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Protein

Interferon alpha-17

Gene

IFNA17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

GO - Molecular functioni

  1. cytokine activity Source: GO_Central
  2. type I interferon receptor binding Source: GO_Central

GO - Biological processi

  1. adaptive immune response Source: GO_Central
  2. B cell differentiation Source: GO_Central
  3. B cell proliferation Source: GO_Central
  4. blood coagulation Source: Reactome
  5. cytokine-mediated signaling pathway Source: GO_Central
  6. defense response to virus Source: UniProtKB-KW
  7. humoral immune response Source: GO_Central
  8. innate immune response Source: GO_Central
  9. natural killer cell activation involved in immune response Source: GO_Central
  10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: GO_Central
  11. regulation of MHC class I biosynthetic process Source: GO_Central
  12. regulation of type I interferon-mediated signaling pathway Source: Reactome
  13. response to exogenous dsRNA Source: GO_Central
  14. response to virus Source: ProtInc
  15. T cell activation involved in immune response Source: GO_Central
  16. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-17
Short name:
IFN-alpha-17
Alternative name(s):
Interferon alpha-88
Interferon alpha-I'
Short name:
LeIF I
Interferon alpha-T
Gene namesi
Name:IFNA17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:5422. IFNA17.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29661.

Polymorphism and mutation databases

BioMutaiIFNA17.
DMDMi585316.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23232 PublicationsAdd
BLAST
Chaini24 – 189166Interferon alpha-17PRO_0000016369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01571.
PRIDEiP01571.

Expressioni

Gene expression databases

CleanExiHS_IFNA17.
GenevestigatoriP01571.

Organism-specific databases

HPAiHPA047557.

Interactioni

Protein-protein interaction databases

BioGridi109673. 6 interactions.
STRINGi9606.ENSP00000411940.

Structurei

3D structure databases

ProteinModelPortaliP01571.
SMRiP01571. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40434.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP01571.
KOiK05414.
OMAiNLEACVI.
OrthoDBiEOG7M98HV.
PhylomeDBiP01571.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01571-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF
60 70 80 90 100
SCLKDRHDFG LPQEEFDGNQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW
110 120 130 140 150
EQSLLEKFST ELYQQLNNLE ACVIQEVGME ETPLMNEDSI LAVRKYFQRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSLSFSTN LQKILRRKD
Length:189
Mass (Da):21,728
Last modified:October 1, 1994 - v2
Checksum:i0448EAEAB9D7FC32
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571H → P in CAA23793 (PubMed:6165082).Curated
Sequence conflicti60 – 601G → E AA sequence (PubMed:1634550).Curated
Sequence conflicti78 – 781S → P in AAA59165 (PubMed:3767336).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti184 – 1841I → R.3 Publications
Corresponds to variant rs9298814 [ dbSNP | Ensembl ].
VAR_013020

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00532 Genomic DNA. Translation: CAA23793.1.
M11026 mRNA. Translation: AAA52725.1.
M38289 mRNA. Translation: AAA59165.1.
AL162420 Genomic DNA. Translation: CAH73185.1.
CH471071 Genomic DNA. Translation: EAW58617.1.
BC096732 mRNA. Translation: AAH96732.1.
BC098355 mRNA. Translation: AAH98355.1.
M71246 mRNA. Translation: AAA52713.1.
CCDSiCCDS6500.1.
PIRiA01835. IVHUA9.
D42753.
I51970.
I56314.
RefSeqiNP_067091.1. NM_021268.2.
UniGeneiHs.282276.

Genome annotation databases

EnsembliENST00000413767; ENSP00000411940; ENSG00000234829.
GeneIDi3451.
KEGGihsa:3451.
UCSCiuc003zos.1. human.

Polymorphism and mutation databases

BioMutaiIFNA17.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00532 Genomic DNA. Translation: CAA23793.1.
M11026 mRNA. Translation: AAA52725.1.
M38289 mRNA. Translation: AAA59165.1.
AL162420 Genomic DNA. Translation: CAH73185.1.
CH471071 Genomic DNA. Translation: EAW58617.1.
BC096732 mRNA. Translation: AAH96732.1.
BC098355 mRNA. Translation: AAH98355.1.
M71246 mRNA. Translation: AAA52713.1.
CCDSiCCDS6500.1.
PIRiA01835. IVHUA9.
D42753.
I51970.
I56314.
RefSeqiNP_067091.1. NM_021268.2.
UniGeneiHs.282276.

3D structure databases

ProteinModelPortaliP01571.
SMRiP01571. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109673. 6 interactions.
STRINGi9606.ENSP00000411940.

Polymorphism and mutation databases

BioMutaiIFNA17.
DMDMi585316.

Proteomic databases

PaxDbiP01571.
PRIDEiP01571.

Protocols and materials databases

DNASUi3451.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000413767; ENSP00000411940; ENSG00000234829.
GeneIDi3451.
KEGGihsa:3451.
UCSCiuc003zos.1. human.

Organism-specific databases

CTDi3451.
GeneCardsiGC09M021227.
HGNCiHGNC:5422. IFNA17.
HPAiHPA047557.
MIMi147583. gene.
neXtProtiNX_P01571.
PharmGKBiPA29661.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40434.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP01571.
KOiK05414.
OMAiNLEACVI.
OrthoDBiEOG7M98HV.
PhylomeDBiP01571.
TreeFamiTF336177.

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Miscellaneous databases

GeneWikiiIFNA17.
GenomeRNAii3451.
NextBioi13596.
PROiP01571.
SOURCEiSearch...

Gene expression databases

CleanExiHS_IFNA17.
GenevestigatoriP01571.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of two closely linked human leukocyte interferon genes."
    Lawn R.M., Adelman J., Dull T.J., Gross M., Goeddel D.V., Ullrich A.
    Science 212:1159-1162(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules."
    Mizoguchi J., Pitha P.M., Raj N.B.K.
    DNA 4:221-232(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "[Cloning and the determination of the nucleotide sequences in 2 genes of human leukocyte interferons]."
    Saveliev V.I., Zlochevsky M.L., Sorokin A.V., Naroditskaya V.A., Bolotin A.P., Demyanova N.G., Kozlov Y.I., Neznanov N.S., Gazaryan K.G., Monastyrskaya G.S., Sverdlov E.D.
    Antibiot. Med. Biotekhnol. 31:592-596(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-184.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Differential expression of interferon genes in a substrain of Namalwa cells."
    Lund B., von Gabain A., Edlund T., Ny T., Lundgren E.
    J. Interferon Res. 5:229-238(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-189, VARIANT ARG-184.
  8. "Purification and characterization of multiple components of human lymphoblastoid interferon-alpha."
    Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q.
    J. Biol. Chem. 267:15210-15216(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-62, FUNCTION.
  9. "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
    Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
    Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-58.
  10. "A new allele of interferon-alpha17 gene encoding IFN-alpha17b is the major variant in human population."
    Hussain M., Tan T., Ni D., Gill D.S., Liao M.-J.
    J. Interferon Cytokine Res. 18:469-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ARG-184.

Entry informationi

Entry nameiIFN17_HUMAN
AccessioniPrimary (citable) accession number: P01571
Secondary accession number(s): Q14639
, Q4KMT4, Q5VZ53, Q7M4Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1994
Last modified: April 29, 2015
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.