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P01572

- IFNA1_MOUSE

UniProt

P01572 - IFNA1_MOUSE

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Protein

Interferon alpha-1

Gene
Ifna1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

GO - Molecular functioni

  1. cytokine activity Source: MGI
  2. type I interferon receptor binding Source: RefGenome

GO - Biological processi

  1. adaptive immune response Source: RefGenome
  2. B cell differentiation Source: RefGenome
  3. B cell proliferation Source: RefGenome
  4. cytokine-mediated signaling pathway Source: RefGenome
  5. defense response to bacterium Source: MGI
  6. defense response to virus Source: MGI
  7. humoral immune response Source: RefGenome
  8. innate immune response Source: RefGenome
  9. natural killer cell activation involved in immune response Source: MGI
  10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
  11. regulation of MHC class I biosynthetic process Source: RefGenome
  12. response to exogenous dsRNA Source: RefGenome
  13. T cell activation involved in immune response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiREACT_198521. TRAF6 mediated IRF7 activation.
REACT_198622. Interferon alpha/beta signaling.
REACT_198627. Regulation of IFNA signaling.
REACT_198649. Factors involved in megakaryocyte development and platelet production.
SABIO-RKP01572.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-1
Short name:
IFN-alpha-1
Gene namesi
Name:Ifna1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:107668. Ifna1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 189166Interferon alpha-1PRO_0000016375Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122 By similarity
Disulfide bondi52 ↔ 162 By similarity
Glycosylationi101 – 1011N-linked (GlcNAc...) Inferred

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP01572.

PTM databases

PhosphoSiteiP01572.

Expressioni

Gene expression databases

BgeeiP01572.
CleanExiMM_IFNA1.
GenevestigatoriP01572.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102751.

Structurei

3D structure databases

ProteinModelPortaliP01572.
SMRiP01572. Positions 24-189.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40434.
GeneTreeiENSGT00590000082966.
HOVERGENiHBG052086.
InParanoidiQ810G7.
KOiK05414.
OMAiSELEVCL.
OrthoDBiEOG7M98HV.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01572-1 [UniParc]FASTAAdd to Basket

« Hide

MARLCAFLMV LAVLSYWPTC SLGCDLPQTH NLRNKRALTL LVQMRRLSPL    50
SCLKDRKDFG FPQEKVDAQQ IKKAQAIPVL SELTQQILNI FTSKDSSAAW 100
NTTLLDSFCN DLHQQLNDLQ GCLMQQVGVQ EFPLTQEDAL LAVRKYFHRI 150
TVYLREKKHS PCAWEVVRAE VWRALSSSAN VLGRLREEK 189
Length:189
Mass (Da):21,646
Last modified:February 8, 2011 - v2
Checksum:iD6F4BC96DCE7D67E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141L → M no nucleotide entry 1 Publication
Sequence conflicti14 – 141L → M in CAA26006. 1 Publication
Sequence conflicti102 – 1021T → A no nucleotide entry 1 Publication
Sequence conflicti102 – 1021T → A in CAA26006. 1 Publication
Sequence conflicti126 – 1261Q → E AA sequence 1 Publication
Sequence conflicti132 – 1321F → P AA sequence 1 Publication
Sequence conflicti139 – 1391A → Y AA sequence 1 Publication
Sequence conflicti145 – 1451K → T AA sequence 1 Publication
Sequence conflicti175 – 1751L → M AA sequence 1 Publication
Sequence conflicti180 – 1812NV → KL AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01974 Genomic DNA. Translation: CAA26006.1.
AY225950 Genomic DNA. Translation: AAO63592.1.
BX530016 Genomic DNA. Translation: CAM22267.1.
CH466527 Genomic DNA. Translation: EDL30958.1.
CCDSiCCDS18347.1.
PIRiA01836. IVMSA1.
S62682.
RefSeqiNP_034632.2. NM_010502.2.
UniGeneiMm.57127.

Genome annotation databases

EnsembliENSMUST00000094972; ENSMUSP00000092580; ENSMUSG00000095498.
GeneIDi15962.
KEGGimmu:15962.
UCSCiuc008toc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01974 Genomic DNA. Translation: CAA26006.1 .
AY225950 Genomic DNA. Translation: AAO63592.1 .
BX530016 Genomic DNA. Translation: CAM22267.1 .
CH466527 Genomic DNA. Translation: EDL30958.1 .
CCDSi CCDS18347.1.
PIRi A01836. IVMSA1.
S62682.
RefSeqi NP_034632.2. NM_010502.2.
UniGenei Mm.57127.

3D structure databases

ProteinModelPortali P01572.
SMRi P01572. Positions 24-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000102751.

PTM databases

PhosphoSitei P01572.

Proteomic databases

PRIDEi P01572.

Protocols and materials databases

DNASUi 15962.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000094972 ; ENSMUSP00000092580 ; ENSMUSG00000095498 .
GeneIDi 15962.
KEGGi mmu:15962.
UCSCi uc008toc.1. mouse.

Organism-specific databases

CTDi 3439.
MGIi MGI:107668. Ifna1.

Phylogenomic databases

eggNOGi NOG40434.
GeneTreei ENSGT00590000082966.
HOVERGENi HBG052086.
InParanoidi Q810G7.
KOi K05414.
OMAi SELEVCL.
OrthoDBi EOG7M98HV.
TreeFami TF336177.

Enzyme and pathway databases

Reactomei REACT_198521. TRAF6 mediated IRF7 activation.
REACT_198622. Interferon alpha/beta signaling.
REACT_198627. Regulation of IFNA signaling.
REACT_198649. Factors involved in megakaryocyte development and platelet production.
SABIO-RK P01572.

Miscellaneous databases

NextBioi 288712.
PROi P01572.
SOURCEi Search...

Gene expression databases

Bgeei P01572.
CleanExi MM_IFNA1.
Genevestigatori P01572.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view ]
PANTHERi PTHR11691. PTHR11691. 1 hit.
Pfami PF00143. Interferon. 1 hit.
[Graphical view ]
PRINTSi PR00266. INTERFERONAB.
SMARTi SM00076. IFabd. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of cloned murine IFN-alpha genes."
    Shaw G.D., Boll W., Taira H., Mantei N., Lengyel P., Weissmann C.
    Nucleic Acids Res. 11:555-573(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Characterization of a mouse interferon gene locus I. Isolation of a cluster of four alpha interferon genes."
    Kelly K.A., Pitha P.M.
    Nucleic Acids Res. 13:805-823(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Characterization of the murine alpha interferon gene family."
    van Pesch V., Lanaya H., Renauld J.C., Michiels T.
    J. Virol. 78:8219-8228(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, GLYCOSYLATION.
    Strain: C57BL/6.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Characterisation and antiproliferative activity of an alpha-type murine interferon from embryonic fibroblasts."
    Beare D., Learmonth M., Wells V., Aitken A., Mallucci L.
    Biochim. Biophys. Acta 1310:81-85(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-51; 124-146 AND 175-181.

Entry informationi

Entry nameiIFNA1_MOUSE
AccessioniPrimary (citable) accession number: P01572
Secondary accession number(s): Q7M0A3, Q810G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 8, 2011
Last modified: September 3, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was named interferon alpha-E (embryonic) based on peptide sequencing (1 Publication). The differences found may be sequencing erros and have not been confirmed by other studies.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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