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Protein

Interferon alpha-17

Gene

IFNA17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • type I interferon receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-17
Short name:
IFN-alpha-17
Alternative name(s):
Interferon alpha-88
Interferon alpha-I'
Short name:
LeIF I
Interferon alpha-T
Gene namesi
Name:IFNA17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000234829.4
HGNCiHGNC:5422 IFNA17
MIMi147583 gene
neXtProtiNX_P01571

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3451
OpenTargetsiENSG00000234829
PharmGKBiPA29661

Polymorphism and mutation databases

BioMutaiIFNA17
DMDMi585316

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 232 PublicationsAdd BLAST23
ChainiPRO_000001636924 – 189Interferon alpha-17Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01571
PeptideAtlasiP01571
PRIDEiP01571

Expressioni

Gene expression databases

CleanExiHS_IFNA17
GenevisibleiP01571 HS

Organism-specific databases

HPAiHPA047557

Interactioni

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • type I interferon receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi109673, 6 interactors
STRINGi9606.ENSP00000411940

Structurei

3D structure databases

ProteinModelPortaliP01571
SMRiP01571
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP01571
KOiK05414
OMAiMEETPLM
PhylomeDBiP01571
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01571-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF
60 70 80 90 100
SCLKDRHDFG LPQEEFDGNQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW
110 120 130 140 150
EQSLLEKFST ELYQQLNNLE ACVIQEVGME ETPLMNEDSI LAVRKYFQRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSLSFSTN LQKILRRKD
Length:189
Mass (Da):21,728
Last modified:October 1, 1994 - v2
Checksum:i0448EAEAB9D7FC32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57H → P in CAA23793 (PubMed:6165082).Curated1
Sequence conflicti60G → E AA sequence (PubMed:1634550).Curated1
Sequence conflicti78S → P in AAA59165 (PubMed:3767336).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013020184I → R3 PublicationsCorresponds to variant dbSNP:rs9298814Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00532 Genomic DNA Translation: CAA23793.1
M11026 mRNA Translation: AAA52725.1
M38289 mRNA Translation: AAA59165.1
AL162420 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58617.1
BC096732 mRNA Translation: AAH96732.1
BC098355 mRNA Translation: AAH98355.1
M71246 mRNA Translation: AAA52713.1
CCDSiCCDS6500.1
PIRiA01835 IVHUA9
D42753
I51970
I56314
RefSeqiNP_067091.1, NM_021268.2
UniGeneiHs.282276

Genome annotation databases

EnsembliENST00000413767; ENSP00000411940; ENSG00000234829
GeneIDi3451
KEGGihsa:3451
UCSCiuc003zos.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIFN17_HUMAN
AccessioniPrimary (citable) accession number: P01571
Secondary accession number(s): Q14639
, Q4KMT4, Q5VZ53, Q7M4Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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