies

Keywords
   Biological processAntiviral defense
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processB cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

B cell proliferation

Inferred from Biological aspect of Ancestor. Source: RefGenome

T cell activation involved in immune response

Inferred from direct assay PubMed 19130550. Source: MGI

adaptive immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytokine-mediated signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

defense response to bacterium

Inferred from direct assay PubMed 15240719. Source: MGI

defense response to virus

Inferred from direct assay PubMed 19130550. Source: MGI

humoral immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

innate immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

natural killer cell activation involved in immune response

Inferred from direct assay PubMed 19130550. Source: MGI

positive regulation of peptidyl-serine phosphorylation of STAT protein

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of MHC class I biosynthetic process

Inferred from Biological aspect of Ancestor. Source: RefGenome

response to exogenous dsRNA

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from direct assay PubMed 19130550. Source: MGI

   Molecular_functioncytokine activity

Inferred from direct assay PubMed 15240719. Source: MGI

type I interferon receptor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.6
Chain24 – 189166Interferon alpha-1
PRO_0000016375

Amino acid modifications

Glycosylation1011N-linked (GlcNAc...) Probable
Disulfide bond24 ↔ 122 By similarity
Disulfide bond52 ↔ 162 By similarity

Experimental info

Sequence conflict141L → M no nucleotide entry Ref.1
Sequence conflict141L → M in CAA26006. Ref.2
Sequence conflict1021T → A no nucleotide entry Ref.1
Sequence conflict1021T → A in CAA26006. Ref.2
Sequence conflict1261Q → E AA sequence Ref.6
Sequence conflict1321F → P AA sequence Ref.6
Sequence conflict1391A → Y AA sequence Ref.6
Sequence conflict1451K → T AA sequence Ref.6
Sequence conflict1751L → M AA sequence Ref.6
Sequence conflict180 – 1812NV → KL AA sequence Ref.6

Sequences

Sequence LengthMass (Da)Tools
P01572 [UniParc].

Last modified February 8, 2011. Version 2.
Checksum: D6F4BC96DCE7D67E

FASTA18921,646
        10         20         30         40         50         60 
MARLCAFLMV LAVLSYWPTC SLGCDLPQTH NLRNKRALTL LVQMRRLSPL SCLKDRKDFG 

        70         80         90        100        110        120 
FPQEKVDAQQ IKKAQAIPVL SELTQQILNI FTSKDSSAAW NTTLLDSFCN DLHQQLNDLQ 

       130        140        150        160        170        180 
GCLMQQVGVQ EFPLTQEDAL LAVRKYFHRI TVYLREKKHS PCAWEVVRAE VWRALSSSAN 


VLGRLREEK 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of cloned murine IFN-alpha genes."
Shaw G.D., Boll W., Taira H., Mantei N., Lengyel P., Weissmann C.
Nucleic Acids Res. 11:555-573(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Characterization of a mouse interferon gene locus I. Isolation of a cluster of four alpha interferon genes."
Kelly K.A., Pitha P.M.
Nucleic Acids Res. 13:805-823(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Characterization of the murine alpha interferon gene family."
van Pesch V., Lanaya H., Renauld J.C., Michiels T.
J. Virol. 78:8219-8228(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, GLYCOSYLATION.
Strain: C57BL/6.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Characterisation and antiproliferative activity of an alpha-type murine interferon from embryonic fibroblasts."
Beare D., Learmonth M., Wells V., Aitken A., Mallucci L.
Biochim. Biophys. Acta 1310:81-85(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-51; 124-146 AND 175-181.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X01974 Genomic DNA. Translation: CAA26006.1.
AY225950 Genomic DNA. Translation: AAO63592.1.
BX530016 Genomic DNA. Translation: CAM22267.1.
CH466527 Genomic DNA. Translation: EDL30958.1.
PIRIVMSA1. A01836.
S62682.
RefSeqNP_034632.2. NM_010502.2.
UniGeneMm.57127.

3D structure databases

ProteinModelPortalP01572.
SMRP01572. Positions 24-189.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000102751.

PTM databases

PhosphoSiteP01572.

Proteomic databases

PRIDEP01572.

Protocols and materials databases

DNASU15962.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000094972; ENSMUSP00000092580; ENSMUSG00000095498.
GeneID15962.
KEGGmmu:15962.
UCSCuc008toc.1. mouse.

Organism-specific databases

CTD3439.
MGIMGI:107668. Ifna1.

Phylogenomic databases

eggNOGNOG40434.
GeneTreeENSGT00590000082966.
HOVERGENHBG052086.
InParanoidQ810G7.
KOK05414.
OMAWEIVRSE.
OrthoDBEOG7M98HV.
TreeFamTF336177.

Enzyme and pathway databases

SABIO-RKP01572.

Gene expression databases

BgeeP01572.
CleanExMM_IFNA1.
GenevestigatorP01572.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR015589. Interferon_alpha.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERPTHR11691. PTHR11691. 1 hit.
PTHR11691:SF9. PTHR11691:SF9. 1 hit.
PfamPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSPR00266. INTERFERONAB.
SMARTSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288712.
PROP01572.
SOURCESearch...

Entry information

Entry nameIFNA1_MOUSE
AccessionPrimary (citable) accession number: P01572
Secondary accession number(s): Q7M0A3, Q810G7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 8, 2011
Last modified: April 16, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot