ID   IFN17_HUMAN             Reviewed;         189 AA.
AC   P01571; Q14639; Q4KMT4; Q5VZ53; Q7M4Q4;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 2.
DT   27-MAR-2024, entry version 195.
DE   RecName: Full=Interferon alpha-17;
DE            Short=IFN-alpha-17;
DE   AltName: Full=Interferon alpha-88;
DE   AltName: Full=Interferon alpha-I';
DE            Short=LeIF I;
DE   AltName: Full=Interferon alpha-T;
DE   Flags: Precursor;
GN   Name=IFNA17;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6165082; DOI=10.1126/science.6165082;
RA   Lawn R.M., Adelman J., Dull T.J., Gross M., Goeddel D.V., Ullrich A.;
RT   "DNA sequence of two closely linked human leukocyte interferon genes.";
RL   Science 212:1159-1162(1981).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3891272; DOI=10.1089/dna.1985.4.221;
RA   Mizoguchi J., Pitha P.M., Raj N.B.K.;
RT   "Efficient expression in Escherichia coli of two species of human
RT   interferon-alpha and their hybrid molecules.";
RL   DNA 4:221-232(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ARG-184.
RX   PubMed=3767336;
RA   Saveliev V.I., Zlochevsky M.L., Sorokin A.V., Naroditskaya V.A.,
RA   Bolotin A.P., Demyanova N.G., Kozlov Y.I., Neznanov N.S., Gazaryan K.G.,
RA   Monastyrskaya G.S., Sverdlov E.D.;
RT   "[Cloning and the determination of the nucleotide sequences in 2 genes of
RT   human leukocyte interferons].";
RL   Antibiot. Med. Biotekhnol. 31:592-596(1986).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 14-189, AND VARIANT ARG-184.
RX   PubMed=4008999; DOI=10.1089/jir.1985.5.229;
RA   Lund B., von Gabain A., Edlund T., Ny T., Lundgren E.;
RT   "Differential expression of interferon genes in a substrain of Namalwa
RT   cells.";
RL   J. Interferon Res. 5:229-238(1985).
RN   [8]
RP   PROTEIN SEQUENCE OF 24-62, AND FUNCTION.
RX   PubMed=1634550; DOI=10.1016/s0021-9258(18)42167-9;
RA   Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C.,
RA   Nguyen N.Y., Hu R.-Q.;
RT   "Purification and characterization of multiple components of human
RT   lymphoblastoid interferon-alpha.";
RL   J. Biol. Chem. 267:15210-15216(1992).
RN   [9]
RP   PROTEIN SEQUENCE OF 24-58.
RX   PubMed=9425112; DOI=10.1042/bj3290295;
RA   Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.;
RT   "Identification of nine interferon-alpha subtypes produced by Sendai virus-
RT   induced human peripheral blood leucocytes.";
RL   Biochem. J. 329:295-302(1998).
RN   [10]
RP   VARIANT ARG-184.
RX   PubMed=9712362; DOI=10.1089/jir.1998.18.469;
RA   Hussain M., Tan T., Ni D., Gill D.S., Liao M.-J.;
RT   "A new allele of interferon-alpha17 gene encoding IFN-alpha17b is the major
RT   variant in human population.";
RL   J. Interferon Cytokine Res. 18:469-477(1998).
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC       Interferon stimulates the production of two enzymes: a protein kinase
CC       and an oligoadenylate synthetase. {ECO:0000269|PubMed:1634550}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; V00532; CAA23793.1; -; Genomic_DNA.
DR   EMBL; M11026; AAA52725.1; -; mRNA.
DR   EMBL; M38289; AAA59165.1; -; mRNA.
DR   EMBL; AL162420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471071; EAW58617.1; -; Genomic_DNA.
DR   EMBL; BC096732; AAH96732.1; -; mRNA.
DR   EMBL; BC098355; AAH98355.1; -; mRNA.
DR   EMBL; M71246; AAA52713.1; -; mRNA.
DR   CCDS; CCDS6500.1; -.
DR   PIR; A01835; IVHUA9.
DR   PIR; D42753; D42753.
DR   PIR; I51970; I51970.
DR   PIR; I56314; I56314.
DR   RefSeq; NP_067091.1; NM_021268.2.
DR   AlphaFoldDB; P01571; -.
DR   SMR; P01571; -.
DR   BioGRID; 109673; 6.
DR   ComplexPortal; CPX-6005; Interferon alpha receptor-ligand complex, IFNA17 variant.
DR   IntAct; P01571; 7.
DR   STRING; 9606.ENSP00000411940; -.
DR   ChEMBL; CHEMBL3856161; -.
DR   BioMuta; IFNA17; -.
DR   DMDM; 585316; -.
DR   jPOST; P01571; -.
DR   MassIVE; P01571; -.
DR   PaxDb; 9606-ENSP00000411940; -.
DR   PeptideAtlas; P01571; -.
DR   ABCD; P01571; 1 sequenced antibody.
DR   Antibodypedia; 24861; 96 antibodies from 17 providers.
DR   DNASU; 3451; -.
DR   Ensembl; ENST00000413767.2; ENSP00000411940.2; ENSG00000234829.4.
DR   GeneID; 3451; -.
DR   KEGG; hsa:3451; -.
DR   MANE-Select; ENST00000413767.2; ENSP00000411940.2; NM_021268.2; NP_067091.1.
DR   UCSC; uc003zos.1; human.
DR   AGR; HGNC:5422; -.
DR   CTD; 3451; -.
DR   DisGeNET; 3451; -.
DR   GeneCards; IFNA17; -.
DR   HGNC; HGNC:5422; IFNA17.
DR   HPA; ENSG00000234829; Not detected.
DR   MIM; 147583; gene.
DR   neXtProt; NX_P01571; -.
DR   OpenTargets; ENSG00000234829; -.
DR   PharmGKB; PA29661; -.
DR   VEuPathDB; HostDB:ENSG00000234829; -.
DR   eggNOG; ENOG502SQAC; Eukaryota.
DR   GeneTree; ENSGT01000000214430; -.
DR   InParanoid; P01571; -.
DR   OMA; ASSCDRY; -.
DR   OrthoDB; 5358931at2759; -.
DR   PhylomeDB; P01571; -.
DR   TreeFam; TF336177; -.
DR   PathwayCommons; P01571; -.
DR   Reactome; R-HSA-909733; Interferon alpha/beta signaling.
DR   Reactome; R-HSA-912694; Regulation of IFNA/IFNB signaling.
DR   Reactome; R-HSA-933541; TRAF6 mediated IRF7 activation.
DR   Reactome; R-HSA-9705671; SARS-CoV-2 activates/modulates innate and adaptive immune responses.
DR   Reactome; R-HSA-983231; Factors involved in megakaryocyte development and platelet production.
DR   SignaLink; P01571; -.
DR   BioGRID-ORCS; 3451; 12 hits in 1041 CRISPR screens.
DR   GeneWiki; IFNA17; -.
DR   GenomeRNAi; 3451; -.
DR   Pharos; P01571; Tbio.
DR   PRO; PR:P01571; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; P01571; Protein.
DR   Bgee; ENSG00000234829; Expressed in ganglionic eminence.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0098586; P:cellular response to virus; NAS:ComplexPortal.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0009615; P:response to virus; TAS:ProtInc.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0060337; P:type I interferon-mediated signaling pathway; NAS:ComplexPortal.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691:SF66; INTERFERON ALPHA-10-RELATED; 1.
DR   PANTHER; PTHR11691; TYPE I INTERFERON; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
DR   Genevisible; P01571; HS.
PE   1: Evidence at protein level;
KW   Antiviral defense; Cytokine; Direct protein sequencing; Disulfide bond;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:1634550,
FT                   ECO:0000269|PubMed:9425112"
FT   CHAIN           24..189
FT                   /note="Interferon alpha-17"
FT                   /id="PRO_0000016369"
FT   DISULFID        24..122
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..162
FT                   /evidence="ECO:0000250"
FT   VARIANT         184
FT                   /note="I -> R (in dbSNP:rs9298814)"
FT                   /evidence="ECO:0000269|PubMed:3767336,
FT                   ECO:0000269|PubMed:4008999, ECO:0000269|PubMed:9712362"
FT                   /id="VAR_013020"
FT   CONFLICT        57
FT                   /note="H -> P (in Ref. 1; CAA23793)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        60
FT                   /note="G -> E (in Ref. 8; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        78
FT                   /note="S -> P (in Ref. 3; AAA59165)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   189 AA;  21728 MW;  0448EAEAB9D7FC32 CRC64;
     MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF SCLKDRHDFG
     LPQEEFDGNQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW EQSLLEKFST ELYQQLNNLE
     ACVIQEVGME ETPLMNEDSI LAVRKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSLSFSTN
     LQKILRRKD
//