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P01572

- IFNA1_MOUSE

UniProt

P01572 - IFNA1_MOUSE

Protein

Interferon alpha-1

Gene

Ifna1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

    GO - Molecular functioni

    1. cytokine activity Source: MGI
    2. type I interferon receptor binding Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. B cell differentiation Source: RefGenome
    3. B cell proliferation Source: RefGenome
    4. cytokine-mediated signaling pathway Source: RefGenome
    5. defense response to bacterium Source: MGI
    6. defense response to virus Source: MGI
    7. humoral immune response Source: RefGenome
    8. innate immune response Source: RefGenome
    9. natural killer cell activation involved in immune response Source: MGI
    10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
    11. regulation of MHC class I biosynthetic process Source: RefGenome
    12. response to exogenous dsRNA Source: RefGenome
    13. T cell activation involved in immune response Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Enzyme and pathway databases

    ReactomeiREACT_198521. TRAF6 mediated IRF7 activation.
    REACT_198622. Interferon alpha/beta signaling.
    REACT_198627. Regulation of IFNA signaling.
    REACT_198649. Factors involved in megakaryocyte development and platelet production.
    SABIO-RKP01572.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon alpha-1
    Short name:
    IFN-alpha-1
    Gene namesi
    Name:Ifna1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:107668. Ifna1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 189166Interferon alpha-1PRO_0000016375Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 122By similarity
    Disulfide bondi52 ↔ 162By similarity
    Glycosylationi101 – 1011N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP01572.

    PTM databases

    PhosphoSiteiP01572.

    Expressioni

    Gene expression databases

    BgeeiP01572.
    CleanExiMM_IFNA1.
    GenevestigatoriP01572.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000102751.

    Structurei

    3D structure databases

    ProteinModelPortaliP01572.
    SMRiP01572. Positions 24-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40434.
    GeneTreeiENSGT00590000082966.
    HOVERGENiHBG052086.
    InParanoidiQ810G7.
    KOiK05414.
    OMAiSELEVCL.
    OrthoDBiEOG7M98HV.
    TreeFamiTF336177.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01572-1 [UniParc]FASTAAdd to Basket

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    MARLCAFLMV LAVLSYWPTC SLGCDLPQTH NLRNKRALTL LVQMRRLSPL    50
    SCLKDRKDFG FPQEKVDAQQ IKKAQAIPVL SELTQQILNI FTSKDSSAAW 100
    NTTLLDSFCN DLHQQLNDLQ GCLMQQVGVQ EFPLTQEDAL LAVRKYFHRI 150
    TVYLREKKHS PCAWEVVRAE VWRALSSSAN VLGRLREEK 189
    Length:189
    Mass (Da):21,646
    Last modified:February 8, 2011 - v2
    Checksum:iD6F4BC96DCE7D67E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141L → M no nucleotide entry (PubMed:6188104)Curated
    Sequence conflicti14 – 141L → M in CAA26006. (PubMed:2987811)Curated
    Sequence conflicti102 – 1021T → A no nucleotide entry (PubMed:6188104)Curated
    Sequence conflicti102 – 1021T → A in CAA26006. (PubMed:2987811)Curated
    Sequence conflicti126 – 1261Q → E AA sequence (PubMed:9244179)Curated
    Sequence conflicti132 – 1321F → P AA sequence (PubMed:9244179)Curated
    Sequence conflicti139 – 1391A → Y AA sequence (PubMed:9244179)Curated
    Sequence conflicti145 – 1451K → T AA sequence (PubMed:9244179)Curated
    Sequence conflicti175 – 1751L → M AA sequence (PubMed:9244179)Curated
    Sequence conflicti180 – 1812NV → KL AA sequence (PubMed:9244179)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01974 Genomic DNA. Translation: CAA26006.1.
    AY225950 Genomic DNA. Translation: AAO63592.1.
    BX530016 Genomic DNA. Translation: CAM22267.1.
    CH466527 Genomic DNA. Translation: EDL30958.1.
    CCDSiCCDS18347.1.
    PIRiA01836. IVMSA1.
    S62682.
    RefSeqiNP_034632.2. NM_010502.2.
    UniGeneiMm.57127.

    Genome annotation databases

    EnsembliENSMUST00000094972; ENSMUSP00000092580; ENSMUSG00000095498.
    GeneIDi15962.
    KEGGimmu:15962.
    UCSCiuc008toc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01974 Genomic DNA. Translation: CAA26006.1 .
    AY225950 Genomic DNA. Translation: AAO63592.1 .
    BX530016 Genomic DNA. Translation: CAM22267.1 .
    CH466527 Genomic DNA. Translation: EDL30958.1 .
    CCDSi CCDS18347.1.
    PIRi A01836. IVMSA1.
    S62682.
    RefSeqi NP_034632.2. NM_010502.2.
    UniGenei Mm.57127.

    3D structure databases

    ProteinModelPortali P01572.
    SMRi P01572. Positions 24-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000102751.

    PTM databases

    PhosphoSitei P01572.

    Proteomic databases

    PRIDEi P01572.

    Protocols and materials databases

    DNASUi 15962.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000094972 ; ENSMUSP00000092580 ; ENSMUSG00000095498 .
    GeneIDi 15962.
    KEGGi mmu:15962.
    UCSCi uc008toc.1. mouse.

    Organism-specific databases

    CTDi 3439.
    MGIi MGI:107668. Ifna1.

    Phylogenomic databases

    eggNOGi NOG40434.
    GeneTreei ENSGT00590000082966.
    HOVERGENi HBG052086.
    InParanoidi Q810G7.
    KOi K05414.
    OMAi SELEVCL.
    OrthoDBi EOG7M98HV.
    TreeFami TF336177.

    Enzyme and pathway databases

    Reactomei REACT_198521. TRAF6 mediated IRF7 activation.
    REACT_198622. Interferon alpha/beta signaling.
    REACT_198627. Regulation of IFNA signaling.
    REACT_198649. Factors involved in megakaryocyte development and platelet production.
    SABIO-RK P01572.

    Miscellaneous databases

    NextBioi 288712.
    PROi P01572.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01572.
    CleanExi MM_IFNA1.
    Genevestigatori P01572.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of cloned murine IFN-alpha genes."
      Shaw G.D., Boll W., Taira H., Mantei N., Lengyel P., Weissmann C.
      Nucleic Acids Res. 11:555-573(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Characterization of a mouse interferon gene locus I. Isolation of a cluster of four alpha interferon genes."
      Kelly K.A., Pitha P.M.
      Nucleic Acids Res. 13:805-823(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Characterization of the murine alpha interferon gene family."
      van Pesch V., Lanaya H., Renauld J.C., Michiels T.
      J. Virol. 78:8219-8228(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, GLYCOSYLATION.
      Strain: C57BL/6.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Characterisation and antiproliferative activity of an alpha-type murine interferon from embryonic fibroblasts."
      Beare D., Learmonth M., Wells V., Aitken A., Mallucci L.
      Biochim. Biophys. Acta 1310:81-85(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-51; 124-146 AND 175-181.

    Entry informationi

    Entry nameiIFNA1_MOUSE
    AccessioniPrimary (citable) accession number: P01572
    Secondary accession number(s): Q7M0A3, Q810G7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Was named interferon alpha-E (embryonic) based on peptide sequencing (PubMed:9244179). The differences found may be sequencing erros and have not been confirmed by other studies.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3