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Protein

Interferon alpha-14

Gene

IFNA14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • cytokine receptor binding Source: ProtInc
  • type I interferon receptor binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733. Interferon alpha/beta signaling.
R-HSA-912694. Regulation of IFNA signaling.
R-HSA-933541. TRAF6 mediated IRF7 activation.
R-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-14
Short name:
IFN-alpha-14
Alternative name(s):
Interferon alpha-H
Short name:
LeIF H
Interferon lambda-2-H
Gene namesi
Name:IFNA14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:5420. IFNA14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29659.

Polymorphism and mutation databases

BioMutaiIFNA14.
DMDMi20178265.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23233 PublicationsAdd
BLAST
Chaini24 – 189166Interferon alpha-14PRO_0000016367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity
Glycosylationi95 – 951N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01570.
PRIDEiP01570.

2D gel databases

REPRODUCTION-2DPAGEP01570.

PTM databases

UniCarbKBiP01570.

Expressioni

Gene expression databases

CleanExiHS_IFNA14.
GenevisibleiP01570. HS.

Organism-specific databases

HPAiHPA047557.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • cytokine receptor binding Source: ProtInc
  • type I interferon receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi109671. 9 interactions.
STRINGi9606.ENSP00000369571.

Structurei

3D structure databases

ProteinModelPortaliP01570.
SMRiP01570. Positions 24-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735. Eukaryota.
ENOG410ZH91. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP01570.
KOiK05414.
OMAiSLNNRRT.
OrthoDBiEOG091G0MJ6.
PhylomeDBiP01570.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPFALMMA LVVLSCKSSC SLGCNLSQTH SLNNRRTLML MAQMRRISPF
60 70 80 90 100
SCLKDRHDFE FPQEEFDGNQ FQKAQAISVL HEMMQQTFNL FSTKNSSAAW
110 120 130 140 150
DETLLEKFYI ELFQQMNDLE ACVIQEVGVE ETPLMNEDSI LAVKKYFQRI
160 170 180
TLYLMEKKYS PCAWEVVRAE IMRSLSFSTN LQKRLRRKD
Length:189
Mass (Da):22,063
Last modified:July 21, 1986 - v3
Checksum:iB6B71E2F0D644FE7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751L → F in CAA23803 (PubMed:6163083).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00542 mRNA. Translation: CAA23803.1.
V00533 Genomic DNA. Translation: CAA23794.1.
X02959 Genomic DNA. Translation: CAA26705.1.
AL162420 Genomic DNA. Translation: CAH73187.1.
CH471071 Genomic DNA. Translation: EAW58616.1.
BC074956 mRNA. Translation: AAH74956.1.
BC104159 mRNA. Translation: AAI04160.1.
BC104160 mRNA. Translation: AAI04161.1.
CCDSiCCDS6501.1.
PIRiA42753.
A92916. IVHU14.
RefSeqiNP_002163.2. NM_002172.2.
UniGeneiHs.93907.

Genome annotation databases

EnsembliENST00000380222; ENSP00000369571; ENSG00000228083.
GeneIDi3448.
KEGGihsa:3448.
UCSCiuc010mis.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00542 mRNA. Translation: CAA23803.1.
V00533 Genomic DNA. Translation: CAA23794.1.
X02959 Genomic DNA. Translation: CAA26705.1.
AL162420 Genomic DNA. Translation: CAH73187.1.
CH471071 Genomic DNA. Translation: EAW58616.1.
BC074956 mRNA. Translation: AAH74956.1.
BC104159 mRNA. Translation: AAI04160.1.
BC104160 mRNA. Translation: AAI04161.1.
CCDSiCCDS6501.1.
PIRiA42753.
A92916. IVHU14.
RefSeqiNP_002163.2. NM_002172.2.
UniGeneiHs.93907.

3D structure databases

ProteinModelPortaliP01570.
SMRiP01570. Positions 24-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109671. 9 interactions.
STRINGi9606.ENSP00000369571.

PTM databases

UniCarbKBiP01570.

Polymorphism and mutation databases

BioMutaiIFNA14.
DMDMi20178265.

2D gel databases

REPRODUCTION-2DPAGEP01570.

Proteomic databases

PaxDbiP01570.
PRIDEiP01570.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380222; ENSP00000369571; ENSG00000228083.
GeneIDi3448.
KEGGihsa:3448.
UCSCiuc010mis.4. human.

Organism-specific databases

CTDi3448.
GeneCardsiIFNA14.
HGNCiHGNC:5420. IFNA14.
HPAiHPA047557.
MIMi147579. gene.
neXtProtiNX_P01570.
PharmGKBiPA29659.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J735. Eukaryota.
ENOG410ZH91. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP01570.
KOiK05414.
OMAiSLNNRRT.
OrthoDBiEOG091G0MJ6.
PhylomeDBiP01570.
TreeFamiTF336177.

Enzyme and pathway databases

ReactomeiR-HSA-909733. Interferon alpha/beta signaling.
R-HSA-912694. Regulation of IFNA signaling.
R-HSA-933541. TRAF6 mediated IRF7 activation.
R-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

GeneWikiiIFNA14.
GenomeRNAii3448.
PROiP01570.
SOURCEiSearch...

Gene expression databases

CleanExiHS_IFNA14.
GenevisibleiP01570. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFN14_HUMAN
AccessioniPrimary (citable) accession number: P01570
Secondary accession number(s): Q5VZ56, Q7M4S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 7, 2016
This is version 162 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.