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P01570

- IFN14_HUMAN

UniProt

P01570 - IFN14_HUMAN

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Protein
Interferon alpha-14
Gene
IFNA14
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

GO - Molecular functioni

  1. cytokine activity Source: RefGenome
  2. cytokine receptor binding Source: ProtInc
  3. type I interferon receptor binding Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. B cell differentiation Source: RefGenome
  2. B cell proliferation Source: RefGenome
  3. T cell activation involved in immune response Source: RefGenome
  4. adaptive immune response Source: RefGenome
  5. blood coagulation Source: Reactome
  6. cytokine-mediated signaling pathway Source: RefGenome
  7. defense response to virus Source: UniProtKB-KW
  8. humoral immune response Source: RefGenome
  9. innate immune response Source: RefGenome
  10. natural killer cell activation involved in immune response Source: RefGenome
  11. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
  12. regulation of MHC class I biosynthetic process Source: RefGenome
  13. regulation of type I interferon-mediated signaling pathway Source: Reactome
  14. response to exogenous dsRNA Source: RefGenome
  15. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-14
Short name:
IFN-alpha-14
Alternative name(s):
Interferon alpha-H
Short name:
LeIF H
Interferon lambda-2-H
Gene namesi
Name:IFNA14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:5420. IFNA14.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23233 Publications
Add
BLAST
Chaini24 – 189166Interferon alpha-14
PRO_0000016367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122 By similarity
Disulfide bondi52 ↔ 162 By similarity
Glycosylationi95 – 951N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01570.
PRIDEiP01570.

2D gel databases

REPRODUCTION-2DPAGEP01570.

PTM databases

PhosphoSiteiP01570.
UniCarbKBiP01570.

Expressioni

Gene expression databases

CleanExiHS_IFNA14.
GenevestigatoriP01570.

Organism-specific databases

HPAiHPA047557.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369571.

Structurei

3D structure databases

ProteinModelPortaliP01570.
SMRiP01570. Positions 24-189.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40434.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP01570.
KOiK05414.
OMAiNNRRTLM.
OrthoDBiEOG7M98HV.
PhylomeDBiP01570.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01570-1 [UniParc]FASTAAdd to Basket

« Hide

MALPFALMMA LVVLSCKSSC SLGCNLSQTH SLNNRRTLML MAQMRRISPF    50
SCLKDRHDFE FPQEEFDGNQ FQKAQAISVL HEMMQQTFNL FSTKNSSAAW 100
DETLLEKFYI ELFQQMNDLE ACVIQEVGVE ETPLMNEDSI LAVKKYFQRI 150
TLYLMEKKYS PCAWEVVRAE IMRSLSFSTN LQKRLRRKD 189
Length:189
Mass (Da):22,063
Last modified:July 21, 1986 - v3
Checksum:iB6B71E2F0D644FE7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751L → F in CAA23803. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00542 mRNA. Translation: CAA23803.1.
V00533 Genomic DNA. Translation: CAA23794.1.
X02959 Genomic DNA. Translation: CAA26705.1.
AL162420 Genomic DNA. Translation: CAH73187.1.
CH471071 Genomic DNA. Translation: EAW58616.1.
BC074956 mRNA. Translation: AAH74956.1.
BC104159 mRNA. Translation: AAI04160.1.
BC104160 mRNA. Translation: AAI04161.1.
CCDSiCCDS6501.1.
PIRiA42753.
A92916. IVHU14.
RefSeqiNP_002163.2. NM_002172.2.
UniGeneiHs.93907.

Genome annotation databases

EnsembliENST00000380222; ENSP00000369571; ENSG00000228083.
GeneIDi3448.
KEGGihsa:3448.
UCSCiuc010mis.3. human.

Polymorphism databases

DMDMi20178265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00542 mRNA. Translation: CAA23803.1 .
V00533 Genomic DNA. Translation: CAA23794.1 .
X02959 Genomic DNA. Translation: CAA26705.1 .
AL162420 Genomic DNA. Translation: CAH73187.1 .
CH471071 Genomic DNA. Translation: EAW58616.1 .
BC074956 mRNA. Translation: AAH74956.1 .
BC104159 mRNA. Translation: AAI04160.1 .
BC104160 mRNA. Translation: AAI04161.1 .
CCDSi CCDS6501.1.
PIRi A42753.
A92916. IVHU14.
RefSeqi NP_002163.2. NM_002172.2.
UniGenei Hs.93907.

3D structure databases

ProteinModelPortali P01570.
SMRi P01570. Positions 24-189.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000369571.

PTM databases

PhosphoSitei P01570.
UniCarbKBi P01570.

Polymorphism databases

DMDMi 20178265.

2D gel databases

REPRODUCTION-2DPAGE P01570.

Proteomic databases

PaxDbi P01570.
PRIDEi P01570.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380222 ; ENSP00000369571 ; ENSG00000228083 .
GeneIDi 3448.
KEGGi hsa:3448.
UCSCi uc010mis.3. human.

Organism-specific databases

CTDi 3448.
GeneCardsi GC09M021239.
HGNCi HGNC:5420. IFNA14.
HPAi HPA047557.
MIMi 147579. gene.
neXtProti NX_P01570.
PharmGKBi PA29659.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40434.
HOGENOMi HOG000230500.
HOVERGENi HBG052086.
InParanoidi P01570.
KOi K05414.
OMAi NNRRTLM.
OrthoDBi EOG7M98HV.
PhylomeDBi P01570.
TreeFami TF336177.

Enzyme and pathway databases

Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Miscellaneous databases

GeneWikii IFNA14.
GenomeRNAii 3448.
NextBioi 13588.
PROi P01570.
SOURCEi Search...

Gene expression databases

CleanExi HS_IFNA14.
Genevestigatori P01570.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view ]
PANTHERi PTHR11691. PTHR11691. 1 hit.
Pfami PF00143. Interferon. 1 hit.
[Graphical view ]
PRINTSi PR00266. INTERFERONAB.
SMARTi SM00076. IFabd. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The structure of eight distinct cloned human leukocyte interferon cDNAs."
    Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.
    Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "DNA sequence of two closely linked human leukocyte interferon genes."
    Lawn R.M., Adelman J., Dull T.J., Gross M., Goeddel D.V., Ullrich A.
    Science 212:1159-1162(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Purification and characterization of multiple components of human lymphoblastoid interferon-alpha."
    Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q.
    J. Biol. Chem. 267:15210-15216(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-55, FUNCTION.
  8. "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
    Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
    Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-53, GLYCOSYLATION AT ASN-95.
  9. "Identification of glycosylated subtypes of interferon-alpha produced by human leukocytes."
    Shirono H., Koga J., Uemura H., Matsuo A.
    Biosci. Biotechnol. Biochem. 58:1714-1715(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-43.
  10. "Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population."
    Hussain M., Gill D.S., Liao M.-J.
    J. Interferon Cytokine Res. 16:853-859(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF POLYMORPHISM.

Entry informationi

Entry nameiIFN14_HUMAN
AccessioniPrimary (citable) accession number: P01570
Secondary accession number(s): Q5VZ56, Q7M4S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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