Reviewed, UniProtKB/Swiss-Prot P01571 (IFN17_HUMAN)

Names and origin

Protein names

Recommended name:
    Interferon alpha-17
Alternative name(s):
    Interferon alpha-I'
      Short name=LeIF I
    Interferon alpha-T
    Interferon alpha-88

Gene names

Name:

IFNA17

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Subcellular location	Secreted.
Sequence similarities	Belongs to the alpha/beta interferon family.

Ontologies

Keywords
Biological process	Antiviral defense
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	defense response Inferred from electronic annotation. Source: InterPro response to virus Ref.2 Traceable author statement. Source: ProtInc
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	interferon-alpha/beta receptor binding Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23
	Chain	24 – 189	166	Interferon alpha-17		PRO_0000016369
Amino acid modifications
	Disulfide bond	24 ↔ 122		By similarity
	Disulfide bond	52 ↔ 162		By similarity
Natural variations
	Natural variant	184	1	I → R: dbSNP rs9298814.		VAR_013020
Experimental info
	Sequence conflict	57	1	H → P in CAA23793. Ref.1
	Sequence conflict	60	1	G → E AA sequence Ref.8
	Sequence conflict	78	1	S → P in AAA59165. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P01571-1 [UniParc]. Last modified October 1, 1994. Version 2. Checksum: 0448EAEAB9D7FC32	FASTA	189	21,728
	10 20 30 40 50 60 MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF SCLKDRHDFG 70 80 90 100 110 120 LPQEEFDGNQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW EQSLLEKFST ELYQQLNNLE 130 140 150 160 170 180 ACVIQEVGME ETPLMNEDSI LAVRKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSLSFSTN LQKILRRKD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence of two closely linked human leukocyte interferon genes." Lawn R.M., Adelman J., Dull T.J., Gross M., Goeddel D.V., Ullrich A. Science 212:1159-1162(1981) [PubMed: 6165082] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules." Mizoguchi J., Pitha P.M., Raj N.B.K. DNA 4:221-232(1985) [PubMed: 3891272] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"[Cloning and the determination of the nucleotide sequences in 2 genes of human leukocyte interferons]." Saveliev V.I., Zlochevsky M.L., Sorokin A.V., Naroditskaya V.A., Bolotin A.P., Demyanova N.G., Kozlov Y.I., Neznanov N.S., Gazaryan K.G., Monastyrskaya G.S., Sverdlov E.D. Antibiot. Med. Biotekhnol. 31:592-596(1986) [PubMed: 3767336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-184.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Differential expression of interferon genes in a substrain of Namalwa cells." Lund B., von Gabain A., Edlund T., Ny T., Lundgren E. J. Interferon Res. 5:229-238(1985) [PubMed: 4008999] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-189, VARIANT ARG-184.
[8]	"Purification and characterization of multiple components of human lymphoblastoid interferon-alpha." Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q. J. Biol. Chem. 267:15210-15216(1992) [PubMed: 1634550] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-62, FUNCTION.
[9]	"Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes." Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N. Biochem. J. 329:295-302(1998) [PubMed: 9425112] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-58.
[10]	"A new allele of interferon-alpha17 gene encoding IFN-alpha17b is the major variant in human population." Hussain M., Tan T., Ni D., Gill D.S., Liao M.-J. J. Interferon Cytokine Res. 18:469-477(1998) [PubMed: 9712362] [Abstract] Cited for: VARIANT ARG-184.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	V00532 Genomic DNA. Translation: CAA23793.1. M11026 mRNA. Translation: AAA52725.1. M38289 mRNA. Translation: AAA59165.1. AL162420 Genomic DNA. Translation: CAH73185.1. CH471071 Genomic DNA. Translation: EAW58617.1. BC096732 mRNA. Translation: AAH96732.1. BC098355 mRNA. Translation: AAH98355.1. M71246 mRNA. Translation: AAA52713.1.
PIR	IVHUA9. A01835. D42753. I51970. I56314.
RefSeq	NP_067091.1.
UniGene	Hs.282276
3D structure databases
HSSP	HSSP built from PDB template 1ITF based on UniProtKB P01563.
SMR	P01571. Positions 24-189.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000214040. Homo sapiens. [Contig view]
GeneID	3451.
KEGG	hsa:3451.
Organism-specific databases
H-InvDB	HIX0034918.
HGNC	HGNC:5422. IFNA17.
MIM	147583. gene.
PharmGKB	PA29661.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P01571.
HOVERGEN	P01571.
Gene expression databases
CleanEx	HS_IFNA17.
GermOnline	ENSG00000186809. Homo sapiens.
Family and domain databases
InterPro	IPR012351. 4_helix_cytokine_core. IPR015589. IFNa. IPR000471. Interferon_abd. [Graphical view]
Gene3D	G3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit.
PANTHER	PTHR11691:SF9. IFNa. 1 hit. PTHR11691. Interferon_abd. 1 hit.
Pfam	PF00143. Interferon. 1 hit. [Graphical view]
PRINTS	PR00266. INTERFERONAB.
ProDom	PD000550. Interferon_abd. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00076. IFabd. 1 hit. [Graphical view]
PROSITE	PS00252. INTERFERON_A_B_D. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	13596.
SOURCE	Search...

Entry information

Entry name

IFN17_HUMAN

Accession

Primary (citable) accession number: P01571
Secondary accession number(s): Q14639 , Q4KMT4, Q5VZ53, Q7M4Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	October 1, 1994
Last modified:	November 25, 2008
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)