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Protein

Interferon alpha-1

Gene

Ifna1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

GO - Molecular functioni

  1. cytokine activity Source: MGI
  2. type I interferon receptor binding Source: GO_Central

GO - Biological processi

  1. adaptive immune response Source: GO_Central
  2. B cell differentiation Source: GO_Central
  3. B cell proliferation Source: GO_Central
  4. cytokine-mediated signaling pathway Source: GO_Central
  5. defense response to bacterium Source: MGI
  6. defense response to virus Source: MGI
  7. humoral immune response Source: GO_Central
  8. innate immune response Source: GO_Central
  9. natural killer cell activation involved in immune response Source: MGI
  10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: GO_Central
  11. regulation of MHC class I biosynthetic process Source: GO_Central
  12. response to exogenous dsRNA Source: GO_Central
  13. T cell activation involved in immune response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiREACT_198521. TRAF6 mediated IRF7 activation.
REACT_198622. Interferon alpha/beta signaling.
REACT_198627. Regulation of IFNA signaling.
REACT_198649. Factors involved in megakaryocyte development and platelet production.
SABIO-RKP01572.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-1
Short name:
IFN-alpha-1
Gene namesi
Name:Ifna1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:107668. Ifna1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 189166Interferon alpha-1PRO_0000016375Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity
Glycosylationi101 – 1011N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP01572.

PTM databases

PhosphoSiteiP01572.

Expressioni

Gene expression databases

BgeeiP01572.
CleanExiMM_IFNA1.
GenevestigatoriP01572.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102751.

Structurei

3D structure databases

ProteinModelPortaliP01572.
SMRiP01572. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40434.
GeneTreeiENSGT00760000119150.
HOVERGENiHBG052086.
InParanoidiP01572.
KOiK05414.
OMAiCAWERIQ.
OrthoDBiEOG7M98HV.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01572-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARLCAFLMV LAVLSYWPTC SLGCDLPQTH NLRNKRALTL LVQMRRLSPL
60 70 80 90 100
SCLKDRKDFG FPQEKVDAQQ IKKAQAIPVL SELTQQILNI FTSKDSSAAW
110 120 130 140 150
NTTLLDSFCN DLHQQLNDLQ GCLMQQVGVQ EFPLTQEDAL LAVRKYFHRI
160 170 180
TVYLREKKHS PCAWEVVRAE VWRALSSSAN VLGRLREEK
Length:189
Mass (Da):21,646
Last modified:February 8, 2011 - v2
Checksum:iD6F4BC96DCE7D67E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141L → M no nucleotide entry (PubMed:6188104)Curated
Sequence conflicti14 – 141L → M in CAA26006. (PubMed:2987811)Curated
Sequence conflicti102 – 1021T → A no nucleotide entry (PubMed:6188104)Curated
Sequence conflicti102 – 1021T → A in CAA26006. (PubMed:2987811)Curated
Sequence conflicti126 – 1261Q → E AA sequence (PubMed:9244179)Curated
Sequence conflicti132 – 1321F → P AA sequence (PubMed:9244179)Curated
Sequence conflicti139 – 1391A → Y AA sequence (PubMed:9244179)Curated
Sequence conflicti145 – 1451K → T AA sequence (PubMed:9244179)Curated
Sequence conflicti175 – 1751L → M AA sequence (PubMed:9244179)Curated
Sequence conflicti180 – 1812NV → KL AA sequence (PubMed:9244179)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01974 Genomic DNA. Translation: CAA26006.1.
AY225950 Genomic DNA. Translation: AAO63592.1.
BX530016 Genomic DNA. Translation: CAM22267.1.
CH466527 Genomic DNA. Translation: EDL30958.1.
CCDSiCCDS18347.1.
PIRiA01836. IVMSA1.
S62682.
RefSeqiNP_034632.2. NM_010502.2.
UniGeneiMm.57127.

Genome annotation databases

EnsembliENSMUST00000094972; ENSMUSP00000092580; ENSMUSG00000095498.
GeneIDi15962.
KEGGimmu:15962.
UCSCiuc008toc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01974 Genomic DNA. Translation: CAA26006.1.
AY225950 Genomic DNA. Translation: AAO63592.1.
BX530016 Genomic DNA. Translation: CAM22267.1.
CH466527 Genomic DNA. Translation: EDL30958.1.
CCDSiCCDS18347.1.
PIRiA01836. IVMSA1.
S62682.
RefSeqiNP_034632.2. NM_010502.2.
UniGeneiMm.57127.

3D structure databases

ProteinModelPortaliP01572.
SMRiP01572. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102751.

PTM databases

PhosphoSiteiP01572.

Proteomic databases

PRIDEiP01572.

Protocols and materials databases

DNASUi15962.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094972; ENSMUSP00000092580; ENSMUSG00000095498.
GeneIDi15962.
KEGGimmu:15962.
UCSCiuc008toc.1. mouse.

Organism-specific databases

CTDi3439.
MGIiMGI:107668. Ifna1.

Phylogenomic databases

eggNOGiNOG40434.
GeneTreeiENSGT00760000119150.
HOVERGENiHBG052086.
InParanoidiP01572.
KOiK05414.
OMAiCAWERIQ.
OrthoDBiEOG7M98HV.
TreeFamiTF336177.

Enzyme and pathway databases

ReactomeiREACT_198521. TRAF6 mediated IRF7 activation.
REACT_198622. Interferon alpha/beta signaling.
REACT_198627. Regulation of IFNA signaling.
REACT_198649. Factors involved in megakaryocyte development and platelet production.
SABIO-RKP01572.

Miscellaneous databases

NextBioi288712.
PROiP01572.
SOURCEiSearch...

Gene expression databases

BgeeiP01572.
CleanExiMM_IFNA1.
GenevestigatoriP01572.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of cloned murine IFN-alpha genes."
    Shaw G.D., Boll W., Taira H., Mantei N., Lengyel P., Weissmann C.
    Nucleic Acids Res. 11:555-573(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Characterization of a mouse interferon gene locus I. Isolation of a cluster of four alpha interferon genes."
    Kelly K.A., Pitha P.M.
    Nucleic Acids Res. 13:805-823(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Characterization of the murine alpha interferon gene family."
    van Pesch V., Lanaya H., Renauld J.C., Michiels T.
    J. Virol. 78:8219-8228(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, GLYCOSYLATION.
    Strain: C57BL/6.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Characterisation and antiproliferative activity of an alpha-type murine interferon from embryonic fibroblasts."
    Beare D., Learmonth M., Wells V., Aitken A., Mallucci L.
    Biochim. Biophys. Acta 1310:81-85(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-51; 124-146 AND 175-181.

Entry informationi

Entry nameiIFNA1_MOUSE
AccessioniPrimary (citable) accession number: P01572
Secondary accession number(s): Q7M0A3, Q810G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 8, 2011
Last modified: February 4, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was named interferon alpha-E (embryonic) based on peptide sequencing (PubMed:9244179). The differences found may be sequencing erros and have not been confirmed by other studies.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.