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P01569

- IFNA5_HUMAN

UniProt

P01569 - IFNA5_HUMAN

Protein

Interferon alpha-5

Gene

IFNA5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
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    Functioni

    Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome
    2. cytokine receptor binding Source: ProtInc
    3. type I interferon receptor binding Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. B cell differentiation Source: RefGenome
    3. B cell proliferation Source: RefGenome
    4. blood coagulation Source: Reactome
    5. cytokine-mediated signaling pathway Source: RefGenome
    6. defense response to virus Source: UniProtKB-KW
    7. humoral immune response Source: RefGenome
    8. innate immune response Source: RefGenome
    9. natural killer cell activation involved in immune response Source: RefGenome
    10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
    11. regulation of MHC class I biosynthetic process Source: RefGenome
    12. regulation of type I interferon-mediated signaling pathway Source: Reactome
    13. response to exogenous dsRNA Source: RefGenome
    14. T cell activation involved in immune response Source: RefGenome
    15. type I interferon signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Enzyme and pathway databases

    ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon alpha-5
    Short name:
    IFN-alpha-5
    Alternative name(s):
    Interferon alpha-61
    Interferon alpha-G
    Short name:
    LeIF G
    Gene namesi
    Name:IFNA5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:5426. IFNA5.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29665.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 189168Interferon alpha-5PRO_0000016362Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 122By similarity
    Disulfide bondi52 ↔ 162By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP01569.
    PRIDEiP01569.

    PTM databases

    PhosphoSiteiP01569.

    Expressioni

    Gene expression databases

    BgeeiP01569.
    CleanExiHS_IFNA5.
    GenevestigatoriP01569.

    Organism-specific databases

    HPAiHPA047557.

    Interactioni

    Protein-protein interaction databases

    BioGridi109665. 1 interaction.
    DIPiDIP-6019N.
    STRINGi9606.ENSP00000369560.

    Structurei

    3D structure databases

    ProteinModelPortaliP01569.
    SMRiP01569. Positions 24-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40434.
    HOGENOMiHOG000230500.
    HOVERGENiHBG052086.
    InParanoidiP01569.
    KOiK05414.
    OMAiHSLSNRR.
    OrthoDBiEOG7M98HV.
    PhylomeDBiP01569.
    TreeFamiTF336177.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01569-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPFVLLMA LVVLNCKSIC SLGCDLPQTH SLSNRRTLMI MAQMGRISPF    50
    SCLKDRHDFG FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW 100
    DETLLDKFYT ELYQQLNDLE ACMMQEVGVE DTPLMNVDSI LTVRKYFQRI 150
    TLYLTEKKYS PCAWEVVRAE IMRSFSLSAN LQERLRRKE 189
    Length:189
    Mass (Da):21,942
    Last modified:August 13, 1987 - v1
    Checksum:iC605992FE2E78043
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02956 Genomic DNA. Translation: CAA26702.1.
    AL162420 Genomic DNA. Translation: CAH73189.1.
    BC093755 mRNA. Translation: AAH93755.1.
    BC093757 mRNA. Translation: AAH93757.1.
    V00541 mRNA. Translation: CAA23802.1.
    CCDSiCCDS6502.1.
    PIRiD25843.
    S43716. IVHUA7.
    RefSeqiNP_002160.1. NM_002169.2.
    UniGeneiHs.37113.

    Genome annotation databases

    EnsembliENST00000259555; ENSP00000259555; ENSG00000147873.
    GeneIDi3442.
    KEGGihsa:3442.
    UCSCiuc011lnh.2. human.

    Polymorphism databases

    DMDMi124457.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02956 Genomic DNA. Translation: CAA26702.1 .
    AL162420 Genomic DNA. Translation: CAH73189.1 .
    BC093755 mRNA. Translation: AAH93755.1 .
    BC093757 mRNA. Translation: AAH93757.1 .
    V00541 mRNA. Translation: CAA23802.1 .
    CCDSi CCDS6502.1.
    PIRi D25843.
    S43716. IVHUA7.
    RefSeqi NP_002160.1. NM_002169.2.
    UniGenei Hs.37113.

    3D structure databases

    ProteinModelPortali P01569.
    SMRi P01569. Positions 24-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109665. 1 interaction.
    DIPi DIP-6019N.
    STRINGi 9606.ENSP00000369560.

    PTM databases

    PhosphoSitei P01569.

    Polymorphism databases

    DMDMi 124457.

    Proteomic databases

    PaxDbi P01569.
    PRIDEi P01569.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259555 ; ENSP00000259555 ; ENSG00000147873 .
    GeneIDi 3442.
    KEGGi hsa:3442.
    UCSCi uc011lnh.2. human.

    Organism-specific databases

    CTDi 3442.
    GeneCardsi GC09M021294.
    HGNCi HGNC:5426. IFNA5.
    HPAi HPA047557.
    MIMi 147565. gene.
    neXtProti NX_P01569.
    PharmGKBi PA29665.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40434.
    HOGENOMi HOG000230500.
    HOVERGENi HBG052086.
    InParanoidi P01569.
    KOi K05414.
    OMAi HSLSNRR.
    OrthoDBi EOG7M98HV.
    PhylomeDBi P01569.
    TreeFami TF336177.

    Enzyme and pathway databases

    Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.

    Miscellaneous databases

    GeneWikii IFNA5.
    GenomeRNAii 3442.
    NextBioi 13564.
    PROi P01569.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01569.
    CleanExi HS_IFNA5.
    Genevestigatori P01569.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "The structure of eight distinct cloned human leukocyte interferon cDNAs."
      Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.
      Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-189.
      Tissue: Spleen.
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-36.

    Entry informationi

    Entry nameiIFNA5_HUMAN
    AccessioniPrimary (citable) accession number: P01569
    Secondary accession number(s): Q52LX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3