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P01570

- IFN14_HUMAN

UniProt

P01570 - IFN14_HUMAN

Protein

Interferon alpha-14

Gene

IFNA14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 3 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome
    2. cytokine receptor binding Source: ProtInc
    3. type I interferon receptor binding Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. B cell differentiation Source: RefGenome
    3. B cell proliferation Source: RefGenome
    4. blood coagulation Source: Reactome
    5. cytokine-mediated signaling pathway Source: RefGenome
    6. defense response to virus Source: UniProtKB-KW
    7. humoral immune response Source: RefGenome
    8. innate immune response Source: RefGenome
    9. natural killer cell activation involved in immune response Source: RefGenome
    10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
    11. regulation of MHC class I biosynthetic process Source: RefGenome
    12. regulation of type I interferon-mediated signaling pathway Source: Reactome
    13. response to exogenous dsRNA Source: RefGenome
    14. T cell activation involved in immune response Source: RefGenome
    15. type I interferon signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Enzyme and pathway databases

    ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon alpha-14
    Short name:
    IFN-alpha-14
    Alternative name(s):
    Interferon alpha-H
    Short name:
    LeIF H
    Interferon lambda-2-H
    Gene namesi
    Name:IFNA14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:5420. IFNA14.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29659.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23233 PublicationsAdd
    BLAST
    Chaini24 – 189166Interferon alpha-14PRO_0000016367Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 122By similarity
    Disulfide bondi52 ↔ 162By similarity
    Glycosylationi95 – 951N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP01570.
    PRIDEiP01570.

    2D gel databases

    REPRODUCTION-2DPAGEP01570.

    PTM databases

    PhosphoSiteiP01570.
    UniCarbKBiP01570.

    Expressioni

    Gene expression databases

    CleanExiHS_IFNA14.
    GenevestigatoriP01570.

    Organism-specific databases

    HPAiHPA047557.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000369571.

    Structurei

    3D structure databases

    ProteinModelPortaliP01570.
    SMRiP01570. Positions 24-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40434.
    HOGENOMiHOG000230500.
    HOVERGENiHBG052086.
    InParanoidiP01570.
    KOiK05414.
    OMAiNNRRTLM.
    OrthoDBiEOG7M98HV.
    PhylomeDBiP01570.
    TreeFamiTF336177.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01570-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPFALMMA LVVLSCKSSC SLGCNLSQTH SLNNRRTLML MAQMRRISPF    50
    SCLKDRHDFE FPQEEFDGNQ FQKAQAISVL HEMMQQTFNL FSTKNSSAAW 100
    DETLLEKFYI ELFQQMNDLE ACVIQEVGVE ETPLMNEDSI LAVKKYFQRI 150
    TLYLMEKKYS PCAWEVVRAE IMRSLSFSTN LQKRLRRKD 189
    Length:189
    Mass (Da):22,063
    Last modified:July 21, 1986 - v3
    Checksum:iB6B71E2F0D644FE7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti175 – 1751L → F in CAA23803. (PubMed:6163083)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00542 mRNA. Translation: CAA23803.1.
    V00533 Genomic DNA. Translation: CAA23794.1.
    X02959 Genomic DNA. Translation: CAA26705.1.
    AL162420 Genomic DNA. Translation: CAH73187.1.
    CH471071 Genomic DNA. Translation: EAW58616.1.
    BC074956 mRNA. Translation: AAH74956.1.
    BC104159 mRNA. Translation: AAI04160.1.
    BC104160 mRNA. Translation: AAI04161.1.
    CCDSiCCDS6501.1.
    PIRiA42753.
    A92916. IVHU14.
    RefSeqiNP_002163.2. NM_002172.2.
    UniGeneiHs.93907.

    Genome annotation databases

    EnsembliENST00000380222; ENSP00000369571; ENSG00000228083.
    GeneIDi3448.
    KEGGihsa:3448.
    UCSCiuc010mis.3. human.

    Polymorphism databases

    DMDMi20178265.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00542 mRNA. Translation: CAA23803.1 .
    V00533 Genomic DNA. Translation: CAA23794.1 .
    X02959 Genomic DNA. Translation: CAA26705.1 .
    AL162420 Genomic DNA. Translation: CAH73187.1 .
    CH471071 Genomic DNA. Translation: EAW58616.1 .
    BC074956 mRNA. Translation: AAH74956.1 .
    BC104159 mRNA. Translation: AAI04160.1 .
    BC104160 mRNA. Translation: AAI04161.1 .
    CCDSi CCDS6501.1.
    PIRi A42753.
    A92916. IVHU14.
    RefSeqi NP_002163.2. NM_002172.2.
    UniGenei Hs.93907.

    3D structure databases

    ProteinModelPortali P01570.
    SMRi P01570. Positions 24-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000369571.

    PTM databases

    PhosphoSitei P01570.
    UniCarbKBi P01570.

    Polymorphism databases

    DMDMi 20178265.

    2D gel databases

    REPRODUCTION-2DPAGE P01570.

    Proteomic databases

    PaxDbi P01570.
    PRIDEi P01570.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380222 ; ENSP00000369571 ; ENSG00000228083 .
    GeneIDi 3448.
    KEGGi hsa:3448.
    UCSCi uc010mis.3. human.

    Organism-specific databases

    CTDi 3448.
    GeneCardsi GC09M021239.
    HGNCi HGNC:5420. IFNA14.
    HPAi HPA047557.
    MIMi 147579. gene.
    neXtProti NX_P01570.
    PharmGKBi PA29659.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40434.
    HOGENOMi HOG000230500.
    HOVERGENi HBG052086.
    InParanoidi P01570.
    KOi K05414.
    OMAi NNRRTLM.
    OrthoDBi EOG7M98HV.
    PhylomeDBi P01570.
    TreeFami TF336177.

    Enzyme and pathway databases

    Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.

    Miscellaneous databases

    GeneWikii IFNA14.
    GenomeRNAii 3448.
    NextBioi 13588.
    PROi P01570.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_IFNA14.
    Genevestigatori P01570.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The structure of eight distinct cloned human leukocyte interferon cDNAs."
      Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.
      Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "DNA sequence of two closely linked human leukocyte interferon genes."
      Lawn R.M., Adelman J., Dull T.J., Gross M., Goeddel D.V., Ullrich A.
      Science 212:1159-1162(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Purification and characterization of multiple components of human lymphoblastoid interferon-alpha."
      Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q.
      J. Biol. Chem. 267:15210-15216(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-55, FUNCTION.
    8. "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
      Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
      Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-53, GLYCOSYLATION AT ASN-95.
    9. "Identification of glycosylated subtypes of interferon-alpha produced by human leukocytes."
      Shirono H., Koga J., Uemura H., Matsuo A.
      Biosci. Biotechnol. Biochem. 58:1714-1715(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-43.
    10. "Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population."
      Hussain M., Gill D.S., Liao M.-J.
      J. Interferon Cytokine Res. 16:853-859(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: ABSENCE OF POLYMORPHISM.

    Entry informationi

    Entry nameiIFN14_HUMAN
    AccessioniPrimary (citable) accession number: P01570
    Secondary accession number(s): Q5VZ56, Q7M4S1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 150 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3