P01569 (IFNA5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon alpha-5
Short name=IFN-alpha-5

Alternative name(s):
Interferon alpha-61
Interferon alpha-G
Short name=LeIF G

Gene names

Name:

IFNA5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Subcellular location	Secreted.
Sequence similarities	Belongs to the alpha/beta interferon family.

Ontologies

Keywords
Biological process	Antiviral defense
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	blood coagulation Traceable author statement. Source: Reactome regulation of type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome response to virus Inferred from electronic annotation. Source: UniProtKB-KW type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW cytokine receptor binding Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.5
	Chain	22 – 189	168	Interferon alpha-5		PRO_0000016362
Amino acid modifications
	Disulfide bond	24 ↔ 122		By similarity
	Disulfide bond	52 ↔ 162		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P01569 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: C605992FE2E78043	FASTA	189	21,942
	10 20 30 40 50 60 MALPFVLLMA LVVLNCKSIC SLGCDLPQTH SLSNRRTLMI MAQMGRISPF SCLKDRHDFG 70 80 90 100 110 120 FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW DETLLDKFYT ELYQQLNDLE 130 140 150 160 170 180 ACMMQEVGVE DTPLMNVDSI LTVRKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSFSLSAN LQERLRRKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural relationship of human interferon alpha genes and pseudogenes." Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., Hochstadt J., Kovacic T., Pasek M., Schamboeck A., Schmid J., Todokoro K., Waelchli M., Nagata S., Weissmann C. J. Mol. Biol. 185:227-260(1985) [PubMed: 4057246] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"The structure of eight distinct cloned human leukocyte interferon cDNAs." Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W. Nature 290:20-26(1981) [PubMed: 6163083] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-189. Tissue: Spleen.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-36.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X02956 Genomic DNA. Translation: CAA26702.1. AL162420 Genomic DNA. Translation: CAH73189.1. BC093755 mRNA. Translation: AAH93755.1. BC093757 mRNA. Translation: AAH93757.1. V00541 mRNA. Translation: CAA23802.1.
IPI	IPI00003077.
PIR	D25843. IVHUA7. S43716.
RefSeq	NP_002160.1. NM_002169.2.
UniGene	Hs.37113.
3D structure databases
ProteinModelPortal	P01569.
SMR	P01569. Positions 24-189.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6019N.
STRING	P01569.
PTM databases
PhosphoSite	P01569.
Polymorphism databases
DMDM	124457.
Proteomic databases
PRIDE	P01569.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380212; ENSP00000369560; ENSG00000147873.
GeneID	3442.
KEGG	hsa:3442.
UCSC	uc003zov.1. human.
Organism-specific databases
CTD	3442.
GeneCards	GC09M021294.
H-InvDB	HIX0201418.
HGNC	HGNC:5426. IFNA5.
MIM	147565. gene.
neXtProt	NX_P01569.
PharmGKB	PA29665.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG21014.
GeneTree	ENSGT00590000082966.
HOGENOM	HBG507173.
HOVERGEN	HBG052086.
InParanoid	P01569.
OMA	RRTLMIM.
OrthoDB	EOG4KKZ45.
PhylomeDB	P01569.
Enzyme and pathway databases
Pathway_Interaction_DB	cd8tcrdownstreampathway. Downstream signaling in naive CD8+ T cells.
Reactome	REACT_604. Hemostasis. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	P01569.
Bgee	P01569.
CleanEx	HS_IFNA5.
Genevestigator	P01569.
GermOnline	ENSG00000147873. Homo sapiens.
Family and domain databases
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR015589. Interferon_alpha. IPR000471. Interferon_alpha/beta/delta. [Graphical view]
Gene3D	G3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit.
KO	K05414.
PANTHER	PTHR11691:SF9. IFNa. 1 hit. PTHR11691. Interferon_abd. 1 hit.
Pfam	PF00143. Interferon. 1 hit. [Graphical view]
PRINTS	PR00266. INTERFERONAB.
SMART	SM00076. IFabd. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00252. INTERFERON_A_B_D. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	13564.
SOURCE	Search...

Entry information

Entry name

IFNA5_HUMAN

Accession

Primary (citable) accession number: P01569
Secondary accession number(s): Q52LX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	August 13, 1987
Last modified:	December 14, 2011
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.