Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P01570 (IFN14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 148. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon alpha-14

Short name=IFN-alpha-14
Alternative name(s):
Interferon alpha-H
Short name=LeIF H
Interferon lambda-2-H
Gene names
Name:IFNA14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Ref.7

Subcellular location

Secreted.

Sequence similarities

Belongs to the alpha/beta interferon family.

Ontologies

Keywords
   Biological processAntiviral defense
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processB cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

B cell proliferation

Inferred from Biological aspect of Ancestor. Source: RefGenome

T cell activation involved in immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

adaptive immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

blood coagulation

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

defense response to virus

Inferred from electronic annotation. Source: UniProtKB-KW

humoral immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

innate immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

natural killer cell activation involved in immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of peptidyl-serine phosphorylation of STAT protein

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of MHC class I biosynthetic process

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of type I interferon-mediated signaling pathway

Traceable author statement. Source: Reactome

response to exogenous dsRNA

Inferred from Biological aspect of Ancestor. Source: RefGenome

type I interferon signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functioncytokine activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytokine receptor binding

Traceable author statement Ref.1. Source: ProtInc

type I interferon receptor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.7 Ref.8 Ref.9
Chain24 – 189166Interferon alpha-14
PRO_0000016367

Amino acid modifications

Glycosylation951N-linked (GlcNAc...) Ref.8
Disulfide bond24 ↔ 122 By similarity
Disulfide bond52 ↔ 162 By similarity

Experimental info

Sequence conflict1751L → F in CAA23803. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P01570 [UniParc].

Last modified July 21, 1986. Version 3.
Checksum: B6B71E2F0D644FE7

FASTA18922,063
        10         20         30         40         50         60 
MALPFALMMA LVVLSCKSSC SLGCNLSQTH SLNNRRTLML MAQMRRISPF SCLKDRHDFE 

        70         80         90        100        110        120 
FPQEEFDGNQ FQKAQAISVL HEMMQQTFNL FSTKNSSAAW DETLLEKFYI ELFQQMNDLE 

       130        140        150        160        170        180 
ACVIQEVGVE ETPLMNEDSI LAVKKYFQRI TLYLMEKKYS PCAWEVVRAE IMRSLSFSTN 


LQKRLRRKD 

« Hide

References

« Hide 'large scale' references
[1]"The structure of eight distinct cloned human leukocyte interferon cDNAs."
Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.
Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"DNA sequence of two closely linked human leukocyte interferon genes."
Lawn R.M., Adelman J., Dull T.J., Gross M., Goeddel D.V., Ullrich A.
Science 212:1159-1162(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Structural relationship of human interferon alpha genes and pseudogenes."
Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., Hochstadt J., Kovacic T., Pasek M., Schamboeck A., Schmid J., Todokoro K., Waelchli M., Nagata S., Weissmann C.
J. Mol. Biol. 185:227-260(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]"Purification and characterization of multiple components of human lymphoblastoid interferon-alpha."
Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q.
J. Biol. Chem. 267:15210-15216(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-55, FUNCTION.
[8]"Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-53, GLYCOSYLATION AT ASN-95.
[9]"Identification of glycosylated subtypes of interferon-alpha produced by human leukocytes."
Shirono H., Koga J., Uemura H., Matsuo A.
Biosci. Biotechnol. Biochem. 58:1714-1715(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-43.
[10]"Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population."
Hussain M., Gill D.S., Liao M.-J.
J. Interferon Cytokine Res. 16:853-859(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: ABSENCE OF POLYMORPHISM.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V00542 mRNA. Translation: CAA23803.1.
V00533 Genomic DNA. Translation: CAA23794.1.
X02959 Genomic DNA. Translation: CAA26705.1.
AL162420 Genomic DNA. Translation: CAH73187.1.
CH471071 Genomic DNA. Translation: EAW58616.1.
BC074956 mRNA. Translation: AAH74956.1.
BC104159 mRNA. Translation: AAI04160.1.
BC104160 mRNA. Translation: AAI04161.1.
CCDSCCDS6501.1.
PIRA42753.
IVHU14. A92916.
RefSeqNP_002163.2. NM_002172.2.
UniGeneHs.93907.

3D structure databases

ProteinModelPortalP01570.
SMRP01570. Positions 24-189.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000369571.

PTM databases

PhosphoSiteP01570.
UniCarbKBP01570.

Polymorphism databases

DMDM20178265.

2D gel databases

REPRODUCTION-2DPAGEP01570.

Proteomic databases

PaxDbP01570.
PRIDEP01570.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380222; ENSP00000369571; ENSG00000228083.
GeneID3448.
KEGGhsa:3448.
UCSCuc010mis.3. human.

Organism-specific databases

CTD3448.
GeneCardsGC09M021239.
HGNCHGNC:5420. IFNA14.
HPAHPA047557.
MIM147579. gene.
neXtProtNX_P01570.
PharmGKBPA29659.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40434.
HOGENOMHOG000230500.
HOVERGENHBG052086.
InParanoidP01570.
KOK05414.
OMANNRRTLM.
OrthoDBEOG7M98HV.
PhylomeDBP01570.
TreeFamTF336177.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.
REACT_6900. Immune System.

Gene expression databases

CleanExHS_IFNA14.
GenevestigatorP01570.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERPTHR11691. PTHR11691. 1 hit.
PfamPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSPR00266. INTERFERONAB.
SMARTSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIFNA14.
GenomeRNAi3448.
NextBio13588.
PROP01570.
SOURCESearch...

Entry information

Entry nameIFN14_HUMAN
AccessionPrimary (citable) accession number: P01570
Secondary accession number(s): Q5VZ56, Q7M4S1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 9, 2014
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM