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P01571

- IFN17_HUMAN

UniProt

P01571 - IFN17_HUMAN

Protein

Interferon alpha-17

Gene

IFNA17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome
    2. type I interferon receptor binding Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. B cell differentiation Source: RefGenome
    3. B cell proliferation Source: RefGenome
    4. blood coagulation Source: Reactome
    5. cytokine-mediated signaling pathway Source: RefGenome
    6. defense response to virus Source: UniProtKB-KW
    7. humoral immune response Source: RefGenome
    8. innate immune response Source: RefGenome
    9. natural killer cell activation involved in immune response Source: RefGenome
    10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
    11. regulation of MHC class I biosynthetic process Source: RefGenome
    12. regulation of type I interferon-mediated signaling pathway Source: Reactome
    13. response to exogenous dsRNA Source: RefGenome
    14. response to virus Source: ProtInc
    15. T cell activation involved in immune response Source: RefGenome
    16. type I interferon signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Enzyme and pathway databases

    ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon alpha-17
    Short name:
    IFN-alpha-17
    Alternative name(s):
    Interferon alpha-88
    Interferon alpha-I'
    Short name:
    LeIF I
    Interferon alpha-T
    Gene namesi
    Name:IFNA17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:5422. IFNA17.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29661.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23232 PublicationsAdd
    BLAST
    Chaini24 – 189166Interferon alpha-17PRO_0000016369Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 122By similarity
    Disulfide bondi52 ↔ 162By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP01571.
    PRIDEiP01571.

    Expressioni

    Gene expression databases

    CleanExiHS_IFNA17.
    GenevestigatoriP01571.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000411940.

    Structurei

    3D structure databases

    ProteinModelPortaliP01571.
    SMRiP01571. Positions 24-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40434.
    HOGENOMiHOG000230500.
    HOVERGENiHBG052086.
    InParanoidiP01571.
    KOiK05414.
    OMAiNQFQKTQ.
    OrthoDBiEOG7M98HV.
    PhylomeDBiP01571.
    TreeFamiTF336177.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01571-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF    50
    SCLKDRHDFG LPQEEFDGNQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW 100
    EQSLLEKFST ELYQQLNNLE ACVIQEVGME ETPLMNEDSI LAVRKYFQRI 150
    TLYLTEKKYS PCAWEVVRAE IMRSLSFSTN LQKILRRKD 189
    Length:189
    Mass (Da):21,728
    Last modified:October 1, 1994 - v2
    Checksum:i0448EAEAB9D7FC32
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571H → P in CAA23793. (PubMed:6165082)Curated
    Sequence conflicti60 – 601G → E AA sequence (PubMed:1634550)Curated
    Sequence conflicti78 – 781S → P in AAA59165. (PubMed:3767336)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti184 – 1841I → R.3 Publications
    Corresponds to variant rs9298814 [ dbSNP | Ensembl ].
    VAR_013020

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00532 Genomic DNA. Translation: CAA23793.1.
    M11026 mRNA. Translation: AAA52725.1.
    M38289 mRNA. Translation: AAA59165.1.
    AL162420 Genomic DNA. Translation: CAH73185.1.
    CH471071 Genomic DNA. Translation: EAW58617.1.
    BC096732 mRNA. Translation: AAH96732.1.
    BC098355 mRNA. Translation: AAH98355.1.
    M71246 mRNA. Translation: AAA52713.1.
    CCDSiCCDS6500.1.
    PIRiA01835. IVHUA9.
    D42753.
    I51970.
    I56314.
    RefSeqiNP_067091.1. NM_021268.2.
    UniGeneiHs.282276.

    Genome annotation databases

    EnsembliENST00000413767; ENSP00000411940; ENSG00000234829.
    GeneIDi3451.
    KEGGihsa:3451.
    UCSCiuc003zos.1. human.

    Polymorphism databases

    DMDMi585316.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00532 Genomic DNA. Translation: CAA23793.1 .
    M11026 mRNA. Translation: AAA52725.1 .
    M38289 mRNA. Translation: AAA59165.1 .
    AL162420 Genomic DNA. Translation: CAH73185.1 .
    CH471071 Genomic DNA. Translation: EAW58617.1 .
    BC096732 mRNA. Translation: AAH96732.1 .
    BC098355 mRNA. Translation: AAH98355.1 .
    M71246 mRNA. Translation: AAA52713.1 .
    CCDSi CCDS6500.1.
    PIRi A01835. IVHUA9.
    D42753.
    I51970.
    I56314.
    RefSeqi NP_067091.1. NM_021268.2.
    UniGenei Hs.282276.

    3D structure databases

    ProteinModelPortali P01571.
    SMRi P01571. Positions 24-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000411940.

    Polymorphism databases

    DMDMi 585316.

    Proteomic databases

    PaxDbi P01571.
    PRIDEi P01571.

    Protocols and materials databases

    DNASUi 3451.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000413767 ; ENSP00000411940 ; ENSG00000234829 .
    GeneIDi 3451.
    KEGGi hsa:3451.
    UCSCi uc003zos.1. human.

    Organism-specific databases

    CTDi 3451.
    GeneCardsi GC09M021227.
    HGNCi HGNC:5422. IFNA17.
    MIMi 147583. gene.
    neXtProti NX_P01571.
    PharmGKBi PA29661.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40434.
    HOGENOMi HOG000230500.
    HOVERGENi HBG052086.
    InParanoidi P01571.
    KOi K05414.
    OMAi NQFQKTQ.
    OrthoDBi EOG7M98HV.
    PhylomeDBi P01571.
    TreeFami TF336177.

    Enzyme and pathway databases

    Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.

    Miscellaneous databases

    GeneWikii IFNA17.
    GenomeRNAii 3451.
    NextBioi 13596.
    PROi P01571.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_IFNA17.
    Genevestigatori P01571.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of two closely linked human leukocyte interferon genes."
      Lawn R.M., Adelman J., Dull T.J., Gross M., Goeddel D.V., Ullrich A.
      Science 212:1159-1162(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules."
      Mizoguchi J., Pitha P.M., Raj N.B.K.
      DNA 4:221-232(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "[Cloning and the determination of the nucleotide sequences in 2 genes of human leukocyte interferons]."
      Saveliev V.I., Zlochevsky M.L., Sorokin A.V., Naroditskaya V.A., Bolotin A.P., Demyanova N.G., Kozlov Y.I., Neznanov N.S., Gazaryan K.G., Monastyrskaya G.S., Sverdlov E.D.
      Antibiot. Med. Biotekhnol. 31:592-596(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-184.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Differential expression of interferon genes in a substrain of Namalwa cells."
      Lund B., von Gabain A., Edlund T., Ny T., Lundgren E.
      J. Interferon Res. 5:229-238(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-189, VARIANT ARG-184.
    8. "Purification and characterization of multiple components of human lymphoblastoid interferon-alpha."
      Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q.
      J. Biol. Chem. 267:15210-15216(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-62, FUNCTION.
    9. "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
      Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
      Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-58.
    10. "A new allele of interferon-alpha17 gene encoding IFN-alpha17b is the major variant in human population."
      Hussain M., Tan T., Ni D., Gill D.S., Liao M.-J.
      J. Interferon Cytokine Res. 18:469-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ARG-184.

    Entry informationi

    Entry nameiIFN17_HUMAN
    AccessioniPrimary (citable) accession number: P01571
    Secondary accession number(s): Q14639
    , Q4KMT4, Q5VZ53, Q7M4Q4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3