P01571 (IFN17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon alpha-17
Short name=IFN-alpha-17

Alternative name(s):
Interferon alpha-88
Interferon alpha-I'
Short name=LeIF I
Interferon alpha-T

Gene names

Name:

IFNA17

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Ref.8
Subcellular location	Secreted.
Sequence similarities	Belongs to the alpha/beta interferon family.

Ontologies

Keywords
Biological process	Antiviral defense
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Traceable author statement. Source: Reactome defense response to virus Inferred from electronic annotation. Source: UniProtKB-KW regulation of type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome response to virus Traceable author statement Ref.2. Source: ProtInc type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular_component	extracellular region Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	interferon-alpha/beta receptor binding Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Ref.8 Ref.9
	Chain	24 – 189	166	Interferon alpha-17		PRO_0000016369
Amino acid modifications
	Disulfide bond	24 ↔ 122		By similarity
	Disulfide bond	52 ↔ 162		By similarity
Natural variations
	Natural variant	184	1	I → R. Ref.3 Ref.7 Ref.10 Corresponds to variant rs9298814 [ dbSNP | Ensembl ].		VAR_013020
Experimental info
	Sequence conflict	57	1	H → P in CAA23793. Ref.1
	Sequence conflict	60	1	G → E AA sequence Ref.8
	Sequence conflict	78	1	S → P in AAA59165. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P01571 [UniParc]. Last modified October 1, 1994. Version 2. Checksum: 0448EAEAB9D7FC32	FASTA	189	21,728
	10 20 30 40 50 60 MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF SCLKDRHDFG 70 80 90 100 110 120 LPQEEFDGNQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW EQSLLEKFST ELYQQLNNLE 130 140 150 160 170 180 ACVIQEVGME ETPLMNEDSI LAVRKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSLSFSTN LQKILRRKD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence of two closely linked human leukocyte interferon genes." Lawn R.M., Adelman J., Dull T.J., Gross M., Goeddel D.V., Ullrich A. Science 212:1159-1162(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules." Mizoguchi J., Pitha P.M., Raj N.B.K. DNA 4:221-232(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"[Cloning and the determination of the nucleotide sequences in 2 genes of human leukocyte interferons]." Saveliev V.I., Zlochevsky M.L., Sorokin A.V., Naroditskaya V.A., Bolotin A.P., Demyanova N.G., Kozlov Y.I., Neznanov N.S., Gazaryan K.G., Monastyrskaya G.S., Sverdlov E.D. Antibiot. Med. Biotekhnol. 31:592-596(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-184.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Differential expression of interferon genes in a substrain of Namalwa cells." Lund B., von Gabain A., Edlund T., Ny T., Lundgren E. J. Interferon Res. 5:229-238(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-189, VARIANT ARG-184.
[8]	"Purification and characterization of multiple components of human lymphoblastoid interferon-alpha." Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q. J. Biol. Chem. 267:15210-15216(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-62, FUNCTION.
[9]	"Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes." Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N. Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-58.
[10]	"A new allele of interferon-alpha17 gene encoding IFN-alpha17b is the major variant in human population." Hussain M., Tan T., Ni D., Gill D.S., Liao M.-J. J. Interferon Cytokine Res. 18:469-477(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT ARG-184.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	V00532 Genomic DNA. Translation: CAA23793.1. M11026 mRNA. Translation: AAA52725.1. M38289 mRNA. Translation: AAA59165.1. AL162420 Genomic DNA. Translation: CAH73185.1. CH471071 Genomic DNA. Translation: EAW58617.1. BC096732 mRNA. Translation: AAH96732.1. BC098355 mRNA. Translation: AAH98355.1. M71246 mRNA. Translation: AAA52713.1.
IPI	IPI00003087.
PIR	IVHUA9. A01835. D42753. I51970. I56314.
RefSeq	NP_067091.1. NM_021268.2.
UniGene	Hs.282276.
3D structure databases
ProteinModelPortal	P01571.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000411940.
Polymorphism databases
DMDM	585316.
Proteomic databases
PaxDb	P01571.
PRIDE	P01571.
Protocols and materials databases
DNASU	3451.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000413767; ENSP00000411940; ENSG00000234829.
GeneID	3451.
KEGG	hsa:3451.
UCSC	uc003zos.1. human.
Organism-specific databases
CTD	3451.
GeneCards	GC09M021227.
HGNC	HGNC:5422. IFNA17.
MIM	147583. gene.
neXtProt	NX_P01571.
PharmGKB	PA29661.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40434.
HOGENOM	HOG000230500.
HOVERGEN	HBG052086.
InParanoid	P01571.
KO	K05414.
OMA	NLEACVI.
OrthoDB	EOG47SSFS.
PhylomeDB	P01571.
Enzyme and pathway databases
Pathway_Interaction_DB	cd8tcrdownstreampathway. Downstream signaling in naive CD8+ T cells.
Reactome	REACT_604. Hemostasis. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	P01571.
CleanEx	HS_IFNA17.
Genevestigator	P01571.
GermOnline	ENSG00000186809. Homo sapiens.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR015589. Interferon_alpha. IPR000471. Interferon_alpha/beta/delta. [Graphical view]
PANTHER	PTHR11691. PTHR11691. 1 hit. PTHR11691:SF9. PTHR11691:SF9. 1 hit.
Pfam	PF00143. Interferon. 1 hit. [Graphical view]
PRINTS	PR00266. INTERFERONAB.
SMART	SM00076. IFabd. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00252. INTERFERON_A_B_D. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3451.
NextBio	13596.
SOURCE	Search...

Entry information

Entry name

IFN17_HUMAN

Accession

Primary (citable) accession number: P01571
Secondary accession number(s): Q14639 , Q4KMT4, Q5VZ53, Q7M4Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	October 1, 1994
Last modified:	May 1, 2013
This is version 129 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.