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Protein

Interferon alpha-5

Gene

IFNA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • cytokine receptor binding Source: ProtInc
  • type I interferon receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-5
Short name:
IFN-alpha-5
Alternative name(s):
Interferon alpha-61
Interferon alpha-G
Short name:
LeIF G
Gene namesi
Name:IFNA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000147873.5
HGNCiHGNC:5426 IFNA5
MIMi147565 gene
neXtProtiNX_P01569

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3442
OpenTargetsiENSG00000147873
PharmGKBiPA29665

Polymorphism and mutation databases

BioMutaiIFNA5
DMDMi124457

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001636222 – 189Interferon alpha-5Add BLAST168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01569
PeptideAtlasiP01569
PRIDEiP01569

PTM databases

iPTMnetiP01569
PhosphoSitePlusiP01569

Expressioni

Gene expression databases

BgeeiENSG00000147873
CleanExiHS_IFNA5
GenevisibleiP01569 HS

Organism-specific databases

HPAiHPA047557

Interactioni

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • cytokine receptor binding Source: ProtInc
  • type I interferon receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi109665, 15 interactors
DIPiDIP-6019N
STRINGi9606.ENSP00000259555

Structurei

3D structure databases

ProteinModelPortaliP01569
SMRiP01569
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP01569
KOiK05414
OMAiEACMMQE
OrthoDBiEOG091G0MJ6
PhylomeDBiP01569
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01569-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPFVLLMA LVVLNCKSIC SLGCDLPQTH SLSNRRTLMI MAQMGRISPF
60 70 80 90 100
SCLKDRHDFG FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW
110 120 130 140 150
DETLLDKFYT ELYQQLNDLE ACMMQEVGVE DTPLMNVDSI LTVRKYFQRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSFSLSAN LQERLRRKE
Length:189
Mass (Da):21,942
Last modified:August 13, 1987 - v1
Checksum:iC605992FE2E78043
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02956 Genomic DNA Translation: CAA26702.1
AL162420 Genomic DNA No translation available.
BC093755 mRNA Translation: AAH93755.1
BC093757 mRNA Translation: AAH93757.1
V00541 mRNA Translation: CAA23802.1
CCDSiCCDS6502.1
PIRiD25843
S43716 IVHUA7
RefSeqiNP_002160.1, NM_002169.2
UniGeneiHs.37113

Genome annotation databases

EnsembliENST00000610521; ENSP00000484479; ENSG00000147873
GeneIDi3442
KEGGihsa:3442
UCSCiuc011lnh.3 human

Similar proteinsi

Entry informationi

Entry nameiIFNA5_HUMAN
AccessioniPrimary (citable) accession number: P01569
Secondary accession number(s): Q52LX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: May 23, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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