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P01569

- IFNA5_HUMAN

UniProt

P01569 - IFNA5_HUMAN

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Protein

Interferon alpha-5

Gene

IFNA5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

  1. cytokine activity Source: RefGenome
  2. cytokine receptor binding Source: ProtInc
  3. type I interferon receptor binding Source: RefGenome

GO - Biological processi

  1. adaptive immune response Source: RefGenome
  2. B cell differentiation Source: RefGenome
  3. B cell proliferation Source: RefGenome
  4. blood coagulation Source: Reactome
  5. cytokine-mediated signaling pathway Source: RefGenome
  6. defense response to virus Source: UniProtKB-KW
  7. humoral immune response Source: RefGenome
  8. innate immune response Source: RefGenome
  9. natural killer cell activation involved in immune response Source: RefGenome
  10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
  11. regulation of MHC class I biosynthetic process Source: RefGenome
  12. regulation of type I interferon-mediated signaling pathway Source: Reactome
  13. response to exogenous dsRNA Source: RefGenome
  14. T cell activation involved in immune response Source: RefGenome
  15. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-5
Short name:
IFN-alpha-5
Alternative name(s):
Interferon alpha-61
Interferon alpha-G
Short name:
LeIF G
Gene namesi
Name:IFNA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:5426. IFNA5.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29665.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 189168Interferon alpha-5PRO_0000016362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01569.
PRIDEiP01569.

PTM databases

PhosphoSiteiP01569.

Expressioni

Gene expression databases

BgeeiP01569.
CleanExiHS_IFNA5.
GenevestigatoriP01569.

Organism-specific databases

HPAiHPA047557.

Interactioni

Protein-protein interaction databases

BioGridi109665. 15 interactions.
DIPiDIP-6019N.
STRINGi9606.ENSP00000369560.

Structurei

3D structure databases

ProteinModelPortaliP01569.
SMRiP01569. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40434.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP01569.
KOiK05414.
OMAiHSLSNRR.
OrthoDBiEOG7M98HV.
PhylomeDBiP01569.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01569-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALPFVLLMA LVVLNCKSIC SLGCDLPQTH SLSNRRTLMI MAQMGRISPF
60 70 80 90 100
SCLKDRHDFG FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW
110 120 130 140 150
DETLLDKFYT ELYQQLNDLE ACMMQEVGVE DTPLMNVDSI LTVRKYFQRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSFSLSAN LQERLRRKE
Length:189
Mass (Da):21,942
Last modified:August 13, 1987 - v1
Checksum:iC605992FE2E78043
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02956 Genomic DNA. Translation: CAA26702.1.
AL162420 Genomic DNA. Translation: CAH73189.1.
BC093755 mRNA. Translation: AAH93755.1.
BC093757 mRNA. Translation: AAH93757.1.
V00541 mRNA. Translation: CAA23802.1.
CCDSiCCDS6502.1.
PIRiD25843.
S43716. IVHUA7.
RefSeqiNP_002160.1. NM_002169.2.
UniGeneiHs.37113.

Genome annotation databases

EnsembliENST00000610521; ENSP00000484479; ENSG00000147873.
GeneIDi3442.
KEGGihsa:3442.
UCSCiuc011lnh.2. human.

Polymorphism databases

DMDMi124457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02956 Genomic DNA. Translation: CAA26702.1 .
AL162420 Genomic DNA. Translation: CAH73189.1 .
BC093755 mRNA. Translation: AAH93755.1 .
BC093757 mRNA. Translation: AAH93757.1 .
V00541 mRNA. Translation: CAA23802.1 .
CCDSi CCDS6502.1.
PIRi D25843.
S43716. IVHUA7.
RefSeqi NP_002160.1. NM_002169.2.
UniGenei Hs.37113.

3D structure databases

ProteinModelPortali P01569.
SMRi P01569. Positions 24-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109665. 15 interactions.
DIPi DIP-6019N.
STRINGi 9606.ENSP00000369560.

PTM databases

PhosphoSitei P01569.

Polymorphism databases

DMDMi 124457.

Proteomic databases

PaxDbi P01569.
PRIDEi P01569.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000610521 ; ENSP00000484479 ; ENSG00000147873 .
GeneIDi 3442.
KEGGi hsa:3442.
UCSCi uc011lnh.2. human.

Organism-specific databases

CTDi 3442.
GeneCardsi GC09M021294.
HGNCi HGNC:5426. IFNA5.
HPAi HPA047557.
MIMi 147565. gene.
neXtProti NX_P01569.
PharmGKBi PA29665.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40434.
GeneTreei ENSGT00760000119150.
HOGENOMi HOG000230500.
HOVERGENi HBG052086.
InParanoidi P01569.
KOi K05414.
OMAi HSLSNRR.
OrthoDBi EOG7M98HV.
PhylomeDBi P01569.
TreeFami TF336177.

Enzyme and pathway databases

Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Miscellaneous databases

GeneWikii IFNA5.
GenomeRNAii 3442.
NextBioi 13564.
PROi P01569.
SOURCEi Search...

Gene expression databases

Bgeei P01569.
CleanExi HS_IFNA5.
Genevestigatori P01569.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view ]
PANTHERi PTHR11691. PTHR11691. 1 hit.
Pfami PF00143. Interferon. 1 hit.
[Graphical view ]
PRINTSi PR00266. INTERFERONAB.
SMARTi SM00076. IFabd. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The structure of eight distinct cloned human leukocyte interferon cDNAs."
    Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.
    Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-189.
    Tissue: Spleen.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36.

Entry informationi

Entry nameiIFNA5_HUMAN
AccessioniPrimary (citable) accession number: P01569
Secondary accession number(s): Q52LX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: October 29, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3